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1. 发明专利

AU2003249284A1 MODULATORS OF CELLULAR PROLIFERATION 未知
公开(公告)号：AU2003249284A1
公开(公告)日：2004-02-02
申请号：AU2003249284
申请日：2003-07-14
申请人： RIGEL PHARMACEUTICALS INC
发明人： HITOSHI YASUMICHI , JENKINS YONCHU , MARKOVTSOV VADIM
IPC分类号： G01N33/50
摘要： The present invention relates to regulation of cellular proliferation. More particularly, the present invention is directed to nucleic acids encoding protein kinase C zeta (PKC-zeta), phospholipase C-beta1 (PLC-beta1), protein tyrosine kinase 2 (FAK), protein tyrosine kinase 2b (FAK2), casein kinase 2 (CK2), cMET tyrosine kinase (cMET), flap structure specific endonuclease 1 (FEN1), REV1 dCMP transferase (REV1), apurinic/apyrimidinic nuclease 1 (APE1), cyclin dependent kinase 3 (CDK3), PIM1 kinase (PIM1), cell division cycle 7 kinase (CDC7L1), cyclin dependent kinase 7 (CDK7), cytokine inducible kinase (CNK), potentially prenylated protein tyrosine phosphatase (PRL-3), serine threonine kinase 2 (STK2) or (NEK4), cyclin dependent serine threonine kinase (NKIAMRE), or histone acetylase (HBO1), which are involved in modulation of cell cycle arrest. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions, antibodies, peptides, cyclic peptides, nucleic acids, RNAi, antisense nucleic acids, and ribozymes, that modulate cell cycle arrest via modulation of protein kinase C zeta (PKC-zeta), phospholipase C-beta1 (PLC-beta1), protein tyrosine kinase 2 (FAK), protein tyrosine kinase 2b (FAK2), casein kinase 2 (CK2), cMET tyrosine kinase (cMET), flap structure specific endonuclease 1 (FEN1), REV1 dCMP transferase (REV1), apurinic/apyrimidinic nuclease 1 (APE1), cyclin dependent kinase 3 (CDK3), PIM1 kinase (PIM1), cell division cycle 7 kinase (CDC7L1), cyclin dependent kinase 7 (CDK7), cytokine inducible kinase (CNK), potentially prenylated protein tyrosine phosphatase (PRL-3), serine threonine kinase 2 (STK2) or (NEK4), cyclin dependent serine threonine kinase (NKIAMRE), or histone acetylase (HBO1), as well as to the use of expression profiles and compositions in diagnosis and therapy related to cell cycle regulation and modulation of cellular proliferation, e.g., for treatment of cancer and other diseases of cellular proliferation.

2. 发明专利

AU2002332441A1 Mre11: modulation of cellular proliferation 未知
公开(公告)号：AU2002332441A1
公开(公告)日：2003-02-17
申请号：AU2002332441
申请日：2002-07-31
申请人： RIGEL PHARMACEUTICALS INC
发明人： HITOSHI YASUMICHI , DEMO SUSAN , JENKINS YONCHU
IPC分类号： C12Q1/34 , G01N33/50 , G01N33/573
摘要： The present invention relates to regulation of cellular proliferation. More particularly, the present invention is directed to nucleic acids encoding MRE11, which is a protein involved in modulation of cellular proliferation. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, and ribozymes, that modulate cellular proliferation via modulation of MRE11; as well as to the use of expression profiles and compositions in diagnosis and therapy related to modulation of cellular proliferation.

3. 发明申请

WO2008118871A2 METHODS OF DETECTING INHIBITORS OF VIF-MEDIATED APOBEC3G DEGRADATION AND HIV 审中-公开
标题翻译：检测VIF介导的APOBEC3G降解和HIV的抑制剂的方法
公开(公告)号：WO2008118871A2
公开(公告)日：2008-10-02
申请号：PCT/US2008058053
申请日：2008-03-24
申请人： RIGEL PHARMACEUTICALS INC , JENKINS YONCHU , SU GUOPING
发明人： JENKINS YONCHU , SU GUOPING
IPC分类号： G01N33/569 , C12Q1/70
CPC分类号： G01N33/56988 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , G01N33/5008 , G01N2500/00
摘要： The invention comprises methods and cell lines for assaying APOBEC3G degradation and methods for identifying inhibitors of APOBEC3G degradation. The invention also provides methods of identifying inhibitors of HIV infection. The methods of the invention are useful for identifying inhibitors of viral infection, in particular, the methods of the invention are useful for treating retroviral infection.
摘要翻译：本发明包括用于测定APOBEC3G降解的方法和细胞系以及鉴定APOBEC3G降解抑制剂的方法。本发明还提供鉴定HIV感染抑制剂的方法。本发明的方法可用于鉴定病毒感染的抑制剂，特别是本发明的方法可用于治疗逆转录病毒感染。

4. 发明专利

ES2320328T3 SAK: MODULACION DE LA PROLIFERACION CELULAR PARA EL TRATAMIENTO DEL CANCER. 未知
公开(公告)号：ES2320328T3
公开(公告)日：2009-05-21
申请号：ES02750377
申请日：2002-07-31
申请人： RIGEL PHARMACEUTICALS INC
发明人： DEMO SUSAN , HITOSHI YASUMICHI , JENKINS YONCHU
IPC分类号： C12Q1/68 , A61K38/00 , A61K39/395 , A61K48/00 , C12Q1/48 , G01N33/53 , G01N33/574
摘要： Un procedimiento para identificar un compuesto capaz de interferir con la unión de un polipéptido de SAK o un fragmento del mismo, comprendiendo el procedimiento las etapas de: (i) combinar un polipéptido de SAK o un fragmento del mismo con un polipéptido de Chk2 y el compuesto, en el que el polipéptido de SAK o el fragmento del mismo tiene actividad cinasa y está codificado por un ácido nucleico que hibrida bajo condiciones rigurosas a un ácido nucleico que codifica un polipéptido que tiene una secuencia de aminoácidos de SEC. ID Nº: 2; y (ii) determinar la unión del polipéptido de SAK o fragmento del mismo a Chk

5. 发明专利

AU2003223661A1 METHODS OF ASSAYING FOR CELL CYCLE MODULATORS 未知
公开(公告)号：AU2003223661A1
公开(公告)日：2003-11-03
申请号：AU2003223661
申请日：2003-04-15
申请人： RIGEL PHARMACEUTICALS INC
发明人： HITOSHI YASUMICHI , JENKINS YONCHU
IPC分类号： C12Q1/68 , G01N33/50 , G01N33/574 , G01N33/68
摘要： The present invention relates to regulation of cellular proliferation. More particularly, the present invention is directed to nucleic acids encoding BRCA-1-Associated Protein-1 (BAP-1), Nuclear Protein 95 (NP95), Fanconi anemia group A protein (FANCA), DEAD/H box polypeptide 9 (DDX9), insulin-like growth factor 1 receptor (IGF1R), ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1), aldehyde dehydrogenase, pyruvate kinase, glucose-6-phosphate dehydrogenase, HCDR-3, DEAD/H box polypeptide 21 (DDX21), serine threonine kinase 15 (ARK2), transmembrane 4 superfamily member 1, or ERCC1, which are involved in modulation of cell cycle arrest. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions, antibodies, peptides, cyclic peptides, nucleic acids, RNAi, antisense nucleic acids, and ribozymes, that modulate cell cycle arrest via modulation of BRCA-1-Associated Protein-1 (BAP-1), Nuclear Protein 95 (NP95), Fanconi anemia group A protein (FANCA), DEAD/H box polypeptide 9 (DDX9), insulin-like growth factor 1 receptor (IGF1R), ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1), aldehyde dehydrogenase, pyruvate kinase, glucose-6-phosphate dehydrogenase, HCDR-3, DEAD/H box polypeptide 21 (DDX21), serine threonine kinase 15 (ARK2), transmembrane 4 superfamily member 1, or ERCC1, as well as to the use of expression profiles and compositions in diagnosis and therapy related to cell cycle regulation and modulation of cellular proliferation, e.g., for treatment of cancer and other diseases of cellular proliferation.

6. 发明申请

WO2015048547A3 METHODS FOR USING AND BIOMARKERS FOR AMPK-ACTIVATING COMPOUNDS 审中-公开
标题翻译： AMPK活化化合物的使用和生物标志物的方法
公开(公告)号：WO2015048547A3
公开(公告)日：2015-06-18
申请号：PCT/US2014057861
申请日：2014-09-26
申请人： RIGEL PHARMACEUTICALS INC , HITOSHI YASUMICHI , JENKINS YONCHU , MARKOVTSOV VADIM , KINSELLA TODD , SUN TIAN-QIANG
发明人： HITOSHI YASUMICHI , JENKINS YONCHU , MARKOVTSOV VADIM , KINSELLA TODD , SUN TIAN-QIANG
IPC分类号： A61P35/00 , A61K31/4427 , A61K31/501 , A61K31/5377
CPC分类号： A61K31/4545 , A61K31/4427 , A61K31/501 , A61K31/5377 , A61K45/06 , C07D401/14 , G01N33/573 , G01N2500/04 , A61K2300/00
摘要： Disclosed are are methods of using AMPK-activating compounds, for example, in the treatment of cancer and disorders of vascular flow. Also disclosed are biomarkers for AMPK and uses thereof, for example, in the diagnosis and treatment of AMPK-linked disorders. In certain embodiments, the AMPK-activating compounds have the structural formula (I), wherein E, J, T, D1, D2, D3, the ring system denoted by "B", T, R3, R4, w and x are as described herein.
摘要翻译：公开了使用AMPK活化化合物的方法，例如用于治疗癌症和血管血流障碍。还公开了AMPK的生物标志物及其用途，例如在诊断和治疗AMPK相关疾病中的用途。在某些实施方案中，AMPK活化化合物具有结构式（I），其中E，J，T，D1，D2，D3，由“B”，T，R3，R4，在此描述。

7. 发明专利

AT419389T 未知
公开(公告)号：AT419389T
公开(公告)日：2009-01-15
申请号：AT02750377
申请日：2002-07-31
申请人： RIGEL PHARMACEUTICALS INC
发明人： DEMO SUSAN , HITOSHI YASUMICHI , JENKINS YONCHU
IPC分类号： C12Q1/68 , A61K38/00 , A61K39/395 , A61K48/00 , C12Q1/48 , G01N33/53 , G01N33/574
摘要： The present invention relates to regulation of cellular proliferation. More particularly, the present invention is directed to nucleic acids encoding SAK, which is a protein kinase involved in modulation of cellular proliferation and cell cycle regulation. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions, antibodies, peptides, cyclic peptides, nucleic acids, RNAi, antisense nucleic acids, and ribozymes, that modulate cell cycle regulation and cellular proliferation via modulation of SAK; as well as to the use of expression profiles and compositions in diagnosis and therapy related to cell cycle regulation and modulation of cellular proliferation, e.g., for treatment of cancer and other diseases of cellular proliferation.

8. 发明专利

AU2003223661A8 Methods of assaying for cell cycle modulators 未知
公开(公告)号：AU2003223661A8
公开(公告)日：2003-11-03
申请号：AU2003223661
申请日：2003-04-15
申请人： RIGEL PHARMACEUTICALS INC
发明人： HITOSHI YASUMICHI , JENKINS YONCHU
IPC分类号： C12Q1/68 , G01N33/50 , G01N33/574 , G01N33/68
摘要： The present invention relates to regulation of cellular proliferation. More particularly, the present invention is directed to nucleic acids encoding BRCA-1-Associated Protein-1 (BAP-1), Nuclear Protein 95 (NP95), Fanconi anemia group A protein (FANCA), DEAD/H box polypeptide 9 (DDX9), insulin-like growth factor 1 receptor (IGF1R), ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1), aldehyde dehydrogenase, pyruvate kinase, glucose-6-phosphate dehydrogenase, HCDR-3, DEAD/H box polypeptide 21 (DDX21), serine threonine kinase 15 (ARK2), transmembrane 4 superfamily member 1, or ERCC1, which are involved in modulation of cell cycle arrest. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions, antibodies, peptides, cyclic peptides, nucleic acids, RNAi, antisense nucleic acids, and ribozymes, that modulate cell cycle arrest via modulation of BRCA-1-Associated Protein-1 (BAP-1), Nuclear Protein 95 (NP95), Fanconi anemia group A protein (FANCA), DEAD/H box polypeptide 9 (DDX9), insulin-like growth factor 1 receptor (IGF1R), ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1), aldehyde dehydrogenase, pyruvate kinase, glucose-6-phosphate dehydrogenase, HCDR-3, DEAD/H box polypeptide 21 (DDX21), serine threonine kinase 15 (ARK2), transmembrane 4 superfamily member 1, or ERCC1, as well as to the use of expression profiles and compositions in diagnosis and therapy related to cell cycle regulation and modulation of cellular proliferation, e.g., for treatment of cancer and other diseases of cellular proliferation.

9. 发明专利

AU2002332441A8 Mre11: modulation of cellular proliferation 未知
公开(公告)号：AU2002332441A8
公开(公告)日：2010-02-11
申请号：AU2002332441
申请日：2002-07-31
申请人： RIGEL PHARMACEUTICALS INC
发明人： HITOSHI YASUMICHI , DEMO SUSAN , JENKINS YONCHU
IPC分类号： C12Q1/68 , A61K38/43 , A61K48/00 , C12N9/00 , C12N9/22 , C12Q1/34 , G01N33/50 , G01N33/573
摘要： The present invention relates to regulation of cellular proliferation. More particularly, the present invention is directed to nucleic acids encoding MRE11, which is a protein involved in modulation of cellular proliferation. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, and ribozymes, that modulate cellular proliferation via modulation of MRE11; as well as to the use of expression profiles and compositions in diagnosis and therapy related to modulation of cellular proliferation.

10. 发明专利

DE60230684D1 未知
公开(公告)号：DE60230684D1
公开(公告)日：2009-02-12
申请号：DE60230684
申请日：2002-07-31
申请人： RIGEL PHARMACEUTICALS INC
发明人： DEMO SUSAN , HITOSHI YASUMICHI , JENKINS YONCHU
IPC分类号： C12Q1/68 , A61K38/00 , A61K39/395 , A61K48/00 , C12Q1/48 , G01N33/53 , G01N33/574
摘要： The present invention relates to regulation of cellular proliferation. More particularly, the present invention is directed to nucleic acids encoding SAK, which is a protein kinase involved in modulation of cellular proliferation and cell cycle regulation. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions, antibodies, peptides, cyclic peptides, nucleic acids, RNAi, antisense nucleic acids, and ribozymes, that modulate cell cycle regulation and cellular proliferation via modulation of SAK; as well as to the use of expression profiles and compositions in diagnosis and therapy related to cell cycle regulation and modulation of cellular proliferation, e.g., for treatment of cancer and other diseases of cellular proliferation.

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