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1. 发明申请

WO2008080138A1 STEREOINVERSION OF AMINO ACIDS 审中-公开
标题翻译：氨基酸的立体异构体
公开(公告)号：WO2008080138A1
公开(公告)日：2008-07-03
申请号：PCT/US2007/088731
申请日：2007-12-21
申请人： RICHMOND CHEMICAL CORPORATION , ARCHER, Ian, Victor James , FOTHERINGHAM, Ian , CARR, Reuben , ARNOLD, Susan, Alison
发明人： ARCHER, Ian, Victor James , FOTHERINGHAM, Ian , CARR, Reuben , ARNOLD, Susan, Alison
IPC分类号： C07C227/30
CPC分类号： C07C227/32 , C07B55/00 , C12P7/58 , C07C229/08
摘要： A process is described to prepare a single enantiomer of an amino acid from its opposite enantiomer or from a racemic mixture, using an oxidase biocatalyst and a supported metal catalyst in separate, sequential reactions in water. The process can be operated in batch or continuous mode.
摘要翻译：描述了一种方法，其中使用氧化酶生物催化剂和负载型金属催化剂，在水中分开连续反应，从其相反对映异构体或外消旋混合物制备氨基酸的单一对映异构体。该过程可以批量或连续模式运行。

2. 发明申请

WO2008108998A3 METHOD TO INCREASE THE YIELD AND IMPROVE PURIFICATION OF PRODUCTS FROM TRANSAMINASE REACTIONS 审中-公开
公开(公告)号：WO2008108998A3
公开(公告)日：2008-09-12
申请号：PCT/US2008/002738
申请日：2008-02-29
申请人： RICHMOND CHEMICAL CORPORATION , FOTHERINGHAM, Ian , OSWALD, Nicholas
发明人： FOTHERINGHAM, Ian , OSWALD, Nicholas
IPC分类号： C12P13/00 , C12P13/04 , C12P13/06 , C12P13/22
摘要： A process for producing high yields of enantioselective amino acids and chiral amines by reacting a keto acid or ketone and an amino acid donor in the presence of a transaminase biocatalyst to produce a keto acid by-product and an amino acid or amine product. Further reacting the keto acid by-product with a peroxide to increase the yield of additional amino acid or amine product.

3. 发明申请

WO2009014722A1 A METHOD FOR DETECTING BIOFUEL PRODUCING MICROBES 审中-公开
标题翻译：一种生物生产微生物检测方法
公开(公告)号：WO2009014722A1
公开(公告)日：2009-01-29
申请号：PCT/US2008/008966
申请日：2008-07-24
申请人： RICHMOND CHEMICAL CORPORATION , FOTHERINGHAM, Ian , KAFTZIK, Nicole , OSWALD, Nicholas
发明人： FOTHERINGHAM, Ian , KAFTZIK, Nicole , OSWALD, Nicholas
IPC分类号： C12Q1/00
CPC分类号： C12Q1/02 , G01N2333/902
摘要： A method for detecting biofuel producing microbes in a colorimetric assay by providing a microbe, a feedstock, and an assay solution. The assay solution contains an alcohol oxidase, a peroxidase, and a peroxidase co-substrate. The microbe is cultured with the feedstock as part of a culture medium that produces a detectable amount of bioalcohol. The culture medium is contacted with the assay solution to produce a colorimetric reaction to screen for a biofuel producing microbe.
摘要翻译：一种通过提供微生物，原料和测定溶液在比色测定中检测生物燃料产生微生物的方法。测定溶液含有醇氧化酶，过氧化物酶和过氧化物酶共底物。将微生物与作为生成可检测量的生物醇的培养基的一部分的原料一起培养。将培养基与测定溶液接触以产生比色反应以筛选生物燃料生产微生物。

4. 发明申请

WO2012071257A1 COMPOSITIONS AND METHODS OF PRODUCING ENTEROKINASE IN YEAST 审中-公开
标题翻译： YEAST生产维生素的组合物和方法
公开(公告)号：WO2012071257A1
公开(公告)日：2012-05-31
申请号：PCT/US2011/061334
申请日：2011-11-18
申请人： ALLERGAN, INC. , FOTHERINGHAM, Ian , SHEFFIELD, Peter J.
发明人： FOTHERINGHAM, Ian , SHEFFIELD, Peter J.
IPC分类号： C12N9/64
CPC分类号： C12P21/06 , C12N9/6424 , C12N15/81
摘要： The present specification disclose polynucleotide molecules encoding an enterokinase, yeast expression constructs including a yeast expression vector and a polynucleotide molecules encoding an enterokinase, yeast cells comprising such a yeast expression construct, methods of producing enterokinase using such yeast cells, and method of cleaving or preparing a recombinant polypeptide using an enterokinase produced by such methods.
摘要翻译：本说明书公开了编码肠激酶的多核苷酸分子，包含酵母表达载体和编码肠激酶的多核苷酸分子的酵母表达构建体，包含这样的酵母表达构建体的酵母细胞，使用这种酵母细胞产生肠激酶的方法，以及切割或制备方法使用由这些方法产生的肠激酶的重组多肽。

5. 发明申请

WO2004081226A3 CARBOXYLIC ACID REDUCTASE POLYPEPTIDE, NUCLEOTIDE SEQUENCE ENCODING SAME AND METHODS OF USE 审中-公开
公开(公告)号：WO2004081226A3
公开(公告)日：2004-09-23
申请号：PCT/US2004/006984
申请日：2004-03-08
申请人： UNIVERSITY OF IOWA RESEARCH FOUNDATION , ROSAZZA, John, P. , DANIELS, Lacy , HE, Aimin , LI, Tao , FOTHERINGHAM, Ian
发明人： ROSAZZA, John, P. , DANIELS, Lacy , HE, Aimin , LI, Tao , FOTHERINGHAM, Ian
IPC分类号： C12N9/00 , C12N1/20 , C12N15/00 , C12Q1/00 , C12Q1/34 , C12Q1/68 , C12P21/06 , C12P21/04 , A61K38/44 , C07H21/04 , C07K1/00 , C07K16/00
摘要： The invention provides the nucleotide sequence and amino acid sequence for the enzyme carboxylic acid reductase isolated from bacteria. Expression cassettes, vectors, transformed cells, and variants are also provided as methods for use of recombinant biocatalytic reagents in production of synthetic, aromatic, aliphatic and alicyclic aldehydes and alcohols.

6. 发明申请

WO2003052374A2 METHODS FOR IDENTIFYING RACEMASES 审中-公开
标题翻译：识别场地的方法
公开(公告)号：WO2003052374A2
公开(公告)日：2003-06-26
申请号：PCT/US2002/024485
申请日：2002-08-02
申请人： THERMOGEN, INC. , FOTHERINGHAM, Ian , ROYER, Sylvain
发明人： FOTHERINGHAM, Ian , ROYER, Sylvain
IPC分类号： G01N
CPC分类号： C12Q1/533 , C12N9/90
摘要： This invention describes methods for the identification of enzymes from the enolase superfamily with racemase activity for industrial applications. The methods comprise obtaining a micro-organism which requires the enzyme with the acquired racemase activity to grow in a selective medium. The micro-organism is transformed with a gene encoding the enzyme, grown in the selective medium supplemented with a substrate of the racemase, and one or more micro-organism(s) that is able to grow in the supplemented selective medium is then isolated, thereby identifying the enzyme with the acquired activity. The methods further comprise genetic alterations of the genes that encode enzymes resulting in the acquired racemase.
摘要翻译：本发明描述了从用于工业应用的消旋酶活性鉴定来自烯醇化酶超家族的酶的方法。所述方法包括获得需要具有获得的消旋酶活性的酶在选择性培养基中生长的微生物。微生物用编码酶的基因转化，在补充有消旋酶底物的选择培养基中生长，然后分离能够在补充的选择培养基中生长的一种或多种微生物，从而鉴定获得的活性的酶。所述方法还包括编码产生所获得的消旋酶的酶的基因的遗传改变。

7. 发明申请

WO2005113759A2 MICROBIAL PRODUCTION OF XYLITOL VIA A HEXOSE PHOSPHATE AND A PENTOSE PHOSPHATE INTERMEDIATE 审中-公开
标题翻译：通过磷酸氢铵和磷酸氢盐中间体生产XYLITOL的微生物
公开(公告)号：WO2005113759A2
公开(公告)日：2005-12-01
申请号：PCT/US2005/017550
申请日：2005-05-19
申请人： BIOTECHNOLOGY RESEARCH AND DEVELOPMENT CORPORATION , ARGRICULTURAL RESEARCH SERVICE, UNITED STATES DEPARTEMENT OF AGRICULTURE , FOTHERINGHAM, Ian , TAYLOR, Paul , DEMIRJIAN, David , OSWALD, Nick, Edinburgh
发明人： FOTHERINGHAM, Ian , TAYLOR, Paul , DEMIRJIAN, David , OSWALD, Nick, Edinburgh
IPC分类号： C12N9/00
CPC分类号： C12P19/02 , C12P7/18 , C12P9/00
摘要： The invention provides methods and compositions for production of xylitol, xylose, or combinations thereof from simple sugars from biosynthetic pathway that utilize D-fructose-6-phosphate and D-xylulose-5-phosphate as pathway intermediates.
摘要翻译：本发明提供了从利用D-果糖-6-磷酸和D-木酮糖-5-磷酸作为途径中间体的生物合成途径的简单糖生产木糖醇，木糖或其组合的方法和组合物。

8. 发明申请

WO2005113774A3 METHODS FOR PRODUCTION OF XYLITOL IN MICROORGANISMS 审中-公开
公开(公告)号：WO2005113774A3
公开(公告)日：2005-12-01
申请号：PCT/US2005/017567
申请日：2005-05-19
申请人： BIOTECHNOLOGY RESEARCH AND DEVELOPMENT CORPORATION , AGRICULTURAL RESEARCH SERVICE, UNITED STATES DEPARTMENT OF AGRICULTURE , TAYLOR, Paul , FOTHERINGHAM, Ian , WYMER, Nathan , SAHA, Badal , DEMIRJIAN, David , SAKAKIBARA, Yoshikiyo , RACINE, Francis, Michael
发明人： TAYLOR, Paul , FOTHERINGHAM, Ian , WYMER, Nathan , SAHA, Badal , DEMIRJIAN, David , SAKAKIBARA, Yoshikiyo , RACINE, Francis, Michael
IPC分类号： C12N1/21 , C12N9/04 , C12N9/12 , C12N9/92 , C12P7/18 , C12P19/02 , C07K14/245
摘要： The invention provides biosynthetic routes to xylitol production that do not require pure D-xylose for synthesis and that can utilize inexpensive substrates such as hemicellulose hydrolysates.

9. 发明申请

WO2004042047A1 MUTANTS FOR THE PREPARATION OF D-AMINO ACIDS 审中-公开
标题翻译：用于制备D-氨基酸的突变体
公开(公告)号：WO2004042047A1
公开(公告)日：2004-05-21
申请号：PCT/EP2003/011432
申请日：2003-10-15
申请人： DEGUSSA AG , MAY, Oliver , BUCHHOLZ, Stefan , SCHWARM, Michael , DRAUZ, Karlheinz , TURNER, Robert J. , FOTHERINGHAM, Ian
发明人： MAY, Oliver , BUCHHOLZ, Stefan , SCHWARM, Michael , DRAUZ, Karlheinz , TURNER, Robert J. , FOTHERINGHAM, Ian
IPC分类号： C12N9/06
CPC分类号： C12R1/19 , C12N9/0024 , C12N9/86 , C12N9/90 , C12P13/04 , C12P41/009
摘要： The present invention relates to specific E. coli mutants which can be used for the synthesis of D-amino acids, and to such a process. The mutants are distinguished by deficiencies in particular enzymes which break down D-amino acids.
摘要翻译：本发明涉及可用于合成D-氨基酸的特异性大肠杆菌突变体，以及这种方法。突变体的特征在于分解D-氨基酸的特定酶的缺陷。

10. 发明公开

EP2179051A1 A METHOD FOR DETECTING BIOFUEL PRODUCING MICROBES 审中-公开
标题翻译：检测生物燃料微生物的方法
公开(公告)号：EP2179051A1
公开(公告)日：2010-04-28
申请号：EP08780298.9
申请日：2008-07-24
申请人： Richmond Chemical Corporation
发明人： FOTHERINGHAM, Ian , KAFTZIK, Nicole , OSWALD, Nicholas
IPC分类号： C12Q1/00
CPC分类号： C12Q1/02 , G01N2333/902
摘要： A method for detecting biofuel producing microbes in a colorimetric assay by providing a microbe, a feedstock, and an assay solution. The assay solution contains an alcohol oxidase, a peroxidase, and a peroxidase co-substrate. The microbe is cultured with the feedstock as part of a culture medium that produces a detectable amount of bioalcohol. The culture medium is contacted with the assay solution to produce a colorimetric reaction to screen for a biofuel producing microbe.
摘要翻译：通过提供微生物，原料和测定溶液，在比色测定中检测生物燃料生产微生物的方法。分析溶液含有醇氧化酶，过氧化物酶和过氧化物酶共底物。微生物与原料一起培养，作为产生可检测量的生物醇的培养基的一部分。培养基与测定溶液接触以产生比色反应以筛选生物燃料生产微生物。

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