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1. 发明申请

WO2008080138A1 STEREOINVERSION OF AMINO ACIDS 审中-公开
标题翻译：氨基酸的立体异构体
公开(公告)号：WO2008080138A1
公开(公告)日：2008-07-03
申请号：PCT/US2007/088731
申请日：2007-12-21
申请人： RICHMOND CHEMICAL CORPORATION , ARCHER, Ian, Victor James , FOTHERINGHAM, Ian , CARR, Reuben , ARNOLD, Susan, Alison
发明人： ARCHER, Ian, Victor James , FOTHERINGHAM, Ian , CARR, Reuben , ARNOLD, Susan, Alison
IPC分类号： C07C227/30
CPC分类号： C07C227/32 , C07B55/00 , C12P7/58 , C07C229/08
摘要： A process is described to prepare a single enantiomer of an amino acid from its opposite enantiomer or from a racemic mixture, using an oxidase biocatalyst and a supported metal catalyst in separate, sequential reactions in water. The process can be operated in batch or continuous mode.
摘要翻译：描述了一种方法，其中使用氧化酶生物催化剂和负载型金属催化剂，在水中分开连续反应，从其相反对映异构体或外消旋混合物制备氨基酸的单一对映异构体。该过程可以批量或连续模式运行。

2. 发明申请

WO2005080265A3 PROCESS FOR PREPARING LITHIUM AMIDE AND A COMPOSITION OBTAINABLE BY SAID PROCESS 审中-公开
公开(公告)号：WO2005080265A3
公开(公告)日：2005-09-01
申请号：PCT/GB2005/000480
申请日：2005-02-14
申请人： AVECIA PHARMACEUTICALS LIMITED , ARCHER, Ian, Victor, James , HAMILL, Noel, Anthony
发明人： ARCHER, Ian, Victor, James , HAMILL, Noel, Anthony
IPC分类号： C01B21/092
摘要： There is provided a process for preparing a lithium amide composition in which in a first step lithium metal is brought into contact with ammonia to form lithium bronze and in a second step the lithium bronze is reacted with a 1,3-diene or an arylolefin, such as butadiene, isoprene, piperylene, dimethylbutadiene, hexadiene, styrene, methyl styrene, divinylbenzene, naphthalene or anthracene, in the presence of a solvent wherein the temperature is maintained at or below the boiling point of ammonia. Examples of solvents include pentane, cyclopentane, hexane, heptane, octane, cyclohexane, toluene, xylene, cumene, ethyl benzene, tetraline, diethyl ether, tetrahydrofuran (THF), 2-methyl-THF, tetrahydropyran, diisopropyl ether, dibutyl ether, dioxan, methyl-tert-butyl ether or glycol ether. Lithium amide compositions obtainable by said process show improved activity, particularly in reactions involving enolate formation.

3. 发明申请

WO2005080265A2 PROCESS FOR PREPARING LITHIUM AMIDE AND A COMPOSITION OBTAINABLE BY SAID PROCESS 审中-公开
标题翻译：制备酰胺和制备方法可以得到的组合物的方法
公开(公告)号：WO2005080265A2
公开(公告)日：2005-09-01
申请号：PCT/GB2005000480
申请日：2005-02-14
申请人： AVECIA PHARMACEUTICALS LTD , ARCHER IAN VICTOR JAMES , HAMILL NOEL ANTHONY
发明人： ARCHER IAN VICTOR JAMES , HAMILL NOEL ANTHONY
IPC分类号： C01B21/092 , C01B21/00
CPC分类号： C01B21/0926
摘要： There is provided a process for preparing a lithium amide composition in which in a first step lithium metal is brought into contact with ammonia to form lithium bronze and in a second step the lithium bronze is reacted with a 1,3-diene or an arylolefin, such as butadiene, isoprene, piperylene, dimethylbutadiene, hexadiene, styrene, methyl styrene, divinylbenzene, naphthalene or anthracene, in the presence of a solvent wherein the temperature is maintained at or below the boiling point of ammonia. Examples of solvents include pentane, cyclopentane, hexane, heptane, octane, cyclohexane, toluene, xylene, cumene, ethyl benzene, tetraline, diethyl ether, tetrahydrofuran (THF), 2-methyl-THF, tetrahydropyran, diisopropyl ether, dibutyl ether, dioxan, methyl-tert-butyl ether or glycol ether. Lithium amide compositions obtainable by said process show improved activity, particularly in reactions involving enolate formation.
摘要翻译：提供了一种制备氨基锂组合物的方法，其中在第一步中，使锂金属与氨接触形成青铜，第二步是将青铜与1,3-二烯烃或芳烃烯烃反应，例如丁二烯，异戊二烯，戊间二烯，二甲基丁二烯，己二烯，苯乙烯，甲基苯乙烯，二乙烯基苯，萘或蒽在溶剂存在下，其中温度保持在氨或沸点以下。溶剂的实例包括戊烷，环戊烷，己烷，庚烷，辛烷，环己烷，甲苯，二甲苯，枯烯，乙苯，四氢化萘，乙醚，四氢呋喃（THF），2-甲基THF，四氢吡喃，二异丙基醚，二丁醚，二恶烷，甲基叔丁基醚或二醇醚。通过所述方法可获得的酰胺组合物显示改善的活性，特别是在涉及烯醇化物形成的反应中。

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