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1. 发明申请

WO2013077832A2 ALUMINUM COMPOSITIONS OF ENHANCED EFFICACY HAVING HIGH HPLC BANDS IL L AND IV 审中-公开
标题翻译：具有高效液相色谱法增强效能的铝组合物IL L和IV
公开(公告)号：WO2013077832A2
公开(公告)日：2013-05-30
申请号：PCT/US2007070374
申请日：2007-11-19
申请人： REHEIS INC , LI ZIJUN , REREK MARK , JANAK KEVIN
发明人： LI ZIJUN , REREK MARK , JANAK KEVIN
IPC分类号： A61K8/26 , A61Q15/00
CPC分类号： A61Q15/00 , A61K8/26
摘要： Novel aluminum antiperspiram compositions of enhanced efficacy activated by both heat and acid are produced comprising basic aluminum salts of having the formula: Al2(OH)6-aXa wherein X is CI-, Br-, I -, or NO3 -. a is from abut 1.1 10 about 1.7, with basic aluminum chloride being the preferred salt. When analyzed by SEC-HPLC at: about 10% concentration (i.e., by 2% A1 ) in water, these compositions exhibit an SEC-HPLC Band I area of less than 10%, a Band III area of at 'least 20%, with a Band III/II area ratio of at l east 0.7. a Band IV area of at least 20%, and have at least 60% aluminum species contained in Bands III and Band IV.
摘要翻译：产生由热和酸热活化的增强功效的新型铝止汗皮组合物，其包含具有下式的碱式铝盐：Al 2（OH）6-aXa，其中X为Cl-，Br-，I - 或NO 3 - 。 a为约1.1×10约1.7，碱性氯化铝为优选的盐。当通过SEC-HPLC分析：在水中约10％浓度（即，2％A1）时，这些组合物显示小于10％的SEC-HPLC带I面积，至少20％的Band III面积，乐队III / II面积比在东部0.7。至少20％的Band IV面积，并且在带III和乐队IV中含有至少60％的铝种类。

2. 发明申请

WO2007098400A3 STABLE BUFERED ALUMINUM COMPOSITIONS HAVING HIGH HPLC BANDS III AND IV CONTAINING CALCIUM/STRONTIUM 审中-公开
标题翻译：具有包含钙/锶的高效液相色谱柱III和IV的稳定的保护的铝组合物
公开(公告)号：WO2007098400A3
公开(公告)日：2010-02-18
申请号：PCT/US2007062306
申请日：2007-02-16
申请人： REHEIS INC , LI ZIJUN , REREK MARK
发明人： LI ZIJUN , REREK MARK
IPC分类号： A61Q15/00 , A61K8/26
CPC分类号： A61K8/26 , A61K2800/52 , A61Q15/00
摘要： A novel aluminum antiperspirant active composition of enhanced efficacy is provided. The composition is activated by both heat and acid and characterized by having high HPLC Band III and high HPLC Band IV, prepared by the addition of an acid such as AlCl3 to (1) the aluminum calcium and/or strontium betaine solutions, where the calcium and/or strontium is derived from a soluble salt such as calcium and/or strontium chloride or nitrate and (2) the aluminum calcium and/or strontium glycine and/or betaine solutions, where calcium and/or strontium is from strongly alkaline calcium/strontium oxide or hydroxide. The novel aluminum compositions derived according to the invention have HPLC Band I of less than 2%; a Band III of at least 20%; a Band III/II ratio of at least about 0.7; and a Band IV of at least 20%.
摘要翻译：提供了一种增强功效的新型铝止汗剂活性组合物。组合物由热和酸两者活化，其特征在于通过加入酸（例如AlCl 3）制备的（1）铝钙和/或锶甜菜碱溶液制备的具有高的HPLC带III和高的HPLC带IV，其中钙和/或锶衍生自可溶性盐如钙和/或氯化锶或硝酸锶和（2）铝钙和/或锶甘氨酸和/或甜菜碱溶液，其中钙和/或锶来自强碱性钙/ 氧化锶或氢氧化物。根据本发明衍生的新型铝组合物具有小于2％的HPLC带I; 至少20％的乐队III; 至少约0.7的Band III / II比率; 和一个至少20％的乐队IV。

3. 发明申请

WO2008063188A2 BETAINE WITH CALCIUM AND/OR STRONTIUM ANTIPERSPIRANTS 审中-公开
标题翻译：与钙和/或锶抗生素的BETAINE
公开(公告)号：WO2008063188A2
公开(公告)日：2008-05-29
申请号：PCT/US2006060512
申请日：2006-11-03
申请人： REHEIS INC , LI ZIJUN , REREK MARK
发明人： LI ZIJUN , REREK MARK
IPC分类号： A61K8/44 , A61Q15/00
CPC分类号： A61Q15/00 , A61K8/19 , A61K8/44
摘要： Aluminum and aluminum-zirconium antiperspirant compositions comprising basic aluminum chlorides that have a particular molecular size distribution defined by having an SEC-HPLC Band III/II ratio of at least 0.5, having SEC-HPLC Band III plus Band II area of at least 70% of the total area and having SEC-HPLC Band I content no more than 5% and containing betaine (trimethylglycine), calcium and/or strontium are disclosed. Also disclosed are the methods of making these compositions and the use thereof in consumer acceptable antiperspirant vehicles such as aerosols, gels, roll-on, sticks and soft solids.
摘要翻译：铝和铝 - 锆止汗剂组合物，其包含碱性氯化铝，其具有通过具有至少0.5的SEC-HPLC Band III / II比率限定的特定分子尺寸分布，SEC-HPLC带III加上带II面积至少为70％的总面积，并且SEC-HPLC带I含量不超过5％，并且含有甜菜碱（三甲基甘氨酸），钙和/或锶。还公开了使这些组合物及其在消费者可接受的止汗剂载体如气溶胶，凝胶，滚涂，粘合剂和软固体中的用途的方法。

4. 发明专利

AU2004258836A1 Compositions containing phenethyl aryl esters as solubilizing agents for active organic compounds 未知
公开(公告)号：AU2004258836A1
公开(公告)日：2005-02-03
申请号：AU2004258836
申请日：2004-06-02
申请人： STEVEN BERTZ , SAMUEL D ARCANGELIS , MAKAROVSKY ILYA , REREK MARK
发明人： MAKAROVSKY ILYA , ARCANGELIS SAMUEL T D , REREK MARK , BERTZ STEVEN H
IPC分类号： C07C67/03 , A01N25/02 , A61K8/37 , A61Q17/04 , A61Q19/08 , C07C67/08
摘要： An active or functional organic compound is solubilized in a phenylethyl ester, e.g. an aryl carboxylic ester of 2-phenylethyl alcohol, as a solvent, cosolvent or additive, to form a composition thereof. Representative active or functional organic compounds include personal care products, e.g. sunscreens containing UVA/UVB absorbing compounds, such as avobenzone and benzophenone-3. Such compositions also show increased critical wavelength and UVA/UVB absorbance ratio performance properties.

5. 发明申请

WO2005009341A3 COMPOSITIONS CONTAINING PHENETHYL ARYL ESTERS AS SOLUBILIZING AGENTS FOR ACTIVE ORGANIC COMPOUNDS 审中-公开
标题翻译：含有作为活性有机化合物增溶剂的乙烯基芳基酯的组合物
公开(公告)号：WO2005009341A3
公开(公告)日：2005-12-22
申请号：PCT/US2004017500
申请日：2004-06-02
申请人： BERTZ STEVEN H , D ARCANGELIS SAMUEL T , MAKAROVSKY ILYA , REREK MARK
发明人： BERTZ STEVEN H , D ARCANGELIS SAMUEL T , MAKAROVSKY ILYA , REREK MARK
IPC分类号： A01N25/02 , A61K8/37 , A61Q17/04 , A61Q19/08 , C07C67/03 , C07C67/08 , C07C67/14 , A01N25/00
CPC分类号： A01N25/02 , A61K8/37 , A61Q17/04 , A61Q19/08 , C07C67/03 , C07C67/08 , C07C69/78 , C07C69/76 , C07C69/80
摘要： An active or functional organic compound is solubilized in a phenylethyl ester, e.g. an aryl carboxylic ester of 2-phenylethyl alcohol, as a solvent, cosolvent or additive, to form a composition thereof. Representative active or functional organic compounds include personal care products, e.g. sunscreens containing UVA/UVB absorbing compounds, such as avobenzone and benzophenone-3. Such compositions also show increased critical wavelength and UVA/UVB absorbance ratio performance properties.
摘要翻译：将活性或功能性有机化合物溶解于苯乙基酯中， 2-苯乙醇的芳基羧酸酯，作为溶剂，共溶剂或添加剂，以形成其组合物。代表性的活性或功能性有机化合物包括个人护理产品，含有UVA / UVB吸收化合物如阿伏苯宗和二苯甲酮-3的防晒剂。这样的组合物还显示出增加的临界波长和UVA / UVB吸收率性能特性。

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