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    • 3. 发明专利
    • Activated aluminum/depolymerized zirconium antiperspirant compositions
    • AU2004324474A1
    • 2006-05-04
    • AU2004324474
    • 2004-10-22
    • LI ZIJUNREHEIS INC
    • LI ZIJUN
    • C09C1/40
    • An aluminum-zirconium antiperspirant composition comprising activated aluminum and depolymerized zirconium species is characterized by an Inductively Coupled Plasma (ICO)-Size Exclusion Chromatograpy (SEC)-HPLC method. A good correlation is obtained between the intensity of the zirconium peak at retention time of about 4.3 minutes to about 4.9 minutes by ICP-SEC-HPLC and the extent of the polymerization of the zirconium species, such that the higher the intensity of the zirconium species, the greater the polymerization of the zirconium species. The extent of the polymerization of zirconium species in the activated aluminum-zirconium salt is affected by the factors and reaction conditions such as the ratio of chloride to zirconium in a zirconium hydroxy chloride (ZHC) solution; the heat treatment of the ZHC glycinate solution; and the concentration of activated basic aluminum chloride (BAC) solution. Controlling the reaction conditions yields a novel aluminum-zirconium antiperspirant salt of enhanced efficacy having activated aluminum and depolymerized zirconium species.
    • 4. 发明申请
    • POLYALUMINUM CALCIUM HYDROXYCHLORIDES AND METHODS OF MAKING THE SAME
    • 聚羟基羟基氯化镁及其制备方法
    • WO2008070218A1
    • 2008-06-12
    • PCT/US2007/075433
    • 2007-08-08
    • Reheis, Inc.LI, ZijunREREK, MarkJANAK, Kevin
    • LI, ZijunREREK, MarkJANAK, Kevin
    • C01F7/00C01F7/16C01F7/56A61Q15/00A61K8/26C02F1/52
    • C01F7/002A61K8/26A61Q15/00C01F7/56C01P2002/87C01P2006/90C02F1/5245
    • A process is provided for the preparation of a novel polyaluminum calcium hydroxychloride composition of enhanced efficiency for water treatment, paper sizing, and antiperspirant applications. The polyaluminum calcium hydroxychloride compositions are prepared via the acidification of higher basicity reaction products to form mid-to-high basicity final products. Two methods are provided for the preparation of higher basicity products, contemplated in the first, and an aqueous acid solution, such as hydrochloric acid, aluminum chloride, or a mixture thereof, is mixed with a strong alkaline calcium salt such as calcium oxide or calcium carbonate and aluminum powder at temperatures greater than 60°C. In a second method, bauxite, aluminum hydrate, or aluminum metal, and calcium aluminate are mixed with hydrochloric acid and are reacted at high temperatures and/or elevated pressures for a certain period of time whereby, when the reaction is complete, the mixtures are filtered to obtain clear solutions. The final PAC-Ca solutions may be dried to powder to have a wide range of basicities from about 40% to about 80%. At lower basicities, the polyaluminum calcium hydroxychloride sales are used preferably as antiperspirants, while at higher basicities, the solutions are used preferably as water treatment chemicals.
    • 提供了一种制备用于水处理,纸张施胶和止汗剂应用的增强效率的新型聚羟基氯化铝羟氯化物组合物的方法。 通过酸化较高的碱性反应产物来制备羟基氯化铝铝组合物,以形成中至高碱性的最终产物。 提供两种方法用于制备较高碱度的产品,首先考虑,酸性溶液如盐酸,氯化铝或其混合物与强碱性钙盐如氧化钙或钙混合 碳酸盐和铝粉末,温度大于60℃。 在第二种方法中,将铝土矿,铝水合物或铝金属和铝酸钙与盐酸混合并在高温和/或高压下反应一段时间,由此当反应完成时,混合物为 过滤以获得明确的解决方案。 最终的PAC-Ca溶液可以被干燥成粉末以具有约40%至约80%的宽范围碱度。 在较低的碱度下,聚羟基氯化钙销售优选用作止汗剂,而在较高碱度下,该溶液优选用作水处理化学品。
    • 5. 发明申请
    • STABLE ALUMINUM/ZIRCONIUM ANTIPERSPIRANT SOLUTION
    • 稳定的铝/ ZIRCONIUM抗反应溶液
    • WO2005009376A2
    • 2005-02-03
    • PCT/US2004/023501
    • 2004-07-09
    • REHEIS,INC.PAREKH, Jawahar, C.LI, Zijun
    • LI, Zijun
    • A61K
    • A61K8/28A61Q15/00
    • A stable aluminum-zirconium aqueous solution of enhanced efficacy having a high concentration free of amino acid and polyhydric alcohol is disclosed. Such aluminum-zirconium salts are selected from aluminum/zirconium tetrachlorohydrate; aluminum/zirconium pentachlorohydrate, and aluminum/zirconium octachlorohydrate in which the aluminum to zirconium (Al/Zr) atomic ratio of said salt falls within the limits of the shaded areas A, B, and C, respectively, of the drawing graph wherein the aluminum/zirconium tetrachlorohydrate has an Al/Zr atomic ratio from about 2 to about 6 and metal/chloride molecular ratio about 0.9 to about 1.25; aluminum/zirconium pentachlorohydrate having Al/Zr atomic ratio from about 6 to about 10 and metal/chloride atomic ratio from about 1.5 to about 1.65; and aluminum/zirconium octachlorohydrate having Al/Zr molecular ratio from about 6 to about 10 and metal/chloride molecular ratio from about 0.9 to about 1.5.
    • 公开了一种具有高浓度的氨基酸和多元醇的高效率的稳定的铝 - 锆水溶液。 这种铝 - 锆盐选自四氯水合铝/锆; 铝/锆五氯水合物,以及所述盐的铝与锆(Al / Zr)原子比分别落在阴影区域A,B和C的限制范围内的铝/锆八水合物,其中铝 /锆四氯水合物具有约2至约6的Al / Zr原子比和约0.9至约1.25的金属/氯化物分子比; 铝/锆五氯水合物,其Al / Zr原子比为约6至约10,金属/氯化物原子比为约1.5至约1.65; 铝/锆八水合物,其Al / Zr分子比为约6至约10,金属/氯化物分子比为约0.9至约1.5。
    • 7. 发明申请
    • STABLE BUFERED ALUMINUM COMPOSITIONS HAVING HIGH HPLC BANDS III AND IV CONTAINING CALCIUM/STRONTIUM
    • 具有包含钙/锶的高效液相色谱柱III和IV的稳定的保护的铝组合物
    • WO2007098400A2
    • 2007-08-30
    • PCT/US2007/062306
    • 2007-02-16
    • REHEIS, INC.LI, ZijunREREK, Mark
    • LI, ZijunREREK, Mark
    • A61Q15/00A61K8/26
    • A61K8/26A61K2800/52A61Q15/00
    • A novel aluminum antiperspirant active composition of enhanced efficacy is provided. The composition is activated by both heat and acid and characterized by having high HPLC Band III and high HPLC Band IV, prepared by the addition of an acid such as AlCl3 to (1) the aluminum calcium and/or strontium betaine solutions, where the calcium and/or strontium is derived from a soluble salt such as calcium and/or strontium chloride or nitrate and (2) the aluminum calcium and/or strontium glycine and/or betaine solutions, where calcium and/or strontium is from strongly alkaline calcium/strontium oxide or hydroxide. The novel aluminum compositions derived according to the invention have HPLC Band I of less than 2%; a Band III of at least 20%; a Band III/II ratio of at least about 0.7; and a Band IV of at least 20%.
    • 提供了一种增强功效的新型铝止汗剂活性组合物。 组合物由热和酸两者活化,其特征在于通过加入酸(例如AlCl 3)制备的(1)铝钙和/或锶甜菜碱溶液制备的具有高的HPLC带III和高的HPLC带IV,其中钙 和/或锶衍生自可溶性盐如钙和/或氯化锶或硝酸锶和(2)铝钙和/或锶甘氨酸和/或甜菜碱溶液,其中钙和/或锶来自强碱性钙/ 氧化锶或氢氧化物。 根据本发明衍生的新型铝组合物具有小于2%的HPLC带I; 至少20%的乐队III; 至少约0.7的Band III / II比率; 和一个至少20%的乐队IV。
    • 8. 发明申请
    • STABLE BUFERED ALUMINUM COMPOSITIONS HAVING HIGH HPLC BANDS III AND IV CONTAINING CALCIUM/STRONTIUM
    • 具有包含钙/锶的高效液相色谱柱III和IV的稳定的保护的铝组合物
    • WO2007098400A3
    • 2010-02-18
    • PCT/US2007062306
    • 2007-02-16
    • REHEIS INCLI ZIJUNREREK MARK
    • LI ZIJUNREREK MARK
    • A61Q15/00A61K8/26
    • A61K8/26A61K2800/52A61Q15/00
    • A novel aluminum antiperspirant active composition of enhanced efficacy is provided. The composition is activated by both heat and acid and characterized by having high HPLC Band III and high HPLC Band IV, prepared by the addition of an acid such as AlCl3 to (1) the aluminum calcium and/or strontium betaine solutions, where the calcium and/or strontium is derived from a soluble salt such as calcium and/or strontium chloride or nitrate and (2) the aluminum calcium and/or strontium glycine and/or betaine solutions, where calcium and/or strontium is from strongly alkaline calcium/strontium oxide or hydroxide. The novel aluminum compositions derived according to the invention have HPLC Band I of less than 2%; a Band III of at least 20%; a Band III/II ratio of at least about 0.7; and a Band IV of at least 20%.
    • 提供了一种增强功效的新型铝止汗剂活性组合物。 组合物由热和酸两者活化,其特征在于通过加入酸(例如AlCl 3)制备的(1)铝钙和/或锶甜菜碱溶液制备的具有高的HPLC带III和高的HPLC带IV,其中钙 和/或锶衍生自可溶性盐如钙和/或氯化锶或硝酸锶和(2)铝钙和/或锶甘氨酸和/或甜菜碱溶液,其中钙和/或锶来自强碱性钙/ 氧化锶或氢氧化物。 根据本发明衍生的新型铝组合物具有小于2%的HPLC带I; 至少20%的乐队III; 至少约0.7的Band III / II比率; 和一个至少20%的乐队IV。
    • 10. 发明申请
    • STABLE ALUMINUM/ZIRCONIUM ANTIPERSPIRANT SOLUTION
    • 稳定的铝/ ZIRCONIUM抗反应溶液
    • WO2005009376B1
    • 2006-08-17
    • PCT/US2004023501
    • 2004-07-09
    • REHEIS INCPAREKH JAWAHAR CLI ZIJUN
    • LI ZIJUN
    • A61K8/00A61K8/26A61K20060101A61K8/04A61K8/28A61Q15/00A61Q19/00
    • A61K8/28A61Q15/00
    • A stable aluminum-zirconium aqueous solution of enhanced efficacy having a high concentration free of amino acid and polyhydric alcohol is disclosed. Such aluminum-zirconium salts are selected from aluminum/zirconium tetrachlorohydrate; aluminum/zirconium pentachlorohydrate, and aluminum/zirconium octachlorohydrate in which the aluminum to zirconium (Al/Zr) atomic ratio of said salt falls within the limits of the shaded areas A, B, and C, respectively, of the drawing graph wherein the aluminum/zirconium tetrachlorohydrate has an Al/Zr atomic ratio from about 2 to about 6 and metal/chloride molecular ratio about 0.9 to about 1.25; aluminum/zirconium pentachlorohydrate having Al/Zr atomic ratio from about 6 to about 10 and metal/chloride atomic ratio from about 1.5 to about 1.65; and aluminum/zirconium octachlorohydrate having Al/Zr molecular ratio from about 6 to about 10 and metal/chloride molecular ratio from about 0.9 to about 1.5.
    • 公开了一种具有高浓度的氨基酸和多元醇的高效率的稳定的铝 - 锆水溶液。 这种铝 - 锆盐选自四氯水合铝/锆; 铝/锆五氯水合物,以及所述盐的铝与锆(Al / Zr)原子比分别落在阴影区域A,B和C的限制范围内的铝/锆八水合物,其中铝 /锆四氯水合物具有约2至约6的Al / Zr原子比和约0.9至约1.25的金属/氯化物分子比; 铝/锆五氯水合物,其Al / Zr原子比为约6至约10,金属/氯化物原子比为约1.5至约1.65; 铝/锆八水合物,其Al / Zr分子比为约6至约10,金属/氯化物分子比为约0.9至约1.5。