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    • 9. 发明申请
    • HERBAL COMPOSITION FOR TREATING VARIOUS DISORDERS INCLUDING PSORIASIS, A PROCESS FOR PREPARATION THEREOF AND METHOD FOR TREATMENT OF SUCH DISORDERS
    • 用于治疗各种疾病的草本组合物,包括PSORIASIS,其制备方法和用于治疗这种疾病的方法
    • WO2003057133A2
    • 2003-07-17
    • PCT/IN2003/000008
    • 2003-01-10
    • LUPIN LIMITEDARORA, Sudershan, K.NARENDAR, SanganabhatlaSRIVASTAVA, VanditaSARAF, Dinesh, BalakrishnaGUPTA, Lavleen, Kumar
    • ARORA, Sudershan, K.NARENDAR, SanganabhatlaSRIVASTAVA, VanditaSARAF, Dinesh, BalakrishnaGUPTA, Lavleen, Kumar
    • A61K
    • A61K36/23A61K36/66A61K2300/00
    • The invention provides a novel herbal composition containing the extracts of the leaves and/or stem of Argemone mexicana plant, optionally containing the extracts of the fruits of Cuminum cyminum , which exhibits useful in vitro, in vivo and interesting immunological and pharmacological activities; a process for preparation thereof; and a method of treatment of psoriasis and related immunological and biological disorders by administration of the said novel herbal composition. The useful in vitro, in vivo and interesting immunological and pharmacological activities exhibited by the extracts and fractions of the leaves and/or stem of Argemone mexicana plant include immunosuppression, lymphoproliferation inhibition, cytokine modulation such as IL-2 inhibition, IFNgamma inhibition, IL-10 induction, keratinocyte proliferation inhibition, keratolytic activity, endothelial cell proliferation inhibition, inhibition of cell adhesion molecule expression such as ICAM-1, NEST inhibition, and enzymes inhibition such as p60src Tyrosine kinase, which are known to be involved in anti-psoriatic activity. The novel herbal composition(s) is useful in the treatment of various disorders, such as psoriasis including plaque psoriasis, gutatte psoriasis, pustular psoriasis and psoriasis of the nails; dermatitis and scleroderma; eczema; inflammatory disorders and other autoimmune diseases like psoriatic arthritis, rheumatoid arthritis, Crohn's disease, multiple sclerosis, irritable bowel disease, ankylosing spondilitis, systemic lupus erythremetosus and Sjogren's syndrome; allergies like asthma and chronic obstructive pulmonary disease and is safe, well-tolerated, non-toxic, with minimal and reversible adverse reactions or side effects, and most importantly, with minimal relapse or recurrence of the disease following completion of a treatment regimen. The invention also describes the presence of phosphodiesterase (III, IV and V) inhibition and 5-Lipoxygenase inhibition in the aqueous, ethanolic or aqueous-ethanolic extracts of fruits of Cuminum cyminum plant.
    • 本发明提供了一种新颖的草药组合物,其含有茄科植物的叶子和/或茎的提取物,任选地含有孜然的果实的提取物,其显示出有用的体外和有趣的免疫学和药理学活性; 其制备方法; 以及通过施用所述新型草药组合物治疗牛皮癣和相关免疫学和生物学疾病的方法。 茄科植物的叶子和/或茎的提取物和级分表现的有用的体外,体内和有趣的免疫学和药理学活性包括免疫抑制,淋巴细胞增殖抑制,细胞因子调节如IL-2抑制,IFNγ抑制,IL- 10诱导,角质形成细胞增殖抑制,角质酶活性,内皮细胞增殖抑制,细胞粘附分子表达的抑制,例如ICAM-1,NEST抑制和酶抑制如p60src酪氨酸激酶,其已知参与抗牛皮癣活性 。 新型草药组合物可用于治疗各种疾病,例如牛皮癣,包括斑块性牛皮癣,胃肠牛皮癣,脓疱性牛皮癣和指甲银屑病; 皮炎和硬皮病; 湿疹; 炎症性疾病和其他自身免疫性疾病如牛皮癣关节炎,类风湿性关节炎,克罗恩病,多发性硬化,肠易激综合征,强直性脊柱炎,系统性红斑狼疮和干燥综合征; 过敏如哮喘和慢性阻塞性肺疾病,是安全,耐受良好,无毒的,具有最小和可逆的不良反应或副作用,最重要的是,在治疗方案完成后,疾病的复发或复发最少。 本发明还描述了在孜然植物的水果,乙醇或乙醇提取物中磷酸二酯酶(III,IV和V)抑制和5-脂氧合酶抑制的存在。