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1. 发明申请

WO2006054162A1 AZABICYCLIC MUSCARINIC RECEPTOR ANTAGONISTS 审中-公开
标题翻译：雅各布氏肌肉受体拮抗剂
公开(公告)号：WO2006054162A1
公开(公告)日：2006-05-26
申请号：PCT/IB2005/003459
申请日：2005-11-18
申请人： RANBAXY LABORATORIES LIMITED , KUMAR, Naresh , SALMAN, Mohammad , KAUR, Kirandeep , MEHTA, Anita , ARORA, Sudershan, K. , CHUGH, Anita
发明人： KUMAR, Naresh , SALMAN, Mohammad , KAUR, Kirandeep , MEHTA, Anita , ARORA, Sudershan, K. , CHUGH, Anita
IPC分类号： C07D409/06 , C07D209/52 , A61K31/403 , A61P11/00
CPC分类号： C07D209/52 , C07D409/06
摘要： The present invention generally relates to muscarinic receptor antagonists, which are useful for treating various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to processes for preparing compounds described herein, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors.
摘要翻译：本发明一般涉及毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病。本发明还涉及制备本文所述化合物的方法，含有所公开化合物的药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。

2. 发明申请

WO2005100373A2 MONOSACCHARIDE DERIVATIVES 审中-公开
标题翻译：单糖衍生物
公开(公告)号：WO2005100373A2
公开(公告)日：2005-10-27
申请号：PCT/IB2005/000974
申请日：2005-04-13
申请人： RANBAXY LABORATORIES LIMITED , SATTIGERI, Viswajanani, Jitendra , ARORA, Sudershan, K. , SALMAN, Mohammad , PALLE, Venkata, P. , RAY, Abhijit , SHIRUMALLA, Raj, Kumar
发明人： SATTIGERI, Viswajanani, Jitendra , ARORA, Sudershan, K. , SALMAN, Mohammad , PALLE, Venkata, P. , RAY, Abhijit , SHIRUMALLA, Raj, Kumar
IPC分类号： C07H
CPC分类号： C07H9/04 , C07H3/02 , C07H15/00
摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies, including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis or allergic rhinitis. Pharmacological compositions containing the compounds of the present invention and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis or allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.
摘要翻译：本发明涉及作为抗炎剂的单糖衍生物。本文公开的化合物可用于抑制和预防炎症和相关病理学，包括炎症和自身免疫性疾病如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒症或过敏性鼻炎。包含本发明化合物的药物组合物，治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，还提供了使用该化合物的瘙痒症或过敏性鼻炎和其它炎性和/或自身免疫性疾病。

3. 发明申请

WO2006024926A1 MONOSACCHARIDE DERIVATIVES 审中-公开
标题翻译：单糖衍生物
公开(公告)号：WO2006024926A1
公开(公告)日：2006-03-09
申请号：PCT/IB2005/002573
申请日：2005-08-31
申请人： RANBAXY LABORATORIES LIMITED , SATTIGERI, Vishwajanani, Jitendra , ARORA, Sudershan, K. , PALLE, Venkata, P. , SALMAN, Mohammad , RAY, Abhijit , SHIRUMALLA, Raj, Kumar , RAUF, Abdul, Rehman, Abdul
发明人： SATTIGERI, Vishwajanani, Jitendra , ARORA, Sudershan, K. , PALLE, Venkata, P. , SALMAN, Mohammad , RAY, Abhijit , SHIRUMALLA, Raj, Kumar , RAUF, Abdul, Rehman, Abdul
IPC分类号： C07H15/18
CPC分类号： C07H15/18
摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies, including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis or allergic rhinitis. Pharmacological compositions containing the compounds of the present invention and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.
摘要翻译：本发明涉及作为抗炎剂的单糖衍生物。本文公开的化合物可用于抑制和预防炎症和相关病理学，包括炎症和自身免疫性疾病如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒症或过敏性鼻炎。包含本发明化合物的药物组合物，治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，还提供了使用该化合物的瘙痒症，过敏性鼻炎和其它炎症和/或自身免疫性疾病。

4. 发明申请

WO2005092907A3 MONOSACCHARIDE DERIVATIVES AS ANTI-CANCER AND ANTI-INFLAMMATORY AGENTS 审中-公开
公开(公告)号：WO2005092907A3
公开(公告)日：2005-10-06
申请号：PCT/IB2005/000803
申请日：2005-03-29
申请人： RANBAXY LABORATORIES LIMITED , SATTIGERI, Viswajanani, Jitendra , ARORA, Sudershan, K. , SALMAN, Mohammad , PALLE, Venkata, P. , YADAV, Gyan, Chand , TANWAR, Madan, Pal , MUKHERJEE, Ashis , NARAYANAN, Ramamurthy , RAUF, Abdul, Rehaman, Abdul , NAIK, Keshav, Prabhakar , SONI, Ajay , RAY, Abhijit , SHIRUMALLA, Raj, Kumar , MOOKHTIAR, Kasim Abbas
发明人： SATTIGERI, Viswajanani, Jitendra , ARORA, Sudershan, K. , SALMAN, Mohammad , PALLE, Venkata, P. , YADAV, Gyan, Chand , TANWAR, Madan, Pal , MUKHERJEE, Ashis , NARAYANAN, Ramamurthy , RAUF, Abdul, Rehaman, Abdul , NAIK, Keshav, Prabhakar , SONI, Ajay , RAY, Abhijit , SHIRUMALLA, Raj, Kumar , MOOKHTIAR, Kasim Abbas
IPC分类号： C07H9/04 , C07H15/00 , C07H3/02 , A61K31/70 , A61K31/7028 , A61K31/7042 , A61P37/00 , A61P35/00 , A61P17/00 , A61P11/06
摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disorder herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection or psoriasis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, and other inflammatory and/or autoimmune disorders, using the compounds are also provided.

5. 发明申请

WO2007063356A3 DERIVATIVES OF PENTOSE MONOSACCHARIDES AS ANTI-INFLAMMATORY COMPOUNDS 审中-公开
公开(公告)号：WO2007063356A3
公开(公告)日：2007-06-07
申请号：PCT/IB2005/003871
申请日：2005-12-22
申请人： RANBAXY LABORATORIES LIMITED , SATTIGERI, Jitendra, Viswajanani , ARORA, Sudershan, K. , SALMAN, Mohammad , PALLE, Venkata, P. , NAGARAJAN, Muthukaman , SHIRUMALLA, Raj Kumar , AULAKH, Gurpreet Kaur , RAY, Abhijit
发明人： SATTIGERI, Jitendra, Viswajanani , ARORA, Sudershan, K. , SALMAN, Mohammad , PALLE, Venkata, P. , NAGARAJAN, Muthukaman , SHIRUMALLA, Raj Kumar , AULAKH, Gurpreet Kaur , RAY, Abhijit
IPC分类号： C07H15/02 , C07H15/18 , C07H15/26 , C07H3/02 , A61K31/7028 , A61K31/7042
摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds of this invention can be useful for inhibition and prevention of inflammation and associated pathologies, including inflammatory and autoimmune diseases, for example, bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection or psoriasis. The present invention also relates to pharmacological compositions containing these monosaccharide derivatives, as well as methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, and other inflammatory and/or auto immune disorders.

6. 发明申请

WO2006111783A1 MONOSACCHARIDE DERIVATIVES AS ANTI-INFLAMMATORY AND/OR ANTI-CANCER AGENTS 审中-公开
标题翻译：单抗衍生物作为抗炎和/或抗癌剂
公开(公告)号：WO2006111783A1
公开(公告)日：2006-10-26
申请号：PCT/IB2005/001039
申请日：2005-04-19
申请人： RANBAXY LABORATORIES LIMITED , SATTIGERI, Vishwajanani, Jitendra , ARORA, Sudershan, K. , SALMAN, Mohammad , PALLE, Venkata, P. , MUKHERJEE, Ashis , RAY, Abhijit , SHIRUMALLA, Raj, Kumar
发明人： SATTIGERI, Vishwajanani, Jitendra , ARORA, Sudershan, K. , SALMAN, Mohammad , PALLE, Venkata, P. , MUKHERJEE, Ashis , RAY, Abhijit , SHIRUMALLA, Raj, Kumar
IPC分类号： C07H9/04 , C07H15/00 , C07H3/02 , A61K31/70 , A61K31/7004 , A61K31/7028 , A61K31/7042 , A61P37/00 , A61P35/00 , A61P17/00 , A61P11/06
CPC分类号： C07H9/04 , C07H3/02 , C07H15/00
摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disorder herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis and allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.
摘要翻译：本发明涉及作为抗炎剂的单糖衍生物。本文中的化合物障碍可用于抑制和预防炎症和相关病理，包括炎症和自身免疫性疾病，例如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒和过敏性鼻炎。含有本文公开的化合物的药理学组合物和治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒，过敏还提供使用该化合物的鼻炎和其它炎性和/或自身免疫性疾病。

7. 发明申请

WO2003007870A2 OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS 审中-公开
标题翻译：恶唑烷酮衍生物作为抗微生物剂
公开(公告)号：WO2003007870A2
公开(公告)日：2003-01-30
申请号：PCT/IB2002/001609
申请日：2002-05-10
申请人： RANBAXY LABORATORIES LIMITED , MEHTA, Anita , ARORA, Sudershan, K. , DAS, Biswajit , RAY, Abhijit , RUDRA, Sonali , RATTAN, Ashok
发明人： MEHTA, Anita , ARORA, Sudershan, K. , DAS, Biswajit , RAY, Abhijit , RUDRA, Sonali , RATTAN, Ashok
IPC分类号： A61K
CPC分类号： C07D263/20 , C07D413/10 , C07D413/12 , C07D413/14
摘要： The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharma-ceutical compositions containing the compounds of the present invention as anti-microbials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.
摘要翻译：本发明涉及某些取代的苯基恶唑烷酮及其合成方法。本发明还涉及含有本发明化合物作为抗微生物剂的药物组合物。这些化合物是有用的抗微生物剂，可有效对抗许多人类和兽医病原体，包括革兰氏阳性好氧细菌如多重耐药葡萄球菌，链球菌和肠球菌以及厌氧微生物，如细菌（Bacterioides spp。）。和梭菌属（Clostridia spp）。物种和酸快速生物如结核分枝杆菌，鸟分枝杆菌和分枝杆菌属。

8. 发明申请

WO2003008389A1 OXAZOLIDINONE DERIVATIVES AS POTENTIAL ANTIMICROBIALS 审中-公开
标题翻译：奥沙利汀衍生物作为潜在抗生素
公开(公告)号：WO2003008389A1
公开(公告)日：2003-01-30
申请号：PCT/IB2002/000167
申请日：2002-01-18
申请人： RANBAXY LABORATORIES LIMITED , MEHTA, Anita , RUDRA, Sonali , RAO, Ajjarapu, Venkata, Subramanya, Raja , DAS, Biswajit , RAY, Abhijit , SRINIVAS, Akella, Satya, Surya, Visweswara , ARORA, Sudershan, K. , RATTAN, Ashok
发明人： MEHTA, Anita , RUDRA, Sonali , RAO, Ajjarapu, Venkata, Subramanya, Raja , DAS, Biswajit , RAY, Abhijit , SRINIVAS, Akella, Satya, Surya, Visweswara , ARORA, Sudershan, K. , RATTAN, Ashok
IPC分类号： C07D241/02
CPC分类号： C07D263/20 , C07D413/10 , C07D413/12 , C07D413/14
摘要： The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacteroides spp. and Clostridium spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.
摘要翻译：本发明涉及某些取代的苯基恶唑烷酮及其合成方法。本发明还涉及含有作为抗微生物剂的本发明化合物的药物组合物。这些化合物是有用的抗微生物剂，对许多人类和兽医病原体有效，包括革兰氏阳性好氧细菌，如多重耐药葡萄球菌，链球菌和肠球菌，以及厌氧生物体如拟杆菌属。和梭菌属（Clostridium spp。）物种和酸性快速生物如结核分枝杆菌，鸟分枝杆菌和分枝杆菌属。

9. 发明申请

WO2003057133A2 HERBAL COMPOSITION FOR TREATING VARIOUS DISORDERS INCLUDING PSORIASIS, A PROCESS FOR PREPARATION THEREOF AND METHOD FOR TREATMENT OF SUCH DISORDERS 审中-公开
标题翻译：用于治疗各种疾病的草本组合物，包括PSORIASIS，其制备方法和用于治疗这种疾病的方法
公开(公告)号：WO2003057133A2
公开(公告)日：2003-07-17
申请号：PCT/IN2003/000008
申请日：2003-01-10
申请人： LUPIN LIMITED , ARORA, Sudershan, K. , NARENDAR, Sanganabhatla , SRIVASTAVA, Vandita , SARAF, Dinesh, Balakrishna , GUPTA, Lavleen, Kumar
发明人： ARORA, Sudershan, K. , NARENDAR, Sanganabhatla , SRIVASTAVA, Vandita , SARAF, Dinesh, Balakrishna , GUPTA, Lavleen, Kumar
IPC分类号： A61K
CPC分类号： A61K36/23 , A61K36/66 , A61K2300/00
摘要： The invention provides a novel herbal composition containing the extracts of the leaves and/or stem of Argemone mexicana plant, optionally containing the extracts of the fruits of Cuminum cyminum , which exhibits useful in vitro, in vivo and interesting immunological and pharmacological activities; a process for preparation thereof; and a method of treatment of psoriasis and related immunological and biological disorders by administration of the said novel herbal composition. The useful in vitro, in vivo and interesting immunological and pharmacological activities exhibited by the extracts and fractions of the leaves and/or stem of Argemone mexicana plant include immunosuppression, lymphoproliferation inhibition, cytokine modulation such as IL-2 inhibition, IFNgamma inhibition, IL-10 induction, keratinocyte proliferation inhibition, keratolytic activity, endothelial cell proliferation inhibition, inhibition of cell adhesion molecule expression such as ICAM-1, NEST inhibition, and enzymes inhibition such as p60src Tyrosine kinase, which are known to be involved in anti-psoriatic activity. The novel herbal composition(s) is useful in the treatment of various disorders, such as psoriasis including plaque psoriasis, gutatte psoriasis, pustular psoriasis and psoriasis of the nails; dermatitis and scleroderma; eczema; inflammatory disorders and other autoimmune diseases like psoriatic arthritis, rheumatoid arthritis, Crohn's disease, multiple sclerosis, irritable bowel disease, ankylosing spondilitis, systemic lupus erythremetosus and Sjogren's syndrome; allergies like asthma and chronic obstructive pulmonary disease and is safe, well-tolerated, non-toxic, with minimal and reversible adverse reactions or side effects, and most importantly, with minimal relapse or recurrence of the disease following completion of a treatment regimen. The invention also describes the presence of phosphodiesterase (III, IV and V) inhibition and 5-Lipoxygenase inhibition in the aqueous, ethanolic or aqueous-ethanolic extracts of fruits of Cuminum cyminum plant.
摘要翻译：本发明提供了一种新颖的草药组合物，其含有茄科植物的叶子和/或茎的提取物，任选地含有孜然的果实的提取物，其显示出有用的体外和有趣的免疫学和药理学活性; 其制备方法; 以及通过施用所述新型草药组合物治疗牛皮癣和相关免疫学和生物学疾病的方法。茄科植物的叶子和/或茎的提取物和级分表现的有用的体外，体内和有趣的免疫学和药理学活性包括免疫抑制，淋巴细胞增殖抑制，细胞因子调节如IL-2抑制，IFNγ抑制，IL- 10诱导，角质形成细胞增殖抑制，角质酶活性，内皮细胞增殖抑制，细胞粘附分子表达的抑制，例如ICAM-1，NEST抑制和酶抑制如p60src酪氨酸激酶，其已知参与抗牛皮癣活性。新型草药组合物可用于治疗各种疾病，例如牛皮癣，包括斑块性牛皮癣，胃肠牛皮癣，脓疱性牛皮癣和指甲银屑病; 皮炎和硬皮病; 湿疹; 炎症性疾病和其他自身免疫性疾病如牛皮癣关节炎，类风湿性关节炎，克罗恩病，多发性硬化，肠易激综合征，强直性脊柱炎，系统性红斑狼疮和干燥综合征; 过敏如哮喘和慢性阻塞性肺疾病，是安全，耐受良好，无毒的，具有最小和可逆的不良反应或副作用，最重要的是，在治疗方案完成后，疾病的复发或复发最少。本发明还描述了在孜然植物的水果，乙醇或乙醇提取物中磷酸二酯酶（III，IV和V）抑制和5-脂氧合酶抑制的存在。

10. 发明申请

WO2003057133A3 HERBAL COMPOSITION FOR TREATING VARIOUS DISORDERS INCLUDING PSORIASIS, A PROCESS FOR PREPARATION THEREOF AND METHOD FOR TREATMENT OF SUCH DISORDERS 审中-公开
公开(公告)号：WO2003057133A3
公开(公告)日：2003-07-17
申请号：PCT/IN2003/000008
申请日：2003-01-10
申请人： LUPIN LIMITED , ARORA, Sudershan, K. , NARENDAR, Sanganabhatla , SRIVASTAVA, Vandita , SARAF, Dinesh, Balakrishna , GUPTA, Lavleen, Kumar
发明人： ARORA, Sudershan, K. , NARENDAR, Sanganabhatla , SRIVASTAVA, Vandita , SARAF, Dinesh, Balakrishna , GUPTA, Lavleen, Kumar
IPC分类号： A61K35/78
摘要： The invention provides a novel herbal composition containing the extracts of the leaves and/or stem of Argemone mexicana plant, optionally containing the extracts of the fruits of Cuminum cyminum , which exhibits useful in vitro, in vivo and interesting immunological and pharmacological activities; a process for preparation thereof; and a method of treatment of psoriasis and related immunological and biological disorders by administration of the said novel herbal composition. The useful in vitro, in vivo and interesting immunological and pharmacological activities exhibited by the extracts and fractions of the leaves and/or stem of Argemone mexicana plant include immunosuppression, lymphoproliferation inhibition, cytokine modulation such as IL-2 inhibition, IFNgamma inhibition, IL-10 induction, keratinocyte proliferation inhibition, keratolytic activity, endothelial cell proliferation inhibition, inhibition of cell adhesion molecule expression such as ICAM-1, NEST inhibition, and enzymes inhibition such as p60src Tyrosine kinase, which are known to be involved in anti-psoriatic activity. The novel herbal composition(s) is useful in the treatment of various disorders, such as psoriasis including plaque psoriasis, gutatte psoriasis, pustular psoriasis and psoriasis of the nails; dermatitis and scleroderma; eczema; inflammatory disorders and other autoimmune diseases like psoriatic arthritis, rheumatoid arthritis, Crohn's disease, multiple sclerosis, irritable bowel disease, ankylosing spondilitis, systemic lupus erythremetosus and Sjogren's syndrome; allergies like asthma and chronic obstructive pulmonary disease and is safe, well-tolerated, non-toxic, with minimal and reversible adverse reactions or side effects, and most importantly, with minimal relapse or recurrence of the disease following completion of a treatment regimen. The invention also describes the presence of phosphodiesterase (III, IV and V) inhibition and 5-Lipoxygenase inhibition in the aqueous, ethanolic or aqueous-ethanolic extracts of fruits of Cuminum cyminum plant.

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