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1. 发明申请

US20050043788A1 Drug-eluting stent 审中-公开
标题翻译：药物洗脱支架
公开(公告)号：US20050043788A1
公开(公告)日：2005-02-24
申请号：US10943636
申请日：2004-09-17
申请人： Qiyi Luo , Yi Zhang , Zhirong Tang , Heng Zhao , Junfei Ll
发明人： Qiyi Luo , Yi Zhang , Zhirong Tang , Heng Zhao , Junfei Ll
IPC分类号： A61K9/00 , A61F2/00 , A61F2/06 , A61F2/84 , A61K31/165 , A61K31/337 , A61K31/343 , A61K31/427 , A61K31/436 , A61K31/4365 , A61K31/4465 , A61K31/4709 , A61K31/505 , A61K31/52 , A61K31/565 , A61K31/616 , A61K31/704 , A61K31/727 , A61K35/74 , A61K35/76 , A61K38/00 , A61K45/00 , A61K48/00 , A61L27/00 , A61L31/00 , A61P5/00 , A61P7/02 , A61P9/10 , A61P35/00 , A61P37/06
CPC分类号： A61L31/10 , A61F2/07 , A61F2002/075 , A61F2250/0067 , A61L31/048 , A61L31/16 , A61L2300/416 , A61L2300/61 , C08L27/12
摘要： The invention relates to a drug eluting stent and a method for making the stent. The stent comprises a stent body and coats covering on the stent body, it is characterized in that: 2-4 coats are provided on the surface of the stent body, wherein at least two coats are drug coats. The drug coats comprise 0.5-99% polymer by weight, 0-10% additive by weight and 0.5-99% active ingredient by weight. A primer layer is provided between the drug coats and the stent body. A compact control-releasing layer is also coated on the surface of the drug coats.
摘要翻译：本发明涉及药物洗脱支架和制造支架的方法。支架包括支架主体和覆盖在支架主体上的外套，其特征在于：在支架主体的表面上设置2-4个涂层，其中至少两个涂层是药物涂层。药物涂层包含0.5-99重量％的聚合物，0-10重量％的添加剂和0.5-99重量％的活性成分。在药物涂层和支架体之间设置底漆层。一个紧凑的控制释放层也涂在药物外套的表面上。

2. 发明申请

US20050033414A1 Drug-eluting stent with multi-layer coatings 审中-公开
标题翻译：药物洗脱支架多层涂层
公开(公告)号：US20050033414A1
公开(公告)日：2005-02-10
申请号：US10943633
申请日：2004-09-17
申请人： Yi Zhang , Qiyi Luo , Zhirong Tang , Junfei Li
发明人： Yi Zhang , Qiyi Luo , Zhirong Tang , Junfei Li
IPC分类号： A61K9/00 , A61F2/00 , A61F2/06 , A61F2/84 , A61K31/165 , A61K31/337 , A61K31/343 , A61K31/427 , A61K31/436 , A61K31/4365 , A61K31/4465 , A61K31/4709 , A61K31/505 , A61K31/52 , A61K31/565 , A61K31/616 , A61K31/704 , A61K31/727 , A61K35/74 , A61K35/76 , A61K38/00 , A61K45/00 , A61K48/00 , A61L27/00 , A61L31/00 , A61P5/00 , A61P7/02 , A61P9/10 , A61P35/00 , A61P37/06
CPC分类号： A61L31/10 , A61F2/07 , A61F2002/075 , A61F2250/0067 , A61L31/048 , A61L31/16 , A61L2300/416 , A61L2300/61 , C08L27/12
摘要： The invention relates to a drug eluting stent and a method for making the stent. The stent comprises a stent body and coats covering on the stent body, it is characterized in that: 2-4 coats are provided on the surface of the stent body, wherein at least two coats are drug coats. The drug coats comprise 0.5-99% polymer by weight, 0-10% additive by weight and 0.5-99% active ingredient by weight. A primer layer is provided between the drug coats and the stent body. A compact control-releasing layer is also coated on the surface of the drug coats.
摘要翻译：本发明涉及药物洗脱支架和制造支架的方法。支架包括支架主体和覆盖在支架主体上的外套，其特征在于：在支架主体的表面上设置2-4个涂层，其中至少两个涂层是药物涂层。药物涂层包含0.5-99重量％的聚合物，0-10重量％的添加剂和0.5-99重量％的活性成分。在药物涂层和支架体之间设置底漆层。一个紧凑的控制释放层也涂在药物外套的表面上。

3. 发明申请

US20130296806A1 INTERVENTION MEDICAL DEVICE AND PREPARATION THEREOF 有权
标题翻译：干预医疗设备及其准备
公开(公告)号：US20130296806A1
公开(公告)日：2013-11-07
申请号：US13703855
申请日：2011-06-13
申请人： Junfei Li , Xi Hu , Chengyun Yue , Dawei Wang , Peng Huang , Zhirong Tang , Qiyi Luo , Zhaohua Chang
发明人： Junfei Li , Xi Hu , Chengyun Yue , Dawei Wang , Peng Huang , Zhirong Tang , Qiyi Luo , Zhaohua Chang
IPC分类号： A61L27/34
CPC分类号： A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2300/42
摘要： The present invention discloses an interventional medical device and methods of making the same. At least one coating layer is disposed on the outer surface of the interventional medical device and the material of the outmost layer of the coating layer is a sulfonate group-containing polymer. In the present invention, the material of the outmost layer of the interventional medical device is a sulfonate group-containing polymer. The polymer is endowed with a same surface property as that of heparin in addition to appropriate hydrophilicity due to the presence of the sulfonate group. After the interventional medical device is implanted into the human body, a hydrophilic surface is formed on the outer surface of the interventional medical device which is also negatively charged in the body fluid. Therefore, cells can easily adhere and grow on the outer surface thereof as a result of the enhanced cell compatibility. Furthermore, due to a surface property that is the same as that of heparin, the material is provided with excellent anticoagulant properties which inhibit the thrombosis and lower down the incidence rate of post-operational complications.
摘要翻译：本发明公开了一种介入医疗装置及其制造方法。至少一个涂层设置在介入医疗装置的外表面上，涂层的最外层的材料是含磺酸基的聚合物。在本发明中，介入医疗装置的最外层的材料是含磺酸基的聚合物。由于存在磺酸盐基，除了适当的亲水性之外，聚合物具有与肝素相同的表面性质。在将介入医疗装置植入人体后，在介入医疗装置的外表面上形成亲水性表面，其也在体液中带负电。因此，由于细胞相容性的增强，细胞可以容易地附着和生长在其外表面上。此外，由于与肝素相同的表面特性，具有优异的抗凝血性，能够抑制血栓形成，降低手术后并发症的发生率。

4. 发明授权

US09433709B2 Interventional medical device and manufacturing method thereof 有权
标题翻译：介入医疗器械及其制造方法
公开(公告)号：US09433709B2
公开(公告)日：2016-09-06
申请号：US14677741
申请日：2015-04-02
申请人： Dadong Zhang , Xu Cai , Chengyun Yue , Junfei Li , Yan Hu , Peng Huang , Zhirong Tang , Qiyi Luo
发明人： Dadong Zhang , Xu Cai , Chengyun Yue , Junfei Li , Yan Hu , Peng Huang , Zhirong Tang , Qiyi Luo
IPC分类号： A61L31/10 , A61L31/14 , A61L31/16 , A61F2/82
CPC分类号： A61L31/10 , A61F2/82 , A61F2250/0067 , A61F2250/0068 , A61L31/146 , A61L31/16 , A61L2300/416 , A61L2420/02 , C08L75/04 , C08L67/04 , C08L89/00 , C08L33/10 , C08L5/08
摘要： An interventional medical device and manufacturing method thereof. The interventional medical device comprises: a stent body (1); a surface of the stent body (1) being provided with a drug releasing structure (3), and drug in the drug releasing structure (3) being drug for suppressing proliferation of adventitial fibroblasts and a drug for suppressing proliferation of intimal and/or smooth muscle cells. In use, after interventional medical device is implanted into a human body, the drug for suppressing proliferation of adventitial fibroblasts carried thereon can promote the compensatory expansion of the vessel, and the drug for suppressing proliferation of intimal cells and/or smooth muscle cells carried thereon can suppress intimal proliferation of the vessel. The combination of the two kinds of drugs greatly reduces the occurrence rate of in-stent restenosis.
摘要翻译：介入医疗装置及其制造方法。介入医疗装置包括：支架主体（1）; 支架体（1）的表面设有药物释放结构（3），药物释放结构（3）中的药物是抑制外膜成纤维细胞增殖的药物和抑制内膜和/或平滑增生的药物肌肉细胞。在使用中，将介入医疗装置植入人体后，用于抑制携带的外膜成纤维细胞增殖的药物可以促进血管的代偿性扩张，并且抑制其上承载的内膜细胞和/或平滑肌细胞增殖的药物可以抑制血管的内膜增殖。两种药物的组合大大降低了支架内再狭窄的发生率。

5. 发明授权

US09226994B2 Intervention medical device and preparation thereof 有权
标题翻译：干预医疗器械及其制备
公开(公告)号：US09226994B2
公开(公告)日：2016-01-05
申请号：US13703855
申请日：2011-06-13
申请人： Junfei Li , Xi Hu , Chengyun Yue , Dawei Wang , Peng Huang , Zhirong Tang , Qiyi Luo , Zhaohua Chang
发明人： Junfei Li , Xi Hu , Chengyun Yue , Dawei Wang , Peng Huang , Zhirong Tang , Qiyi Luo , Zhaohua Chang
IPC分类号： A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16
CPC分类号： A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2300/42
摘要： The present invention discloses an interventional medical device and methods of making the same. At least one coating layer is disposed on the outer surface of the interventional medical device and the material of the outmost layer of the coating layer is a sulfonate group-containing polymer. In the present invention, the material of the outmost layer of the interventional medical device is a sulfonate group-containing polymer. The polymer is endowed with a same surface property as that of heparin in addition to appropriate hydrophilicity due to the presence of the sulfonate group. After the interventional medical device is implanted into the human body, a hydrophilic surface is formed on the outer surface of the interventional medical device which is also negatively charged in the body fluid. Therefore, cells can easily adhere and grow on the outer surface thereof as a result of the enhanced cell compatibility. Furthermore, due to a surface property that is the same as that of heparin, the material is provided with excellent anticoagulant properties which inhibit the thrombosis and lower down the incidence rate of post-operational complications.
摘要翻译：本发明公开了一种介入医疗装置及其制造方法。至少一个涂层设置在介入医疗装置的外表面上，涂层的最外层的材料是含磺酸基的聚合物。在本发明中，介入医疗装置的最外层的材料是含磺酸基的聚合物。由于存在磺酸盐基，除了适当的亲水性之外，聚合物具有与肝素相同的表面性质。在将介入医疗装置植入人体后，在介入医疗装置的外表面上形成亲水性表面，其也在体液中带负电。因此，由于细胞相容性的增强，细胞可以容易地附着和生长在其外表面上。此外，由于与肝素相同的表面特性，具有优异的抗凝血性，能够抑制血栓形成，降低手术后并发症的发生率。

6. 发明授权

US09205180B2 Method and device for loading medical appliance with medicaments and/or polymers 有权
标题翻译：用药物和/或聚合物装载医疗器具的方法和装置
公开(公告)号：US09205180B2
公开(公告)日：2015-12-08
申请号：US13522819
申请日：2011-01-19
申请人： Jie Zhang , Bo Yi , Changsheng Wu , Zhirong Tang , Qiyi Luo
发明人： Jie Zhang , Bo Yi , Changsheng Wu , Zhirong Tang , Qiyi Luo
IPC分类号： A61L33/00 , A61L31/06 , A61L31/16 , A61F2/91
CPC分类号： A61F2/82 , A61F2/91 , A61F2240/001 , A61F2250/0068 , A61L31/06 , A61L31/16 , A61L2300/416 , B05C21/00 , C08L67/04
摘要： A method and a device for loading a medical appliance with a medicament and/or polymer includes capturing images of a plurality of grooves or holes of the medical appliance using an image capturing device; performing digital image processing on the image of each of the grooves or holes to obtain a pattern of each of the grooves or holes; calculating a central position of the pattern of each of the grooves or holes, and determining a loading position of each of the grooves or holes based on the central position; and adjusting a relative position between a loading device and the medical appliance to align an outlet of the loading device with the loading position of the medical appliance, and loading each of the grooves or holes with the medicament and/or polymer. The method and device can load the medical appliance with the medicament and/or polymer fast and efficiently.
摘要翻译：一种用于装载具有药物和/或聚合物的医疗器具的方法和装置包括使用图像捕获装置捕获医疗器具的多个凹槽或孔的图像; 对每个凹槽或孔的图像执行数字图像处理以获得每个凹槽或孔的图案; 计算每个凹槽或孔的图案的中心位置，以及基于中心位置确定每个凹槽或孔的装载位置; 以及调整加载装置和医疗器具之间的相对位置，以将装载装置的出口与医疗器具的装载位置对齐，并且用药物和/或聚合物装载每个凹槽或孔。该方法和装置可以快速且有效地加载具有药物和/或聚合物的医疗器具。

7. 发明申请

US20110238157A1 CORONARY ARTERY VASCULAR STENT WITH MEDICINE CARRYING SLOTS 有权
标题翻译：冠状动脉血管支架与药物携带
公开(公告)号：US20110238157A1
公开(公告)日：2011-09-29
申请号：US13127548
申请日：2009-11-02
申请人： Yan Li , Changchun Wang , Jianjun Li , Zhiyong Xie , Zhirong Tang , Qiyi Luo
发明人： Yan Li , Changchun Wang , Jianjun Li , Zhiyong Xie , Zhirong Tang , Qiyi Luo
IPC分类号： A61F2/82
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91508 , A61F2002/91558 , A61F2230/0054 , A61F2250/0068
摘要： The present invention discloses a coronary artery vascular stent with drug carrying slots (2), comprising a plurality of main supporting unit rings (1,8) and connecting rods (4,6). Said main supporting unit rings comprise a plurality of unit waves. There are drug carrying slots (2) at the outer surface of the rods of said unit waves, characterized in that the total slot length of the drug carrying slots (2) is 60%-75% of the total wave rod length of the main supporting unit rings (1,8).
摘要翻译：本发明公开了一种具有药物携带槽（2）的冠状动脉血管支架，包括多个主支撑单元环（1,8）和连接杆（4,6）。所述主支撑单元环包括多个单位波。在所述单位波的杆的外表面上存在药物携带槽（2），其特征在于，药物携带槽（2）的总槽长度为主要波长杆长度的60％-75％支撑单元环（1,8）。

8. 发明授权

US09398968B2 Method and device for loading medical appliance with drugs and/or polymers 有权
标题翻译：用药物和/或聚合物装载医疗器具的方法和装置
公开(公告)号：US09398968B2
公开(公告)日：2016-07-26
申请号：US13387927
申请日：2010-07-09
申请人： Jie Zhang , Bo Yi , Changsheng Wu , Zhirong Tang , Qiyi Luo
发明人： Jie Zhang , Bo Yi , Changsheng Wu , Zhirong Tang , Qiyi Luo
IPC分类号： A61F2/915 , G06T7/00
CPC分类号： A61F2/915 , A61F2230/0054 , A61F2240/001 , A61F2250/0068 , G06T7/73 , G06T2207/10004 , G06T2207/30164
摘要： A method for loading a medical appliance with a medicament and/or a polymer is disclosed, the medical appliance comprising one or more grooves or holes loaded with the medicament and/or polymer. The method comprising the steps of: 1) capturing an image of the grooves or holes of the medical appliance, wherein the image contains at least one complete pattern of the grooves or holes; 2) performing digital image processing on the captured image to obtain the pattern of the grooves or holes; 3) calculating a central position of the pattern of the grooves or holes, and determining an actual central position of the grooves or holes based on the central position; 4) adjusting a relative position of a loading device to the medical appliance to align an outlet of the loading device with the actual central position of the grooves or holes; and 5) opening the outlet of the loading device to load the grooves or holes. A device for loading a medical appliance with a medicament and/or a polymer is further disclosed.
摘要翻译：公开了一种用于装载具有药物和/或聚合物的医疗器具的方法，所述医疗器具包括装载有药物和/或聚合物的一个或多个凹槽或孔。该方法包括以下步骤：1）捕获医疗器具的凹槽或孔的图像，其中图像包含凹槽或孔的至少一个完整图案; 2）对拍摄图像执行数字图像处理以获得凹槽或孔的图案; 3）计算凹槽或孔的图案的中心位置，并且基于中心位置确定凹槽或孔的实际中心位置; 4）调节装载装置相对于医疗器具的相对位置，以将装载装置的出口与凹槽或孔的实际中心位置对齐; 和5）打开装载装置的出口以加载凹槽或孔。进一步公开了一种用于装载具有药物和/或聚合物的医疗器具的装置。

9. 发明授权

US09089446B2 Coronary artery vascular stent with medicine carrying slots 有权
标题翻译：冠状动脉血管支架与药物携带槽
公开(公告)号：US09089446B2
公开(公告)日：2015-07-28
申请号：US13127548
申请日：2009-11-02
申请人： Yan Li , Changchun Wang , Jianjun Li , Zhiyong Xie , Zhirong Tang , Qiyi Luo
发明人： Yan Li , Changchun Wang , Jianjun Li , Zhiyong Xie , Zhirong Tang , Qiyi Luo
IPC分类号： A61F2/06 , A61F2/88 , A61F2/82 , A61F2/915 , A61F2/91
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91508 , A61F2002/91558 , A61F2230/0054 , A61F2250/0068
摘要： The present invention discloses a coronary artery vascular stent with drug carrying slots (2), comprising a plurality of main supporting unit rings (1,8) and connecting rods (4,6). Said main supporting unit rings comprise a plurality of unit waves. There are drug carrying slots (2) at the outer surface of the rods of said unit waves, characterized in that the total slot length of the drug carrying slots (2) is 60%-75% of the total wave rod length of the main supporting unit rings (1,8).
摘要翻译：本发明公开了一种具有药物携带槽（2）的冠状动脉血管支架，包括多个主支撑单元环（1,8）和连接杆（4,6）。所述主支撑单元环包括多个单位波。在所述单位波的杆的外表面上存在药物携带槽（2），其特征在于，药物携带槽（2）的总槽长度为主要波长杆长度的60％-75％支撑单元环（1,8）。

10. 发明申请

US20120294499A1 METHOD AND DEVICE FOR LOADING MEDICAL APPLIANCE WITH MEDICAMENTS AND/OR POLYMERS 有权
标题翻译：用于装载医疗器具和/或聚合物的方法和装置
公开(公告)号：US20120294499A1
公开(公告)日：2012-11-22
申请号：US13522819
申请日：2011-01-19
申请人： Jie Zhang , Bo Yi , Changsheng Wu , Zhirong Tang , Qiyi Luo
发明人： Jie Zhang , Bo Yi , Changsheng Wu , Zhirong Tang , Qiyi Luo
IPC分类号： G06K9/00
CPC分类号： A61F2/82 , A61F2/91 , A61F2240/001 , A61F2250/0068 , A61L31/06 , A61L31/16 , A61L2300/416 , B05C21/00 , C08L67/04
摘要： A method and a device for loading a medical appliance with a medicament and/or polymer includes capturing images of a plurality of grooves or holes of the medical appliance using an image capturing device; performing digital image processing on the image of each of the grooves or holes to obtain a pattern of each of the grooves or holes; calculating a central position of the pattern of each of the grooves or holes, and determining a loading position of each of the grooves or holes based on the central position; and adjusting a relative position between a loading device and the medical appliance to align an outlet of the loading device with the loading position of the medical appliance, and loading each of the grooves or holes with the medicament and/or polymer. The method and device can load the medical appliance with the medicament and/or polymer fast and efficiently.
摘要翻译：一种用于加载具有药物和/或聚合物的医疗器械的方法和装置包括使用图像捕获装置捕获医疗器具的多个凹槽或孔的图像; 对每个凹槽或孔的图像执行数字图像处理以获得每个凹槽或孔的图案; 计算每个凹槽或孔的图案的中心位置，以及基于中心位置确定每个凹槽或孔的装载位置; 以及调整加载装置和医疗器具之间的相对位置，以将装载装置的出口与医疗器具的装载位置对齐，并且用药物和/或聚合物装载每个凹槽或孔。该方法和装置可以快速且有效地加载具有药物和/或聚合物的医疗器具。

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