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1. 发明授权

US10463341B2 Analysis of mitral regurgitation from slit orifices by ultrasonic imaging 有权
公开(公告)号：US10463341B2
公开(公告)日：2019-11-05
申请号：US13991551
申请日：2011-12-15
申请人： Qifeng Wei , Karl E. Thiele , Ajit P. Yoganathan , Choon-Hwai Yap
发明人： Qifeng Wei , Karl E. Thiele , Ajit P. Yoganathan , Choon-Hwai Yap
IPC分类号： A61B8/06 , A61B8/14 , A61B8/00 , A61B8/08
摘要： An ultrasonic diagnostic imaging system is described which quantifies regurgitant flow through a plurality of pinhole leaks or a slit leak of a mitral valve. A plurality of orifice locations of a leaking valve are identified and Doppler values obtained from a flow velocity field proximal each orifice. The Doppler values of each flow velocity field vectorially relating to the orifice location are processed to produce a measure of flow through the orifice. The flow measurements for a plurality of such orifices are summed to produce a quantified measure of regurgitant flow through a plurality of pinhole leaks or along a slit leak.

2. 发明申请

US20130261458A1 ANALYSIS OF MITRAL REGURGITATION FROM SLIT ORIFICES BY ULTRASONIC IMAGING 审中-公开
标题翻译：通过超声波成像从狭缝分析中分析麻醉药物
公开(公告)号：US20130261458A1
公开(公告)日：2013-10-03
申请号：US13991551
申请日：2011-12-15
申请人： Qifeng Wei , Karl E. Thiele , Ajit P. Yoganathan , Choon-Hwai Yap
发明人： Qifeng Wei , Karl E. Thiele , Ajit P. Yoganathan , Choon-Hwai Yap
IPC分类号： A61B8/06 , A61B8/00 , A61B8/14 , A61B8/08
CPC分类号： A61B8/06 , A61B8/145 , A61B8/4444 , A61B8/4488 , A61B8/463 , A61B8/483 , A61B8/488 , A61B8/5207 , A61B8/5223
摘要： An ultrasonic diagnostic imaging system is described which quantifies regurgitant flow through a plurality of pinhole leaks or a slit leak of a mitral valve. A plurality of orifice locations of a leaking valve are identified and Doppler values obtained from a flow velocity field proximal each orifice. The Doppler values of each flow velocity field vectorially relating to the orifice location are processed to produce a measure of flow through the orifice. The flow measurements for a plurality of such orifices are summed to produce a quantified measure of regurgitant flow through a plurality of pinhole leaks or along a slit leak.
摘要翻译：描述了超声波诊断成像系统，其定量通过多个针孔泄漏或二尖瓣的狭缝泄漏的反流量。识别泄漏阀的多个孔位置，并从每个孔附近的流速场获得多普勒值。对与孔口位置进行矢量相关的每个流速场的多普勒值进行处理，以产生通过孔口的流量的量度。将多个这样的孔的流量测量相加以产生通过多个针孔泄漏或沿着狭缝泄漏的回流量的量化测量。

3. 发明授权

US4640292A Extending sample volume in pulsed Doppler systems 失效
标题翻译：在脉冲多普勒系统中扩展样本体积
公开(公告)号：US4640292A
公开(公告)日：1987-02-03
申请号：US827670
申请日：1986-02-10
申请人： Alexander Tykulsky , Karl E. Thiele , Leslie I. Halberg
发明人： Alexander Tykulsky , Karl E. Thiele , Leslie I. Halberg
IPC分类号： A61B8/06 , G01P5/24 , A61B10/00
CPC分类号： A61B8/06 , G01P5/244
摘要： The sampling volume of a pulsed Doppler system is increased to a length greater than that corresponding to one pulse by sampling the reflections of each launched pulse a plurality of successive times and accumulating the samples.
摘要翻译：脉冲多普勒系统的采样体积通过对多个连续次数的每次发射脉冲的反射进行采样而增加到比对应于一个脉冲的长度的长度，并且累积样本。

4. 发明授权

US5669386A Ultrasonic flow measurement system employing cross-correlation of baseband reflection data 失效
标题翻译：超声波流量测量系统采用基带反射数据的互相关
公开(公告)号：US5669386A
公开(公告)日：1997-09-23
申请号：US692789
申请日：1996-07-31
申请人： Karl E. Thiele , Richard A. Hager , David W. Clark , Jerome F. Witt
发明人： Karl E. Thiele , Richard A. Hager , David W. Clark , Jerome F. Witt
IPC分类号： A61B8/06 , G01P5/22 , G01P5/24 , G01S7/531 , G01S15/89 , A61B8/00 , A61B8/12
CPC分类号： G01S15/8979 , G01P5/22 , G01P5/244 , G01S7/52044
摘要： An ultrasound flow measurement system converts each of plural groups of reflection sample values from scatterers, into baseband complex data values and enables a velocity determination from just two lag samples. A cross correlation function derives a first cross-correlation value between a first set of complex data values that are derived at a first common sample time, during succeeding transmit events, and a second set of complex data values that are derived at a second common sample time, during succeeding transmit events. A second cross-correlation function derives a second cross-correlation value between the first set of complex data values and a third set of complex data values that are derived at the common second sample time. A local oscillator synchronizes both the baseband conversion and cross-correlation operation, and exhibits a rate of change of phase per sample time. A processor relates the rate of change of phase of the local oscillation signal, the first cross-correlation value and the second cross-correlation value to derive the velocity of the ultrasound scatterers. In particular, the first and second cross-correlation values enable establishment of a linear function defining the phase of the cross-correlation function of the complex data values. The rate of change of phase of the local oscillation signal enables establishment of a further linear function. The intersection of the two linear functions identifies the time at which a maxima occurs of the cross-correlation function, thereby enabling derivation of the velocity of the scatterers.
摘要翻译：超声波流量测量系统将来自散射体的多组反射样本值中的每一个转换为基带复合数据值，并且仅使用两个滞后样本的速度确定。互相关函数导出在第一公共采样时间，后续发送事件期间导出的第一组复数据值和在第二公共样本中导出的第二组复数据值之间的第一互相关值时间，在成功的传输事件。第二互相关函数导出第一组复数据值之间的第二互相关值和在公共第二采样时间导出的第三组复数数据值。本地振荡器同步基带转换和互相关操作，并且显示每个采样时间的相位变化率。处理器涉及本地振荡信号的相位变化率，第一互相关值和第二互相关值，以导出超声波散射体的速度。特别地，第一和第二互相关值使得能够建立定义复数数据值的互相关函数的相位的线性函数。本地振荡信号的相位变化率使得能够建立进一步的线性函数。两个线性函数的交点识别互相关函数发生最大值的时间，从而能够推导出散射体的速度。

5. 发明申请

US20100016725A1 MULTI-BEAM TRANSMIT ISOLATION 审中-公开
标题翻译：多波束发射隔离
公开(公告)号：US20100016725A1
公开(公告)日：2010-01-21
申请号：US12519902
申请日：2007-12-19
申请人： Karl E. Thiele
发明人： Karl E. Thiele
IPC分类号： A61B8/14
CPC分类号： G01S7/52077 , G01S7/5208 , G01S7/5209 , G01S7/52093 , G01S7/52095 , G01S15/8925 , G01S15/8927
摘要： A method for isolating ultrasound transmit beams and reducing cross-transmit beam interference in a multi-beam system involves transmitting a first ultrasound beam at a first and second positive angle and transmitting a second ultrasound beam at a first and second negative angle. The method further involves receiving a first, second, third, and fourth composite signals, where each of the composite signals includes a return signal and a reflected component. The method further includes applying a finite impulse response filter to the first and third composite signals and the second and fourth composite signals to obtain an average of the first and second composite signals and an average of the second and fourth composite signals and remove the reflected components.
摘要翻译：用于隔离超声波发射波束并减少多波束系统中的交叉发射波束干扰的方法包括以第一和第二正角度发射第一超声波束，并以第一和第二负角度发射第二超声波束。该方法还包括接收第一，第二，第三和第四复合信号，其中每个复合信号包括返回信号和反射分量。该方法还包括对第一和第三复合信号以及第二和第四复合信号应用有限脉冲响应滤波器以获得第一和第二复合信号的平均值以及第二和第四复合信号的平均值并去除反射分量。

6. 发明申请

US20090184955A1 METHOD AND APPARATUS FOR VOLUME RENDERING USING DEPTH WEIGHTED COLORIZATION 有权
标题翻译：使用深度加权色彩的体积渲染的方法和装置
公开(公告)号：US20090184955A1
公开(公告)日：2009-07-23
申请号：US12302946
申请日：2007-05-29
申请人： Karl E. Thiele
发明人： Karl E. Thiele
IPC分类号： G06T15/00 , G09G5/02 , G06K9/00
CPC分类号： G06T15/06 , G06T15/08 , G06T15/40
摘要： A method of volume rendering includes obtaining data (52) representative of a first composited plane of one or more anatomical structures and calculating data (54) of a second composited plane as a function of a first composited plane. The data of the second composited plane is indicative of a measure of depth of the one or more anatomical structures along respective ray cast lines. The method also includes determining (56) depth weighted color values between two different colorization palettes as a function of the measure of depths of the second composited plane. The determined depth weighted color values are applied (58) to the first composited plane for producing a volume rendering image with depth weighted colorization.
摘要翻译：体绘制的方法包括获得代表一个或多个解剖结构的第一合成平面的数据（52），并且计算作为第一合成平面的函数的第二合成平面的数据（54）。第二合成平面的数据指示沿着相应的射线投射线的一个或多个解剖结构的深度的度量。该方法还包括根据第二合成平面深度的度量来确定（56）两个不同着色调色板之间的深度加权色值。将确定的深度加权颜色值（58）应用于第一合成平面以产生具有深度加权着色的体绘制图像。

7. 发明申请

US20080097204A1 Method and System for Generating 3D Ultrasound Image Data and Viewing Media 审中-公开
标题翻译：用于生成3D超声图像数据和查看媒体的方法和系统
公开(公告)号：US20080097204A1
公开(公告)日：2008-04-24
申请号：US11572649
申请日：2005-07-21
申请人： Karl E. Thiele , Mary Kay Bianchi , Hugo Matthieu Visser , Murray Fulton Gillies
发明人： Karl E. Thiele , Mary Kay Bianchi , Hugo Matthieu Visser , Murray Fulton Gillies
IPC分类号： A61B8/00
CPC分类号： G01S15/8993
摘要： According to one embodiment of the present disclosure, a method of providing 3D data sets for stand-alone use includes providing a 3D viewing program on a computer readable media and providing at least one 3D data set on the same computer readable media, wherein responsive to a computer activation of the 3D viewing program, the 3D viewing program operates to provide a 3D rendering based upon the at least one 3D data set.
摘要翻译：根据本公开的一个实施例，提供用于独立使用的3D数据集的方法包括在计算机可读介质上提供3D观看程序，并在同一计算机可读介质上提供至少一个3D数据集，其中响应于 3D查看程序的计算机激活，3D观看程序操作以基于至少一个3D数据集提供3D渲染。

8. 发明授权

US06824514B2 System and method for visualizing scene shift in ultrasound scan sequence 失效
标题翻译：用于可视化超声扫描序列中的场景偏移的系统和方法
公开(公告)号：US06824514B2
公开(公告)日：2004-11-30
申请号：US10270278
申请日：2002-10-11
申请人： McKee D. Poland , Karl E. Thiele
发明人： McKee D. Poland , Karl E. Thiele
IPC分类号： A61B800
CPC分类号： G06T7/254 , A61B8/483 , G06T7/33
摘要： A system and method for visualizing scene shift over successive ultrasound scan frames is disclosed. In one embodiment the invention is a system for real-time visualization of scene shift in an ultrasound scan, comprising an ultrasound receiver for developing a first ultrasound image and a second ultrasound image, border formation software for determining a first border corresponding to the first ultrasound image and a second border corresponding to the second ultrasound image, and image misalignment detection software for overlaying the first border on the second border to determine whether the first border aligns with the second border. Corresponding systems, methods and computer-readable media are also disclosed.
摘要翻译：公开了用于可视化连续超声扫描帧的场景偏移的系统和方法。在一个实施例中，本发明是一种用于超声扫描中的场景偏移的实时可视化的系统，包括用于开发第一超声图像和第二超声图像的超声波接收器，用于确定对应于第一超声波的第一边界的边界形成软件图像和对应于第二超声波图像的第二边界，以及图像未对准检测软件，用于将第一边界覆盖在第二边界上，以确定第一边界是否与第二边界对齐。还公开了相应的系统，方法和计算机可读介质。

9. 发明授权

US6126602A Phased array acoustic systems with intra-group processors 有权
标题翻译：具有组内处理器的相控阵声学系统
公开(公告)号：US6126602A
公开(公告)日：2000-10-03
申请号：US398353
申请日：1999-09-17
申请人： Bernard J. Savord , Karl E. Thiele
发明人： Bernard J. Savord , Karl E. Thiele
IPC分类号： A61B8/00 , A61B8/08 , G01S7/52 , G01S7/521 , G01S15/89 , G10K11/34
CPC分类号： G01S15/8925 , A61B8/4494 , G01S15/8927 , G01S7/5202 , G01S7/52046 , G01S7/52079 , G01S7/5208 , G10K11/346 , A61B8/08 , A61B8/483 , G01S15/899 , G01S7/52023
摘要： The disclosed ultrasound imaging apparatus and method use a transducer array with a very large number of transducer elements or a transducer array with many more transducer elements than beamformer channels. The imaging apparatus includes a transmit array including a multiplicity of transducer elements allocated into several transmit sub-arrays, and a receive array including a multiplicity of transducer elements allocated into several receive sub-arrays. The apparatus also includes several intra-group transmit processors, connected to the transmit sub-arrays, constructed and arranged to generate a transmit acoustic beam directed into a region of interest, and several intra-group receive processors connected to the receive sub-arrays. Each intra-group receive processor is arranged to receive, from the transducer elements of the connected sub-array, transducer signals in response to echoes from the transmit acoustic beam. Each intra-group receive processor includes delay and summing elements constructed to delay and sum the received transducer signals. The apparatus also includes a receive beamformer including several processing channels connected to the intra-group receive processors, wherein each processing channel includes a beamformer delay constructed and arranged to synthesize receive beams from the echos by delaying signals received from the intra-group receive processor, and a beamformer summer (a summing junction) constructed and arranged to receive and sum signals from the processing channels. An image generator is constructed and arranged to form an image of the region of interest based on signals received from the receive beamformer. The apparatus is practical in size, cost and complexity and is sufficiently fast to provide two-dimensional or three-dimensional images of moving body organs.
摘要翻译：所公开的超声成像设备和方法使用具有非常大量的换能器元件的换能器阵列或具有比波束形成器通道更多的换能器元件的换能器阵列。成像装置包括发射阵列，其包括被分配到多个发射子阵列中的多个换能器元件，以及包括被分配到多个接收子阵列中的多个换能器元件的接收阵列。该装置还包括连接到发射子阵列的几个组内发射处理器，其被构造和布置成生成被引导到感兴趣区域中的发射声波束以及连接到接收子阵列的几个组内接收处理器。每个组内接收处理器被布置成响应于来自发射声束的回波从接收的子阵列的换能器元件接收换能器信号。每个组内接收处理器包括构造成对所接收的换能器信号进行延迟和求和的延迟和求和元件。该装置还包括接收波束形成器，其包括连接到组内接收处理器的若干处理通道，其中每个处理通道包括波束形成器延迟，波束形成器延迟被构造和布置成通过延迟从组内接收处理器接收的信号来合成来自回波的接收波束，和一个波束形成器夏天（一个求和点）构造和布置成从处理通道接收和求和信号。一个图像发生器被构造和布置成基于从接收波束形成器接收的信号形成感兴趣区域的图像。该装置的尺寸，成本和复杂性是实用的，并且足够快以提供移动身体器官的二维或三维图像。

10. 发明授权

US5462057A Ultrasound imaging system using line splicing and parallel receive beam formation 失效
标题翻译：超声成像系统使用线拼接和平行接收束形成
公开(公告)号：US5462057A
公开(公告)日：1995-10-31
申请号：US287762
申请日：1994-08-09
申请人： Thomas J. Hunt , Benjamin M. Herrick , Kimberly K. Robertson , Karl E. Thiele , J. Mark Ziel
发明人： Thomas J. Hunt , Benjamin M. Herrick , Kimberly K. Robertson , Karl E. Thiele , J. Mark Ziel
IPC分类号： A61B8/00 , G01S7/52 , G01S15/89 , G10K11/34
CPC分类号： G01S7/52095 , G01S15/8977 , G01S7/52046 , G10K11/341
摘要： In a phased array ultrasound imaging system, a high quality image is obtained by a combination of line splicing and parallel receive beamforming. Two transmit pulses, one focused in the near field and one focused in the far field, are transmitted sequentially at each steering angle. The transmitted ultrasound energy is preferably focused both in azimuth and in elevation. Ultrasound echos are simultaneously received along two receive scan lines spaced angularly on opposite sides of each transmit scan line. Signals received in response to the near field and far field transmit pulses are spliced together to provide signals that represent a high quality image throughout the region of interest. Image artifacts are reduced by blending the received signals near the splice between the near field and the far field, by dynamically steering the receive scan lines to reduce the effect of line warping, and by weighted averaging of adjacent scan lines.
摘要翻译：在相控阵超声成像系统中，通过线拼接和并行接收波束形成的组合获得高质量图像。两个发射脉冲，一个聚焦在近场中，一个聚焦在远场中，在每个转向角顺序传输。发射的超声能量优选地以方位角和仰角聚焦。超声回波同时沿两个接收扫描线接收，每条扫描线在每个发射扫描线的相对侧成角度地间隔开。响应于近场和远场发射脉冲而接收的信号被拼接在一起，以提供表示感兴趣区域中的高质量图像的信号。通过将近场和远场之间的拼接附近的接收信号进行混合，通过动态地控制接收扫描线以减少线翘曲的影响以及通过相邻扫描线的加权平均来减少图像伪影。

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