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1. 发明申请

US20050171010A1 NOVEL ANTIBACTERIAL AGENTS 有权
标题翻译：新型抗菌剂
公开(公告)号：US20050171010A1
公开(公告)日：2005-08-04
申请号：US10274557
申请日：2002-10-21
申请人： Qi-Qi Chen , John Griffin , Thomas Jenkins , J. Judice , Martin Linsell , Michael Leadbetter , YongQi Mu
发明人： Qi-Qi Chen , John Griffin , Thomas Jenkins , J. Judice , Martin Linsell , Michael Leadbetter , YongQi Mu
IPC分类号： A61K38/00 , C07K9/00 , A61K38/14
CPC分类号： C07K9/008 , A61K38/00
摘要： Novel antibacterial agents that act as multibinding agents are disclosed. The compounds of the invention comprise from 2-10 ligands covalently connected, each of said ligands being capable of binding to a transglycosylase enzyme substrate thereby modulating the biological processes/functions thereof.
摘要翻译：公开了作为多结合剂的新型抗菌剂。本发明的化合物包含共价连接的2-10个配体，每个所述配体能够结合转糖基酶底物，从而调节其生物学过程/功能。

2. 发明申请

US20070196859A1 Novel antibacterial agents 审中-公开
标题翻译：新型抗菌剂
公开(公告)号：US20070196859A1
公开(公告)日：2007-08-23
申请号：US11603329
申请日：2006-11-21
申请人： Burton Christensen , Edmund Moran , John Griffin , J. Judice , YongQi Mu , John Pace , Mathai Mammen , James Aggen
发明人： Burton Christensen , Edmund Moran , John Griffin , J. Judice , YongQi Mu , John Pace , Mathai Mammen , James Aggen
IPC分类号： A61K38/14 , A61K31/43 , A61K31/545 , A61K31/407
CPC分类号： C07D477/12 , C07D499/32 , C07D499/44 , C07D501/56
摘要： This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked ) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands has a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, penicillinase enzyme, cephalosporinase enzyme, a transglycosylase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.
摘要翻译：本发明涉及作为抗菌剂的新型多结合化合物（试剂）。本发明的多相结合化合物包含2-10个配体，其通过连接体或连接体共价连接，其中所述各单体（即，未连接）状态的所述配体具有结合涉及细胞壁生物合成和代谢的酶的能力用于合成细菌细胞壁和/或细菌细胞表面的前体因而干扰细胞壁的合成和/或代谢。特别地，本发明的多相结合化合物包含通过接头或接头共价连接的2-10个配体，其中每个所述配体具有能够结合青霉素结合蛋白的配体结构域，转肽酶，转肽酶的底物， β-内酰胺酶，青霉素酶，头孢菌素酶，转糖基酶或转糖基酶酶底物; 优选地，配体选自β-内酰胺或糖肽类抗菌剂。

3. 发明申请

US20070154948A1 Novel antibacterial agents 审中-公开
公开(公告)号：US20070154948A1
公开(公告)日：2007-07-05
申请号：US11603286
申请日：2006-11-21
申请人： Burton Christensen , Edmund Moran , John Griffin , J. Judice , YongQi Mu , John Pace , Mathai Mammen , James Aggen
发明人： Burton Christensen , Edmund Moran , John Griffin , J. Judice , YongQi Mu , John Pace , Mathai Mammen , James Aggen
IPC分类号： A61K31/545 , A61K38/16 , A61K31/43 , C07D499/44 , C07D487/04
CPC分类号： C07D477/12 , C07D499/32 , C07D499/44 , C07D501/56
摘要： This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands has a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

4. 发明申请

US20070134729A1 Novel antibacterial agents 审中-公开
标题翻译：新型抗菌剂
公开(公告)号：US20070134729A1
公开(公告)日：2007-06-14
申请号：US11603287
申请日：2006-11-21
申请人： Burton Christensen , Edmund Moran , John Griffin , J. Judice , YongQi Mu , John Pace , Mathai Mammen , James Aggen
发明人： Burton Christensen , Edmund Moran , John Griffin , J. Judice , YongQi Mu , John Pace , Mathai Mammen , James Aggen
IPC分类号： A61K38/16 , A61K31/43 , A61K31/545 , A61K31/407
CPC分类号： C40B30/04 , A61K31/00 , A61K47/54 , A61K47/55 , A61K47/552 , A61K47/60 , C07C233/36 , C07C233/78 , C07C237/24 , C07C271/20 , C07C321/04 , C07C323/12 , C07C335/08 , C07C335/32 , C07C2603/18 , C07D207/333 , C07D211/58 , C07D215/56 , C07D233/90 , C07D235/30 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D413/14 , C07D471/04 , C07D471/14 , C07D473/00 , C07D473/34 , C07D475/04 , C07D475/08 , C07D487/04 , C07D487/06 , C07D493/04 , C07D493/06 , C07H19/20 , C12Q1/26 , C12Q1/44 , C12Q1/48 , C12Q1/533 , C40B40/04 , G01N33/573 , G01N33/6842 , G01N33/6845 , G01N33/92 , G01N2500/00 , G01N2500/04 , G01N2800/044 , Y02A50/401 , Y02A50/57 , Y10S530/807
摘要： This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands has a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.
摘要翻译：本发明涉及作为抗菌剂的新型多结合化合物（试剂）。本发明的多相结合化合物包含2-10个配体，其通过连接体或连接体共价连接，其中所述各单体（即，未连接）状态的所述配体具有结合涉及细胞壁生物合成和代谢的酶的能力用于合成细菌细胞壁和/或细菌细胞表面的前体因而干扰细胞壁的合成和/或代谢。特别地，本发明的多相结合化合物包含通过接头或接头共价连接的2-10个配体，其中每个所述配体具有能够结合青霉素结合蛋白的配体结构域，转肽酶，转肽酶的底物， β-内酰胺酶，pencillinase酶，头孢菌素酶，转糖基酶或转糖基酶酶底物; 优选地，配体选自β-内酰胺或糖肽类抗菌剂。

5. 发明授权

US08924334B2 Method and system for generating a surgical training module 有权
标题翻译：用于产生外科训练模块的方法和系统
公开(公告)号：US08924334B2
公开(公告)日：2014-12-30
申请号：US11660098
申请日：2005-08-12
申请人： Gerard Lacey , Donncha Mary Ryan , Derek Cassidy , John Griffin , Laurence Griffin
发明人： Gerard Lacey , Donncha Mary Ryan , Derek Cassidy , John Griffin , Laurence Griffin
IPC分类号： G06N5/00 , G06F1/00 , G09B23/28 , G09B7/00 , G09B9/00
CPC分类号： G09B23/28 , G09B7/00 , G09B9/00
摘要： A system (1) comprises a physical surgical simulator (11) which transmits data concerning physical movement of training devices to an analysis engine (12). The engine (12) automatically generates rules for a rule base (13a) in a learning system (13). The learning system (13) also comprises content objects (13b) and 3D scenario objects (13c). A linked set of a 3D scenario object (13c), a rule base (13a), and a content object (13b) are together a lesson (10). Another simulator (14) is operated by a student. This transmits data concerning physical movement of training devices by a student to a verification engine (15). The verification engine (15) interfaces with the rule base (13a) to display the lesson in the manner defined by the lesson rule base (13a). It calculates performance measures defined in the lesson rule base (13a). It also records the performance measures into a lesson record (18) and it adapts the display of the lesson in line with the parameters defined in the lesson rule base (13a).
摘要翻译：系统（1）包括物理外科模拟器（11），其将关于训练装置的物理运动的数据发送到分析引擎（12）。引擎（12）在学习系统（13）中自动生成规则库（13a）的规则。学习系统（13）还包括内容对象（13b）和3D场景对象（13c）。一个3D场景对象（13c），一个规则库（13a）和一个内容对象（13b）的链接集合在一起（10）。另一个模拟器（14）由学生操作。这将有关学生的训练装置的身体移动的数据发送到验证引擎（15）。验证引擎（15）与规则库（13a）接口以由课程规则库（13a）定义的方式显示课程。它计算课程规则库（13a）中定义的性能度量。它还将性能测量记录到课程记录（18）中，并且使课程的显示符合课程规则库（13a）中定义的参数。