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1. 发明申请

US20080039611A1 Cross-linked glycopeptide-cephalosporin antibiotics 有权
公开(公告)号：US20080039611A1
公开(公告)日：2008-02-14
申请号：US11895553
申请日：2007-08-24
申请人： Paul Fatheree , Martin Linsell , Daniel Long , Daniel Marquess , Edmund Moran , Matthew Nodwell , S. Derek Turner , James Aggen
发明人： Paul Fatheree , Martin Linsell , Daniel Long , Daniel Marquess , Edmund Moran , Matthew Nodwell , S. Derek Turner , James Aggen
IPC分类号： C07K9/00
CPC分类号： A61K31/545 , A61K38/00 , C07D277/40 , C07D277/42 , C07D407/12 , C07D407/14 , C07D501/00 , C07D501/46 , C07K9/008
摘要： This invention provides cross-linked glycopeptide—cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.

2. 发明申请

US20070225329A1 Aryl aniline beta2 adrenergic receptor agonists 有权
标题翻译：芳基苯胺β2肾上腺素受体激动剂
公开(公告)号：US20070225329A1
公开(公告)日：2007-09-27
申请号：US11805101
申请日：2007-05-22
申请人： Edmund Moran , John Jacobsen , Michael Leadbetter , Matthew Nodwell , Sean Trapp , James Aggen , Timothy Church
发明人： Edmund Moran , John Jacobsen , Michael Leadbetter , Matthew Nodwell , Sean Trapp , James Aggen , Timothy Church
IPC分类号： A61K31/47
CPC分类号： A61K31/4706 , A61K31/136 , A61K31/277 , A61K31/325 , A61K31/33 , A61K31/343 , A61K31/35 , A61K31/36 , A61K31/381 , A61K31/385 , A61K31/405 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/47 , A61K31/4704 , A61K31/4709 , A61K31/58 , C07C213/04 , C07C215/34 , C07C215/60 , C07C217/84 , C07C229/38 , C07C233/43 , C07C317/36 , C07D213/75 , C07D215/227 , C07D215/26 , C07D231/22 , C07D239/38 , C07D239/42 , C07D239/47 , C07D239/69 , C07D277/46 , C07D311/80 , C07D321/10 , C07D401/12 , C07D409/12 , C07D413/12 , A61K2300/00
摘要： The invention provides novel β2 adrenergic receptor agonist compounds of formula (I): wherein R1-R13 and w have any of the values described in the specification. The invention also provides combinations of such compounds and other therapeutic agents, pharmaceutical compositions comprising such compounds and combinations, methods of using such compounds to treat diseases associated with β2 adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.
摘要翻译：本发明提供新的β2肾上腺素能受体激动剂式（I）化合物：其中R 1 -R 13和w具有任何值在说明书中描述。本发明还提供了这些化合物和其它治疗剂的组合，包含这些化合物和组合的药物组合物，使用这些化合物治疗与β2肾上腺素能受体活性有关的疾病的方法，以及可用于制备此类化合物。

3. 发明申请

US20060019991A1 Diaryl ether beta2 adrenergic receptor agonists 有权
标题翻译：二芳基醚β2肾上腺素能受体激动剂
公开(公告)号：US20060019991A1
公开(公告)日：2006-01-26
申请号：US11185295
申请日：2005-07-20
申请人： Robert McKinnell , Edmund Moran
发明人： Robert McKinnell , Edmund Moran
IPC分类号： A61K31/4704 , A61K31/428 , A61K31/16 , A61K31/137
CPC分类号： C07C217/80 , C07C217/60 , C07C233/43 , C07C233/80 , C07C255/54 , C07D215/26
摘要： The invention provides novel β2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with β2 adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.
摘要翻译：本发明提供了新的β2肾上腺素能受体激动剂化合物。本发明还提供包含这些化合物的药物组合物，使用这些化合物治疗与β2肾上腺素能受体活性相关的疾病的方法，以及可用于制备这些化合物的方法和中间体。

4. 发明申请

US20050239691A1 Cross-linked glycopeptide - cephalosporin antibiotics 有权
标题翻译：交联糖肽 - 头孢菌素类抗生素
公开(公告)号：US20050239691A1
公开(公告)日：2005-10-27
申请号：US11172303
申请日：2005-06-30
申请人： Paul Fatheree , Martin Linsell , Daniel Long , Daniel Marquess , Edmund Moran , Matthew Nodwell , S. Turner , James Aggen
发明人： Paul Fatheree , Martin Linsell , Daniel Long , Daniel Marquess , Edmund Moran , Matthew Nodwell , S. Turner , James Aggen
IPC分类号： C07D501/46 , A01N37/46 , A61K31/545 , A61K38/00 , A61K38/04 , A61P31/00 , A61P31/04 , C07D277/40 , C07D277/42 , C07D407/12 , C07D407/14 , C07D501/00 , C07D501/14 , C07D501/20 , C07K7/02 , C07K9/00 , A61K38/14
CPC分类号： A61K31/545 , A61K38/00 , C07D277/40 , C07D277/42 , C07D407/12 , C07D407/14 , C07D501/00 , C07D501/46 , C07K9/008
摘要： This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
摘要翻译：本发明提供可用作抗生素的交联糖肽 - 头孢菌素化合物及其药学上可接受的盐。本发明还提供含有这些化合物的药物组合物; 使用这些化合物治疗哺乳动物细菌感染的方法; 以及可用于制备这些化合物的方法和中间体。

5. 发明申请

US20050026818A1 Cross-linked glycopeptide-cephalosporin antibiotics 有权
公开(公告)号：US20050026818A1
公开(公告)日：2005-02-03
申请号：US10888849
申请日：2004-07-09
申请人： Paul Fatheree , Martin Linsell , Daniel Marquess , Sean Trapp , Edmund Moran , James Aggen
发明人： Paul Fatheree , Martin Linsell , Daniel Marquess , Sean Trapp , Edmund Moran , James Aggen
IPC分类号： A61K38/14 , A61P31/04 , C07D501/00 , C07K7/64 , C07K9/00
CPC分类号： C07K7/64 , C07D501/00 , C07K9/008
摘要： This invention provides cross-linked glycopeptide—cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.

6. 发明申请

US20080108558A1 Cross-linked glycopeptide-cephalosporin antibiotics 有权
公开(公告)号：US20080108558A1
公开(公告)日：2008-05-08
申请号：US11977604
申请日：2007-10-25
申请人： Paul Fatheree , Martin Linsell , Daniel Long , Daniel Marquess , Edmund Moran , Matthew Nodwell , S. Derek Turner , James Aggen
发明人： Paul Fatheree , Martin Linsell , Daniel Long , Daniel Marquess , Edmund Moran , Matthew Nodwell , S. Derek Turner , James Aggen
IPC分类号： A61K38/14 , C07K9/00 , A61P31/04
CPC分类号： A61K31/545 , A61K38/00 , C07D277/40 , C07D277/42 , C07D407/12 , C07D407/14 , C07D501/00 , C07D501/46 , C07K9/008
摘要： This invention provides cross-linked glycopeptide—cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.

7. 发明申请

US20080039374A1 Cross-lined glycopeptide-cephalosporin antibiotics 有权
标题翻译：交叉型糖肽 - 头孢菌素抗生素
公开(公告)号：US20080039374A1
公开(公告)日：2008-02-14
申请号：US11895555
申请日：2007-08-24
申请人： Paul Fatheree , Martin Linsell , Daniel Long , Daniel Marquess , Edmund Moran , Matthew Nodwell , S. Derek Turner , James Aggen
发明人： Paul Fatheree , Martin Linsell , Daniel Long , Daniel Marquess , Edmund Moran , Matthew Nodwell , S. Derek Turner , James Aggen
IPC分类号： A61K38/12 , A61P31/04
CPC分类号： A61K31/545 , A61K38/00 , C07D277/40 , C07D277/42 , C07D407/12 , C07D407/14 , C07D501/00 , C07D501/46 , C07K9/008
摘要： This invention provides cross-linked glycopeptide—cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.
摘要翻译：本发明提供可用作抗生素的交联糖肽 - 头孢菌素化合物及其药学上可接受的盐。本发明还提供含有这些化合物的药物组合物; 使用这些化合物治疗哺乳动物细菌感染的方法; 以及可用于制备这些化合物的方法和中间体。

8. 发明申请

US20070196859A1 Novel antibacterial agents 审中-公开
标题翻译：新型抗菌剂
公开(公告)号：US20070196859A1
公开(公告)日：2007-08-23
申请号：US11603329
申请日：2006-11-21
申请人： Burton Christensen , Edmund Moran , John Griffin , J. Judice , YongQi Mu , John Pace , Mathai Mammen , James Aggen
发明人： Burton Christensen , Edmund Moran , John Griffin , J. Judice , YongQi Mu , John Pace , Mathai Mammen , James Aggen
IPC分类号： A61K38/14 , A61K31/43 , A61K31/545 , A61K31/407
CPC分类号： C07D477/12 , C07D499/32 , C07D499/44 , C07D501/56
摘要： This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked ) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands has a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, penicillinase enzyme, cephalosporinase enzyme, a transglycosylase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.
摘要翻译：本发明涉及作为抗菌剂的新型多结合化合物（试剂）。本发明的多相结合化合物包含2-10个配体，其通过连接体或连接体共价连接，其中所述各单体（即，未连接）状态的所述配体具有结合涉及细胞壁生物合成和代谢的酶的能力用于合成细菌细胞壁和/或细菌细胞表面的前体因而干扰细胞壁的合成和/或代谢。特别地，本发明的多相结合化合物包含通过接头或接头共价连接的2-10个配体，其中每个所述配体具有能够结合青霉素结合蛋白的配体结构域，转肽酶，转肽酶的底物， β-内酰胺酶，青霉素酶，头孢菌素酶，转糖基酶或转糖基酶酶底物; 优选地，配体选自β-内酰胺或糖肽类抗菌剂。

9. 发明申请

US20070179179A1 Beta2-adrenergic receptor agonists 有权
标题翻译： β2-肾上腺素能受体激动剂
公开(公告)号：US20070179179A1
公开(公告)日：2007-08-02
申请号：US11784148
申请日：2007-04-05
申请人： Edmund Moran , Seok-Ki Choi
发明人： Edmund Moran , Seok-Ki Choi
IPC分类号： A61K31/4709 , A61K31/444 , A61K31/4178 , A61K31/4184 , A61K31/403 , A61K31/404 , A61K31/382 , A61K31/165 , C40B30/06 , C40B40/04
CPC分类号： A61K45/06 , A61K31/137 , A61K31/167 , A61K31/403 , A61K31/404 , A61K31/4164 , A61K31/4706 , C07C215/60 , C07C215/68 , C07C233/43 , C40B40/00
摘要： Disclosed are multibinding compounds which are β2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.
摘要翻译：公开了作为β2肾上腺素能受体激动剂的多重联结化合物，并且可用于治疗和预防呼吸系统疾病如哮喘，支气管炎。它们也可用于治疗神经系统损伤和早产。

10. 发明申请

US20060189517A1 Cross-linked glycopeptide-cephalosporin antibiotics 有权
公开(公告)号：US20060189517A1
公开(公告)日：2006-08-24
申请号：US11405331
申请日：2006-04-17
申请人： Paul Fatheree , Martin Linsell , Daniel Marquess , Sean Trapp , Edmund Moran , James Aggen
发明人： Paul Fatheree , Martin Linsell , Daniel Marquess , Sean Trapp , Edmund Moran , James Aggen
IPC分类号： A61K38/14 , C07K9/00
CPC分类号： C07K7/64 , C07D501/00 , C07K9/008
摘要： This invention provides cross-linked glycopeptide—cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.

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