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1. 发明申请

WO2010075115A2 BODY-ASSOCIATED RECEIVER AND METHOD 审中-公开
标题翻译：身体相关接收者和方法
公开(公告)号：WO2010075115A2
公开(公告)日：2010-07-01
申请号：PCT/US2009/068128
申请日：2009-12-15
申请人： PROTEUS BIOMEDICAL, INC. , ROBERTSON, Timothy , OMIDVAR, Fataneh , BEHZADI, Yashar , ARNE, Lawrence , ROWBERRY, Kenneth , HUTCHISON, James , LEICHNER, Robert , SAVAGE, George , THOMPSON, Andrew , ZDEBLICK, Mark , KREIDLER, Marc , HAFEZI, Hooman , DUCK, Robert
发明人： ROBERTSON, Timothy , OMIDVAR, Fataneh , BEHZADI, Yashar , ARNE, Lawrence , ROWBERRY, Kenneth , HUTCHISON, James , LEICHNER, Robert , SAVAGE, George , THOMPSON, Andrew , ZDEBLICK, Mark , KREIDLER, Marc , HAFEZI, Hooman , DUCK, Robert
IPC分类号： A61B5/05 , A61B5/048 , H04B13/00
CPC分类号： A61M5/1723 , A61B5/0006 , A61B5/0028 , A61B5/02055 , A61B5/0404 , A61B5/04085 , A61B5/0428 , A61B5/053 , A61B5/11 , A61B5/1112 , A61B5/145 , A61B5/14532 , A61B5/4094 , A61B2560/0209 , A61B2560/0412 , A61B2560/0468 , A61B2562/0219 , A61M5/1452 , A61M5/172 , G06F19/34 , G06F19/3418 , H04B13/005
摘要： Receivers, which may be external or implantable, are provided. Aspects of receivers of the invention include the presence of one or more of: a high power-low power module; an intermediary module; a power supply module configured to activate and deactivate one or more power supplies to a high power processing block; a serial peripheral interface bus connecting master and slave blocks; and a multi-purpose connector. Receivers of the invention may be configured to receive a conductively transmitted signal. Also provided are systems that include the receivers, as well as methods of using the same. Additionally systems and methods are disclosed for using a receiver for coordinating with dosage delivery systems.
摘要翻译：提供可能是外部或可植入的接收器。本发明的接收机的方面包括存在一个或多个：高功率低功率模块; 中介模块; 电源模块，被配置为激活和去激活一个或多个电源给高功率处理块; 连接主站和从站的串行外设接口总线; 和多用途连接器。本发明的接收机可以被配置为接收电传送的信号。还提供了包括接收器的系统，以及使用它们的方法。另外公开了使用接收器来配合给药系统的系统和方法。

2. 发明申请

WO2012015757A1 METHODS AND APPARATUS FOR TISSUE STIMULATION CONFIGURATION 审中-公开
标题翻译：组织刺激配置的方法和装置
公开(公告)号：WO2012015757A1
公开(公告)日：2012-02-02
申请号：PCT/US2011/045233
申请日：2011-07-25
申请人： PROTEUS BIOMEDICAL, INC. , ZDEBLICK, Mark , LEICHNER, Robert , BERKMAN, Jeffrey
发明人： ZDEBLICK, Mark , LEICHNER, Robert , BERKMAN, Jeffrey
IPC分类号： A61N1/36 , A61N1/362 , A61N1/05 , A61N1/08
CPC分类号： A61N1/056 , A61N1/37205 , A61N1/37264 , A61N1/37288
摘要： Apparatus, methods, and system for stimulating tissue by using one or more individually addressable satellite units on a lead configured by one or more communication units disposed on the lead are described. In one aspect, the apparatus comprises at least one lead configured for insertion into a subject's body and the lead comprises at least one conduction path, one or more of satellite units located at a distal end of the lead, at least one communication unit disposed on the lead, a connector disposed on a proximal end of the lead, wherein the connector is configured to be coupled to an implantable pulse generator. The satellite units comprise one or more electrodes configured to interact with the body and the communication unit comprises control circuitry configured to communicate with an external device and the satellite units.
摘要翻译：描述了通过在一个或多个设置在引线上的通信单元配置的引线上使用一个或多个可单独寻址的卫星单元来刺激组织的装置，方法和系统。在一个方面，该装置包括至少一个引线，其被配置用于插入到被检者的身体中，并且引线包括至少一个传导路径，位于引线远端的一个或多个卫星单元，至少一个通信单元所述引线，设置在所述引线的近端上的连接器，其中所述连接器被配置为耦合到可植入脉冲发生器。卫星单元包括配置成与身体相互作用的一个或多个电极，并且通信单元包括被配置为与外部设备和卫星单元进行通信的控制电路。

3. 发明申请

WO2009131749A2 INTEGRATED CIRCUIT IMPLEMENTATION AND FAULT CONTROL SYSTEM, DEVICE, AND METHOD 审中-公开
标题翻译：集成电路实现和故障控制系统，设备和方法
公开(公告)号：WO2009131749A2
公开(公告)日：2009-10-29
申请号：PCT/US2009/035586
申请日：2009-02-27
申请人： PROTEUS BIOMEDICAL, INC. , BI, Yafei , LI, Haifeng , ZDEBLICK, Mark , THOMPSON, Todd , LEICHNER, Robert
发明人： BI, Yafei , LI, Haifeng , ZDEBLICK, Mark , THOMPSON, Todd , LEICHNER, Robert
CPC分类号： A61N1/05 , A61N1/025 , A61N1/37 , A61N1/378
摘要： Apparatus and methods enable robust, reliable control for implantable medical devices, including cardiac pacemakers, defibrillators and cardiac resynchronization devices. Integrated circuits in the devices have minimized interfaces, can derive power from the interface signals, and have high voltage and latch-up protection. A device lead has a power generation circuit and a switching circuit using cascaded PMOS transistors for operating with a stable voltage despite fluctuations in the supplied voltage. The lead has control electronics that provide a very low impedance between an electrode and a lead conductor during most of the duration of a pacing pulse, but during a brief initial portion of the pacing pulse, provide a very high impedance to permit charging up a power supply that is local to the control electronics. A method of stabilizing the external impedance and a system for fault detection and fault recovery for an implantable device are also provided.
摘要翻译：装置和方法能够对可植入医疗装置（包括心脏起搏器，除颤器和心脏再同步装置）进行可靠的，可靠的控制。器件中的集成电路具有最小化的接口，可以从接口信号中获取功率，并具有高电压和闭锁保护。器件引线具有发电电路和使用级联PMOS晶体管的开关电路，用于尽管工作电压的波动，以稳定的电压工作。引线具有控制电子学，其在起搏脉冲的大部分持续时间期间在电极和引线导体之间提供非常低的阻抗，但是在起搏脉冲的短暂初始部分期间，提供非常高的阻抗以允许充电电力供应是本地控制电子产品。还提供了稳定外部阻抗的方法和用于可植入装置的故障检测和故障恢复的系统。

4. 发明申请

WO2010080843A2 INGESTION-RELATED BIOFEEDBACK AND PERSONALIZED MEDICAL THERAPY METHOD AND SYSTEM 审中-公开
标题翻译：注射相关的生物安全和个性化医疗治疗方法和系统
公开(公告)号：WO2010080843A2
公开(公告)日：2010-07-15
申请号：PCT/US2010/020269
申请日：2010-01-06
申请人： PROTEUS BIOMEDICAL, INC. , JENSEN, Marc , LEICHNER, Robert , BEAULIEU, Patrick , AU-YEUNG, Kit Yee , ARNE, Lawrence , ZDEBLICK, Mark , THOMPSON, Andrew , SAVAGE, George , ROBERTSON, Timothy , BEHZADI, Yashar
发明人： JENSEN, Marc , LEICHNER, Robert , BEAULIEU, Patrick , AU-YEUNG, Kit Yee , ARNE, Lawrence , ZDEBLICK, Mark , THOMPSON, Andrew , SAVAGE, George , ROBERTSON, Timothy , BEHZADI, Yashar
IPC分类号： A61B1/00 , A61B5/02 , A61B5/0482 , H04B13/00
CPC分类号： A61B5/073 , A61B5/0002 , A61B5/021 , A61B5/024 , A61B5/1112 , A61B5/486 , A61B5/6833 , G06F19/00 , G06F19/3456 , G06F19/3481 , G16H10/60 , G16H20/00 , G16H20/10 , H04B13/005
摘要： Methods, devices and systems for acquiring information useful to support a patient in implementing and adhering to a medically prescribed therapy plan are provided. The therapy may incorporate biofeedback methods and/or personalized therapy aspects. A method includes steps of receiving, by a receiving device, biometric information associated with an ingestible event marker; analyzing, by a computing device having a microprocessor configured to perform a biometric information analysis, the biometric information; and determining a therapeutic recommendation at least partly on the basis of the analysis and/or integrating biofeedback techniques into patient therapy or activity. A system includes a biometric information module to receive biometric information associated with an ingestible event marker; an analysis module to analyze the biometric information; and a determination module to optionally determine and communicate a therapeutic recommendation at least partly on the basis of the analysis.
摘要翻译：提供了用于获取有助于支持患者实施和遵守医学上规定的治疗方案的信息的方法，装置和系统。该疗法可以包括生物反馈方法和/或个性化治疗方面。一种方法包括以下步骤：由接收装置接收与可摄取事件标记相关联的生物特征信息; 通过具有微处理器的计算设备分析生物特征信息; 以及至少部分地基于分析和/或将生物反馈技术集成到患者治疗或活动中来确定治疗推荐。一种系统包括用于接收与可摄取事件标记相关联的生物特征信息的生物特征信息模块; 分析生物特征信息的分析模块; 以及确定模块，用于至少部分地基于分析来可选地确定和传达治疗推荐。

5. 发明申请

WO2007075974A3 IMPLANTABLE INTEGRATED CIRCUIT 审中-公开
公开(公告)号：WO2007075974A3
公开(公告)日：2007-07-05
申请号：PCT/US2006/048944
申请日：2006-12-22
申请人： PROTEUS BIOMEDICAL, INC. , ZDEBLICK, Mark , LEICHNER, Robert , ARIA, Behard , JANI, Nilay , LI, Haifeng , THOMPSON, Todd , ARNE, Lawrence , ROBERTSON, Timothy , BI, Yafei , GELFANDBEIN, Vladimier
发明人： ZDEBLICK, Mark , LEICHNER, Robert , ARIA, Behard , JANI, Nilay , LI, Haifeng , THOMPSON, Todd , ARNE, Lawrence , ROBERTSON, Timothy , BI, Yafei , GELFANDBEIN, Vladimier
IPC分类号： A61B5/04
摘要： Embodiments of the present invention enable robust, reliable control functionality for effectors present on intraluminal, e.g., vascular leads, as well as other types of implantable devices. Embodiments of the invention enable the required functionality for accurate long term control of effectors units, even ones present on multiplex carrier configurations, while provide for low power consumption. Aspects of the invention include implantable integrated circuits that have power extraction; energy storage; communication; and device configuration functional blocks, where these functional blocks are all present in a single integrated circuit on an intraluminal-sized support. Also provided by the invention are effector assemblies that include the integrated circuits, as well as implantable medical devices, e.g., pulse generators that include the same, as well as systems and kits thereof and methods of using the same, e.g., in pacing applications, including cardiac resynchronization therapy (CRT) applications.

6. 发明申请

WO2012033923A3 MAINTAINING HIGH PACE RATE CHARGE BALANCE 审中-公开
公开(公告)号：WO2012033923A3
公开(公告)日：2012-03-15
申请号：PCT/US2011/050842
申请日：2011-09-08
申请人： PROTEUS BIOMEDICAL, INC. , LEICHNER, Robert , BERKMAN, Jeffrey , ZDEBLICK, Mark
发明人： LEICHNER, Robert , BERKMAN, Jeffrey , ZDEBLICK, Mark
IPC分类号： A61N1/36 , A61N1/362 , A61N1/08
摘要： Disclosed are a charge balance apparatus and a method for balancing at least one pacing electrode electrically coupled to the charge balance circuit. The charge balance apparatus receives a pace waveform from a pulse generator and provides a balanced flow of charge to the at least one pacing electrode. A charge monitor circuit is electrically coupled to the at least one pacing electrode and measures a flow of charge through the at least one pacing electrode in a first direction. A logic circuit interrupts a flow of charge in a second direction when a measured flow of charge in the second direction is substantially equal to a measured flow of charge in the first direction.

7. 发明申请

WO2010080768A2 METHOD, SYSTEM AND DEVICE FOR ACOUSTIC AND PHOTONIC TOMOGRAPHY 审中-公开
标题翻译：用于声学和光子断层摄影术的方法，系统和装置
公开(公告)号：WO2010080768A2
公开(公告)日：2010-07-15
申请号：PCT/US2010/020152
申请日：2010-01-05
申请人： PROTEUS BIOMEDICAL, INC. , LEICHNER, Robert
发明人： LEICHNER, Robert
IPC分类号： A61B5/02 , A61B8/06 , A61B5/042
CPC分类号： A61B5/1076 , A61B5/0422 , A61B5/0464 , A61N1/37
摘要： Methods and devices for determining the distance between a location emitting an acoustic, photonic, or electromagnetic waveform and a location detecting the emitted waveform are provided. In certain applications the emitting and/or sensing locations may be selected from within a human, mammalian, or animal body. The subject methods and devices find use in a variety of different applications, including cardiac resynchronization therapy. In certain aspects, a bioelectric signal pathway carries a pulse from cardiac pacing pulse generator to deliver a pacing pulse to a heart while protecting a bioelectric measurement device from interference from the pacing pulse.
摘要翻译：提供了用于确定发射声波，光子或电磁波的位置与检测发射波形的位置之间的距离的方法和设备。在某些应用中，可以从人类，哺乳动物或动物体内选择发射和/或感测位置。本主题的方法和装置可用于各种不同的应用，包括心脏再同步治疗。在某些方面，生物电信号路径携带来自心脏起搏脉冲发生器的脉冲以将起搏脉冲递送至心脏，同时保护生物电测量装置免受起搏脉冲的干扰。

8. 发明申请

WO2009140291A2 CONTINUOUS FIELD TOMOGRAPHY SYSTEMS AND METHODS OF USING THE SAME 审中-公开
标题翻译：连续的田间计量系统及其使用方法
公开(公告)号：WO2009140291A2
公开(公告)日：2009-11-19
申请号：PCT/US2009/043653
申请日：2009-05-12
申请人： PROTEUS BIOMEDICAL, INC. , ARNE, Lawrence , BANOS, Orlando , BEHZADI, Yashar , COLLIOU, Olivier , COSTELLO, Benedict , LEICHNER, Robert , MOON, Gregory , ROBERTSON, Timothy , SAVAGE, George , THOMPSON, Todd , ZDEBLICK, Mark
发明人： ARNE, Lawrence , BANOS, Orlando , BEHZADI, Yashar , COLLIOU, Olivier , COSTELLO, Benedict , LEICHNER, Robert , MOON, Gregory , ROBERTSON, Timothy , SAVAGE, George , THOMPSON, Todd , ZDEBLICK, Mark
IPC分类号： A61B5/0402 , A61B5/0408
CPC分类号： A61B5/046 , A61B5/0006 , A61B5/0031 , A61B5/0422 , A61B5/0536 , A61B5/0538 , A61B5/4519 , A61B5/743 , A61B5/7435 , A61B6/503 , A61B8/0883 , G06F19/00
摘要： Continuous field tomography systems are provided. Aspects of systems include a data aggregating module configured to receive both continuous field tomography data and non-continuous field physiological data and produce an aggregated data product from these disparate types of data. Also provided are methods of using systems of the invention in a variety of different applications, including diagnostic and therapeutic applications. The systems and methods of the invention find use in a variety of different applications, such as cardiac related applications.
摘要翻译：提供连续场断层摄影系统。系统的方面包括数据聚合模块，其配置为接收连续场断层摄影数据和非连续场生理数据，并从这些不同类型的数据产生聚合数据产物。还提供了在各种不同应用中使用本发明的系统的方法，包括诊断和治疗应用。本发明的系统和方法可用于各种不同的应用，例如心脏相关应用。

9. 发明公开

EP2385781A2 INGESTION-RELATED BIOFEEDBACK AND PERSONALIZED MEDICAL THERAPY METHOD AND SYSTEM 审中-公开
标题翻译：营养生物反馈和个性化的药物治疗制度和相关程序
公开(公告)号：EP2385781A2
公开(公告)日：2011-11-16
申请号：EP10729473.8
申请日：2010-01-06
申请人： Proteus Biomedical, Inc.
发明人： JENSEN, Marc , LEICHNER, Robert , BEAULIEU, Patrick , AU-YEUNG, Kit Yee , ARNE, Lawrence , ZDEBLICK, Mark , THOMPSON, Andrew , SAVAGE, George , ROBERTSON, Timothy , BEHZADI, Yashar
IPC分类号： A61B1/00 , A61B5/02 , A61B5/0482 , H04B13/00
CPC分类号： A61B5/073 , A61B5/0002 , A61B5/021 , A61B5/024 , A61B5/1112 , A61B5/486 , A61B5/6833 , G06F19/00 , G06F19/3456 , G06F19/3481 , G16H10/60 , G16H20/00 , G16H20/10 , H04B13/005
摘要： Methods, devices and systems for acquiring information useful to support a patient in implementing and adhering to a medically prescribed therapy plan are provided. The therapy may incorporate biofeedback methods and/or personalized therapy aspects. A method includes steps of receiving, by a receiving device, biometric information associated with an ingestible event marker; analyzing, by a computing device having a microprocessor configured to perform a biometric information analysis, the biometric information; and determining a therapeutic recommendation at least partly on the basis of the analysis and/or integrating biofeedback techniques into patient therapy or activity. A system includes a biometric information module to receive biometric information associated with an ingestible event marker; an analysis module to analyze the biometric information; and a determination module to optionally determine and communicate a therapeutic recommendation at least partly on the basis of the analysis.

10. 发明公开

EP2276400A2 CONTINUOUS FIELD TOMOGRAPHY SYSTEMS AND METHODS OF USING THE SAME 审中-公开
标题翻译：与连续场和申请流程。层析成像系统
公开(公告)号：EP2276400A2
公开(公告)日：2011-01-26
申请号：EP09747375.5
申请日：2009-05-12
申请人： Proteus Biomedical, Inc.
发明人： ARNE, Lawrence , BANOS, Orlando , BEHZADI, Yashar , COLLIOU, Olivier , COSTELLO, Benedict , LEICHNER, Robert , MOON, Gregory , ROBERTSON, Timothy , SAVAGE, George , THOMPSON, Todd , ZDEBLICK, Mark
IPC分类号： A61B5/0402 , A61B5/0408
CPC分类号： A61B5/046 , A61B5/0006 , A61B5/0031 , A61B5/0422 , A61B5/0536 , A61B5/0538 , A61B5/4519 , A61B5/743 , A61B5/7435 , A61B6/503 , A61B8/0883 , G06F19/00
摘要： Continuous field tomography systems are provided. Aspects of systems include a data aggregating module configured to receive both continuous field tomography data and non-continuous field physiological data and produce an aggregated data product from these disparate types of data. Also provided are methods of using systems of the invention in a variety of different applications, including diagnostic and therapeutic applications. The systems and methods of the invention find use in a variety of different applications, such as cardiac related applications.

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