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1. 发明申请

WO2010080765A2 HIGH-THROUGHPUT PRODUCTION OF INGESTIBLE EVENT MARKERS 审中-公开
标题翻译：高效率生产不可思议的事件标记
公开(公告)号：WO2010080765A2
公开(公告)日：2010-07-15
申请号：PCT/US2010/020142
申请日：2010-01-05
申请人： PROTEUS BIOMEDICAL, INC. , HAFEZI, Hooman , ZDEBLICK, Mark , AU-YEUNG, Kityee , MOON, Gregory , DUCK, Robert , HOLEN, Maria , ROBERTSON, Timothy , SNYDER, Eric , FOLENA, Mauro , COSTELLO, Benedict , RAO, Pratish
发明人： HAFEZI, Hooman , ZDEBLICK, Mark , AU-YEUNG, Kityee , MOON, Gregory , DUCK, Robert , HOLEN, Maria , ROBERTSON, Timothy , SNYDER, Eric , FOLENA, Mauro , COSTELLO, Benedict , RAO, Pratish
IPC分类号： A61K9/50 , A61K9/20 , G01N33/50 , A61B5/00
CPC分类号： A61B5/073 , A61B5/0031 , A61B5/4238 , A61B5/4255 , A61B2560/0406 , A61B2562/12 , A61B2562/162 , B01L3/545 , B30B11/34 , Y10T29/49885 , Y10T29/5191
摘要： High-throughput ingestible event marker manufacturing systems are provided. The systems include an assembly unit configured to stably associate an ingestible event marker with a carrier to produce a product. Also provided are manufacturing methods to produce such products which include assembling an ingestible event marker with an assembly unit configured to stably associate an ingestible event marker with a carrier.
摘要翻译：提供高通量可摄入事件标记制造系统。系统包括组装单元，其被配置为稳定地将可摄入事件标记与载体相关联以产生产物。还提供了制造这样的产品的制造方法，其包括将可摄取事件标记与组装单元组合，其被配置为将可摄取事件标记与载体稳定相关联。

2. 发明申请

WO2010057063A3 PACING AND STIMULATION SYSTEM, DEVICE AND METHOD 审中-公开
公开(公告)号：WO2010057063A3
公开(公告)日：2010-05-20
申请号：PCT/US2009/064487
申请日：2009-11-13
申请人： PROTEUS BIOMEDICAL, INC. , ZDEBLICK, Mark
发明人： ZDEBLICK, Mark
IPC分类号： A61N1/36 , A61N1/04 , A61N1/02
摘要： System, device and method of variable pacing and stimulation are provided. In one example device, one or more lead integrated circuits may programmably control one or more variability parameters. One or more electrodes may provide electrical stimulation. Each electrode may be individually addressable by at least one of the lead integrated circuits and controlled by at least one variability parameter. Electrodes may be intentionally shorted together during time intervals that fall between times of stimulus, so as to dissipate potentials that might otherwise persist and cause electrode degradation.

3. 发明申请

WO2010057046A3 MULTIPLEXED MULTI-ELECTRODE NEUROSTIMULATION DEVICES 审中-公开
公开(公告)号：WO2010057046A3
公开(公告)日：2010-05-20
申请号：PCT/US2009/064468
申请日：2009-11-13
申请人： PROTEUS BIOMEDICAL, INC. , ZDEBLICK, Mark , THOMPSON, Todd , JENSEN, Marc , COLLIOU, Olivier , STRAND, Angela
发明人： ZDEBLICK, Mark , THOMPSON, Todd , JENSEN, Marc , COLLIOU, Olivier , STRAND, Angela
IPC分类号： A61N1/36 , A61N1/05 , A61N1/02
摘要： Implantable stimulation devices are provided. Aspects of the devices include a multiplexed multi-electrode component configured for neural stimulation. The multiplexed multi-electrode component includes two or more individually addressable satellite electrode structures electrically coupled to a common conductor. The satellite structures include a hermetically sealed integrated circuit controller operatively coupled to one or more electrodes. Also provided are systems that include the devices of the invention, as well as methods of using the systems and devices in a variety of different applications.

4. 发明申请

WO2009131749A2 INTEGRATED CIRCUIT IMPLEMENTATION AND FAULT CONTROL SYSTEM, DEVICE, AND METHOD 审中-公开
标题翻译：集成电路实现和故障控制系统，设备和方法
公开(公告)号：WO2009131749A2
公开(公告)日：2009-10-29
申请号：PCT/US2009/035586
申请日：2009-02-27
申请人： PROTEUS BIOMEDICAL, INC. , BI, Yafei , LI, Haifeng , ZDEBLICK, Mark , THOMPSON, Todd , LEICHNER, Robert
发明人： BI, Yafei , LI, Haifeng , ZDEBLICK, Mark , THOMPSON, Todd , LEICHNER, Robert
CPC分类号： A61N1/05 , A61N1/025 , A61N1/37 , A61N1/378
摘要： Apparatus and methods enable robust, reliable control for implantable medical devices, including cardiac pacemakers, defibrillators and cardiac resynchronization devices. Integrated circuits in the devices have minimized interfaces, can derive power from the interface signals, and have high voltage and latch-up protection. A device lead has a power generation circuit and a switching circuit using cascaded PMOS transistors for operating with a stable voltage despite fluctuations in the supplied voltage. The lead has control electronics that provide a very low impedance between an electrode and a lead conductor during most of the duration of a pacing pulse, but during a brief initial portion of the pacing pulse, provide a very high impedance to permit charging up a power supply that is local to the control electronics. A method of stabilizing the external impedance and a system for fault detection and fault recovery for an implantable device are also provided.
摘要翻译：装置和方法能够对可植入医疗装置（包括心脏起搏器，除颤器和心脏再同步装置）进行可靠的，可靠的控制。器件中的集成电路具有最小化的接口，可以从接口信号中获取功率，并具有高电压和闭锁保护。器件引线具有发电电路和使用级联PMOS晶体管的开关电路，用于尽管工作电压的波动，以稳定的电压工作。引线具有控制电子学，其在起搏脉冲的大部分持续时间期间在电极和引线导体之间提供非常低的阻抗，但是在起搏脉冲的短暂初始部分期间，提供非常高的阻抗以允许充电电力供应是本地控制电子产品。还提供了稳定外部阻抗的方法和用于可植入装置的故障检测和故障恢复的系统。

5. 发明申请

WO2008112577A1 IN-BODY DEVICE HAVING A MULTI-DIRECTIONAL TRANSMITTER 审中-公开
标题翻译：具有多方向发射器的身体设备
公开(公告)号：WO2008112577A1
公开(公告)日：2008-09-18
申请号：PCT/US2008/056296
申请日：2008-03-07
申请人： PROTEUS BIOMEDICAL, INC. , COLLIOU, Olivier , ROBERTSON, Timothy , ZDEBLICK, Mark
发明人： COLLIOU, Olivier , ROBERTSON, Timothy , ZDEBLICK, Mark
IPC分类号： A61B5/00
CPC分类号： H01Q9/30 , A61B5/0031 , A61B5/0205 , A61B5/073 , A61B5/1104 , A61B2562/08 , H01Q1/273 , H01Q21/29
摘要： Multi-directional transmitters for in-body devices, such as implantable and ingestible devices, are provided. Aspects of the in-body multi-direction transmitters of the invention include signal transmitters configured to transmit an identifying signal in at least two different directions in an x-y plane. Embodiments of the in-body devices are configured to emit a detectable signal upon contact with a target physiological site. Also provided are methods of making and using the devices of the invention.
摘要翻译：提供用于体内装置的多向发射器，例如可植入和可摄取装置。本发明的体内多方向发射机的方面包括被配置为在x-y平面中以至少两个不同方向发射识别信号的信号发射机。身体内装置的实施例被配置为在与目标生理部位接触时发出可检测信号。还提供了制造和使用本发明的装置的方法。

6. 发明申请

WO2007028035A2 IMPLANTABLE ZERO-WIRE COMMUNICATIONS SYSTEM 审中-公开
标题翻译：可插拔的ZERO-WIRE通信系统
公开(公告)号：WO2007028035A2
公开(公告)日：2007-03-08
申请号：PCT/US2006/034258
申请日：2006-09-01
申请人： PROTEUS BIOMEDICAL, INC. , ZDEBLICK, Mark , ROBERTSON, Timothy
发明人： ZDEBLICK, Mark , ROBERTSON, Timothy
IPC分类号： G08C17/00
CPC分类号： A61B5/0022 , A61B5/0028 , A61B5/0031 , A61B5/01 , A61B5/0215 , A61B5/026 , A61B5/0265 , A61B5/145 , A61B5/14535 , A61B5/415 , A61B5/418 , A61B5/6862 , A61B5/6876 , A61M5/172 , A61N1/37217 , A61N1/37223 , G06F19/00 , H02J50/20 , Y02A90/26
摘要： The present invention provides implantable systems that communicate wirelessly with each other using a unique format that enables devices configurations and applications heretofore not possible. Embodiments of the present invention provide communication apparatuses and methods for exchanging information with implantable medical devices. In some embodiments, two implantable devices communicate with each other using quasi-electrostatic signal transmission in a long wavelength/low frequency electromagnetic band, with the patient's body acting as a conductive medium.
摘要翻译：本发明提供了使用能够使设备配置和应用迄今不可能的唯一格式彼此无线通信的可植入系统。本发明的实施例提供了与可植入医疗装置交换信息的通信装置和方法。在一些实施例中，两个可植入装置通过长波长/低频电磁波带中的准静电信号传输彼此进行通信，患者的身体用作导电介质。

7. 发明申请

WO2006042039A2 CONTINUOUS FIELD TOMOGRAPHY 审中-公开
标题翻译：连续现场测量
公开(公告)号：WO2006042039A2
公开(公告)日：2006-04-20
申请号：PCT/US2005/036035
申请日：2005-10-06
申请人： PROTEUS BIOMEDICAL, INC. , SAVAGE, George, M. , ZDEBLICK, Mark , COSTELLO, Ben , THOMPSON, Todd , COLLIOU, Olivier , ROBERTSON, Timothy
发明人： SAVAGE, George, M. , ZDEBLICK, Mark , COSTELLO, Ben , THOMPSON, Todd , COLLIOU, Olivier , ROBERTSON, Timothy
IPC分类号： A61B8/02
CPC分类号： A61B5/1107 , A61B5/0031 , A61B5/686 , A61B8/12 , A61B8/488 , A61B8/56 , A61B2562/046 , A61N1/3627 , A61N1/365
摘要： Methods for evaluating motion of a tissue, such as of a cardiac location, e.g., heart wall, via continuous field tomography are provided. In the subject methods, a continuous field (e.g., an electrical, mechanical, electro-mechanical, or other field) sensing element is stably associated with the tissue location. A property of the applied continuous field is detected with the sensing element to evaluate movement of the tissue location. Also provided are systems, devices and related compositions for practicing the subject methods. The subject methods and devices find use in a variety of different applications, including cardiac resynchronization therapy.
摘要翻译：提供了通过连续场断层摄影评估诸如心脏位置（例如心脏壁）的组织运动的方法。在主题方法中，连续场（例如，电，机械，机电或其他场）感测元件与组织位置稳定地相关联。使用感测元件检测所施加的连续场的特性，以评估组织位置的运动。还提供了用于实践主题方法的系统，装置和相关组合物。主题方法和设备可用于各种不同的应用，包括心脏再同步治疗。

8. 发明申请

WO2006029090A3 METHODS AND APPARATUS FOR TISSUE ACTIVATION AND MONITORING 审中-公开
公开(公告)号：WO2006029090A3
公开(公告)日：2006-03-16
申请号：PCT/US2005/031559
申请日：2005-09-01
申请人： PROTEUS BIOMEDICAL, INC. , ZDEBLICK, Mark
发明人： ZDEBLICK, Mark
IPC分类号： A61B5/00
摘要： Techniques for controlling one or more modular circuits ("satellites") that are intended for placement in a subject's body. The one or more satellites are controlled by sending signals over a bus that includes first and second conduction paths. Also coupled to the bus in system embodiments is a device such as a pacemaker that provides power and includes control circuitry. Each satellite includes satellite circuitry and one or more effectors that interact with the tissue. The satellite circuitry is coupled to the bus, and thus interfaces the controller to the one or more effectors, which may function as actuators, sensors, or both. The effectors may be electrodes that are used to introduce analog electrical signals ( e.g ., one or more pacing pulses) into the tissue in the local areas where the electrodes are positioned ( e.g ., heart muscles) or to sense analog signals ( e.g ., a propagating depolarization signal) within the tissue.

9. 发明申请

WO2004052182A2 METHOD AND SYSTEM FOR MONITORING AND TREATING HEMODYNAMIC PARAMETERS 审中-公开
标题翻译：用于监测和处理血液动力学参数的方法和系统
公开(公告)号：WO2004052182A2
公开(公告)日：2004-06-24
申请号：PCT/US2003/039524
申请日：2003-12-11
申请人： PROTEUS BIOMEDICAL, INC.
发明人： ZDEBLICK, Mark , SAVAGE, George, M.
IPC分类号： A61B
CPC分类号： A61B5/036 , A61B5/0422 , A61B18/1492 , A61B18/22 , A61B2562/02 , A61N1/0529 , A61N1/0551 , A61N1/0553 , A61N1/056
摘要： A multiplexed medical carrier provides for sensing one or more patient parameters and/or delivering energy via separately identifiable effectors. The carrier includes a body and at least two electrical conductors coupled with at least two effectors. Effectors may be any combination of sensors, actuators or both. Sensors may measure such parameters as pressure, oxygen content, volume, conductivity, fluid flow rate, or any other chemical or physical parameters. Actuators may be used, for example, to pace a heart, stimulate muscle or neural tissue, broadcast ultrasonic energy, emit light, heat or other forms of radiation, or deliver any form of energy or substance. A method for collecting medical data from a patient includes interrogating a network of multiplexed sensors residing on parallel conductors in the patient, including addressing a first addressable sensor in the network to obtain data and addressing a second addressable sensor in the network to obtain data.
摘要翻译：复用的医疗载体提供用于感测一个或多个患者参数和/或通过单独识别的效应器递送能量。载体包括主体和与至少两个效应器耦合的至少两个电导体。效应器可以是传感器，致动器或两者的任何组合。传感器可以测量诸如压力，氧含量，体积，电导率，流体流速或任何其它化学或物理参数的参数。例如，可以使用致动器来调节心脏，刺激肌肉或神经组织，广播超声能量，发射光，热或其他形式的辐射，或递送任何形式的能量或物质。一种用于从患者收集医学数据的方法包括询问驻留在患者的并行导体上的复用传感器网络，包括寻址网络中的第一可寻址传感器以获得数据并寻址网络中的第二可寻址传感器以获得数据。

10. 发明申请

WO2013009786A2 POLYPHARMACY CO-PACKAGED MEDICATION DOSING UNIT INCLUDING COMMUNICATION SYSTEM THEREFOR 审中-公开
公开(公告)号：WO2013009786A2
公开(公告)日：2013-01-17
申请号：PCT/US2012/046124
申请日：2012-07-10
申请人： PROTEUS BIOMEDICAL, INC. , ROBERTSON, Timothy , MOON, Gregory , COSTELLO, Benedict , ZDEBLICK, Mark , HAFEZI, Hooman
发明人： ROBERTSON, Timothy , MOON, Gregory , COSTELLO, Benedict , ZDEBLICK, Mark , HAFEZI, Hooman
IPC分类号： A61J7/04 , G06Q50/22 , B65D51/24 , A61J1/00 , G08B21/02
CPC分类号： A61J3/007 , A61B5/0002 , A61B5/073 , A61B5/4839 , A61B2560/0412 , A61J7/0084 , A61J7/04 , A61J7/0418 , A61J7/0436 , A61J7/0481 , A61J2200/30 , A61J2205/60 , G06F19/00 , G06F19/3462 , H01Q1/273 , Y10T29/49826
摘要： A custom medication dosing unit is disclosed. The custom medication dosing unit includes a housing having a shell element provided with a bottom surface and a circumferential edge extending from the bottom surface and a portion defining an opening for accommodating a medication. A first closure element provided with a circumferential edge is placed on the circumferential edge of the shell element in an adhering and closing manner. A medication is disposed within the opening defined between the shell element and the first closure element. A circuit module is associated within the first closure element. A system includes the custom medication dosing unit operative to communicate with a local node. Also disclosed is a method of manufacturing the custom medication dosing unit.
摘要翻译：公开了一种定制药物剂量单元。定制药物剂量单元包括具有壳体元件的壳体，壳体元件设置有底表面和从底表面延伸的圆周边缘和限定用于容纳药物的开口的部分。设置有周向边缘的第一闭合元件以粘附和闭合的方式放置在壳体元件的周缘上。药物设置在壳体元件和第一封闭元件之间限定的开口内。电路模块关联在第一闭合元件内。系统包括用于与本地节点通信的定制药物给药单元。还公开了一种制造定制药物给药单元的方法。

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