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1. 发明授权

US07720694B2 Pharmaceutical verification network 有权
标题翻译：制药验证网
公开(公告)号：US07720694B2
公开(公告)日：2010-05-18
申请号：US11609443
申请日：2006-12-12
申请人： Prasant Potuluri , David J. Brady , Michael Fuller
发明人： Prasant Potuluri , David J. Brady , Michael Fuller
IPC分类号： G06Q10/00
CPC分类号： G06F19/3462 , G06F19/00 , G06Q50/22 , G06Q50/24
摘要： Embodiments of the present invention relate to systems and methods for communicating pharmaceutical verification information between a server and a node using a network. A node includes a pharmaceutical identification and verification system. The verification information includes a known spectral signature of a known pharmaceutical and a corresponding known pharmaceutical name and dosage strength of the known pharmaceutical. The server stores the verification information in a server database. The node receives the verification information from the server, stores the verification information in the client database, reads a pharmaceutical name and dosage strength from a container enclosing a pharmaceutical, obtains a detected spectral signature for the pharmaceutical, and compares the detected spectral signature to the at least one known spectral signature. The pharmaceutical identification and verification system includes a static multimodal multiplex spectrometer. The verification information can also include a spectral signature of a known container.
摘要翻译：本发明的实施例涉及用于在服务器和使用网络的节点之间传送药物验证信息的系统和方法。节点包括药物识别和验证系统。验证信息包括已知药物的已知光谱特征和已知药物的相应的已知药物名称和剂量强度。服务器将验证信息存储在服务器数据库中。节点从服务器接收验证信息，将验证信息存储在客户端数据库中，从包含药品的容器读取药品名称和剂量强度，获得检测到的药品光谱特征，并将检测到的光谱特征与至少一个已知的光谱特征。药物鉴定和验证系统包括静态多模式多重光谱仪。验证信息还可以包括已知容器的光谱签名。

2. 发明授权

US07218395B2 Rapid pharmaceutical identification and verification system 有权
公开(公告)号：US07218395B2
公开(公告)日：2007-05-15
申请号：US11454923
申请日：2006-06-19
申请人： Stephen T. Kaye , Prasant Potuluri , David J. Brady , Michael Fuller , Michael E. Sullivan
发明人： Stephen T. Kaye , Prasant Potuluri , David J. Brady , Michael Fuller , Michael E. Sullivan
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/44 , B07C5/344 , G01J3/02 , G01J3/0264 , G01J3/28 , G01J3/2846 , G01J2003/4424 , G01N21/3563 , G01N21/3577 , G01N21/359 , G01N21/65 , G01N21/9508 , G01N2021/3595 , G01N2021/651 , G01N2201/129
摘要： A prescription verification system includes a database that contains a plurality of spectral signatures corresponding to identified pharmaceuticals. A multimodal multiplex sampling (MMS) spectrometer obtains a spectra of a pharmaceutical to be identified and verified. The pharmaceutical can be inside or out of a vial. The prescription verification system includes algorithms for matching spectra of pharmaceuticals to be verified obtaining using the MMS spectrometer to spectral signatures contained in the database corresponding to identified pharmaceuticals. The prescription verification system further includes algorithms for identifying such pharmaceuticals to be verified.

3. 发明授权

US07505130B2 Static two-dimensional aperture coding for multimodal multiplex spectroscopy 有权
标题翻译：用于多模式多光谱的静态二维孔径编码
公开(公告)号：US07505130B2
公开(公告)日：2009-03-17
申请号：US11942420
申请日：2007-11-19
申请人： David J. Brady , Scott T. McCain , Michael E. Gehm , Michael E. Sullivan , Prasant Potuluri
发明人： David J. Brady , Scott T. McCain , Michael E. Gehm , Michael E. Sullivan , Prasant Potuluri
IPC分类号： G01J3/04 , G01J3/28
CPC分类号： G01J3/2846 , G01J3/02 , G01J3/0205 , G01J3/0208 , G01J3/0218 , G01J3/0229
摘要： A class of aperture coded spectrometer is optimized for the spectral characterization of diffuse sources. The instrument achieves high throughput and high spatial resolution by replacing the slit of conventional dispersive spectrometers with a spatial filter or mask. A number of masks can be used including Harmonic masks, Legendre masks, and Hadamard masks.
摘要翻译：一类孔径编码光谱仪针对扩散源的光谱特征进行了优化。该仪器通过用空间滤波器或掩模代替常规色散光谱仪的狭缝，实现了高通量和高空间分辨率。可以使用多个掩模，包括谐波掩模，Legendre面具和Hadamard面具。

4. 发明申请

US20100209004A1 SPECTROSCOPIC CHEMICAL COMPOUND IDENTIFICATION 有权
标题翻译：光谱化学化合物鉴定
公开(公告)号：US20100209004A1
公开(公告)日：2010-08-19
申请号：US12705955
申请日：2010-02-15
申请人： Prasant Potuluri , David J. Brady
发明人： Prasant Potuluri , David J. Brady
IPC分类号： G06N5/02 , G01J3/28 , G01J3/44 , G06K9/62
CPC分类号： G01N21/31 , G01N21/65 , G01N21/9508 , G01N33/15 , G01N2021/651 , G01N2201/0221
摘要： A spectroscopic chemical compound identification system includes a container, a memory, a spectrometer, and a processor. The container receives unknown chemical compound. The memory stores a plurality of spectral signatures corresponding to known chemical compounds. The spectrometer measures a spectral signature of the unknown chemical compound through the container. The processor is connected to the memory and the spectrometer, performs a comparison of the spectral signature with at least one of the plurality of spectral signatures, and determines the identity of the unknown chemical compound from the comparison. The system can be housed in a portable handheld housing. A chemical compound can include a pharmaceutical or controlled substance. The system can be also be used to determine if a pharmaceutical or controlled substance is present within an unknown mixture of chemical compounds.
摘要翻译：光谱化学化合物识别系统包括容器，存储器，光谱仪和处理器。容器收到未知的化合物。存储器存储对应于已知化合物的多个光谱特征。光谱仪通过容器测量未知化合物的光谱特征。处理器连接到存储器和光谱仪，执行光谱特征与多个光谱特征中的至少一个的比较，并从比较中确定未知化合物的身份。该系统可以容纳在便携式手持式外壳中。化合物可以包括药物或受控物质。该系统还可用于确定未知的化合物混合物内是否存在药物或受控物质。

5. 发明授权

US07616306B2 Compressive sampling and signal inference 有权
标题翻译：压缩采样和信号推断
公开(公告)号：US07616306B2
公开(公告)日：2009-11-10
申请号：US11831832
申请日：2007-07-31
申请人： David J. Brady , Nikos Pitsianis , Xiaobai Sun , Prasant Potuluri
发明人： David J. Brady , Nikos Pitsianis , Xiaobai Sun , Prasant Potuluri
IPC分类号： G01J3/28
CPC分类号： G06T9/00 , H04N19/105 , H04N19/12 , H04N19/132 , H04N19/14 , H04N19/176 , H04N19/18 , H04N19/184 , H04N19/59 , H04N19/593 , H04N19/63
摘要： An optical wavemeter includes a slit, a diffraction grating, a mask, a complementary grating, and a detector. A monochromatic source is incident on the slit. The diffraction grating produces an image of the slit in an image plane at a horizontal position that is wavelength dependent. The mask has a two-dimensional pattern of transmission variations and produces different vertical intensity channels for different spectral channels. The complementary grating produces a stationary image of the slit independent of wavelength. The detector measures vertical variations in intensity of the stationary image, and the mask is created so that the number of measurements made by the detector is less than the number of spectral channels sampled.
摘要翻译：光波长计包括狭缝，衍射光栅，掩模，互补光栅和检测器。单色源入射在狭缝上。衍射光栅在波长相关的水平位置处在像平面中产生狭缝的图像。掩模具有传输变化的二维图案，并为不同的光谱通道产生不同的垂直强度通道。互补光栅产生独立于波长的狭缝的静止图像。检测器测量静止图像的强度的垂直变化，并且创建掩模，使得由检测器进行的测量的数量小于采样的频谱通道的数量。

6. 发明授权

US07463179B2 Compressive sampling and signal inference 失效
标题翻译：压缩采样和信号推断
公开(公告)号：US07463179B2
公开(公告)日：2008-12-09
申请号：US11831855
申请日：2007-07-31
申请人： David J. Brady , Nikos Pitsianis , Xiaobai Sun , Prasant Potuluri
发明人： David J. Brady , Nikos Pitsianis , Xiaobai Sun , Prasant Potuluri
IPC分类号： H03M1/12
CPC分类号： G06T9/00 , H04N19/105 , H04N19/12 , H04N19/132 , H04N19/14 , H04N19/176 , H04N19/18 , H04N19/184 , H04N19/59 , H04N19/593 , H04N19/63
摘要： An optical signal is compressively sampled using an optical component to encode multiplex measurements. A mapping from the optical signal to a detector array is created using spatial and/or spectral dispersion. Signals transmitted by a plurality of transmissive elements of the optical component are detected at each sensor of a plurality of sensors of the detector array dispersed spatially with respect to the optical component. Each sensor of a plurality of sensors produces a measurement resulting in a number of measurements. A number of estimated optical signal values is calculated from the number of measurements and a transmission function. The transmission function is selected so that the number of measurements is less than the number of estimated optical signal values.
摘要翻译：使用光学部件对光信号进行压缩采样以对多重测量进行编码。使用空间和/或光谱色散创建从光信号到检测器阵列的映射。在相对于光学部件在空间上分散的检测器阵列的多个传感器的每个传感器的每个传感器处检测由光学部件的多个透射元件发送的信号。多个传感器中的每个传感器产生测量，导致多个测量。根据测量次数和传输函数计算出多个估计的光信号值。选择发送功能，使得测量次数小于估计的光信号值的数量。

7. 发明授权

US07379181B2 Structured coded aperture fiber bundles 失效
标题翻译：结构编码孔径光纤束
公开(公告)号：US07379181B2
公开(公告)日：2008-05-27
申请号：US11421903
申请日：2006-06-02
申请人： David J. Brady , Prasant Potuluri , Michael E. Sullivan
发明人： David J. Brady , Prasant Potuluri , Michael E. Sullivan
IPC分类号： G01J3/04 , G01J3/12
CPC分类号： G01J3/02 , G01J3/0216 , G01J3/0218 , G01J3/0221 , G01J3/0229 , G01J3/2803 , G01J3/2846 , G02B2207/129
摘要： A spatial filter for an optical system, such as an optical spectrometer, collects and spatially filters light using a fiber bundle having a plurality of fibers disposed therein. At an input end of the fiber bundle, the fibers are typically packed tightly together to optimize the collection efficiency. At an output end, the fibers are spread out from the fiber bundle and arranged within a two-dimensional output area according to a two-dimensional pattern corresponding to a coded aperture function. As a result, the two-dimensional pattern of the output end spatially filters the light collected by the input end. Corresponding methods are also described.
摘要翻译：用于诸如光谱仪的光学系统的空间滤光器使用其中布置有多个光纤的纤维束聚集并空间地过滤光。在纤维束的输入端，通常将纤维紧密地包装在一起以优化收集效率。在输出端，根据与编码孔径函数对应的二维图案，纤维从纤维束展开并布置在二维输出区域内。结果，输出端的二维图案对输入端收集的光进行空间滤波。还描述了相应的方法。

8. 发明申请

US20070165220A1 Structured Coded Aperture Fiber Bundles 失效
标题翻译：结构编码孔径光纤束
公开(公告)号：US20070165220A1
公开(公告)日：2007-07-19
申请号：US11421903
申请日：2006-06-02
申请人： David J. Brady , Prasant Potuluri , Michael E. Sullivan
发明人： David J. Brady , Prasant Potuluri , Michael E. Sullivan
IPC分类号： G01J3/04
CPC分类号： G01J3/02 , G01J3/0216 , G01J3/0218 , G01J3/0221 , G01J3/0229 , G01J3/2803 , G01J3/2846 , G02B2207/129
摘要： A spatial filter for an optical system, such as an optical spectrometer, collects and spatially filters light using a fiber bundle having a plurality of fibers disposed therein. At an input end of the fiber bundle, the fibers are typically packed tightly together to optimize the collection efficiency. At an output end, the fibers are spread out from the fiber bundle and arranged within a two-dimensional output area according to a two-dimensional pattern corresponding to a coded aperture function. As a result, the two-dimensional pattern of the output end spatially filters the light collected by the input end. Corresponding methods are also described.
摘要翻译：用于诸如光谱仪的光学系统的空间滤光器使用其中布置有多根纤维的纤维束聚集并空间地过滤光。在纤维束的输入端，通常将纤维紧密包装在一起，以优化收集效率。在输出端，根据与编码孔径函数对应的二维图案，纤维从纤维束展开并布置在二维输出区域内。结果，输出端的二维图案对输入端收集的光进行空间滤波。还描述了相应的方法。

9. 发明授权

US08731959B2 Spectroscopic chemical compound identification 有权
标题翻译：光谱化学鉴定
公开(公告)号：US08731959B2
公开(公告)日：2014-05-20
申请号：US12705955
申请日：2010-02-15
申请人： Prasant Potuluri , David J. Brady
发明人： Prasant Potuluri , David J. Brady
IPC分类号： G06Q10/00 , G01J3/42 , C12Q1/00 , G01J3/04 , G01J3/28
CPC分类号： G01N21/31 , G01N21/65 , G01N21/9508 , G01N33/15 , G01N2021/651 , G01N2201/0221
摘要： A spectroscopic chemical compound identification system includes a container, a memory, a spectrometer, and a processor. The container receives unknown chemical compound. The memory stores a plurality of spectral signatures corresponding to known chemical compounds. The spectrometer measures a spectral signature of the unknown chemical compound through the container. The processor is connected to the memory and the spectrometer, performs a comparison of the spectral signature with at least one of the plurality of spectral signatures, and determines the identity of the unknown chemical compound from the comparison. The system can be housed in a portable handheld housing. A chemical compound can include a pharmaceutical or controlled substance. The system can be also be used to determine if a pharmaceutical or controlled substance is present within an unknown mixture of chemical compounds.
摘要翻译：光谱化学化合物识别系统包括容器，存储器，光谱仪和处理器。容器收到未知的化合物。存储器存储对应于已知化合物的多个光谱特征。光谱仪通过容器测量未知化合物的光谱特征。处理器连接到存储器和光谱仪，执行光谱特征与多个光谱特征中的至少一个的比较，并从比较中确定未知化合物的身份。该系统可以容纳在便携式手持式外壳中。化合物可以包括药物或受控物质。该系统还可用于确定未知的化合物混合物内是否存在药物或受控物质。

10. 发明申请

US20090080735A1 MACHINE VISION AND SPECTROSCOPIC PHARMACEUTICAL VERIFICATION 失效
标题翻译：机器视觉和光谱药学验证
公开(公告)号：US20090080735A1
公开(公告)日：2009-03-26
申请号：US12326558
申请日：2008-12-02
申请人： Kenneth Wayne Chapman , John E. Stranzl, JR. , Evan C. Cull , Prasant Potuluri , David J. Brady
发明人： Kenneth Wayne Chapman , John E. Stranzl, JR. , Evan C. Cull , Prasant Potuluri , David J. Brady
IPC分类号： G06K9/00
CPC分类号： G06T7/0004 , G06F19/3462 , G06T7/97 , G06T2207/10152 , G06T2207/30108
摘要： A pharmaceutical solid in a prescription vial is identified from an optical property of the pharmaceutical solid using light reflected from two different light sources. For each known pharmaceutical solid, an optical property of the known pharmaceutical solid is stored. The prescription vial is illuminated with a first light source and a first image is recorded. The prescription vial is then illuminated with a second light source and a second image is recorded. The first image and the second image are processed to find an optical property of the pharmaceutical solid. The optical property found is compared to the stored optical properties. The identity of the pharmaceutical solid is determined from the comparison. The first light source and the second light source are selected to remove artifacts of the prescription bottle or to enhance or suppress two-dimensional or three-dimensional effects on the surface of the pharmaceutical solid.
摘要翻译：使用从两个不同光源反射的光，从药物固体的光学性质鉴定处方小瓶中的药物固体。对于每种已知的药物固体，存储已知药物固体的光学性质。用第一光源照射处方小瓶，并记录第一个图像。然后用第二光源照射处方小瓶，并记录第二个图像。处理第一图像和第二图像以找到药物固体的光学特性。将所发现的光学性质与存储的光学性质进行比较。根据比较确定药物固体的特性。选择第一光源和第二光源以去除处方瓶的伪影，或增强或抑制药物固体表面上的二维或三维效应。

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