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1. 发明授权

US07842806B2 Pyridopyrimidone derivatives, preparation thereof, therapeutic use thereof 失效
标题翻译：吡啶并嘧啶衍生物，其制备方法，治疗用途
公开(公告)号：US07842806B2
公开(公告)日：2010-11-30
申请号：US12166431
申请日：2008-07-02
申请人： Pierre Perreaut , Samir Jegham , Bernard Bourrie , Pierre Casellas , Jean-Robert Labrosse , Florence Durand
发明人： Pierre Perreaut , Samir Jegham , Bernard Bourrie , Pierre Casellas , Jean-Robert Labrosse , Florence Durand
IPC分类号： C07D471/00
CPC分类号： C07D471/04
摘要： The disclosure relates to pyrido[2,3-d]pyrimidone compounds, to the preparation thereof and to the therapeutic use thereof, wherein said compounds are of general formula (I): in the form of a base or of an addition salt with an acid which is pharmaceutically acceptable, in the form of hydrates or of solvates, and also in the form of enantiomers, diastereoisomers and a mixture thereof. The disclosure also relates to processes for preparing said compounds, to pharmaceutical compositions containing a compound of general formula (I), and to the therapeutic use of said compounds and compositions.
摘要翻译：本公开涉及吡啶并[2,3-d]嘧啶酮化合物，其制备方法及其治疗用途，其中所述化合物为通式（I）：以碱的形式或加成盐与其为药学上可接受的，为水合物或溶剂化物形式，也为对映异构体，非对映异构体及其混合物的形式。本公开还涉及制备所述化合物的方法，含有通式（I）化合物的药物组合物以及所述化合物和组合物的治疗用途。

2. 发明授权

US07544682B2 Pyrido-pyrimidine derivatives, preparation thereof, and therapeutic use thereof 有权
标题翻译：吡啶并嘧啶衍生物及其制备方法及其治疗用途
公开(公告)号：US07544682B2
公开(公告)日：2009-06-09
申请号：US11651376
申请日：2007-01-08
申请人： Bernard Bourrie , Pierre Casellas , Samir Jegham , Pierre Perreaut
发明人： Bernard Bourrie , Pierre Casellas , Samir Jegham , Pierre Perreaut
IPC分类号： A61K31/5355 , A61K31/519 , C07D471/04 , A61P35/00 , C07D405/04 , C07D491/113 , C07D495/10 , C07D497/10 , C07D211/44 , C07D317/48
CPC分类号： C07D471/04
摘要： The disclosure concerns pyrido[2,3-d]pyrimidine derivatives, their preparation and their therapeutic application, of general formula (I) and acid addition salts, hydrates and solvates thereof, as well as in the form of enantiomers, diastereoisomers and mixtures thereof. The disclosure also concerns methods for preparing said derivatives, pharmaceutical compositions containing a compound of general formula (I), and their therapeutic use.
摘要翻译：本公开涉及通式（I）的吡啶并[2,3-d]嘧啶衍生物及其制备方法及其治疗应用，以及其对映异构体，非对映异构体及其混合物的酸加成盐，水合物和溶剂化物。本公开还涉及制备所述衍生物的方法，含有通式（I）的化合物的药物组合物及其治疗用途。

3. 发明授权

US07504406B2 Derivatives of pyrido[2,3-d]pyrimidine, the preparation thereof, and the therapeutic application of the same 有权
标题翻译：吡啶并[2,3-d]嘧啶的衍生物及其制备方法及其治疗应用
公开(公告)号：US07504406B2
公开(公告)日：2009-03-17
申请号：US11955583
申请日：2007-12-13
申请人： Bernard Bourrie , Pierre Casellas , Samir Jegham , Claude Muneaux , Pierre Perreaut
发明人： Bernard Bourrie , Pierre Casellas , Samir Jegham , Claude Muneaux , Pierre Perreaut
IPC分类号： C07D471/04 , A61K31/519
CPC分类号： C07D471/04
摘要： The invention relates to derivatives of pyrido[2,3-d]pyrimidine, to the preparation thereof, and to the therapeutic application of the same.
摘要翻译：本发明涉及吡啶并[2,3-d]嘧啶的衍生物及其制备方法及其治疗应用。

4. 发明申请

US20090233923A1 PYRIDO-PYRIMIDINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF 有权
标题翻译：吡啶二吡啶衍生物，其制备方法及其治疗方法
公开(公告)号：US20090233923A1
公开(公告)日：2009-09-17
申请号：US12415256
申请日：2009-03-31
申请人： Bernard Bourrie , Pierre Casellas , Samir Jegham , Pierre Perreaut
发明人： Bernard Bourrie , Pierre Casellas , Samir Jegham , Pierre Perreaut
IPC分类号： A61K31/5377 , C07D471/04 , A61K31/519 , A61P35/00
CPC分类号： C07D471/04
摘要： The disclosure concerns pyrido[2,3-d]pyrimidine derivatives, their preparation and their therapeutic application, of general formula (I): and acid addition salts, hydrates and solvates thereof, as well as in the form of enantiomers, diastereoisomers and mixtures thereof. The disclosure also concerns methods for preparing said derivatives, pharmaceutical compositions containing a compound of general formula (I), and their therapeutic use.
摘要翻译：本公开涉及通式（I）的吡啶并[2,3-d]嘧啶衍生物及其制备方法及其治疗应用：及其酸加成盐，水合物和溶剂化物，以及对映异构体，非对映异构体和混合物的形式其中。本公开还涉及制备所述衍生物的方法，含有通式（I）的化合物的药物组合物及其治疗用途。

5. 发明授权

US08008310B2 Derivatives of pyrido[2,3-d]pyrimidine, the preparation thereof, and the therapeutic application of the same 有权
标题翻译：吡啶并[2,3-d]嘧啶的衍生物及其制备方法及其治疗应用
公开(公告)号：US08008310B2
公开(公告)日：2011-08-30
申请号：US12362656
申请日：2009-01-30
申请人： Bernard Bourrie , Pierre Casellas , Samir Jegham , Claude Muneaux , Pierre Perreaut
发明人： Bernard Bourrie , Pierre Casellas , Samir Jegham , Claude Muneaux , Pierre Perreaut
IPC分类号： C07D471/04 , A61K31/519 , A61P35/00
CPC分类号： C07D471/04
摘要： Derivatives of pyrido[2,3-d]pyrimidine are provided having formula (I) with Ar1, Ar2 and R1 as defined herein, which are useful for treating cell proliferative conditions, and to the preparation thereof, and to the therapeutic application of the same.
摘要翻译：提供吡啶并[2,3-d]嘧啶的衍生物，其具有如本文所定义的具有本文定义的Ar1，Ar2和R1的式（I），其可用于治疗细胞增殖状况及其制备，以及治疗应用相同。

6. 发明申请

US20070167469A1 Pyrido-pyrimidine derivatives, preparation thereof, and therapeutic use thereof 有权
标题翻译：吡啶并嘧啶衍生物及其制备方法及其治疗用途
公开(公告)号：US20070167469A1
公开(公告)日：2007-07-19
申请号：US11651376
申请日：2007-01-08
申请人： Bernard Bourrie , Pierre Casellas , Samir Jegham , Pierre Perreaut
发明人： Bernard Bourrie , Pierre Casellas , Samir Jegham , Pierre Perreaut
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D471/04
摘要： The disclosure concerns pyrido[2,3-d]pyrimidine derivatives, their preparation and their therapeutic application, of general formula (I) and acid addition salts, hydrates and solvates thereof, as well as in the form of enantiomers, diastereoisomers and mixtures thereof. The disclosure also concerns methods for preparing said derivatives, pharmaceutical compositions containing a compound of general formula (I), and their therapeutic use.
摘要翻译：本公开涉及通式（I）的吡啶并[2,3-d]嘧啶衍生物及其制备方法及其治疗应用，以及其对映异构体，非对映异构体及其混合物的酸加成盐，水合物和溶剂化物。本公开还涉及制备所述衍生物的方法，含有通式（I）的化合物的药物组合物及其治疗用途。

7. 发明授权

US07893259B2 Pyrido-pyrimidine derivatives, preparation thereof, and therapeutic use thereof 有权
标题翻译：吡啶并嘧啶衍生物及其制备方法及其治疗用途
公开(公告)号：US07893259B2
公开(公告)日：2011-02-22
申请号：US12415256
申请日：2009-03-31
申请人： Bernard Bourrie , Pierre Casellas , Samir Jegham , Pierre Perreaut
发明人： Bernard Bourrie , Pierre Casellas , Samir Jegham , Pierre Perreaut
IPC分类号： C07D471/04 , A61P35/00 , A61P35/02
CPC分类号： C07D471/04
摘要： The disclosure concerns pyrido[2,3-d]pyrimidine derivatives, their preparation and their therapeutic application, of general formula (I): and acid addition salts, hydrates and solvates thereof, as well as in the form of enantiomers, diastereoisomers and mixtures thereof. The disclosure also concerns methods for preparing said derivatives, pharmaceutical compositions containing a compound of general formula (I), and their therapeutic use.
摘要翻译：本公开涉及通式（I）的吡啶并[2,3-d]嘧啶衍生物及其制备方法及其治疗应用：及其酸加成盐，水合物和溶剂化物，以及对映异构体，非对映异构体和混合物的形式其中。本公开还涉及制备所述衍生物的方法，含有通式（I）的化合物的药物组合物及其治疗用途。

8. 发明授权

US06433185B1 N-(arylsulphonyl) amino acid derivatives, process for their preparation and pharmaceutical compositions containing them 失效
标题翻译： N-（芳基磺酰基）氨基酸衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US06433185B1
公开(公告)日：2002-08-13
申请号：US09948011
申请日：2001-09-06
申请人： Bernard Ferrari , Jean Gougat , Claude Muneaux , Yvette Muneaux , Pierre Perreaut , Claudine Planchenault
发明人： Bernard Ferrari , Jean Gougat , Claude Muneaux , Yvette Muneaux , Pierre Perreaut , Claudine Planchenault
IPC分类号： C07D295192
CPC分类号： C07D239/06 , C07C311/19 , C07D233/22 , C07D233/24 , C07D233/26 , C07D295/185 , C07D403/12
摘要： The invention relates to compounds of formula in which R1 to R9, R16 and R17 are as defined in claim 1. These compounds are pharmacologically active.
摘要翻译：本发明涉及式1化合物，其中R1至R9，R16和R17如权利要求1所定义。这些化合物具有药理活性。

9. 发明授权

US06313120B1 N-(arylsulfonyl) amino acid derivatives, process for their preparation and pharmaceutical compositions containing them 失效
标题翻译： N-（芳基磺酰基）氨基酸衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US06313120B1
公开(公告)日：2001-11-06
申请号：US09593067
申请日：2000-06-13
申请人： Bernard Ferrari , Jean Gougat , Claude Muneaux , Yvette Muneaux , Pierre Perreaut , Claudine Planchenault
发明人： Bernard Ferrari , Jean Gougat , Claude Muneaux , Yvette Muneaux , Pierre Perreaut , Claudine Planchenault
IPC分类号： A61K315377
CPC分类号： C07D239/06 , C07C311/19 , C07D233/22 , C07D233/24 , C07D233/26 , C07D295/185 , C07D403/12
摘要： The invention relates to compounds of formula in which R1 to R9, R16 and R17 are as defined in Claim 1. These compounds are pharmacologically active.
摘要翻译：本发明涉及式1的化合物，其中R 1至R 9，R 16和R 17如权利要求1所定义。这些化合物具有药理活性。

10. 发明授权

US5268375A Dinitrogen heterocyclic derivatives N-substituted by a biphenylmethyl group, and the pharmaceutical compositions in which they are present 失效
标题翻译：通过联苯甲基N-取代的二氮杂环衍生物及其存在的药物组合物
公开(公告)号：US5268375A
公开(公告)日：1993-12-07
申请号：US843239
申请日：1992-02-28
申请人： Claude Bernhart , Bernard Ferrari , Pierre Perreaut
发明人： Claude Bernhart , Bernard Ferrari , Pierre Perreaut
IPC分类号： A61K31/505 , A61P9/00 , A61P9/12 , A61P27/02 , A61P43/00 , C07D233/70 , C07D235/02 , C07D239/22 , C07D239/70 , C07D403/10 , C07D413/10 , C07D417/10 , C07D233/36 , A61K31/415 , C07D239/36
CPC分类号： C07D235/02 , C07D239/22 , C07D239/70 , C07D403/10 , C07D413/10 , C07D417/10 , Y02P20/55
摘要： This invention relates to compounds of formula ##STR1## in which: R.sub.1 and R.sub.2 are similar or different and are each independently hydrogen or a group selected from CO.sub.2 N.dbd.C(NH.sub.2).sub.2, CONHNHCONH.sub.2, CONHNHCSNH.sub.2, C(OC.sub.2 H.sub.5).dbd.NCO.sub.2 CH.sub.3, COCH.sub.2 CO.sub.2 H.sub.5, N(OH)-CONHCOOC.sub.2 NCO.sub.2 CH.sub.3, COCH.sub.2 CO.sub.2 H.sub.5, N(OH)-CONHCOOC.sub.2 H.sub.5, C(OC.sub.2 H.sub.5).dbd.NH or a nitrogen heterocycle; with the proviso that at least one of the substituents R.sub.1 or R.sub.2 is other than hydrogen;R.sub.3 is a hydrogen, a C.sub.1 -C.sub.6 alkyl, a C.sub.2 -C.sub.6 alkenyl, a C.sub.3 -C.sub.7 cycloalkyl, a phenyl, a phenylalkyl, or a phenylalkenyl;R.sub.4 and R.sub.5 are each independently a C.sub.1 -C.sub.6 alkyl, a C.sub.3 -C.sub.7 cycloalkyl, a phenyl or a phenylalkyl; orR.sub.4 and R.sub.5, bonded together, are either a group of the formula (CH.sub.2).sub.n or a group of the formula (CH.sub.2).sub.p Y (CH.sub.2).sub.q, in which Y is either an oxygen atom, or a sulfur atom, or a substituted carbon atom, or a group N-R.sub.6, in which R.sub.6 is a hydrogen, a C.sub.1 -C.sub.4 alkyl, a phenylalkyl, a C.sub.1 -C.sub.4 alkylcarbonyl, a C.sub.1 -C.sub.4 halogenoalkylcarbonyl, a C.sub.1 -C.sub.4 polyhalogenoalkylcarbonyl, a benzolyl, an .alpha.-aminoacyl or a N-protecting group, or R.sub.4 and R.sub.5, together with the carbon atom to which they are bonded, form an indane or an adamantine; p+q=m; n is an integer between 2 and 11; m is an integer between 2 and 5; X is an oxygen or a sulfur atom; and z and t are zero or z+t=1; and its salts.
摘要翻译：本发明涉及式（I）的化合物，其中：R 1和R 2相同或不同，各自独立地为氢或选自CO 2 N = C（NH 2）2，CONHNHCONH 2，CONHNHCSNH 2，C（OC 2 H 5）= NCO2CH3，COCH2CO2H5，N（OH）-CONHCOOC2NCO2CH3，COCH2CO2H5，N（OH）-CONHCOOC2H5，C（OC2H5）= NH或氮杂环; 条件是至少一个取代基R 1或R 2不是氢; R 3是氢，C 1 -C 6烷基，C 2 -C 6烯基，C 3 -C 7环烷基，苯基，苯基烷基或苯基烯基; R 4和R 5各自独立地为C 1 -C 6烷基，C 3 -C 7环烷基，苯基或苯基烷基; 或者R 4和R 5键合在一起，是式（CH 2）n的基团或式（CH 2）p Y（CH 2）q的基团，其中Y是氧原子或硫原子，或取代的碳原子或基团N-R6，其中R6是氢，C1-C4烷基，苯基烷基，C1-C4烷基羰基，C1-C4卤代烷基羰基，C1-C4多卤代烷基羰基，苯甲酰基， α-氨基酰基或N-保护基，或R 4和R 5与它们所键合的碳原子一起形成二氢化茚或金刚烷; p + q = m; n是2和11之间的整数; m是2和5之间的整数; X是氧或硫原子; z和t为零或z + t = 1; 及其盐。

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