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1. 发明授权

US5268375A Dinitrogen heterocyclic derivatives N-substituted by a biphenylmethyl group, and the pharmaceutical compositions in which they are present 失效
标题翻译：通过联苯甲基N-取代的二氮杂环衍生物及其存在的药物组合物
公开(公告)号：US5268375A
公开(公告)日：1993-12-07
申请号：US843239
申请日：1992-02-28
申请人： Claude Bernhart , Bernard Ferrari , Pierre Perreaut
发明人： Claude Bernhart , Bernard Ferrari , Pierre Perreaut
IPC分类号： A61K31/505 , A61P9/00 , A61P9/12 , A61P27/02 , A61P43/00 , C07D233/70 , C07D235/02 , C07D239/22 , C07D239/70 , C07D403/10 , C07D413/10 , C07D417/10 , C07D233/36 , A61K31/415 , C07D239/36
CPC分类号： C07D235/02 , C07D239/22 , C07D239/70 , C07D403/10 , C07D413/10 , C07D417/10 , Y02P20/55
摘要： This invention relates to compounds of formula ##STR1## in which: R.sub.1 and R.sub.2 are similar or different and are each independently hydrogen or a group selected from CO.sub.2 N.dbd.C(NH.sub.2).sub.2, CONHNHCONH.sub.2, CONHNHCSNH.sub.2, C(OC.sub.2 H.sub.5).dbd.NCO.sub.2 CH.sub.3, COCH.sub.2 CO.sub.2 H.sub.5, N(OH)-CONHCOOC.sub.2 NCO.sub.2 CH.sub.3, COCH.sub.2 CO.sub.2 H.sub.5, N(OH)-CONHCOOC.sub.2 H.sub.5, C(OC.sub.2 H.sub.5).dbd.NH or a nitrogen heterocycle; with the proviso that at least one of the substituents R.sub.1 or R.sub.2 is other than hydrogen;R.sub.3 is a hydrogen, a C.sub.1 -C.sub.6 alkyl, a C.sub.2 -C.sub.6 alkenyl, a C.sub.3 -C.sub.7 cycloalkyl, a phenyl, a phenylalkyl, or a phenylalkenyl;R.sub.4 and R.sub.5 are each independently a C.sub.1 -C.sub.6 alkyl, a C.sub.3 -C.sub.7 cycloalkyl, a phenyl or a phenylalkyl; orR.sub.4 and R.sub.5, bonded together, are either a group of the formula (CH.sub.2).sub.n or a group of the formula (CH.sub.2).sub.p Y (CH.sub.2).sub.q, in which Y is either an oxygen atom, or a sulfur atom, or a substituted carbon atom, or a group N-R.sub.6, in which R.sub.6 is a hydrogen, a C.sub.1 -C.sub.4 alkyl, a phenylalkyl, a C.sub.1 -C.sub.4 alkylcarbonyl, a C.sub.1 -C.sub.4 halogenoalkylcarbonyl, a C.sub.1 -C.sub.4 polyhalogenoalkylcarbonyl, a benzolyl, an .alpha.-aminoacyl or a N-protecting group, or R.sub.4 and R.sub.5, together with the carbon atom to which they are bonded, form an indane or an adamantine; p+q=m; n is an integer between 2 and 11; m is an integer between 2 and 5; X is an oxygen or a sulfur atom; and z and t are zero or z+t=1; and its salts.
摘要翻译：本发明涉及式（I）的化合物，其中：R 1和R 2相同或不同，各自独立地为氢或选自CO 2 N = C（NH 2）2，CONHNHCONH 2，CONHNHCSNH 2，C（OC 2 H 5）= NCO2CH3，COCH2CO2H5，N（OH）-CONHCOOC2NCO2CH3，COCH2CO2H5，N（OH）-CONHCOOC2H5，C（OC2H5）= NH或氮杂环; 条件是至少一个取代基R 1或R 2不是氢; R 3是氢，C 1 -C 6烷基，C 2 -C 6烯基，C 3 -C 7环烷基，苯基，苯基烷基或苯基烯基; R 4和R 5各自独立地为C 1 -C 6烷基，C 3 -C 7环烷基，苯基或苯基烷基; 或者R 4和R 5键合在一起，是式（CH 2）n的基团或式（CH 2）p Y（CH 2）q的基团，其中Y是氧原子或硫原子，或取代的碳原子或基团N-R6，其中R6是氢，C1-C4烷基，苯基烷基，C1-C4烷基羰基，C1-C4卤代烷基羰基，C1-C4多卤代烷基羰基，苯甲酰基， α-氨基酰基或N-保护基，或R 4和R 5与它们所键合的碳原子一起形成二氢化茚或金刚烷; p + q = m; n是2和11之间的整数; m是2和5之间的整数; X是氧或硫原子; z和t为零或z + t = 1; 及其盐。

2. 发明授权

US5274104A N-substituted heterocyclic derivatives useful in the treatment of cardiovascular disorders 失效
标题翻译：可用于治疗心血管疾病的N-取代的杂环衍生物
公开(公告)号：US5274104A
公开(公告)日：1993-12-28
申请号：US901145
申请日：1992-06-19
申请人： Joelle Arnaud , Jean-Louis Assens , Claude Bernhart , Bernard Ferrari , Frederique Haudricourt , Pierre Perreaut
发明人： Joelle Arnaud , Jean-Louis Assens , Claude Bernhart , Bernard Ferrari , Frederique Haudricourt , Pierre Perreaut
IPC分类号： A61K31/415 , A61K31/4184 , A61K31/496 , A61K31/505 , A61P9/00 , A61P9/12 , A61P27/02 , A61P43/00 , C07D233/70 , C07D233/84 , C07D235/02 , C07D239/36 , C07D239/40 , C07D403/10 , C07D403/12 , C07D413/12 , C07D417/12 , C12N9/99 , A61K31/42 , C07D233/54 , C07D257/04 , C07D271/06 , C07D271/08
CPC分类号： C07D235/02 , C07D233/70 , C07D403/10 , Y02P20/55
摘要： The present invention relates to N-substituted heterocyclic derivatives of formula: ##STR1## processes for their preparation, and pharmaceutical compositions which contain them. The compounds according to the invention are non-peptide compounds which oppose the action of angiotensin II. The compounds according to the invention are thus useful in the treatment of cardiovascular disorders such as hypertension and heart failure.
摘要翻译：本发明涉及下式的N-取代的杂环衍生物：其制备方法和含有它们的药物组合物。根据本发明的化合物是反对血管紧张素II作用的非肽化合物。因此，根据本发明的化合物可用于治疗心血管疾病如高血压和心力衰竭。

3. 发明授权

US06433185B1 N-(arylsulphonyl) amino acid derivatives, process for their preparation and pharmaceutical compositions containing them 失效
标题翻译： N-（芳基磺酰基）氨基酸衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US06433185B1
公开(公告)日：2002-08-13
申请号：US09948011
申请日：2001-09-06
申请人： Bernard Ferrari , Jean Gougat , Claude Muneaux , Yvette Muneaux , Pierre Perreaut , Claudine Planchenault
发明人： Bernard Ferrari , Jean Gougat , Claude Muneaux , Yvette Muneaux , Pierre Perreaut , Claudine Planchenault
IPC分类号： C07D295192
CPC分类号： C07D239/06 , C07C311/19 , C07D233/22 , C07D233/24 , C07D233/26 , C07D295/185 , C07D403/12
摘要： The invention relates to compounds of formula in which R1 to R9, R16 and R17 are as defined in claim 1. These compounds are pharmacologically active.
摘要翻译：本发明涉及式1化合物，其中R1至R9，R16和R17如权利要求1所定义。这些化合物具有药理活性。

4. 发明授权

US06313120B1 N-(arylsulfonyl) amino acid derivatives, process for their preparation and pharmaceutical compositions containing them 失效
标题翻译： N-（芳基磺酰基）氨基酸衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US06313120B1
公开(公告)日：2001-11-06
申请号：US09593067
申请日：2000-06-13
申请人： Bernard Ferrari , Jean Gougat , Claude Muneaux , Yvette Muneaux , Pierre Perreaut , Claudine Planchenault
发明人： Bernard Ferrari , Jean Gougat , Claude Muneaux , Yvette Muneaux , Pierre Perreaut , Claudine Planchenault
IPC分类号： A61K315377
CPC分类号： C07D239/06 , C07C311/19 , C07D233/22 , C07D233/24 , C07D233/26 , C07D295/185 , C07D403/12
摘要： The invention relates to compounds of formula in which R1 to R9, R16 and R17 are as defined in Claim 1. These compounds are pharmacologically active.
摘要翻译：本发明涉及式1的化合物，其中R 1至R 9，R 16和R 17如权利要求1所定义。这些化合物具有药理活性。

5. 发明授权

US07157454B2 Derivatives of n-(arylsulfonyl)beta-aminoacids comprising a substituted aminomethyl group, the preparation method thereof and the pharmaceutical compositions containing same 有权
标题翻译：包含取代氨基甲基的正 - （芳基磺酰基）β-氨基酸的衍生物，其制备方法和含有其的药物组合物
公开(公告)号：US07157454B2
公开(公告)日：2007-01-02
申请号：US10472674
申请日：2002-03-27
申请人： Bernard Ferrari , Jean Gougat , Yvette Muneaux , Pierre Perreaut , Lionel Sarran
发明人： Bernard Ferrari , Jean Gougat , Yvette Muneaux , Pierre Perreaut , Lionel Sarran
IPC分类号： C07D295/18 , C07D211/34 , C07D307/81 , C07D405/12 , C07C237/30 , C07C311/19 , A61K31/40
CPC分类号： C07D213/40 , C07C311/19 , C07D205/04 , C07D211/34 , C07D213/76 , C07D215/36 , C07D233/64 , C07D271/12 , C07D277/80 , C07D295/155 , C07D295/185 , C07D307/52 , C07D307/54 , C07D307/79 , C07D307/81 , C07D317/46 , C07D317/60 , C07D317/66 , C07D319/18 , C07D333/24 , C07D333/62 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D495/04
摘要： The invention relates to compounds of formula: These compounds show affinity for the bradykinin receptors with selectivity towards the B1 receptors; they may be used for the preparation of medicinal products intended for treating or preventing inflammation pathologies and persistent or chronic inflammatory diseases.
摘要翻译：本发明涉及式的化合物：这些化合物对对缓激肽受体具有对B 1受体的选择性的亲和力; 它们可用于制备旨在治疗或预防炎症病症和持续或慢性炎性疾病的药用产品。

6. 发明授权

US06610882B2 N-(arylsulphonyl) amino acid derivatives 失效
标题翻译： N-（芳基磺酰基）氨基酸衍生物
公开(公告)号：US06610882B2
公开(公告)日：2003-08-26
申请号：US10165299
申请日：2002-06-07
申请人： Bernard Ferrari , Jean Gougat , Claude Muneaux , Yvette Muneaux , Pierre Perreaut , Claudine Planchenault
发明人： Bernard Ferrari , Jean Gougat , Claude Muneaux , Yvette Muneaux , Pierre Perreaut , Claudine Planchenault
IPC分类号： C07C31119
CPC分类号： C07D239/06 , C07C311/19 , C07D233/22 , C07D233/24 , C07D233/26 , C07D295/185 , C07D403/12
摘要： The invention relates to compounds of formula in which R1 to R9, R16 and R17 are as defined in claim 1. These compounds are pharmacologically active.
摘要翻译：本发明涉及式1化合物，其中R1至R9，R16和R17如权利要求1所定义。这些化合物具有药理活性。

7. 发明授权

US06100278A N-(arylsulphonyl)amino acid derivatives, process for their preparation and pharmaceutical compositions containing them 有权
标题翻译： N-（芳基磺酰基）氨基酸衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US06100278A
公开(公告)日：2000-08-08
申请号：US434333
申请日：1999-11-04
申请人： Bernard Ferrari , Jean Gougat , Claude Muneaux , Yvette Muneaux , Pierre Perreaut , Claudine Planchenault
发明人： Bernard Ferrari , Jean Gougat , Claude Muneaux , Yvette Muneaux , Pierre Perreaut , Claudine Planchenault
IPC分类号： C07D295/18 , A61K31/00 , A61K31/40 , A61K31/415 , A61K31/4164 , A61K31/4178 , A61K31/47 , A61K31/4709 , A61K31/505 , A61P19/02 , A61P29/00 , A61P43/00 , C07C311/19 , C07C311/20 , C07D207/06 , C07D207/20 , C07D233/22 , C07D233/24 , C07D233/26 , C07D239/06 , C07D295/185 , C07D401/12 , C07D403/12 , C07K5/023 , C07D401/14
CPC分类号： C07D239/06 , C07C311/19 , C07D233/22 , C07D233/24 , C07D233/26 , C07D295/185 , C07D403/12
摘要： The invention relates compounds of formula ##STR1## in which R.sub.1 to R.sub.9, R.sub.16 and R.sub.17 are as defined in claim 1.These compounds are pharmacologically active.
摘要翻译：本发明涉及其中R 1至R 9，R 16和R 17如权利要求1中所定义的式的化合物。这些化合物具有药理活性。

8. 发明授权

US6015812A N-(arylsulphonyl)amino acid derivatives having bradykinin receptor affinity 失效
标题翻译：具有缓激肽受体亲和力的N-（芳基磺酰基）氨基酸衍生物
公开(公告)号：US6015812A
公开(公告)日：2000-01-18
申请号：US101214
申请日：1998-07-02
申请人： Bernard Ferrari , Jean Gougat , Claude Muneaux , Yvette Muneaux , Pierre Perreaut , Claudine Planchenault
发明人： Bernard Ferrari , Jean Gougat , Claude Muneaux , Yvette Muneaux , Pierre Perreaut , Claudine Planchenault
IPC分类号： C07D295/18 , A61K31/00 , A61K31/40 , A61K31/415 , A61K31/4164 , A61K31/4178 , A61K31/47 , A61K31/4709 , A61K31/505 , A61P19/02 , A61P29/00 , A61P43/00 , C07C311/19 , C07C311/20 , C07D207/06 , C07D207/20 , C07D233/22 , C07D233/24 , C07D233/26 , C07D239/06 , C07D295/185 , C07D401/12 , C07D403/12 , C07K5/023 , A61K31/18 , A61K31/535 , C07D413/12
CPC分类号： C07D239/06 , C07C311/19 , C07D233/22 , C07D233/24 , C07D233/26 , C07D295/185 , C07D403/12
摘要： The invention relates to compounds of formula ##STR1## in which R.sub.1 to R.sub.9, R.sub.16 and R.sub.17 are defined in claim 1. These compounds are pharmacologically active.
摘要翻译： PCT No.PCT / FR97 / 00026 Sec。 371日期：1998年7月2日 102（e）1998年7月2日PCT PCT 1997年1月7日PCT公布。公开号WO97 / 25315 PCT 日期1997年7月17日本发明涉及其中R 1至R 9，R 16和R 17如权利要求1中所定义的通式化合物。这些化合物具有药理活性。

9. 发明授权

US07544682B2 Pyrido-pyrimidine derivatives, preparation thereof, and therapeutic use thereof 有权
标题翻译：吡啶并嘧啶衍生物及其制备方法及其治疗用途
公开(公告)号：US07544682B2
公开(公告)日：2009-06-09
申请号：US11651376
申请日：2007-01-08
申请人： Bernard Bourrie , Pierre Casellas , Samir Jegham , Pierre Perreaut
发明人： Bernard Bourrie , Pierre Casellas , Samir Jegham , Pierre Perreaut
IPC分类号： A61K31/5355 , A61K31/519 , C07D471/04 , A61P35/00 , C07D405/04 , C07D491/113 , C07D495/10 , C07D497/10 , C07D211/44 , C07D317/48
CPC分类号： C07D471/04
摘要： The disclosure concerns pyrido[2,3-d]pyrimidine derivatives, their preparation and their therapeutic application, of general formula (I) and acid addition salts, hydrates and solvates thereof, as well as in the form of enantiomers, diastereoisomers and mixtures thereof. The disclosure also concerns methods for preparing said derivatives, pharmaceutical compositions containing a compound of general formula (I), and their therapeutic use.
摘要翻译：本公开涉及通式（I）的吡啶并[2,3-d]嘧啶衍生物及其制备方法及其治疗应用，以及其对映异构体，非对映异构体及其混合物的酸加成盐，水合物和溶剂化物。本公开还涉及制备所述衍生物的方法，含有通式（I）的化合物的药物组合物及其治疗用途。

10. 发明授权

US07504406B2 Derivatives of pyrido[2,3-d]pyrimidine, the preparation thereof, and the therapeutic application of the same 有权
标题翻译：吡啶并[2,3-d]嘧啶的衍生物及其制备方法及其治疗应用
公开(公告)号：US07504406B2
公开(公告)日：2009-03-17
申请号：US11955583
申请日：2007-12-13
申请人： Bernard Bourrie , Pierre Casellas , Samir Jegham , Claude Muneaux , Pierre Perreaut
发明人： Bernard Bourrie , Pierre Casellas , Samir Jegham , Claude Muneaux , Pierre Perreaut
IPC分类号： C07D471/04 , A61K31/519
CPC分类号： C07D471/04
摘要： The invention relates to derivatives of pyrido[2,3-d]pyrimidine, to the preparation thereof, and to the therapeutic application of the same.
摘要翻译：本发明涉及吡啶并[2,3-d]嘧啶的衍生物及其制备方法及其治疗应用。

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