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1. 发明授权

US07008370B2 Method and device for transcranial magnetic stimulation 有权
标题翻译：经颅磁刺激的方法和装置
公开(公告)号：US07008370B2
公开(公告)日：2006-03-07
申请号：US10820290
申请日：2004-04-08
申请人： Phillipp Tanner , Andreas Hartlep , Henrik Wist , Kerstin Wendicke , Thomas Weyh
发明人： Phillipp Tanner , Andreas Hartlep , Henrik Wist , Kerstin Wendicke , Thomas Weyh
IPC分类号： A61N2/00
CPC分类号： A61N2/02 , A61B5/0484 , A61B5/055
摘要： The invention relates to a method for stimulating specific areas of a brain using an induction device, comprising the following steps: recording the spatial structure of the head, in particular the brain; generating a simulation model of the induction device; and arranging the induction device relative to the head such that a specific area of the brain determined by means of the simulation model of the induction device is stimulated by a current flowing in the induction device, as well as to a method for stimulating specific areas of a brain using an induction device, comprising the following steps: recording the spatial structure of the head, in particular the brain; generating a simulation model of the head; and arranging the induction device relative to the head such that a specific area of the brain determined by means of the simulation model of the head is stimulated by a current flowing in the induction device, as well as to a device for stimulating specific areas of a brain using an induction device connected to a marker.
摘要翻译：本发明涉及一种使用感应装置刺激脑的特定区域的方法，包括以下步骤：记录头部，特别是脑部的空间结构; 产生感应装置的仿真模型; 以及相对于头部布置感应装置，使得通过感应装置的模拟模型确定的脑的特定区域被在感应装置中流动的电流刺激，以及用于刺激感应装置的特定区域的方法使用感应装置的脑，包括以下步骤：记录头部，特别是脑部的空间结构; 产生头部的模拟模型; 以及相对于头部布置感应装置，使得通过头部的模拟模型确定的脑的特定区域由在感应装置中流动的电流以及用于刺激感应装置的特定区域的装置大脑使用连接到标记的感应装置。

2. 发明授权

US06827681B2 Method and device for transcranial magnetic stimulation 有权
标题翻译：经颅磁刺激的方法和装置
公开(公告)号：US06827681B2
公开(公告)日：2004-12-07
申请号：US10003476
申请日：2001-11-01
申请人： Phillipp Tanner , Andreas Hartlep , Henrik Wist , Kerstin Wendicke , Thomas Weyh
发明人： Phillipp Tanner , Andreas Hartlep , Henrik Wist , Kerstin Wendicke , Thomas Weyh
IPC分类号： A61N200
CPC分类号： A61N2/02 , A61B5/0484 , A61B5/055
摘要： The invention relates to a method for stimulating specific areas of a brain using an induction device (1), comprising the following steps: recording the spatial structure of the head, in particular the brain; generating a simulation model of the induction device (1); and arranging the induction device (1) relative to the head such that a specific area of the brain determined by means of the simulation model of the induction device (1) is stimulated by a current flowing in the induction device (1), as well as to a method for stimulating specific areas of a brain using an induction device (1), comprising the following steps: recording the spatial structure of the head, in particular the brain; generating a simulation model of the head; and arranging the induction device (1) relative to the head such that a specific area of the brain determined by means of the simulation model of the head is stimulated by a current flowing in the induction device (1), as well as to a device for stimulating specific areas of a brain using an induction device (1) connected to a marker (1a).
摘要翻译：本发明涉及一种使用感应装置（1）刺激脑的特定区域的方法，包括以下步骤：记录头部，特别是脑部的空间结构; 产生感应装置（1）的仿真模型; 以及相对于头部布置感应装置（1），使得通过感应装置（1）的模拟模型确定的脑的特定区域由在感应装置（1）中流动的电流也被刺激关于使用感应装置（1）刺激脑的特定区域的方法，包括以下步骤：记录头部，特别是脑部的空间结构; 产生头部的模拟模型; 以及相对于头部布置感应装置（1），使得通过头部的模拟模型确定的脑的特定区域由在感应装置（1）中流动的电流以及装置用于使用连接到标记（1a）的感应装置（1）刺激大脑的特定区域。

3. 发明授权

US09901413B2 Targeted infusion of agents for treatment of ALS 有权
公开(公告)号：US09901413B2
公开(公告)日：2018-02-27
申请号：US11251548
申请日：2005-10-14
申请人： Andreas Hartlep , Christoph Pedain
发明人： Andreas Hartlep , Christoph Pedain
IPC分类号： A61B90/00 , A61B34/20 , A61B5/0478 , A61B5/055 , A61B5/00 , A61B17/00 , A61B34/10
CPC分类号： A61B90/36 , A61B5/0478 , A61B5/055 , A61B5/4839 , A61B34/10 , A61B34/20 , A61B2017/00039 , A61B2034/2055
摘要： A system and method for treating Amyotrophic Lateral Sclerosis (ALS) by delivery of an agent within the brain. At least one image of a target region is acquired, and at least one magnetic resonance diffusion tensor imaging (MR-DTI) scan of the target region is acquired. A diffusion tensor is calculated from the at least one MR-DTI scan, and at least one of an agent distribution and an agent concentration from the images and the calculated diffusion tensor is calculated. Using at least one of the calculated diffusion tensor, the images, the calculated agent distribution, and the calculated agent concentration, the placement of a delivery instrument is planned to deliver the agent to the target region to achieve a desired agent concentration and/or agent distribution within the target region.

4. 发明申请

US20110066133A1 INTRACRANIAL CATHETER 有权
公开(公告)号：US20110066133A1
公开(公告)日：2011-03-17
申请号：US12950223
申请日：2010-11-19
申请人： Andreas Hartlep , Christoph Pedain
发明人： Andreas Hartlep , Christoph Pedain
IPC分类号： A61M25/14
CPC分类号： A61M25/007 , A61M25/0009 , A61M25/0021 , A61M2025/006
摘要： A catheter having an outer profile which is formed such that a path length along an outer surface of the catheter is greater than the corresponding length of the catheter, and to a method for determining the shape of a catheter, and wherein the elasticity and/or conductivity of the tissue into which the catheter is to be introduced is taken into account in order to determine the outer profile of the catheter.
摘要翻译：一种具有外形轮廓的导管，其形成为使得沿着导管的外表面的路径长度大于导管的相应长度，以及用于确定导管形状的方法，并且其中弹性和/或考虑到要导入导管的组织的导电性，以便确定导管的外部轮廓。

5. 发明授权

US07883492B2 Catheter with portions that can change in volume 有权
标题翻译：导管与部分可以改变体积
公开(公告)号：US07883492B2
公开(公告)日：2011-02-08
申请号：US12049534
申请日：2008-03-17
申请人： Stephan Mittermeyer , Andreas Hartlep
发明人： Stephan Mittermeyer , Andreas Hartlep
IPC分类号： A61M29/00
CPC分类号： A61M25/0023 , A61M25/0045 , A61M2005/14292 , A61M2025/0057 , A61M2025/006 , A61M2025/1052
摘要： A catheter for administering a substance into body tissues includes an elongated catheter body that has at least one portion of the length of the catheter body that expands after the catheter is inserted in the patient's body. The portion that expands provides a seal against backflow of the substance along the outer surface of the catheter body and away from the intended treatment area.
摘要翻译：用于将物质施用到身体组织中的导管包括细长的导管体，其具有导管主体的长度的至少一部分，其在将导管插入患者体内后扩张。膨胀的部分提供密封，以防止物质沿着导管主体的外表面并远离预期治疗区域的回流。

6. 发明申请

US20070244387A1 RISK ASSESSMENT FOR PLANNED TRAJECTORIES 有权
标题翻译：计划性TRAJECTORIES的风险评估
公开(公告)号：US20070244387A1
公开(公告)日：2007-10-18
申请号：US11697823
申请日：2007-04-09
申请人： Maria Rodriguez Ponce , Christoph Pedain , Andreas Hartlep
发明人： Maria Rodriguez Ponce , Christoph Pedain , Andreas Hartlep
IPC分类号： A61B5/05 , A61B8/00
CPC分类号： G06F19/321 , A61B34/10 , A61B34/20 , A61B90/11 , A61B90/36 , A61B2034/107 , A61B2034/2055 , A61B2034/256 , A61M2005/14292 , G06F19/00 , G16H40/63 , G16H50/30 , G16H50/50
摘要： A method for planning the placement of a device in a body includes analyzing information of at least part of the internal structure of the body of a patient to determine if at least one specific or critical region or structure lies within a region of interest, said region of interest within a predetermined distance of the planned trajectory of the device in the body. Then, a level of risk is assessed to the at least one specific or critical region or structure that is within the region of interest.
摘要翻译：一种用于规划装置在身体中的放置的方法包括分析患者身体的至少部分内部结构的信息，以确定至少一个特定或关键区域或结构是否位于感兴趣区域内，所述区域在设备在体内的计划轨迹的预定距离内感兴趣。然后，将风险级别评估为感兴趣区域内的至少一个特定或关键区域或结构。

7. 发明申请

US20060195030A1 Fiber tracking phantom 有权
公开(公告)号：US20060195030A1
公开(公告)日：2006-08-31
申请号：US11318346
申请日：2005-12-23
申请人： George Ogrezeanu , Andreas Hartlep
发明人： George Ogrezeanu , Andreas Hartlep
IPC分类号： A61B5/05 , A61B6/00
CPC分类号： A61B6/583 , A61B5/055 , A61B5/7207 , A61B2560/0228 , G01R33/56341 , G01R33/58
摘要： A phantom for use with diffusion tensor imaging includes a container and a plurality of structures within the container. The structures have anisotropic properties, wherein when the phantom is subjected to diffusion tensor imaging, the structures provide data that is recognized as fiber bundles. The structures can be formed, for example, from cloth tape, silk, wood, glass fibers cord (synthetic and viscose) and/or microfibers.

8. 发明申请

US20060094953A1 Targeted infusion of agents for treatment of ALS 有权
标题翻译：靶向输注用于治疗ALS的药剂
公开(公告)号：US20060094953A1
公开(公告)日：2006-05-04
申请号：US11251548
申请日：2005-10-14
申请人： Andreas Hartlep , Christoph Pedain
发明人： Andreas Hartlep , Christoph Pedain
IPC分类号： A61B5/05
CPC分类号： A61B90/36 , A61B5/0478 , A61B5/055 , A61B5/4839 , A61B34/10 , A61B34/20 , A61B2017/00039 , A61B2034/2055
摘要： A system and method for treating Amyotrophic Lateral Sclerosis (ALS) by delivery of an agent within the brain. At least one image of a target region is acquired, and at least one magnetic resonance diffusion tensor imaging (MR-DTI) scan of the target region is acquired. A diffusion tensor is calculated from the at least one MR-DTI scan, and at least one of an agent distribution and an agent concentration from the images and the calculated diffusion tensor is calculated. Using at least one of the calculated diffusion tensor, the images, the calculated agent distribution, and the calculated agent concentration, the placement of a delivery instrument is planned to deliver the agent to the target region to achieve a desired agent concentration and/or agent distribution within the target region.
摘要翻译：一种通过在脑内递送药物来治疗肌萎缩性侧索硬化症（ALS）的系统和方法。获取目标区域的至少一个图像，并且获取目标区域的至少一个磁共振扩散张量成像（MR-DTI）扫描。从至少一个MR-DTI扫描计算扩散张量，并且计算来自图像和所计算的扩散张量的试剂分布和试剂浓度中的至少一个。使用所计算的扩散张量，图像，计算的药物分布和计算的药物浓度中的至少一个，计划递送仪器的放置以将药剂递送至靶区域以实现所需药剂浓度和/或药剂分布在目标区域内。

9. 发明授权

US08702580B2 Method and device for assisting in a tissue treatment 有权
标题翻译：用于辅助组织处理的方法和装置
公开(公告)号：US08702580B2
公开(公告)日：2014-04-22
申请号：US11244867
申请日：2005-10-06
申请人： Andreas Hartlep , Christoph Pedain
发明人： Andreas Hartlep , Christoph Pedain
IPC分类号： A61M3/00
CPC分类号： G16H50/50 , G06F19/00
摘要： A method for planning to treat tissue by administering a substance which emits energy or can interact with administered energy to a body, such as body tissue, wherein a dispersion of the substance in the body is simulated, and to a system or device for planning administering a substance and administering energy to a body or in body tissue. The device includes a data capture unit configured to detect patient-specific parameters, wherein the patient-specific parameters can be used to describe a dispersion behavior of the substance in the body or body tissue; a computational unit operatively coupled to the data capture unit, said computational unit configured to obtain the patient-specific parameters from the data capture unit; a database accessible by the computational unit, wherein the database includes data for describing characteristics of a particular type of tissue or a particular body structure, data for describing mechanisms for supplying energy, and/or data for describing the effect on tissue of a substance in combination with supplied energy, the computational unit being configured to retrieve and/or store said data in the database; and an input unit via which a user can input treatment-specific data to the computational unit, wherein the computational unit is configured to simulate the plan based on at least one of the patient-specific data, data stored in the database, or user input data.
摘要翻译：一种用于通过施用发射能量或可以与施用的能量相互作用的物质来计划治疗组织的方法，所述身体例如身体组织，其中物质在体内的分散体被模拟，并且用于规划管理物质并向体内或身体组织施用能量。该装置包括被配置为检测患者特异性参数的数据捕获单元，其中可以使用患者特异性参数来描述物质在体内或身体组织中的分散行为; 计算单元，可操作地耦合到所述数据捕获单元，所述计算单元被配置为从所述数据捕获单元获取患者特定参数; 由计算单元访问的数据库，其中数据库包括用于描述特定类型的组织或特定身体结构的特征的数据，用于描述用于供应能量的机制的数据和/或用于描述对物质组织的影响的数据与所提供的能量组合，所述计算单元被配置为在所述数据库中检索和/或存储所述数据; 以及输入单元，用户可以通过该单元将计算单元输入治疗特定数据，其中所述计算单元被配置为基于所述患者特定数据，存储在所述数据库中的数据或用户输入中的至少一个来模拟所述计划数据。

10. 发明授权

US08014848B2 Visualization of procedural guidelines for a medical procedure 有权
标题翻译：可视化医疗程序的程序指南
公开(公告)号：US08014848B2
公开(公告)日：2011-09-06
申请号：US11115093
申请日：2005-04-26
申请人： Rainer Birkenbach , Christoph Pedain , Andreas Hartlep , Raghu Raghavan , Martin Brady
发明人： Rainer Birkenbach , Christoph Pedain , Andreas Hartlep , Raghu Raghavan , Martin Brady
IPC分类号： A61B5/05
CPC分类号： A61B90/36 , A61B34/10 , A61B34/20 , A61B2034/107 , A61B2034/2055 , A61B2034/2068 , A61B2034/2072
摘要： The visualization of procedural guidelines for a medical procedure, in which a medical instrument is shown in an image representation of a body portion including an area in which a medical procedure is to be carried out, wherein, in the vicinity of the functional portion of the instrument, regions or locations are indicated which are of special relevance to the procedure according to established guidelines for said procedure.
摘要翻译：可视化的医疗程序的程序指南，其中医疗器械被显示在包括要执行医疗程序的区域的身体部位的图像表示中，其中在该功能部分的附近指示与所述程序的既定指导方针相关的手段，区域或位置。

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