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1. 发明授权

US5060526A Laminated semiconductor sensor with vibrating element 失效
标题翻译：具有振动元件的层压半导体传感器
公开(公告)号：US5060526A
公开(公告)日：1991-10-29
申请号：US358771
申请日：1989-05-30
申请人： Phillip W. Barth , Kurt E. Petersen , Joseph R. Mallon, Jr.
发明人： Phillip W. Barth , Kurt E. Petersen , Joseph R. Mallon, Jr.
IPC分类号： G01L1/10 , G01L9/00 , H01L29/84
CPC分类号： G01L9/0019
摘要： An electromechanical sensor is provided which comprises: a first silicon wafer which defines a resonant element; wherein the resonant element is doped with approximately the same impurity concentration as a background dopant concentration of the first wafer; and a second single crystal wafer which defines a device for coupling mechanical stress from the second wafer to the resonant element; wherein the first and second wafers are fusion bonded together.

2. 发明授权

US4882933A Accelerometer with integral bidirectional shock protection and controllable viscous damping 失效
标题翻译：具有整体双向冲击保护和可控粘性阻尼的加速度计
公开(公告)号：US4882933A
公开(公告)日：1989-11-28
申请号：US202081
申请日：1988-06-03
申请人： Kurt E. Petersen , Phillip W. Barth
发明人： Kurt E. Petersen , Phillip W. Barth
IPC分类号： G01P1/00 , G01P15/08 , G01P15/12
CPC分类号： G01P15/12 , G01P1/003 , G01P15/0802 , G01P2015/0828
摘要： A micromachined accelerometer includes integral bidirectional shock protection and controllable viscous damping. The accelerometer includes a frame in which a seismic mass is disposed and coupled to the frame by one or more cantilever beams. Upper and lower stops are provided around the periphery of the seismic mass and around the interior of the frame to limit the travel distance of the seismic mass. The accelerometer is fabricated, preferably from monocrystalline silicon, by defining an annular recess which extends into a first surface of a silicon substrate. Next, a layer is formed over the surface of the substrate but not in contact with the lower surface of the recessed region. An annular-shaped region of the substrate extending from the bottom surface of the substrate to the layer is then removed to define the seismic mass and frame. Finally, portions of the layer are removed to define the cantilever beams and integral bidirectional stops.
摘要翻译：微机械加速度计包括整体双向冲击保护和可控粘性阻尼。加速度计包括框架，其中地震质量块通过一个或多个悬臂梁布置并耦合到框架。上部和下部挡块设置在震动周围的周围，并围绕框架的内部，以限制地震块的行进距离。通过限定延伸到硅衬底的第一表面中的环形凹槽来制造加速度计，优选地由单晶硅制成。接下来，在基板的表面上形成层，但不与凹陷区域的下表面接触。然后，从衬底的底表面延伸到层的衬底的环形区域被去除以限定地震质量和框架。最后，去除层的部分以限定悬臂梁和整体双向挡块。

3. 发明授权

US5062302A Laminated semiconductor sensor with overpressure protection 失效
标题翻译：具有超压保护功能的层压半导体传感器
公开(公告)号：US5062302A
公开(公告)日：1991-11-05
申请号：US574387
申请日：1990-08-27
申请人： Kurt E. Petersen , Phillip W. Barth , Janusz Bryzek , Joseph R. Mallon, Jr.
发明人： Kurt E. Petersen , Phillip W. Barth , Janusz Bryzek , Joseph R. Mallon, Jr.
IPC分类号： G01L9/00 , G01L19/06
CPC分类号： G01L19/0618 , G01L19/0636 , G01L9/0042 , G01L9/0054 , G01L9/0073 , Y10S73/04
摘要： An electromechanical sensor is provided which comprises: first semiconductor wafer including a first stop surface residing in a first shallow recessed region of the first wafer; a second semiconductor wafer; wherein the first and second semiconductor wafers are laminated together such that the first recessed region of the first wafer and the second wafer define a first chamber in which the first stop surface and the second wafer are disposed close enough together such that the first stop surface restrains the second wafer from deflecting beyond the first stop surface; and an apparatus for measuring deflection of the second wafer.
摘要翻译：提供了一种机电传感器，其包括：第一半导体晶片，其包括位于第一晶片的第一浅凹陷区域中的第一停止表面; 第二半导体晶片; 其中所述第一和第二半导体晶片被层压在一起，使得所述第一晶片和所述第二晶片的所述第一凹陷区域限定第一室，其中所述第一止动表面和所述第二晶片被设置得足够靠近在一起，使得所述第一止动表面限制所述第二晶片从所述第一止动表面偏转; 以及用于测量第二晶片的偏转的装置。

4. 发明授权

US4904978A Mechanical sensor for high temperature environments 失效
标题翻译：用于高温环境的机械传感器
公开(公告)号：US4904978A
公开(公告)日：1990-02-27
申请号：US187687
申请日：1988-04-29
申请人： Phillip W. Barth , Kurt E. Petersen
发明人： Phillip W. Barth , Kurt E. Petersen
IPC分类号： G01L9/04 , G01L9/00 , H01L29/84
CPC分类号： G01L9/0055 , G01L9/0042
摘要： A force or pressure sensor includes a monocrystalline silicon diaphragm coated with silicon dioxide upon which single crystalline silicon resistors are fused in a low profile pattern on the surface. The resistors are almost perfectly electrically isolated from each other and from the underlying silicon substrate. The structure is fabricated by forming resistors in a first wafer and then affixing that surface of the first wafer to the silicon dioxide layer on the second wafer. All of the first wafer except for the resistors has been removed, and metal contact capable of resisting elevated temperatures are formed to provide electrical connections to the resistors.

5. 发明申请

US20080286151A1 APPARATUS FOR PERFORMING HEAT-EXCHANGING CHEMICAL REACTIONS 有权
标题翻译：用于执行热交换化学反应的装置
公开(公告)号：US20080286151A1
公开(公告)日：2008-11-20
申请号：US10719073
申请日：2003-11-21
申请人： Ronald Chang , Douglas B. Dority , Lee A. Christel , Robert Yuan , Kurt E. Petersen
发明人： Ronald Chang , Douglas B. Dority , Lee A. Christel , Robert Yuan , Kurt E. Petersen
IPC分类号： G01N33/48
CPC分类号： B01L7/52 , B01J19/0093 , B01J2219/00788 , B01J2219/00873 , B01J2219/00963 , B01J2219/0097 , B01L3/508 , B01L9/00 , B01L2300/042 , B01L2300/0858 , B01L2300/1827 , F28D2021/0077 , F28F13/00 , G01N21/0332 , G01N35/0099 , G01N2035/00376 , G01N2035/0405 , Y10T436/2575
摘要： An apparatus for controlling the temperature of a reaction mixture contained in a chamber of a reaction vessel comprises a thermal surface for contacting a flexible wall of the chamber and an automated machine for increasing the pressure in the chamber. The pressure increase in the chamber is sufficient to force the flexible wall to conform to the thermal surface for good thermal conductance. The apparatus also includes at least one thermal element for heating or cooling the surface to induce a temperature change within the chamber.
摘要翻译：用于控制包含在反应容器的室中的反应混合物的温度的装置包括用于接触室的柔性壁的热表面和用于增加室中的压力的自动化机器。室中的压力增加足以迫使柔性壁与热表面一致，以获得良好的导热性。该装置还包括至少一个热元件，用于加热或冷却表面以引起腔室内的温度变化。

6. 发明授权

US06887693B2 Device and method for lysing cells, spores, or microorganisms 有权
标题翻译：用于裂解细胞，孢子或微生物的装置和方法
公开(公告)号：US06887693B2
公开(公告)日：2005-05-03
申请号：US10006848
申请日：2001-11-07
申请人： William A. McMillan , Kurt E. Petersen , Lee A. Christel , Ronald Chang , Farzad Pourahmadi , Jesus Ching , Gregory T. A. Kovacs , M. Allen Northrup
发明人： William A. McMillan , Kurt E. Petersen , Lee A. Christel , Ronald Chang , Farzad Pourahmadi , Jesus Ching , Gregory T. A. Kovacs , M. Allen Northrup
IPC分类号： C12M1/33 , C12N13/00
CPC分类号： C12M47/06 , B01L2400/0622 , B01L2400/0644
摘要： A device for lysing components (e.g., cells, spores, or microorganisms) of a fluid sample comprises a cartridge having a lysing chamber for receiving the sample and having at least one solid phase in the lysing chamber for capturing the sample components to be lysed. An ultrasonic transducer is coupled to a wall of the lysing chamber to transfer ultrasonic energy to the captured sample components.
摘要翻译：用于裂解流体样品的组分（例如，细胞，孢子或微生物）的装置包括具有用于接收样品并在裂解室中具有至少一个固相以用于捕获要裂解的样品组分的裂解室的筒。超声换能器耦合到裂解室的壁以将超声能量转移到捕获的样品组分。

7. 发明授权

US06660228B1 Apparatus for performing heat-exchanging, chemical reactions 有权
标题翻译：反应容器
公开(公告)号：US06660228B1
公开(公告)日：2003-12-09
申请号：US09468690
申请日：1999-12-21
申请人： Ronald Chang , Douglas B. Dority , Lee A. Christel , Robert Yuan , Kurt E. Petersen
发明人： Ronald Chang , Douglas B. Dority , Lee A. Christel , Robert Yuan , Kurt E. Petersen
IPC分类号： B01L300
CPC分类号： B01L7/52 , B01J19/0093 , B01J2219/00788 , B01J2219/00873 , B01J2219/00963 , B01J2219/0097 , B01L3/508 , B01L9/00 , B01L2300/042 , B01L2300/0858 , B01L2300/1827 , F28D2021/0077 , F28F13/00 , G01N21/0332 , G01N35/0099 , G01N2035/00376 , G01N2035/0405 , Y10T436/2575
摘要： The present invention provides an apparatus for performing heat-exchanging chemical reactions, such as nucleic acid amplification. The apparatus includes a reaction vessel having a chamber for holding a sample for chemical reaction and optical detection. The vessel has a rigid frame defining the side walls of the chamber, and flexible sheets attached to opposite sides of the frame to form opposing major walls of the chamber. The frame further includes a port and a channel connecting the port to the chamber. The temperature of the sample is controlled by opposing plates positioned to receive the chamber of the vessel between them. The apparatus also includes a plunger which is inserted into the channel of the vessel to seal the port and increase pressure in the chamber. The increased pressure forces the flexible major walls of the chamber to contact and conform to the surfaces of the plates, thus ensuring optimal thermal conductance between the plates and the chamber. The apparatus also includes thermal elements for heating or cooling the plates, as well as optics for detecting analytes in the sample.
摘要翻译：本发明提供了一种用于进行诸如核酸扩增的热交换化学反应的装置。该装置包括具有用于保持用于化学反应和光学检测的样品的室的反应容器。容器具有限定室的侧壁的刚性框架，以及附接到框架的相对侧的柔性片以形成腔室的相对的主壁。框架还包括端口和将端口连接到室的通道。样品的温度通过相对的板来控制，所述相对的板定位成在它们之间容纳容器的腔室。该装置还包括插入容器的通道以密封端口并增加腔室中的压力的柱塞。增加的压力迫使室的柔性主壁与板的表面接触并且符合板的表面，从而确保板和室之间的最佳热传导。该装置还包括用于加热或冷却板的热元件以及用于检测样品中分析物的光学元件。

8. 发明授权

US06565815B1 Heat exchanging, optically interrogated chemical reaction assembly 有权
标题翻译：热交换，光学询问化学反应组装
公开(公告)号：US06565815B1
公开(公告)日：2003-05-20
申请号：US09194374
申请日：2000-07-25
申请人： Ronald Chang , Lee A. Christel , Gregory T. A. Kovacs , William A. McMillan , M. Allen Northrup , Kurt E. Petersen , Farzad Pourahmadi , Steven J. Young , Robert Yuan , Douglas B. Dority
发明人： Ronald Chang , Lee A. Christel , Gregory T. A. Kovacs , William A. McMillan , M. Allen Northrup , Kurt E. Petersen , Farzad Pourahmadi , Steven J. Young , Robert Yuan , Douglas B. Dority
IPC分类号： F28D700
CPC分类号： G01N21/75 , B01J19/0093 , B01J2219/00783 , B01J2219/0081 , B01J2219/00822 , B01J2219/00828 , B01J2219/00833 , B01J2219/00871 , B01J2219/00873 , B01J2219/00961 , B01J2219/0097 , B01J2219/00986 , B01L3/505 , B01L3/508 , B01L7/52 , B01L2300/042 , B01L2300/0809 , B01L2300/0858 , B01L2300/168 , B01L2300/1805 , F28D2021/0077 , F28F3/12 , F28F21/04 , F28F2280/10 , G01N21/0303 , G01N21/0332 , G01N2035/00326
摘要： The present invention provides a reaction vessel and apparatus for performing heat-exchanging reactions. The vessel has a chamber for holding a sample, the chamber being defined by a plurality of walls, at least two of the walls being light transmissive to provide optical windows to the chamber. The apparatus comprises at least one heating surface for contacting at least one of the plurality of walls, a heat source for heating the surface, and optics positioned to optically interrogate the chamber while the heating surface is in contact with at least one of the plurality of walls. The optics include at least one light source for transmitting light to the chamber through a first one of the light transmissive walls and at least one detector for detecting light exiting the chamber through a second one of the light transmissive walls.
摘要翻译：本发明提供一种用于进行热交换反应的反应容器和装置。容器具有用于保持样品的室，所述室由多个壁限定，至少两个壁是透光的，以向室提供光学窗口。该装置包括用于接触多个壁中的至少一个的至少一个加热表面，用于加热该表面的热源，以及定位成光学询问该室的光学器件，同时该加热表面与多个壁板中的至少一个接触墙壁所述光学器件包括至少一个光源，用于通过第一透光壁将光传输到室，以及至少一个检测器，用于检测通过第二透光壁离开室的光。

9. 发明授权

US4317611A Optical ray deflection apparatus 失效
标题翻译：光线偏转装置
公开(公告)号：US4317611A
公开(公告)日：1982-03-02
申请号：US150839
申请日：1980-05-19
申请人： Kurt E. Petersen
发明人： Kurt E. Petersen
IPC分类号： G02B26/08 , G02B26/10 , G03F7/20 , G09F9/37 , H04N1/113 , G02B27/17
CPC分类号： G03F7/70291 , G02B26/08 , G02B26/10 , G09F9/372
摘要： Torsional type optical ray deflection apparatus essentially comprises a pair of etched plates, one of which is single crystal semiconductor material such as silicon, and the other is a suitable insulating material such as glass. The semiconductor plate is etched to form an elongated bar of the material having a wider central portion which forms a reflecting surface armature of suitable area suspended internally of the rectangular frame formed by the remainder of the semiconductor plate. The insulating plate is etched to leave an annuloidal depression centrally of the plate. An elongated land in the center of the insulating plate underlies the reflecting surface area and the torsion bars in order to support the torsion bar-reflector structure in the direction normal to the longitudinal axis while allowing rotation about that axis. Planar electrodes are laid down in the bottom of the depression in the insulating plate for exerting an electrostatic force between one of the electrodes and the semiconductor armature, thereby causing angular displacement about the longitudinal axis of the torsion bars which will deflect rays of light incident to the reflecting surface portion.
摘要翻译：扭转型光线偏转装置基本上包括一对蚀刻板，其中之一是单晶半导体材料如硅，另一种是合适的绝缘材料如玻璃。蚀刻半导体板以形成具有较宽中心部分的材料的细长条，该中心部形成由半导体板的其余部分形成的矩形框架内部悬挂的合适区域的反射表面电枢。蚀刻绝缘板以在板的中心留下环形凹陷。在绝缘板的中心的细长的平台位于反射表面区域和扭杆之下，以便在垂直于纵向轴线的方向上支撑扭杆反射器结构，同时允许围绕该轴线旋转。平面电极放置在绝缘板的凹陷的底部，用于在电极和半导体电枢之间施加静电力，从而引起围绕扭杆的纵向轴线的角位移，这将扭曲入射到反射面部。

10. 发明申请

US20120171758A1 Device for extracting nucleic acid from a sample 有权
标题翻译：从样品中提取核酸的装置
公开(公告)号：US20120171758A1
公开(公告)日：2012-07-05
申请号：US11977615
申请日：2007-10-24
申请人： Kurt E. Petersen , Michael T. Taylor , Farzad Pourahmadi , William A. McMillan , Ronald Chang , Stanley H. Sakai , Jesus Ching , Douglas B. Dority , Phillip Belgrader , M. Allen Northrup
发明人： Kurt E. Petersen , Michael T. Taylor , Farzad Pourahmadi , William A. McMillan , Ronald Chang , Stanley H. Sakai , Jesus Ching , Douglas B. Dority , Phillip Belgrader , M. Allen Northrup
IPC分类号： C12M1/34 , C12M1/00
CPC分类号： B01L3/502 , B01L7/52 , B01L2200/10 , B01L2300/0654 , B01L2300/0681 , B01L2300/0809 , B01L2300/087 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , C12N1/066 , C12N13/00 , Y10S435/81 , Y10S436/805 , Y10S436/806 , Y10S436/807 , Y10S436/809 , Y10S436/829 , Y10T137/87716 , Y10T137/88046 , Y10T436/255
摘要： The present invention provides a cartridge for analyzing a fluid sample. The cartridge provides for the efficient separation of cells or viruses in the sample from the remaining sample fluid, lysis of the cells or viruses to release the analyte (e.g., nucleic acid) therefrom, and optionally chemical reaction and/or detection of the analyte. The cartridge is useful in a variety of diagnostic, life science research, environmental, or forensic applications for determining the presence or absence of one or more analytes in a sample.
摘要翻译：本发明提供一种用于分析流体样品的盒。盒提供用于有效分离样品中的细胞或病毒与剩余的样品流体，裂解细胞或病毒以从其中分离分析物（例如核酸），以及任选地分析物的化学反应和/或检测。墨盒可用于各种诊断，生命科学研究，环境或法医应用，用于确定样品中一种或多种分析物的存在或不存在。

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