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1. 发明授权

US09073053B2 Apparatus and method for cell disruption 有权
标题翻译：细胞破裂的装置和方法
公开(公告)号：US09073053B2
公开(公告)日：2015-07-07
申请号：US11233629
申请日：2005-09-22
申请人： Michael T. Taylor , Phillip Belgrader , Farzad Pourahmadi , William A. McMillan , Ronald Chang , Stanley H. Sakai , Jesus Ching
发明人： Michael T. Taylor , Phillip Belgrader , Farzad Pourahmadi , William A. McMillan , Ronald Chang , Stanley H. Sakai , Jesus Ching
IPC分类号： C12N1/06 , B01L3/00 , C12M1/00
CPC分类号： B01L3/502 , B01L2200/10 , B01L2300/0681 , B01L2400/0487 , B01L2400/0644 , B01L2400/0655 , C12M47/06
摘要： An apparatus for disrupting cells or viruses comprises a container having a chamber for holding the cells or viruses. The container includes at least one flexible wall defining the chamber. The apparatus also includes a transducer for impacting an external surface of the flexible wall to generate pressure waves in the chamber. The apparatus also includes a pressure source for increasing the pressure in the chamber. The pressurization of the chamber ensures effective coupling between the transducer and the flexible wall. The apparatus may also include beads in the chamber for rupturing the cells or viruses.
摘要翻译：用于破坏细胞或病毒的装置包括具有用于保持细胞或病毒的室的容器。容器包括限定腔室的至少一个柔性壁。该装置还包括用于冲击柔性壁的外表面的换能器，以在腔室中产生压力波。该装置还包括用于增加腔室中的压力的压力源。室的加压确保换能器与柔性壁之间的有效耦合。该装置还可以包括室中的珠子，用于破裂细胞或病毒。

2. 发明申请

US20120295269A1 METHOD FOR SEPARATING AN ANALYTE FROM A SAMPLE 有权
标题翻译：从样品中分离分析物的方法
公开(公告)号：US20120295269A1
公开(公告)日：2012-11-22
申请号：US13552950
申请日：2012-07-19
申请人： Farzad Pourahmadi , William A. McMillan , Jesus Ching , Ronald Chang , Lee A. Christel , Gregory T.A. Kovacs , M. Allen Northrup , Kurt E. Petersen
发明人： Farzad Pourahmadi , William A. McMillan , Jesus Ching , Ronald Chang , Lee A. Christel , Gregory T.A. Kovacs , M. Allen Northrup , Kurt E. Petersen
IPC分类号： C07H1/08 , C12S3/20 , C12Q1/68
CPC分类号： C12N15/1017 , B01D15/00 , B01L7/52 , B01L2400/0622 , B01L2400/0644 , C12M47/06 , G01N1/34 , Y10T436/255
摘要： An analyte is separated from a fluid sample by introducing the sample into a cartridge having a sample port and a first flow path extending from the sample port. The first flow path includes an extraction chamber containing a solid support for capturing the analyte from the sample. The cartridge has a second flow path for eluting the captured analyte from the extraction chamber, the second flow diverging from the first flow path after passing through the extraction chamber. The sample is forced to flow through the extraction chamber and into a waste chamber, thereby capturing the analyte with the solid support as the sample flows through the extraction chamber. The captured analyte is then eluted from the extraction chamber by forcing an elution fluid to flow through the extraction chamber and along the second flow path.
摘要翻译：将样品通过将样品引入具有样品端口和从样品端口延伸的第一流路的盒中而将分析物与流体样品分离。第一流路包括提取室，其包含用于从样品捕获分析物的固体支持物。所述筒具有用于从所述提取室洗脱所捕获的分析物的第二流动路径，所述第二流在通过所述提取室之后从所述第一流动路径发散。样品被迫流过提取室并进入废物室，从而当样品流过提取室时用固体支持物捕获分析物。然后通过迫使洗脱液体流过提取室并沿着第二流动路径，将捕获的分析物从萃取室洗脱。

3. 发明申请

US20120288924A1 CARTRIDGE FOR CONDUCTING A CHEMICAL REACTION 有权
标题翻译：用于进行化学反应的墨盒
公开(公告)号：US20120288924A1
公开(公告)日：2012-11-15
申请号：US13436475
申请日：2012-03-30
申请人： Kurt E. Peterson , William A. McMillan , Farzad Pourahmadi , Ronald Chang , Douglas B. Dority
发明人： Kurt E. Peterson , William A. McMillan , Farzad Pourahmadi , Ronald Chang , Douglas B. Dority
IPC分类号： G01N21/59 , C12M1/34 , G01N33/48
CPC分类号： B01L7/52 , B01L3/502 , B01L2200/10 , B01L2300/0654 , B01L2300/0681 , B01L2300/0858 , B01L2300/087 , B01L2300/123 , B01L2300/14 , B01L2300/168 , B01L2300/18 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , C12Q1/6844 , G01N33/5302 , Y10T436/25 , Y10T436/25375 , Y10T436/2575
摘要： A cartridge for conducting a chemical reaction includes a body having at least one flow path formed therein. The cartridge also includes a reaction vessel extending from the body for holding a reaction mixture for chemical reaction and optical detection. The vessel comprises a rigid frame defining the side walls of a reaction chamber. The frame includes at least one channel connecting the flow path to the chamber. The vessel also includes flexible films or sheets attached to opposite sides of the rigid frame to form opposing major walls of the chamber. In addition, at least two of the side walls are optically transmissive and angularly offset from each to permit real-time optical detection of analyte in the reaction chamber.
摘要翻译：用于进行化学反应的药筒包括具有形成在其中的至少一个流路的主体。药筒还包括从身体延伸的反应容器，用于保持用于化学反应和光学检测的反应混合物。容器包括限定反应室侧壁的刚性框架。该框架包括连接到该腔室的流动路径的至少一个通道。容器还包括附接到刚性框架的相对侧的柔性膜或片，以形成腔室的相对的主壁。此外，至少两个侧壁是光学透射的并且与每个侧壁成角度地偏移以允许对反应室中的分析物的实时光学检测。

4. 发明申请

US20110165562A1 METHOD FOR SEPARATING AN ANALYTE FROM A SAMPLE 有权
标题翻译：从样品中分离分析物的方法
公开(公告)号：US20110165562A1
公开(公告)日：2011-07-07
申请号：US13042203
申请日：2011-03-07
申请人： Farzad Pourahmadi , William A. McMillan , Jesus Ching , Ronald Chang , Lee A. Christel , Gregory T.A. Kovacs , M. Allen Northrup , Kurt E. Petersen
发明人： Farzad Pourahmadi , William A. McMillan , Jesus Ching , Ronald Chang , Lee A. Christel , Gregory T.A. Kovacs , M. Allen Northrup , Kurt E. Petersen
IPC分类号： C12Q1/68 , C12S3/20 , C07H1/06
CPC分类号： C12N15/1017 , B01D15/00 , B01L7/52 , B01L2400/0622 , B01L2400/0644 , C12M47/06 , G01N1/34 , Y10T436/255
摘要： An analyte is separated from a fluid sample by introducing the sample into a cartridge having a sample port and a first flow path extending from the sample port. The first flow path includes an extraction chamber containing a solid support for capturing the analyte from the sample. The cartridge has a second flow path for eluting the captured analyte from the extraction chamber, the second flow diverging from the first flow path after passing through the extraction chamber. The sample is forced to flow through the extraction chamber and into a waste chamber, thereby capturing the analyte with the solid support as the sample flows through the extraction chamber. The captured analyte is then eluted from the extraction chamber by forcing an elution fluid to flow through the extraction chamber and along the second flow path.
摘要翻译：将样品通过将样品引入具有样品端口和从样品端口延伸的第一流路的盒中而将分析物与流体样品分离。第一流路包括提取室，其包含用于从样品捕获分析物的固体支持物。所述筒具有用于从所述提取室洗脱所捕获的分析物的第二流动路径，所述第二流在通过所述提取室之后从所述第一流动路径发散。样品被迫流过提取室并进入废物室，从而当样品流过提取室时用固体支持物捕获分析物。然后通过迫使洗脱液体流过提取室并沿着第二流动路径，将捕获的分析物从萃取室洗脱。

5. 发明申请

US20100068706A1 METHOD FOR SEPARATING AN ANALYTE FROM A SAMPLE 有权
标题翻译：从样品中分离分析物的方法
公开(公告)号：US20100068706A1
公开(公告)日：2010-03-18
申请号：US12370527
申请日：2009-02-12
申请人： Farzad Pourahmadi , William A. McMillan , Jesus Ching , Ronald Chang , Lee A. Christel , Gregory T.A. Kovacs , M. Allen Northrup , Kurt E. Petersen
发明人： Farzad Pourahmadi , William A. McMillan , Jesus Ching , Ronald Chang , Lee A. Christel , Gregory T.A. Kovacs , M. Allen Northrup , Kurt E. Petersen
IPC分类号： C07H1/06 , C12Q1/68
CPC分类号： C12N15/1017 , B01D15/00 , B01L7/52 , B01L2400/0622 , B01L2400/0644 , C12M47/06 , G01N1/34 , Y10T436/255
摘要： An analyte is separated from a fluid sample by introducing the sample into a cartridge having a sample port and a first flow path extending from the sample port. The first flow path includes an extraction chamber containing a solid support for capturing the analyte from the sample. The cartridge has a second flow path for eluting the captured analyte from the extraction chamber, the second flow diverging from the first flow path after passing through the extraction chamber. The sample is forced to flow through the extraction chamber and into a waste chamber, thereby capturing the analyte with the solid support as the sample flows through the extraction chamber. The captured analyte is then eluted from the extraction chamber by forcing an elution fluid to flow through the extraction chamber and along the second flow path.
摘要翻译：将样品通过将样品引入具有样品端口和从样品端口延伸的第一流路的盒中而将分析物与流体样品分离。第一流路包括提取室，其包含用于从样品捕获分析物的固体支持物。所述筒具有用于从所述提取室洗脱所捕获的分析物的第二流动路径，所述第二流在通过所述提取室之后从所述第一流动路径发散。样品被迫流过提取室并进入废物室，从而当样品流过提取室时用固体支持物捕获分析物。然后通过迫使洗脱液体流过提取室并沿着第二流动路径，将捕获的分析物从萃取室洗脱。

6. 发明申请

US20100050742A1 INTEGRATED AIRBORNE SUBSTANCE COLLECTION AND DETECTION SYSTEM 有权
标题翻译：一体化航空物质收集和检测系统
公开(公告)号：US20100050742A1
公开(公告)日：2010-03-04
申请号：US11510073
申请日：2006-08-24
申请人： Allen Northrup , Farzad Pourahmadi , Bob Yuan , Amy J. Devitt
发明人： Allen Northrup , Farzad Pourahmadi , Bob Yuan , Amy J. Devitt
IPC分类号： G01N7/00
CPC分类号： G01N1/2202 , G01N1/2273 , G01N15/14 , G01N2015/0046
摘要： A collection and detection system is directed to a combined system in which a detect to warn system is integrated with a detect to treat system. Such a combined system provides multi-levels of detection to determine the presence and identity of one or more different types of specific particles. In some applications, the combined system is configured to detect and identify one or more different types of specific biological particles such as toxins and pathogens. The combined system includes a first level detection device, in which the presence of one or more toxins and/or pathogens are detected, and a second level detection device. Upon detection by the first level detection device, the second level detection device performs a second level of detection in which the one or more toxins and/or pathogens are identified.
摘要翻译：收集和检测系统被引导到组合系统，其中警报系统的检测与检测处理系统集成。这样的组合系统提供多级检测以确定一种或多种不同类型的特定颗粒的存在和身份。在一些应用中，组合系统被配置为检测和识别一种或多种不同类型的特定生物颗粒，例如毒素和病原体。组合系统包括其中检测到一种或多种毒素和/或病原体的存在的第一级检测装置和第二级检测装置。在被第一级检测装置检测到时，第二级别检测装置执行其中识别出一种或多种毒素和/或病原体的第二检测水平。

7. 发明申请

US20050042137A1 Cartridge for conducting a chemical reaction 有权
标题翻译：用于进行化学反应的墨盒
公开(公告)号：US20050042137A1
公开(公告)日：2005-02-24
申请号：US10955811
申请日：2004-09-29
申请人： Kurt Petersen , William McMillan , Farzad Pourahmadi , Ronald Chang , Douglas Dority
发明人： Kurt Petersen , William McMillan , Farzad Pourahmadi , Ronald Chang , Douglas Dority
IPC分类号： B01L3/00 , B01L7/00 , G01N31/22
CPC分类号： B01L7/52 , B01L3/502 , B01L2200/10 , B01L2300/0654 , B01L2300/0681 , B01L2300/0858 , B01L2300/087 , B01L2300/123 , B01L2300/14 , B01L2300/168 , B01L2300/18 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , C12Q1/6844 , G01N33/5302 , Y10T436/25 , Y10T436/25375 , Y10T436/2575
摘要： A cartridge for conducting a chemical reaction includes a body having at least one flow path formed therein. The cartridge also includes a reaction vessel extending from the body for holding a reaction mixture for chemical reaction and optical detection. The vessel comprises a rigid frame defining the side walls of a reaction chamber. The frame includes at least one channel connecting the flow path to the chamber. The vessel also includes flexible films or sheets attached to opposite sides of the rigid frame to form opposing major walls of the chamber. In addition, at least two of the side walls are optically transmissive and angularly offset from each to permit real-time optical detection of analyte in the reaction chamber.
摘要翻译：用于进行化学反应的药筒包括具有形成在其中的至少一个流路的主体。药筒还包括从身体延伸的反应容器，用于保持用于化学反应和光学检测的反应混合物。容器包括限定反应室侧壁的刚性框架。该框架包括连接到该腔室的流动路径的至少一个通道。容器还包括附接到刚性框架的相对侧的柔性膜或片，以形成腔室的相对的主壁。此外，至少两个侧壁是光学透射的并且与每个侧壁成角度地偏移以允许对反应室中的分析物的实时光学检测。

8. 发明授权

US08268603B2 Apparatus and method for cell disruption 有权
标题翻译：细胞破裂的装置和方法
公开(公告)号：US08268603B2
公开(公告)日：2012-09-18
申请号：US11234656
申请日：2005-09-22
申请人： Michael T. Taylor , Phillip Belgrader , Farzad Pourahmadi , William A. McMillan , Ronald Chang , Jesus Ching
发明人： Michael T. Taylor , Phillip Belgrader , Farzad Pourahmadi , William A. McMillan , Ronald Chang , Jesus Ching
IPC分类号： C12N13/00 , C12M1/33 , C12M3/08
CPC分类号： B01L3/502 , B01L7/52 , B01L2200/10 , B01L2300/0654 , B01L2300/0681 , B01L2300/087 , B01L2300/14 , B01L2400/0487 , B01L2400/0622 , B01L2400/0644 , C12M47/06
摘要： An apparatus for disrupting cells or viruses comprises a container having a chamber for holding the cells or viruses. The container includes at least one flexible wall defining the chamber. The apparatus also includes a transducer for impacting an external surface of the flexible wall to generate pressure waves in the chamber. The apparatus also includes a pressure source for increasing the pressure in the chamber. The pressurization of the chamber ensures effective coupling between the transducer and the flexible wall. The apparatus may also include beads in the chamber for rupturing the cells or viruses.
摘要翻译：用于破坏细胞或病毒的装置包括具有用于保持细胞或病毒的室的容器。容器包括限定腔室的至少一个柔性壁。该装置还包括用于冲击柔性壁的外表面的换能器，以在腔室中产生压力波。该装置还包括用于增加腔室中的压力的压力源。室的加压确保换能器与柔性壁之间的有效耦合。该装置还可以包括室中的珠子，用于破裂细胞或病毒。

9. 发明授权

US07785868B2 Apparatus to automatically lyse a sample 有权
标题翻译：用于自动裂解样品的装置
公开(公告)号：US07785868B2
公开(公告)日：2010-08-31
申请号：US11290653
申请日：2005-11-29
申请人： Bob Yuan , Allen Northrup , Farzad Pourahmadi
发明人： Bob Yuan , Allen Northrup , Farzad Pourahmadi
IPC分类号： C12M1/42
CPC分类号： C12M47/06 , B01F11/0266
摘要： A standalone bench top laboratory instrument designed to disrupt, or lyse, cells, spores and tissue samples using ultrasonic energy. The lysing device is programmable, allowing the user control over the sample volume, sonication power level, and lysing duration in order to optimize lysing protocols for specific targets. Once a lysing protocol is entered, the device automatically lyses the sample according to the entered lysing protocol. The lysing device also provides a cooling feature, enabled by a heat exchanging sub-assembly, to prevent the sample from exceeding a maximum set temperature.
摘要翻译：一种独立的台式实验室仪器，旨在利用超声波能量破坏或溶解细胞，孢子和组织样品。裂解装置是可编程的，允许用户控制样品体积，超声功率水平和裂解持续时间，以优化特定靶标的裂解方案。一旦输入了裂解协议，设备将根据输入的裂解协议自动分析样品。裂解装置还提供通过热交换子组件实现的冷却特征，以防止样品超过最大设定温度。

10. 发明申请

US20080048874A1 Integrated airborne substance collection and detection system 有权
标题翻译：综合空气中物质收集和检测系统
公开(公告)号：US20080048874A1
公开(公告)日：2008-02-28
申请号：US11509872
申请日：2006-08-24
申请人： Allen Northrup , Farzad Pourahmadi , Bob Yuan , Amy J. Devitt
发明人： Allen Northrup , Farzad Pourahmadi , Bob Yuan , Amy J. Devitt
IPC分类号： G08B21/00 , C12M3/00
CPC分类号： G08B21/12 , G01N1/2273 , G01N2001/2217
摘要： A collection and detection system is configured as a detect to warn system in which the presence of specific types of particles are detected, and may or may not be identified. An air collection module intakes ambient air, detect the presence of one or more different types of airborne particles within the ambient air, and collect the airborne particles, such as within a fluid. A triggering mechanism is positioned to continuously monitor the airflow, to determine one or more characteristics of the airborne particles. If those measured characteristics match specific known characteristics, a trigger signal is generated. In response, a confirmation device performs a detection method on a fluid solution including the airflow particles to determine the presence of one or more different types of specific biological particles.
摘要翻译：收集和检测系统被配置为检测到警告系统，其中检测到特定类型的粒子的存在，并且可以或可以不被识别。空气收集模块进入环境空气，检测在环境空气中存在一种或多种不同类型的空气中的颗粒，并收集空气中的颗粒，例如在流体内。定位触发机构以连续监测气流，以确定空气中的颗粒的一个或多个特性。如果这些测量特性符合特定的已知特性，则产生触发信号。作为响应，确认装置对包括气流颗粒的流体溶液执行检测方法以确定一种或多种不同类型的特定生物颗粒的存在。

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