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1. 发明授权

US5840544A DNA encoding rantes homolog from prostate 失效
标题翻译：编码前列腺同源物的DNA
公开(公告)号：US5840544A
公开(公告)日：1998-11-24
申请号：US633682
申请日：1996-04-17
申请人： Phillip R. Hawkins , Olga Bandman , Lynn E. Murry
发明人： Phillip R. Hawkins , Olga Bandman , Lynn E. Murry
IPC分类号： C12N15/02 , A61K31/00 , A61K38/00 , A61K45/00 , A61K48/00 , A61P11/00 , A61P11/06 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/00 , A61P37/08 , C07K14/52 , C07K14/715 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/19 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566
CPC分类号： C07K14/523 , A61K38/00 , A61K48/00 , C12N2799/026 , Y10S930/14
摘要： The present invention provides a polynucleotide PTEC (prostate expressed chemokine) isolated from a prostate cDNA library which identifies and encodes a novel human rantes homolog PTEC (prostate expressed chemokine). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding PTEC. The invention also provides for the therapeutic use of purified PTEC in the treatment of immune deficiency diseases, and for the therapeutic use of antisense molecules, antibodies, antagonists or inhibitors in the treatment of conditions or diseases associated with the expression of PTEC. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, or fragments thereof, or antibodies which specifically bind to the polypeptide.
摘要翻译：本发明提供从前列腺cDNA文库分离的多肽PTEC（前列腺表达的趋化因子），该文库鉴定并编码新的人类同源物PTEC（前列腺表达的趋化因子）。本发明提供了包含编码PTEC的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供了纯化的PTEC在治疗免疫缺陷疾病中的治疗用途，以及用于治疗与PTEC表达相关的病症或疾病的反义分子，抗体，拮抗剂或抑制剂的治疗用途。本发明还描述了利用包含特异性结合多肽的多核苷酸或其片段或抗体的诊断组合物的诊断测定法。

2. 发明授权

US06303297B1 Database for storage and analysis of full-length sequences 失效
标题翻译：数据库用于存储和分析全长序列
公开(公告)号：US06303297B1
公开(公告)日：2001-10-16
申请号：US08969987
申请日：1997-11-13
申请人： Steve E. Lincoln , Tod M. Klingler , Janice Au-Young , Y. Tom Tang , Richard D. Goold , Ingrid E. Akerblom , Jeffrey J. Seilhamer , Phillip R. Hawkins , Lynn E. Murry , Angelo M. Delegeane , Wendy B. Levine , Jennifer L. Hillman , Surya K. Goli , Christina M. Altus , Olga Bandman , Samuel T. LaBrie , Purvi Shah
发明人： Steve E. Lincoln , Tod M. Klingler , Janice Au-Young , Y. Tom Tang , Richard D. Goold , Ingrid E. Akerblom , Jeffrey J. Seilhamer , Phillip R. Hawkins , Lynn E. Murry , Angelo M. Delegeane , Wendy B. Levine , Jennifer L. Hillman , Surya K. Goli , Christina M. Altus , Olga Bandman , Samuel T. LaBrie , Purvi Shah
IPC分类号： C12Q168
CPC分类号： C12N9/6445 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K14/82 , C07K16/303 , C12Q1/68 , C12Q1/6809 , G01N33/574 , G06F19/18 , G06F19/22 , G06F19/28
摘要： The present invention is a computerized storage and retrieval system for genetic information and related annotated information. The data of the system is stored in a relational database which interfaces with public databases to allow analysis both within the database of the invention and between information within that database and external public databases. The sequence data is edited before entry into the system, and is stored in a curated, functional clustering organization. The information associated with the data is stored in an expression database that is linked to the storage of the sequence data.
摘要翻译：本发明是用于遗传信息和相关注释信息的计算机化存储和检索系统。系统的数据存储在与公共数据库接口的关系数据库中，以便在本发明的数据库内以及该数据库内的信息和外部公共数据库之间进行分析。序列数据在进入系统之前进行编辑，并存储在策略化的功能集群组织中。与数据相关联的信息存储在链接到序列数据的存储的表达式数据库中。

3. 发明授权

US06238666B1 RANTES homolog antibody 失效
标题翻译： RANTES同系物抗体
公开(公告)号：US06238666B1
公开(公告)日：2001-05-29
申请号：US09395918
申请日：1999-09-14
申请人： Phillip R. Hawkins , Olga Bandman , Lynn E. Murry
发明人： Phillip R. Hawkins , Olga Bandman , Lynn E. Murry
IPC分类号： A61K39395
CPC分类号： C07K14/523 , A61K38/00 , A61K48/00 , C12N2799/026 , Y10S930/14
摘要： The present invention provides a polynucleotide (PTEC) isolated from a prostate cDNA library which identifies and encodes a human rantes homolog (PTEC). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding PTEC. The invention also provides for the therapeutic use of purified PTEC in the treatment of immune deficiency diseases, and for the therapeutic use of antisense molecules, antibodies, antagonists or inhibitors in the treatment of conditions or diseases associated with the expression of PTEC. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, or fragments thereof, or antibodies which specifically bind to the polypeptide.
摘要翻译：本发明提供从前列腺cDNA文库分离的多核苷酸（PTEC），其鉴定并编码人类群同系物（PTEC）。本发明提供了包含编码PTEC的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供了纯化的PTEC在治疗免疫缺陷疾病中的治疗用途，以及用于治疗与PTEC表达相关的病症或疾病的反义分子，抗体，拮抗剂或抑制剂的治疗用途。本发明还描述了利用包含特异性结合多肽的多核苷酸或其片段或抗体的诊断组合物的诊断测定法。

4. 发明授权

US06204021B1 DNA encoding a cytokine 失效
标题翻译：编码细胞因子的DNA
公开(公告)号：US06204021B1
公开(公告)日：2001-03-20
申请号：US08792013
申请日：1997-01-31
申请人： Olga Bandman , Phillip R. Hawkins , Lynn E. Murry , Surya K. Goli
发明人： Olga Bandman , Phillip R. Hawkins , Lynn E. Murry , Surya K. Goli
IPC分类号： C12N1500
CPC分类号： C07K14/52
摘要： The present invention provides novel human cytokines (designated individually as NHC-1 and NHC-2, and collectively as NHC) and polynucleotides which identify and encode NHC. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NHC and a method for producing NHC. The invention also provides for use of NHC and agonists, antibodies, or antagonists specifically binding NHC, in the prevention and treatment of diseases associated with expression of NHC. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NHC for the treatment of diseases associated with the expression of NHC. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NHC.
摘要翻译：本发明提供新型人细胞因子（单独命名为NHC-1和NHC-2，统称为NHC）和识别和编码NHC的多核苷酸。本发明还提供了包含编码NHC的核酸序列和生产NHC的方法的遗传工程表达载体和宿主细胞。本发明还提供使用NHC和特异性结合NHC的激动剂，抗体或拮抗剂来预防和治疗与NHC表达有关的疾病。另外，本发明提供了将反义分子用于编码NHC的多核苷酸用于治疗与NHC表达有关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合NHC的抗体的诊断测定法。

5. 发明授权

US6015883A Rantes homolog from prostate 失效
标题翻译：来自前列腺的Rantes同系物
公开(公告)号：US6015883A
公开(公告)日：2000-01-18
申请号：US936772
申请日：1997-09-24
申请人： Phillip R. Hawkins , Olga Bandman , Lynn E. Murry
发明人： Phillip R. Hawkins , Olga Bandman , Lynn E. Murry
IPC分类号： C12N15/02 , A61K31/00 , A61K38/00 , A61K45/00 , A61K48/00 , A61P11/00 , A61P11/06 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/00 , A61P37/08 , C07K14/52 , C07K14/715 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/19 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , A61K38/19
CPC分类号： C07K14/523 , A61K38/00 , A61K48/00 , C12N2799/026 , Y10S930/14
摘要： The present invention provides a polynucleotide (PTEC) isolated from a prostate cDNA library which identifies and encodes a novel human rantes homolog PTEC (prostate expressed chemokine). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding PTEC. The invention also provides for the therapeutic use of purified PTEC in the treatment of immune deficiency diseases, and for the therapeutic use of antisense molecules, antibodies, antagonists or inhibitors in the treatment of conditions or diseases associated with the expression of PTEC. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, or fragments thereof, or antibodies which specifically bind to the polypeptide.
摘要翻译：本发明提供从前列腺cDNA文库分离的多核苷酸（PTEC），其鉴定并编码新的人类群同系物PTEC（前列腺表达的趋化因子）。本发明提供了包含编码PTEC的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供了纯化的PTEC在治疗免疫缺陷疾病中的治疗用途，以及用于治疗与PTEC表达相关的病症或疾病的反义分子，抗体，拮抗剂或抑制剂的治疗用途。本发明还描述了利用包含特异性结合多肽的多核苷酸或其片段或抗体的诊断组合物的诊断测定法。

6. 发明授权

US06054290A Human vesicle binding protein 失效
标题翻译：人体囊泡结合蛋白
公开(公告)号：US06054290A
公开(公告)日：2000-04-25
申请号：US857213
申请日：1997-05-15
申请人： Olga Bandman , Phillip R. Hawkins , Lynn E. Murry
发明人： Olga Bandman , Phillip R. Hawkins , Lynn E. Murry
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , C12N15/11 , C07H21/04 , C12N15/85
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides a human vesicle binding protein (MVBP) and polynucleotides which identify and encode MVBP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention provides methods for producing MVBP and for treating or preventing disorders associated with expression of MVBP.
摘要翻译：本发明提供了人囊泡结合蛋白（MVBP）和识别和编码MVBP的多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。此外，本发明提供了产生MVBP并用于治疗或预防与MVBP表达相关的病症的方法。

7. 发明授权

US5885798A DNA encoding a monocyte activating cytokine 失效
标题翻译：编码单核细胞激活细胞因子的DNA
公开(公告)号：US5885798A
公开(公告)日：1999-03-23
申请号：US705868
申请日：1996-08-28
申请人： Olga Bandman , Roger Coleman , Janice Au-Young , Lynn E. Murry
发明人： Olga Bandman , Roger Coleman , Janice Au-Young , Lynn E. Murry
IPC分类号： A61K38/00 , C07K14/52 , C12N15/19 , C12N15/64
CPC分类号： C07K14/52 , A61K38/00
摘要： The present invention provides novel monocyte activating cytokine (MAC) and a polynucleotide encoding MAC. The invention also provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding MAC. The invention also provides for the production and use of substantially purified MAC in pharmaceutical compositions for the treatment of cancer and disease of the immune system. The invention also describes diagnostic assays which utilize the polynucleotide to hybridize with the transcripts encoding MAC and antibodies which specifically bind to MAC.
摘要翻译：本发明提供新型单核细胞激活细胞因子（MAC）和编码MAC的多核苷酸。本发明还提供了包含编码MAC的核酸序列的基因工程表达载体和宿主细胞。本发明还提供用于治疗癌症和免疫系统疾病的药物组合物中基本上纯化的MAC的生产和使用。本发明还描述了利用多核苷酸与编码MAC的转录物和特异性结合MAC的抗体杂交的诊断测定法。

8. 发明授权

US06534275B1 Cellubrevin homologs 失效
公开(公告)号：US06534275B1
公开(公告)日：2003-03-18
申请号：US09483665
申请日：2000-01-14
申请人： Susan G. Stuart , Phillip R. Hawkins , Jeffrey J. Seilhamer , Lynn E. Murry
发明人： Susan G. Stuart , Phillip R. Hawkins , Jeffrey J. Seilhamer , Lynn E. Murry
IPC分类号： G01N3353
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode novel cellubrevins (cb). The present invention also provides for antisense molecules to the nucleotide sequences which encode cbs, expression vectors for the production of purified CBs, antibodies capable of binding specifically to CBs, hybridization probes or oligonucleotides for the detecting the induction of CB encoding nucleotide sequences, genetically engineered host cells for the expression of CBs, diagnostic tests for activated, inflamed or diseased cells and/or tissues based on CB-encoding nucleic acid molecules and antibodies capable of binding specifically to CBs.

9. 发明授权

US5935812A Human GTP binding protein gamma-3 失效
标题翻译：人GTP结合蛋白γ-3
公开(公告)号：US5935812A
公开(公告)日：1999-08-10
申请号：US715527
申请日：1996-09-18
申请人： Olga Bandman , Surya K. Goli , Lynn E. Murry
发明人： Olga Bandman , Surya K. Goli , Lynn E. Murry
IPC分类号： G01N33/50 , A61K38/00 , A61K39/395 , A61K45/00 , A61P35/00 , C07K14/705 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N33/15 , G01N33/566 , C12P21/00
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides a polynucleotide which identifies and encodes a novel human GTP binding protein gamma-3 (HGPG) and HGPG itself. The invention provides for genetically engineered expression vectors, host cells containing the vector and a method for producing HGPG. The invention also provides a method for identifying pharmaceutical compositions inhibiting the expression and activity of HGPG and for the use of such compositions for the treatment of cancer. The invention also provides diagnostic assays which utilize the polynucleotide to hybridize with the transcripts encoding HGPG or anti-HGPG antibodies which specifically bind to HGPG in normal or diseased tissues.
摘要翻译：本发明提供鉴定和编码新的人GTP结合蛋白γ-3（HGPG）和HGPG本身的多核苷酸。本发明提供了遗传工程表达载体，含有载体的宿主细胞和用于产生HGPG的方法。本发明还提供了用于鉴定抑制HGPG的表达和活性以及使用这些组合物治疗癌症的药物组合物的方法。本发明还提供了利用多核苷酸与编码在正常或患病组织中特异性结合HGPG的HGPG或抗HGPG抗体的转录物进行杂交的诊断测定。

10. 发明授权

US5972658A DNA encoding lung growth factor variant 失效
标题翻译：编码肺生长因子变体的DNA
公开(公告)号：US5972658A
公开(公告)日：1999-10-26
申请号：US760745
申请日：1996-12-05
申请人： Olga Bandman , Surya K. Goli , Lynn E. Murry
发明人： Olga Bandman , Surya K. Goli , Lynn E. Murry
IPC分类号： A61K38/00 , C07K14/475 , C12N1/21 , C12N15/12 , C12N15/00 , C07H21/04 , C12N1/15
CPC分类号： C07K14/475 , A61K38/00
摘要： The present invention provides a human lung growth factor variant (LGFV) and polynucleotides which identify and encode LGFV. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding LGFV and a method for producing LGFV. The invention also provides for agonists, antibodies, or antagonists specifically binding LGFV, and their use, in the prevention and treatment of diseases associated with expression of LGFV. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding LGFV for the treatment of diseases associated with the expression of LGFV. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding LGFV.
摘要翻译：本发明提供了人肺生长因子变体（LGFV）和鉴定和编码LGFV的多核苷酸。本发明还提供了遗传工程改造的表达载体和包含编码LGFV的核酸序列的宿主细胞和用于产生LGFV的方法。本发明还提供了特异性结合LGFV的激动剂，抗体或拮抗剂及其在预防和治疗与LGFV表达相关的疾病中的用途。另外，本发明提供了反义分子用于编码LGFV的多核苷酸用于治疗与LGFV表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合LGFV的抗体的诊断测定法。

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