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1. 发明授权

US06303297B1 Database for storage and analysis of full-length sequences 失效
标题翻译：数据库用于存储和分析全长序列
公开(公告)号：US06303297B1
公开(公告)日：2001-10-16
申请号：US08969987
申请日：1997-11-13
申请人： Steve E. Lincoln , Tod M. Klingler , Janice Au-Young , Y. Tom Tang , Richard D. Goold , Ingrid E. Akerblom , Jeffrey J. Seilhamer , Phillip R. Hawkins , Lynn E. Murry , Angelo M. Delegeane , Wendy B. Levine , Jennifer L. Hillman , Surya K. Goli , Christina M. Altus , Olga Bandman , Samuel T. LaBrie , Purvi Shah
发明人： Steve E. Lincoln , Tod M. Klingler , Janice Au-Young , Y. Tom Tang , Richard D. Goold , Ingrid E. Akerblom , Jeffrey J. Seilhamer , Phillip R. Hawkins , Lynn E. Murry , Angelo M. Delegeane , Wendy B. Levine , Jennifer L. Hillman , Surya K. Goli , Christina M. Altus , Olga Bandman , Samuel T. LaBrie , Purvi Shah
IPC分类号： C12Q168
CPC分类号： C12N9/6445 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K14/82 , C07K16/303 , C12Q1/68 , C12Q1/6809 , G01N33/574 , G06F19/18 , G06F19/22 , G06F19/28
摘要： The present invention is a computerized storage and retrieval system for genetic information and related annotated information. The data of the system is stored in a relational database which interfaces with public databases to allow analysis both within the database of the invention and between information within that database and external public databases. The sequence data is edited before entry into the system, and is stored in a curated, functional clustering organization. The information associated with the data is stored in an expression database that is linked to the storage of the sequence data.
摘要翻译：本发明是用于遗传信息和相关注释信息的计算机化存储和检索系统。系统的数据存储在与公共数据库接口的关系数据库中，以便在本发明的数据库内以及该数据库内的信息和外部公共数据库之间进行分析。序列数据在进入系统之前进行编辑，并存储在策略化的功能集群组织中。与数据相关联的信息存储在链接到序列数据的存储的表达式数据库中。

2. 发明授权

US06204021B1 DNA encoding a cytokine 失效
标题翻译：编码细胞因子的DNA
公开(公告)号：US06204021B1
公开(公告)日：2001-03-20
申请号：US08792013
申请日：1997-01-31
申请人： Olga Bandman , Phillip R. Hawkins , Lynn E. Murry , Surya K. Goli
发明人： Olga Bandman , Phillip R. Hawkins , Lynn E. Murry , Surya K. Goli
IPC分类号： C12N1500
CPC分类号： C07K14/52
摘要： The present invention provides novel human cytokines (designated individually as NHC-1 and NHC-2, and collectively as NHC) and polynucleotides which identify and encode NHC. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NHC and a method for producing NHC. The invention also provides for use of NHC and agonists, antibodies, or antagonists specifically binding NHC, in the prevention and treatment of diseases associated with expression of NHC. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NHC for the treatment of diseases associated with the expression of NHC. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NHC.
摘要翻译：本发明提供新型人细胞因子（单独命名为NHC-1和NHC-2，统称为NHC）和识别和编码NHC的多核苷酸。本发明还提供了包含编码NHC的核酸序列和生产NHC的方法的遗传工程表达载体和宿主细胞。本发明还提供使用NHC和特异性结合NHC的激动剂，抗体或拮抗剂来预防和治疗与NHC表达有关的疾病。另外，本发明提供了将反义分子用于编码NHC的多核苷酸用于治疗与NHC表达有关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合NHC的抗体的诊断测定法。

3. 发明授权

US5858710A Tumor-associated kazal inhibitor-like polypeptides and encoding polynucleotides 失效
标题翻译：肿瘤相关的kazal抑制剂样多肽和编码多核苷酸
公开(公告)号：US5858710A
公开(公告)日：1999-01-12
申请号：US744670
申请日：1996-11-06
申请人： Olga Bandman , Surya K. Goli , Lynn E. Murry
发明人： Olga Bandman , Surya K. Goli , Lynn E. Murry
IPC分类号： G01N33/574 , A61K38/00 , A61K38/55 , A61K39/395 , A61P1/00 , A61P35/00 , C07K14/81 , C07K16/38 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/15 , C12Q1/68 , C07K14/435 , C12N15/70 , C12N15/79
CPC分类号： C07K14/8135 , A61K38/00
摘要： The present invention provides a human tumor-associated Kazal inhibitor (TAKI) and polynucleotides which identify and encode TAKI. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding TAKI and a method for producing TAKI. The invention also provides for agonists, antibodies, or antagonists specifically binding TAKI, and their use, in the prevention and treatment of intestinal diseases including cancer. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding TAKI for the treatment of diseases associated with the expression of TAKI. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding TAKI.
摘要翻译：本发明提供了一种人肿瘤相关的卡马尔抑制剂（TAKI）和鉴定和编码TAKI的多核苷酸。本发明还提供了基因工程表达载体和宿主细胞，其包含编码TAKI的核酸序列和产生TAKI的方法。本发明还提供了特异性结合TAKI的激动剂，抗体或拮抗剂及其在预防和治疗包括癌症的肠道疾病中的用途。另外，本发明提供反义分子用于编码TAKI的多核苷酸用于治疗与TAKI表达相关的疾病。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合TAKI的抗体的诊断测定法。

4. 发明授权

US5935812A Human GTP binding protein gamma-3 失效
标题翻译：人GTP结合蛋白γ-3
公开(公告)号：US5935812A
公开(公告)日：1999-08-10
申请号：US715527
申请日：1996-09-18
申请人： Olga Bandman , Surya K. Goli , Lynn E. Murry
发明人： Olga Bandman , Surya K. Goli , Lynn E. Murry
IPC分类号： G01N33/50 , A61K38/00 , A61K39/395 , A61K45/00 , A61P35/00 , C07K14/705 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N33/15 , G01N33/566 , C12P21/00
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides a polynucleotide which identifies and encodes a novel human GTP binding protein gamma-3 (HGPG) and HGPG itself. The invention provides for genetically engineered expression vectors, host cells containing the vector and a method for producing HGPG. The invention also provides a method for identifying pharmaceutical compositions inhibiting the expression and activity of HGPG and for the use of such compositions for the treatment of cancer. The invention also provides diagnostic assays which utilize the polynucleotide to hybridize with the transcripts encoding HGPG or anti-HGPG antibodies which specifically bind to HGPG in normal or diseased tissues.
摘要翻译：本发明提供鉴定和编码新的人GTP结合蛋白γ-3（HGPG）和HGPG本身的多核苷酸。本发明提供了遗传工程表达载体，含有载体的宿主细胞和用于产生HGPG的方法。本发明还提供了用于鉴定抑制HGPG的表达和活性以及使用这些组合物治疗癌症的药物组合物的方法。本发明还提供了利用多核苷酸与编码在正常或患病组织中特异性结合HGPG的HGPG或抗HGPG抗体的转录物进行杂交的诊断测定。

5. 发明授权

US5972658A DNA encoding lung growth factor variant 失效
标题翻译：编码肺生长因子变体的DNA
公开(公告)号：US5972658A
公开(公告)日：1999-10-26
申请号：US760745
申请日：1996-12-05
申请人： Olga Bandman , Surya K. Goli , Lynn E. Murry
发明人： Olga Bandman , Surya K. Goli , Lynn E. Murry
IPC分类号： A61K38/00 , C07K14/475 , C12N1/21 , C12N15/12 , C12N15/00 , C07H21/04 , C12N1/15
CPC分类号： C07K14/475 , A61K38/00
摘要： The present invention provides a human lung growth factor variant (LGFV) and polynucleotides which identify and encode LGFV. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding LGFV and a method for producing LGFV. The invention also provides for agonists, antibodies, or antagonists specifically binding LGFV, and their use, in the prevention and treatment of diseases associated with expression of LGFV. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding LGFV for the treatment of diseases associated with the expression of LGFV. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding LGFV.
摘要翻译：本发明提供了人肺生长因子变体（LGFV）和鉴定和编码LGFV的多核苷酸。本发明还提供了遗传工程改造的表达载体和包含编码LGFV的核酸序列的宿主细胞和用于产生LGFV的方法。本发明还提供了特异性结合LGFV的激动剂，抗体或拮抗剂及其在预防和治疗与LGFV表达相关的疾病中的用途。另外，本发明提供了反义分子用于编码LGFV的多核苷酸用于治疗与LGFV表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合LGFV的抗体的诊断测定法。

6. 发明授权

US5958699A Tumor-associated Kazal inhibitor 失效
标题翻译：肿瘤相关Kazal抑制剂
公开(公告)号：US5958699A
公开(公告)日：1999-09-28
申请号：US149933
申请日：1998-09-09
申请人： Olga Bandman , Surya K. Goli , Lynn E. Murry
发明人： Olga Bandman , Surya K. Goli , Lynn E. Murry
IPC分类号： G01N33/574 , A61K38/00 , A61K38/55 , A61K39/395 , A61P1/00 , A61P35/00 , C07K14/81 , C07K16/38 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/15 , C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C07K14/8135 , A61K38/00
摘要： The present invention provides a human tumor-associated Kazal inhibitor (TAKI) and polynucleotides which identify and encode TAKI. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding TAKI and a method for producing TAKI. The invention also provides for agonists, antibodies, or antagonists specifically binding TAKI, and their use, in the prevention and treatment of intestinal diseases including cancer. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding TAKI for the treatment of diseases associated with the expression of TAKI. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding TAKI.
摘要翻译：本发明提供了一种人肿瘤相关的卡马尔抑制剂（TAKI）和鉴定和编码TAKI的多核苷酸。本发明还提供了基因工程表达载体和宿主细胞，其包含编码TAKI的核酸序列和产生TAKI的方法。本发明还提供了特异性结合TAKI的激动剂，抗体或拮抗剂及其在预防和治疗包括癌症的肠道疾病中的用途。另外，本发明提供反义分子用于编码TAKI的多核苷酸用于治疗与TAKI表达相关的疾病。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合TAKI的抗体的诊断测定法。

7. 发明授权

US06379913B1 Human serine carboxypeptidase 失效
标题翻译：人丝氨酸羧肽酶
公开(公告)号：US06379913B1
公开(公告)日：2002-04-30
申请号：US09299689
申请日：1999-04-26
申请人： Olga Bandman , Phillip R. Hawkins , Jennifer L. Hillman , Preeti Lal , Surya K. Goli
发明人： Olga Bandman , Phillip R. Hawkins , Jennifer L. Hillman , Preeti Lal , Surya K. Goli
IPC分类号： C12N948
CPC分类号： C12N9/48 , A61K38/00
摘要： The present invention provides a human serine carboxypeptidase (CPEPT) and polynucleotides which identify and encode CPEPT. The invention also provides expression vectors, host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating disorders associated with expression of CPEPT.
摘要翻译：本发明提供了人丝氨酸羧肽酶（CPEPT）和识别和编码CPEPT的多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。本发明还提供了治疗与CPEPT表达相关的疾病的方法。

8. 发明授权

US5837493A Human galectins 失效
标题翻译：人类半乳凝素
公开(公告)号：US5837493A
公开(公告)日：1998-11-17
申请号：US788584
申请日：1997-01-23
申请人： Jennifer L. Hillman , Surya K. Goli , Olga Bandman , Phillip R. Hawkins , Joanne R. Petithory
发明人： Jennifer L. Hillman , Surya K. Goli , Olga Bandman , Phillip R. Hawkins , Joanne R. Petithory
IPC分类号： C12N15/09 , A61K38/00 , A61K45/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/68 , C12N15/00 , C07H21/04 , C12N1/20
CPC分类号： C07K14/4726 , A61K38/00
摘要： The present invention provides two novel human galectins (designated individually as GAL-5HA and GAL-5HB, and collectively as GAL-5H) and polynucleotides which identify and encode GAL-5H. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding GAL-5H and a method for producing GAL-5H. The invention also provides for use of GAL-5H and agonists, antibodies, or antagonists specifically binding GAL-5H, in the prevention and treatment of diseases associated with expression of GAL-5H. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding GAL-5H for the treatment of diseases associated with the expression of GAL-5H. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding GAL-5H.
摘要翻译：本发明提供两种新型人半乳凝素（单独命名为GAL-5HA和GAL-5HB，统称为GAL-5H）和识别和编码GAL-5H的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码GAL-5H的核酸序列和产生GAL-5H的方法。本发明还提供使用GAL-5H和特异性结合GAL-5H的激动剂，抗体或拮抗剂来预防和治疗与GAL-5H表达相关的疾病。另外，本发明提供了反义分子用于编码GAL-5H的多核苷酸用于治疗与GAL-5H表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合GAL-5H的抗体的诊断测定法。

9. 发明授权

US5925521A Human serine carboxypeptidase 失效
公开(公告)号：US5925521A
公开(公告)日：1999-07-20
申请号：US828488
申请日：1997-03-31
申请人： Olga Bandman , Phillip R. Hawkins , Jennifer L. Hillman , Preeti Lal , Surya K. Goli
发明人： Olga Bandman , Phillip R. Hawkins , Jennifer L. Hillman , Preeti Lal , Surya K. Goli
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61K45/00 , A61P3/10 , A61P9/10 , A61P9/12 , A61P13/12 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/28 , A61P39/02 , A61P43/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/48 , C12N9/64 , C12N15/57 , C12Q1/68 , C12N15/63
CPC分类号： C12N9/48 , A61K38/00
摘要： The present invention provides a human serine carboxypeptidase (CPEPT) and polynucleotides which identify and encode CPEPT. The invention also provides expression vectors, host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating disorders associated with expression of CPEPT.

10. 发明授权

US5840569A Human GTP-binding proteins 失效
标题翻译：人类GTP结合蛋白
公开(公告)号：US5840569A
公开(公告)日：1998-11-24
申请号：US766551
申请日：1996-12-12
申请人： Jennifer L. Hillman , Olga Bandman , Phillip R. Hawkins , Surya K. Goli
发明人： Jennifer L. Hillman , Olga Bandman , Phillip R. Hawkins , Surya K. Goli
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , A61P43/00 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12Q1/68
CPC分类号： C07K14/4722 , A61K38/00
摘要： The present invention provides three novel GTP-binding proteins (designated individually as BND-1, BND-2, and BND-3, and collectively as BND) and polynucleotides which identify and encode BND. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding BND and a method for producing BND. The invention also provides for use of BND and agonists, antibodies, or antagonists specifically binding BND, in the prevention and treatment of diseases associated with expression of BND. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding BND for the treatment of diseases associated with the expression of BND. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding BND.
摘要翻译：本发明提供了三种新型GTP结合蛋白（分别命名为BND-1，BND-2和BND-3，共同称为BND）和识别和编码BND的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码BND的核酸序列和生产BND的方法。本发明还提供使用BND和特异性结合BND的激动剂，抗体或拮抗剂来预防和治疗与BND表达相关的疾病。另外，本发明提供反义分子用于编码BND的多核苷酸用于治疗与BND表达相关的疾病。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合BND的抗体的诊断测定法。

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