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1. 发明申请

US20060008382A1 Microfluidic system for chemical analysis 有权
标题翻译：微流控系统进行化学分析
公开(公告)号：US20060008382A1
公开(公告)日：2006-01-12
申请号：US10885471
申请日：2004-07-06
申请人： Philippe Salamitou , Joyce Wong , Bhavani Raghuraman , Jagdish Shah , Ronald Van Hal , Robert Schroeder , Patrick Tabeling
发明人： Philippe Salamitou , Joyce Wong , Bhavani Raghuraman , Jagdish Shah , Ronald Van Hal , Robert Schroeder , Patrick Tabeling
IPC分类号： G01N21/00
CPC分类号： B01L3/502715 , B01L3/502707 , B01L3/50273
摘要： A microfluidic system for performing fluid analysis is described having: (a) a submersible housing having a fluid analysis means and a power supply to provide power to said system; and (b) a substrate for receiving a fluid sample, having embedded therein a fluid sample inlet, a reagent inlet, a fluid sample outlet, and a mixing region in fluid communication with the fluid sample inlet, the reagent inlet, and the fluid sample outlet, and wherein the substrate includes a fluid drive means for moving the fluid sample through the substrate, and wherein the substrate interconnects with the housing. At least a portion of the fluid analysis means may be embedded in the substrate.
摘要翻译：描述了一种用于执行流体分析的微流体系统，其具有：（a）具有流体分析装置的潜水壳体和向所述系统提供动力的电源; （b）用于接收流体样品的基板，其中嵌入有流体样品入口，试剂入口，流体样品出口和与流体样品入口，试剂入口和流体样品流体连通的混合区域出口，并且其中所述基板包括用于使所述流体样品通过所述基板移动的流体驱动装置，并且其中所述基板与所述壳体相互连接。流体分析装置的至少一部分可以嵌入衬底中。

2. 发明授权

US07799278B2 Microfluidic system for chemical analysis 有权
标题翻译：微流控系统进行化学分析
公开(公告)号：US07799278B2
公开(公告)日：2010-09-21
申请号：US10885471
申请日：2004-07-06
申请人： Philippe Salamitou , Joyce Wong , Bhavani Raghuraman , Jagdish Shah , Ronald E. G. Van Hal , Robert J. Schroeder , Patrick Jean René Tabeling
发明人： Philippe Salamitou , Joyce Wong , Bhavani Raghuraman , Jagdish Shah , Ronald E. G. Van Hal , Robert J. Schroeder , Patrick Jean René Tabeling
IPC分类号： G01N21/00
CPC分类号： B01L3/502715 , B01L3/502707 , B01L3/50273
摘要： A microfluidic system for performing fluid analysis is described having: (a) a submersible housing having a fluid analysis means and a power supply to provide power to said system; and (b) a substrate for receiving a fluid sample, having embedded therein a fluid sample inlet, a reagent inlet, a fluid sample outlet, and a mixing region in fluid communication with the fluid sample inlet, the reagent inlet, and the fluid sample outlet, and wherein the substrate includes a fluid drive means for moving the fluid sample through the substrate, and wherein the substrate interconnects with the housing. At least a portion of the fluid analysis means may be embedded in the substrate.
摘要翻译：描述了一种用于执行流体分析的微流体系统，其具有：（a）具有流体分析装置的潜水壳体和向所述系统提供动力的电源; （b）用于接收流体样品的基板，其中嵌入有流体样品入口，试剂入口，流体样品出口和与流体样品入口，试剂入口和流体样品流体连通的混合区域出口，并且其中所述基板包括用于使所述流体样品通过所述基板移动的流体驱动装置，并且其中所述基板与所述壳体相互连接。流体分析装置的至少一部分可以嵌入衬底中。

3. 发明授权

US07695629B2 Microfluidic separator 失效
标题翻译：微流控分离器
公开(公告)号：US07695629B2
公开(公告)日：2010-04-13
申请号：US12390158
申请日：2009-02-20
申请人： Philippe Salamitou , Joyce Wong , Bhavani Raghuraman , Jagdish Shah , Ronald E. G. Van Hal , Robert J. Schroeder , Patrick Jean René Tabeling
发明人： Philippe Salamitou , Joyce Wong , Bhavani Raghuraman , Jagdish Shah , Ronald E. G. Van Hal , Robert J. Schroeder , Patrick Jean René Tabeling
IPC分类号： B01D61/00 , B01D63/00
CPC分类号： B01D67/0062 , B01D17/085 , B01D19/0031 , B01D61/18 , B01L3/502753 , B01L2200/0673 , B01L2300/0681 , B01L2300/0864 , B01L2300/161 , B01L2400/0487 , E21B43/38 , E21B47/10 , E21B49/081 , E21B49/10 , G01N1/4005 , G01N33/28 , G01N2001/4016 , Y10T436/25375
摘要： The present invention provides methods and apparatus for separating and/or analyzing fluids of interest. According to principles of the present invention, fluid analysis is accomplished with microfluidic devices and may be reported in real-time or near real-time in a subterranean environment. In addition or alternative to oilfield applications, the principles of the present invention contemplate separation in a laboratory or other environment for biological sample separation and analytical chemistry applications. The present invention is capable of separating liquid-liquid mixtures or emulsions in a microfluidic device without fouling.
摘要翻译：本发明提供了用于分离和/或分析感兴趣的流体的方法和装置。根据本发明的原理，使用微流体装置实现流体分析，并且可以在地下环境中实时或接近实时地报告。除了油田应用之外或替代，本发明的原理考虑了在实验室或其他环境中的分离用于生物样品分离和分析化学应用。本发明能够分离微流体装置中的液体 - 液体混合物或乳液而不会结垢。

4. 发明申请

US20090183871A1 MICROFLUIDIC SEPARATOR 失效
标题翻译：微流分离器
公开(公告)号：US20090183871A1
公开(公告)日：2009-07-23
申请号：US12390158
申请日：2009-02-20
申请人： Philippe Salamitou , Joyce Wong , Bhavani Raghuraman , Jagdish Shah , Ronald E. G. Van Hal , Robert J. Schroeder , Patrick Jean Rene Tabeling
发明人： Philippe Salamitou , Joyce Wong , Bhavani Raghuraman , Jagdish Shah , Ronald E. G. Van Hal , Robert J. Schroeder , Patrick Jean Rene Tabeling
IPC分类号： B01D61/00 , B01D19/00 , B01D61/32 , E21B47/00
CPC分类号： B01D67/0062 , B01D17/085 , B01D19/0031 , B01D61/18 , B01L3/502753 , B01L2200/0673 , B01L2300/0681 , B01L2300/0864 , B01L2300/161 , B01L2400/0487 , E21B43/38 , E21B47/10 , E21B49/081 , E21B49/10 , G01N1/4005 , G01N33/28 , G01N2001/4016 , Y10T436/25375
摘要： The present invention provides methods and apparatus for separating and/or analyzing fluids of interest. According to principles of the present invention, fluid analysis is accomplished with microfluidic devices and may be reported in real-time or near real-time in a subterranean environment. In addition or alternative to oilfield applications, the principles of the present invention contemplate separation in a laboratory or other environment for biological sample separation and analytical chemistry applications. The present invention is capable of separating liquid-liquid mixtures or emulsions in a microfluidic device without fouling.
摘要翻译：本发明提供了用于分离和/或分析感兴趣的流体的方法和装置。根据本发明的原理，使用微流体装置实现流体分析，并且可以在地下环境中实时或接近实时地报告。除了油田应用之外或替代，本发明的原理考虑了在实验室或其他环境中的分离用于生物样品分离和分析化学应用。本发明能够分离微流体装置中的液体 - 液体混合物或乳液而不会结垢。

5. 发明授权

US08028562B2 High pressure and high temperature chromatography 有权
标题翻译：高压和高温色谱
公开(公告)号：US08028562B2
公开(公告)日：2011-10-04
申请号：US11958049
申请日：2007-12-17
申请人： Jagdish Shah , Neil William Bostrom , Oleg Zhdaneev , Bhavani Raghuraman , Kristofer Gunnar Paso
发明人： Jagdish Shah , Neil William Bostrom , Oleg Zhdaneev , Bhavani Raghuraman , Kristofer Gunnar Paso
IPC分类号： G01N30/02
CPC分类号： G01N33/2823 , E21B47/10 , G01N30/22 , G01N30/32 , G01N30/88 , G01N2030/8809 , G01N2030/8854
摘要： Methods and related systems are described for high pressure chromatographic analysis. The described system includes a flowpath adapted to flow a mobile phase and the sample at high pressures, an injector adapted to inject the fluid sample into a flowpath, a separation column adapted to operate at high pressures for separating various components, a detector and a processor that calculates the amount of at least one component of the fluid sample. The system can operate a pressures above 20 atm or even 100 atm, and temperatures above about 100 degrees Celsius. The system can deployed in a wellbore in a subterranean rock formation, and include fluid collection system for obtaining the fluid sample downhole. The system can also be located close to a wellhead and includes a tap in fluid communication with a surface flowline carrying produced fluids and the injector.
摘要翻译：描述了用于高压色谱分析的方法和相关系统。所描述的系统包括适于流动流动相和高压下的样品的流路，适于将流体样品注入流路的注射器，适于在高压下操作以分离各种组分的分离柱，检测器和处理器其计算流体样品的至少一个组分的量。该系统可以操作压力高于20atm，甚至100 atm，温度高于约100摄氏度。该系统可以部署在地下岩层中的井眼中，并且包括用于在井下获得流体样品的流体收集系统。该系统还可以靠近井口定位，并且包括与携带产生的流体的表面流线和喷射器流体连通的龙头。

6. 发明申请

US20090151426A1 HIGH PRESSURE AND HIGH TEMPERATURE CHROMATOGRAPHY 有权
标题翻译：高压和高温色谱
公开(公告)号：US20090151426A1
公开(公告)日：2009-06-18
申请号：US11958049
申请日：2007-12-17
申请人： Jagdish Shah , Neil William Bostrom , Oleg Zhdaneev , Bhavani Raghuraman , Kristofer Gunnar Paso
发明人： Jagdish Shah , Neil William Bostrom , Oleg Zhdaneev , Bhavani Raghuraman , Kristofer Gunnar Paso
IPC分类号： G01N30/02
CPC分类号： G01N33/2823 , E21B47/10 , G01N30/22 , G01N30/32 , G01N30/88 , G01N2030/8809 , G01N2030/8854
摘要： Methods and related systems are described for high pressure chromatographic analysis. The described system includes a flowpath adapted to flow a mobile phase and the sample at high pressures, an injector adapted to inject the fluid sample into a flowpath, a separation column adapted to operate at high pressures for separating various components, a detector and a processor that calculates the amount of at least one component of the fluid sample. The system can operate a pressures above 20 atm or even 100 atm, and temperatures above about 100 degrees Celsius. The system can deployed in a wellbore in a subterranean rock formation, and include fluid collection system for obtaining the fluid sample downhole. The system can also be located close to a wellhead and includes a tap in fluid communication with a surface flowline carrying produced fluids and the injector.
摘要翻译：描述了用于高压色谱分析的方法和相关系统。所描述的系统包括适于流动流动相和高压下的样品的流路，适于将流体样品注入流路的注射器，适于在高压下操作以分离各种组分的分离柱，检测器和处理器其计算流体样品的至少一个组分的量。该系统可以操作压力高于20atm，甚至100 atm，温度高于约100摄氏度。该系统可以部署在地下岩层中的井眼中，并且包括用于在井下获得流体样品的流体收集系统。该系统还可以靠近井口定位，并且包括与携带产生的流体的表面流线和喷射器流体连通的龙头。

7. 发明授权

US08250904B2 Multi-stage injector for fluid analysis 有权
标题翻译：用于流体分析的多级注射器
公开(公告)号：US08250904B2
公开(公告)日：2012-08-28
申请号：US12039437
申请日：2008-02-28
申请人： Jagdish Shah , William H. Steinecker , Neil William Bostrom , Bhavani Raghuraman
发明人： Jagdish Shah , William H. Steinecker , Neil William Bostrom , Bhavani Raghuraman
IPC分类号： G01N30/04
CPC分类号： G01N30/20 , G01N2030/202
摘要： The present invention generally recites a method, system and apparatus for fluid analysis and more specifically recites a method system and apparatus for multistage injection of a fluid to be analyzed into a fluid analysis instrument.
摘要翻译：本发明总体上叙述了用于流体分析的方法，系统和装置，并且更具体地说明了用于将要分析的流体多级注射到流体分析仪器中的方法系统和装置。

8. 发明申请

US20090158815A1 MULTI-STAGE INJECTOR FOR FLUID ANALYSIS 有权
标题翻译：多级注射器用于流体分析
公开(公告)号：US20090158815A1
公开(公告)日：2009-06-25
申请号：US12039437
申请日：2008-02-28
申请人： Jagdish Shah , William H. Steinecker , Neil William Bostrom , Bhavani Raghuraman
发明人： Jagdish Shah , William H. Steinecker , Neil William Bostrom , Bhavani Raghuraman
IPC分类号： G01N30/04
CPC分类号： G01N30/20 , G01N2030/202
摘要： The present invention generally recites a method, system and apparatus for fluid analysis and more specifically recites a method system and apparatus for multistage injection of a fluid to be analyzed into a fluid analysis instrument.
摘要翻译：本发明总体上叙述了用于流体分析的方法，系统和装置，并且更具体地说明了用于将要分析的流体多级注射到流体分析仪器中的方法系统和装置。

9. 发明授权

US06898339B2 Multiple mode pre-loadable fiber optic pressure and temperature sensor 有权
标题翻译：多模式预加载光纤压力和温度传感器
公开(公告)号：US06898339B2
公开(公告)日：2005-05-24
申请号：US10233355
申请日：2002-12-16
申请人： Jagdish Shah , Robert Schroeder , Philip Dryden , Rogerio Ramos , Raghu Madhavan
发明人： Jagdish Shah , Robert Schroeder , Philip Dryden , Rogerio Ramos , Raghu Madhavan
IPC分类号： G01J1/04 , G01J1/42 , G01L11/02 , G01M11/02 , G02B6/00
CPC分类号： G01M11/0221
摘要： A multiple mode pre-loadable fiber optic pressure and temperature sensor includes a generally cylindrical structure having at least one compression element, a fiber optic having a Bragg grating in contact with one side of the compression element, a diaphragm in contact with the other side of the compression element, and a fluid port in fluid communication with the diaphragm. According to preferred aspects of the, a groove is provided in at least one compression element for receiving the fiber optic. The sensor is pre-loaded by straining the diaphragm over the adjacent compression element when the cover is attached. The compression element in contact with the diaphragm preferably has a contoured surface contacting the diaphragm and the diaphragm is stretched to match that contour. By varying the contour of the compression element and the thickness of the diaphragm, the dynamic range of the sensor can be changed. The preferred diaphragm has a variable thickness and is made as an integral part of the structure. The sensor can be operated in normal, reverse, or differential mode.
摘要翻译：多模式预加载光纤压力和温度传感器包括具有至少一个压缩元件的大致圆柱形结构，具有与压缩元件的一侧接触的布拉格光栅的光纤，与另一侧接触的光阑压缩元件和与隔膜流体连通的流体端口。根据优选的方面，在至少一个用于接收光纤的压缩元件中设置有凹槽。当安装盖时，传感器通过将隔膜压在相邻的压缩元件上而进行预加载。与隔膜接触的压缩元件优选地具有与隔膜接触的轮廓表面，并且隔膜被拉伸以匹配该轮廓。通过改变压缩元件的轮廓和膜片的厚度，可以改变传感器的动态范围。优选的隔膜具有可变的厚度并且被制成为该结构的组成部分。传感器可以在正常，反向或差动模式下运行。

10. 发明授权

US08778059B2 Differential acceleration chromatography 有权
标题翻译：差速加速色谱法
公开(公告)号：US08778059B2
公开(公告)日：2014-07-15
申请号：US11949362
申请日：2007-12-03
申请人： William H. Steinecker , Jagdish Shah , Oleg Zhdaneev , Gordon R. Lambertus , Hua Chen
发明人： William H. Steinecker , Jagdish Shah , Oleg Zhdaneev , Gordon R. Lambertus , Hua Chen
IPC分类号： G01N30/60 , B01D53/02 , G01N30/26 , G01N30/56
CPC分类号： B01D15/22 , G01N30/32 , G01N30/52 , G01N30/54 , G01N30/6065 , G01N2030/324 , G01N2030/524
摘要： Methods and related systems are described for improving component separations in chromatography through novel techniques. The improvements in separation is due primarily to the provision of differential acceleration of the components being separated. Various systems and methods for providing differential acceleration are described including: increasing the cross section of the column towards the column outlet, changing the thickness or other composition of stationary phase within the column, and providing a temperature and/or mobile phase velocity gradient along the column.
摘要翻译：描述了通过新技术改进色谱分离的方法和相关系统。分离的改进主要是由于提供了被分离的部件的差速加速。描述了用于提供差速加速度的各种系统和方法，其包括：将塔的横截面增加到塔出口，改变柱内的固定相的厚度或其它组成，以及沿着柱提供温度和/或流动相速度梯度柱。

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