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1. 发明授权

US5964095A Method and apparatus for cryogenic storage of thermolabile products 失效
标题翻译：用于低温储存的不耐热产品的方法和装置
公开(公告)号：US5964095A
公开(公告)日：1999-10-12
申请号：US877763
申请日：1997-06-16
申请人： Philip Henry Coelho , Terry Wolf , Pablo Rubinstein
发明人： Philip Henry Coelho , Terry Wolf , Pablo Rubinstein
IPC分类号： B65D81/38 , B65G1/00 , B65G1/137 , F25C5/14 , F25D3/10 , F25D25/00 , G01N35/00
CPC分类号： F25D3/10 , F25D25/00 , F25D3/105 , G01N35/0099
摘要： A device for cryoprotecting thermolabile products. A container (20) receives an annular rack (40) which is sealed by an enclosure (60). The enclosure (60) includes an outer stationary toroid (70) and a rotatable core (90). A robotic arm (160) is adapted to move and is supported by the core (90). The robotic arm (160) accesses an interior of the enclosure (60). An access portal (80) allows removal and placement of thermolabile products constrained by a holder (150). The robotic arm (160) accesses product and holder (150) and embarks upon controlled freezing of the product and its location in the rack (40) until subsequent retrieval. A computer controls the rate of freezing and stores in memory the location of all of the stored products. The robotic arm (160) reads the product in storage to assure the correct product is being accessed.
摘要翻译：用于低温保护耐热产品的装置。容器（20）容纳由壳体（60）密封的环形齿条（40）。外壳（60）包括外固定环形（70）和可旋转芯（90）。机械臂（160）适于移动并被芯（90）支撑。机械手臂（160）进入外壳（60）的内部。入口入口（80）允许移除和放置由保持器（150）约束的热不稳定产品。机器人手臂（160）进入产品和支架（150），并开始控制产品的冻结及其在支架（40）中的位置，直到随后的取回。计算机控制冷冻速率并在存储器中存储所有存储的产品的位置。机器人手臂（160）在存储器中读取产品，以确保访问正确的产品。

2. 发明授权

US5638686A Method and apparatus for cryogenic storage of thermolabile products 失效
标题翻译：用于低温储存的不耐热产品的方法和装置
公开(公告)号：US5638686A
公开(公告)日：1997-06-17
申请号：US393558
申请日：1995-02-23
申请人： Philip Henry Coelho , Terry Wolf , Pablo Rubinstein
发明人： Philip Henry Coelho , Terry Wolf , Pablo Rubinstein
IPC分类号： B65D81/38 , B65G1/00 , F25C5/14 , F25D3/10 , F25D25/00 , G01N35/00 , F25B19/00
CPC分类号： F25D3/10 , F25D25/00 , F25D3/105 , G01N35/0099
摘要： A device for cryoprotecting thermolabile products. A container (20) receives an annular rack (40) which is sealed by an enclosure (60). The enclosure (60) includes an outer stationary toroid (70) and a rotatable core (90). A robotic arm (160) is adapted to move and is supported by the core (90). The robotic arm (160) accesses an interior of the enclosure (60). An access portal (80) allows removal and placement of thermolabile products constrained by a holder (150). The robotic arm (160) accesses product and holder (150) and embarks upon controlled freezing of the product and its location in the rack (40) until subsequent retrieval. A computer controls the rate of freezing and stores in memory the location of all of the stored products. The robotic arm (160) reads the product in storage to assure the correct product is being accessed.
摘要翻译：用于低温保护耐热产品的装置。容器（20）容纳由壳体（60）密封的环形齿条（40）。外壳（60）包括外固定环形（70）和可旋转芯（90）。机械臂（160）适于移动并被芯（90）支撑。机械手臂（160）进入外壳（60）的内部。入口入口（80）允许移除和放置由保持器（150）约束的热不稳定产品。机器人手臂（160）进入产品和支架（150），并开始控制产品的冻结及其在支架（40）中的位置，直到随后的取回。计算机控制冷冻速率并在存储器中存储所有存储的产品的位置。机器人手臂（160）在存储器中读取产品，以确保访问正确的产品。

3. 发明授权

US5103651A Plasma storage freezer and thermal transport device 失效
标题翻译：等离子体储存冷冻器和热交换装置
公开(公告)号：US5103651A
公开(公告)日：1992-04-14
申请号：US575836
申请日：1990-08-31
申请人： Philip H. Coelho , Terry Wolf
发明人： Philip H. Coelho , Terry Wolf
IPC分类号： A61J1/00 , A01N1/02 , A61J1/16 , A61J3/00 , F25D3/06
CPC分类号： A61J1/165 , A01N1/02 , A01N1/0252 , A01N1/0273 , F25D3/06 , F25D2303/0831 , F25D2331/804 , F25D2400/30 , F25D2400/36 , F25D2400/38
摘要： A thermal transport device having a hollow within which a plasma storage freezer is deployed. The freezer acts as a cold "battery" by having a eutectic fluid contained therewithin. The freezer is placed in a commercial, powered refrigeration unit for chilling ("charging") the eutectic fluid of the plasma storage freezer to approximately -30.degree. C. The freezer is then deployed within the thermal transport device and sent to a remote locale for collecting blood plasma. Blood plasma is disposed between a central heat sink and lateral heat sinks of the freezer freezing the blood plasma quickly and maintaininig its initial high quality because of negligible time loss for freezing. Ultimately, the device is returned to a commercial powered refrigeration unit for ("recharging") rechilling the eutectic fluid for subsequent reuse.

4. 发明授权

US5557943A Rapid cooling through a thin flexible membrane 失效
标题翻译：通过薄柔性膜快速冷却
公开(公告)号：US5557943A
公开(公告)日：1996-09-24
申请号：US986525
申请日：1992-12-07
申请人： Philip H. Coelho , Terry Wolf
发明人： Philip H. Coelho , Terry Wolf
IPC分类号： A01N1/00 , A23L3/36 , A61J3/00 , A61M1/02 , F25D9/00 , F25D17/02 , H25D17/02
CPC分类号： A23L3/36 , A23L3/364 , A61M1/0277 , F25D17/02 , F25D9/005 , F25D2331/809 , F25D2400/10 , F25D2400/28 , F25D2400/30
摘要： Rapid cooling or freezing of foodstuffs, perishables or blood products is accomplished by using a thin film membrane to totally envelope the foodstuffs or blood product only during the heat extraction period. This thin film encapsulation system closes around the item and is held tightly to the item by atmospheric and/or hydrostatic pressure. Once the item is encapsulated, low temperature heat transfer fluids are then circulated on the exterior surface of the membrane, thus extracting the heat within the item through the thickness of the membrane. Upon completion of the necessary chilling or freezing, the atmospheric and/or hydrostatic pressure is withdrawn and the chilled or frozen item is extracted.
摘要翻译：食品，易腐食品或血液制品的快速冷却或冷冻是通过使用薄膜膜仅在热提取期间完全包封食品或血液制品来实现的。该薄膜封装系统围绕物品封闭，并通过大气和/或静水压力紧紧地保持在物品上。一旦物品被封装，低温传热流体然后在膜的外表面上循环，从而通过膜的厚度提取物品内的热量。完成必要的冷却或冷冻后，取出大气和/或静水压力，并提取冷冻或冷冻物品。

5. 发明授权

US5939023A Fibrinogen processing apparatus method and container 失效
标题翻译：纤维蛋白原处理装置的方法和容器
公开(公告)号：US5939023A
公开(公告)日：1999-08-17
申请号：US653359
申请日：1996-05-24
申请人： Philip H. Coelho , Terry Wolf
发明人： Philip H. Coelho , Terry Wolf
IPC分类号： A61J1/05 , A61J1/00 , A61J1/14 , A61K35/14 , A61K38/17 , A61L26/00 , A61L31/00 , A61M1/02 , B01D9/00 , B05D1/18 , C07K1/30 , C07K14/745 , C07K14/75 , B01L3/00
CPC分类号： A61J1/1412 , A61J1/1462 , A61J1/1487 , A61M1/0272 , A61M1/0277 , B01D9/0013 , C07K14/75 , A61J1/10 , A61J2205/30 , A61M1/0281 , A61M2202/0449
摘要： An instrumentality for promulgating the cryoprecipitation of fibrinogen from a blood product. The instrumentality contemplates a container for the blood product, an apparatus for creating the fibrinogen within the container and a method of manipulating the container within the apparatus and subsequently after fibrinogen has been formed. The apparatus includes a receiver within which the container is supported, a motion transfer device for the receiver to impart motion to the container while simultaneously subjecting the container to a temperature differential to cause heat transfer. The motion imparted to the container results in a thin coating of the blood product being disposed on an interior surface of the container which, in turn, is exposed to a heat transfer fluid through the wall of the container. Successive coatings placed on an interior of the container are timed such that each coating is placed on a previous coating that has changed phase. Flexure of the container after the contents of the container have been frozen can occur by providing a vacuum within the container causing an implosion of frozen material. Subsequent phase change back to a liquid and then a second freeze/thaw followed by centrifugation causes a cryo-fraction to be precipitated therefrom. The container within which the blood product is housed includes an opening for admission of the blood product therewithin, an outlet for extraction of fibrinogen and access to a source which can provide a pressure differential vis a vis the interior and exterior of the container. Information of the temperature profile within the container may also be provided.
摘要翻译：从血液制品中颁发纤维蛋白原的冷沉淀的手段。仪器考虑了用于血液制品的容器，用于在容器内产生纤维蛋白原的装置，以及在装置内操作容器并且随后在形成纤维蛋白原之后的方法。该装置包括容器被支撑在其中的接收器，用于接收器的运动传递装置，以向容器施加运动，同时使容器经受温差以引起热传递。赋予容器的运动导致血液制品的薄涂层被设置在容器的内表面上，而这又暴露于通过容器壁的传热流体。放置在容器内部的连续涂层被定时，使得每个涂层被放置在改变阶段的先前涂层上。在容器内容物已被冷冻之后容器的弯曲可以通过在容器内提供真空而导致冻结材料的内爆而发生。随后的相变回液体，然后第二次冷冻/解冻，然后离心导致冷冻馏分从其中沉淀。容纳血液制品的容器包括用于容纳血液制品的开口，用于提取纤维蛋白原的出口和进入能够相对于容器的内部和外部提供压差的源。还可以提供容器内的温度曲线的信息。

6. 发明授权

US5261255A Device for fractionating constituent components of a substance using cryoprecipitation 失效
$Device for fractionating constituent components of a substance using cryoprecipitation$
标题翻译：用于使用冷沉淀分级物质的构成成分的装置
公开(公告)号：US5261255A
公开(公告)日：1993-11-16
申请号：US789293
申请日：1991-11-08
申请人： Philip H. Coelho , Terry Wolf
发明人： Philip H. Coelho , Terry Wolf
IPC分类号： A61M1/02 , F25D17/02 , C07G7/00
CPC分类号： A61M1/025 , A61M2202/0449
摘要： A method and device for fractionating pouches of cryoprecipitable material including a membrane which provides a barrier within an interior of the device with the membrane receiving the pouches of cryoprecipitable material therewithin. The interior of the device includes a sump having a heat transfer fluid stored therein and maintained at a temperature which is to be achieved by the cryoprecipitable material as it cycles between freezing and thawing. The pouch of material, after placement within the membrane, is exposed (through the membrane) to hydrostatic forces associated with the heat transfer fluid in the sump collapsing the membrane on the pouch while pulsating jets impinge indirectly upon the pouch through the membrane. In this way, as the contents within the pouch change temperature, circulation of the fluid within the pouch occurs for more rapid realization of the cycling target temperatures for the cryoprecipitable material within the pouch. In one form, a single sump includes both a heating and cooling element for cycling the heat transfer fluid. In another form, two separate sumps respectively store "hot" heat transfer fluid and "cold" heat transfer fluid for alternate cycling. After plural cycles, the fractionated component of cryoprecipitable material is centrifuged and then separated.
摘要翻译：一种用于分馏可冷沉淀材料袋的方法和装置，包括膜，该膜在装置的内部提供阻挡层，膜在其中容纳可冷冻可渗透材料的袋。该装置的内部包括具有储存在其中的传热流体的贮槽，并且保持在当冷冻和解冻之间循环时可由冷冻可沉积材料实现的温度。材料袋在放置在膜内之后被暴露（通过膜）到与贮槽中的传热流体相关联的静水力，使膜上的膜收缩，同时脉动喷嘴间接地冲击穿过膜的袋。以这种方式，随着袋内的内容改变温度，发生袋内的流体的循环，以更快速地实现袋内的可冷冻可消耗材料的循环目标温度。在一种形式中，单个贮槽包括用于循环传热流体的加热和冷却元件。在另一种形式中，两个分开的贮槽分别存储“热”传热流体和“冷”传热流体，用于交替循环。经过多次循环后，将可分解的可冷冻材料的组分离心分离。

7. 发明授权

US5168712A Rapid cooling through a thin flexible membrane 失效
标题翻译：通过薄柔性膜快速冷却
公开(公告)号：US5168712A
公开(公告)日：1992-12-08
申请号：US495765
申请日：1990-03-19
申请人： Philip H. Coelho , Terry Wolf
发明人： Philip H. Coelho , Terry Wolf
IPC分类号： A01N1/00 , A23L3/36 , A61J3/00 , A61M1/02 , F25D9/00 , F25D17/02
CPC分类号： A23L3/36 , A23L3/364 , A61M1/0277 , F25D17/02 , F25D9/005 , F25D2331/809 , F25D2400/10 , F25D2400/28 , F25D2400/30
摘要： Rapid cooling or freezing of foodstuffs, perishables or blood products is accomplished by using a thin film membrane to totally envelope the foodstuffs or blood product only during the heat extraction period. This thin film encapsulation system closes around the item and is held tightly to the item by atmospheric and/or hydrostatic pressure. Once the item is encapsulated, low temperature heat transfer fluids are then circulated on the exterior surface of the membrane, thus extracting the heat within the item through the thickness of the membrane. Upon completion of the necessary chilling or freezing, the atmospheric and/or hydrostatic pressure is withdrawn and the chilled or frozen item is extracted.

8. 发明授权

US5750658A Fibrinogen processing apparatus, method and container 失效
公开(公告)号：US5750658A
公开(公告)日：1998-05-12
申请号：US653641
申请日：1996-05-24
申请人： Philip H. Coelho , Terry Wolf
发明人： Philip H. Coelho , Terry Wolf
IPC分类号： A61J1/05 , A61J1/00 , A61J1/14 , A61K35/14 , A61K38/17 , A61L26/00 , A61L31/00 , A61M1/02 , B01D9/00 , B05D1/18 , C07K1/30 , C07K14/745 , C07K14/75 , B01L3/00 , C07K1/00
CPC分类号： A61J1/1412 , A61J1/1462 , A61J1/1487 , A61M1/0272 , A61M1/0277 , B01D9/0013 , C07K14/75 , A61J1/10 , A61J2205/30 , A61M1/0281 , A61M2202/0449
摘要： An instrumentality for promulgating the cryoprecipitation of fibrinogen from a blood product. The instrumentality contemplates a container for the blood product, an apparatus for creating the fibrinogen within the container and a method of manipulating the container within the apparatus and subsequently after fibrinogen has been formed. The apparatus includes a receiver within which the container is supported, a motion transfer device for the receiver to impart motion to the container while simultaneously subjecting the container to a temperature differential to cause heat transfer. The motion imparted to the container results in a thin coating of the blood product being disposed on an interior surface of the container which, in turn, is exposed to a heat transfer fluid through the wall of the container. Successive coatings placed on an interior of the container are timed such that each coating is placed on a previous coating that has changed phase. Flexure of the container after the contents of the container have been frozen can occur by providing a vacuum within the container causing an implosion of frozen material. Subsequent phase change back to a liquid and then a second freeze/thaw followed by centrifugation causes a cryo-fraction to be precipitated therefrom. The container within which the blood product is housed includes an opening for admission of the blood product therewithin, an outlet for extraction of fibrinogen and access to a source which can provide a pressure differential vis a vis the interior and exterior of the container. Information of the temperature profile within the container may also be provided.

9. 发明授权

US5520885A Fibrinogen processing apparatus, method and container 失效
标题翻译：纤维蛋白原处理装置，方法和容器
公开(公告)号：US5520885A
公开(公告)日：1996-05-28
申请号：US5989
申请日：1993-01-19
申请人： Philip H. Coelho , Terry Wolf
发明人： Philip H. Coelho , Terry Wolf
IPC分类号： A61J1/05 , A61J1/00 , A61J1/14 , A61K35/14 , A61K38/17 , A61L26/00 , A61L31/00 , A61M1/02 , B01D9/00 , B05D1/18 , C07K1/30 , C07K14/745 , C07K14/75 , B01L7/00
CPC分类号： A61J1/1412 , A61J1/1462 , A61J1/1487 , A61M1/0272 , A61M1/0277 , B01D9/0013 , C07K14/75 , A61J1/10 , A61J2205/30 , A61M1/0281 , A61M2202/0449
摘要： An instrumentality for promulgating the cryoprecipitation of fibrinogen from a blood product. The instrumentality contemplates a container for the blood product, an apparatus for creating the fibrinogen within the container and a method of manipulating the container within the apparatus and subsequently after fibrinogen has been formed. The apparatus includes a receiver within which the container is supported, a motion transfer device for the receiver to impart motion to the container while simultaneously subjecting the container to a temperature differential to cause heat transfer. The motion imparted to the container results in a thin coating of the blood product being disposed on an interior surface of the container which, in turn, is exposed to a heat transfer fluid through the wall of the container. Successive coatings placed on an interior of the container are timed such that each coating is placed on a previous coating that has changed phase. Flexure of the container after the contents of the container have been frozen can occur by providing a vacuum within the container causing an implosion of frozen material. Subsequent phase change back to a liquid and then a second freeze/thaw followed by centrifugation causes a cryo-fraction to be precipitated therefrom. The container within which the blood product is housed includes an opening for admission of the blood product therewithin, an outlet for extraction of fibrinogen and access to a source which can provide a pressure differential vis a vis the interior and exterior of the container. Information of the temperature profile within the container may also be provided.
摘要翻译：从血液制品中颁发纤维蛋白原的冷沉淀的手段。仪器考虑了用于血液制品的容器，用于在容器内产生纤维蛋白原的装置，以及在装置内操作容器并且随后在形成纤维蛋白原之后的方法。该装置包括容器被支撑在其中的接收器，用于接收器的运动传递装置，以向容器施加运动，同时使容器经受温差以引起热传递。赋予容器的运动导致血液制品的薄涂层被设置在容器的内表面上，而这又暴露于通过容器壁的传热流体。放置在容器内部的连续涂层被定时，使得每个涂层被放置在改变阶段的先前涂层上。在容器内容物已被冷冻之后容器的弯曲可以通过在容器内提供真空而导致冻结材料的内爆而发生。随后的相变回液体，然后第二次冷冻/解冻，然后离心导致冷冻馏分从其中沉淀。容纳血液制品的容器包括用于容纳血液制品的开口，用于提取纤维蛋白原的出口和进入能够相对于容器的内部和外部提供压差的源。还可以提供容器内的温度曲线的信息。

10. 发明授权

US5243833A Device for thawing frozen transfusion material and method therefore 失效
标题翻译：因此，解冻冷冻输液的装置及方法
公开(公告)号：US5243833A
公开(公告)日：1993-09-14
申请号：US789696
申请日：1991-11-08
申请人： Philip H. Coelho , Terry Wolf
发明人： Philip H. Coelho , Terry Wolf
IPC分类号： A61M5/44
CPC分类号： A61M5/445 , A61M2205/366 , Y10S604/903
摘要： A method and device for thawing pouches of frozen transfusion material including a membrane which provides a barrier within an interior of the device with the membrane receiving the pouches of frozen material therewithin. The interior of the device includes a sump having thawing fluid stored therein and maintained at a constant target temperature which is to be achieved by the frozen transfusion material to be thawed. The pouch of material to be thawed, after placement within the membrane, is exposed (through the membrane) to hydrostatic forces associated with the fluid in the sump collapsing the membrane on the pouch while pulsating jets impinge indirectly upon the pouch through the membrane. In this way, as the contents within the pouch thaw, circulation of the fluid within the pouch occurs for more rapid realization of the target temperature for the fluid within the pouch.
摘要翻译：一种用于解冻冷冻输液材料袋的方法和装置，包括在所述装置的内部提供屏障的膜，所述膜在其中接收冷冻材料袋。该装置的内部包括具有存储在其中的解冻流体并保持在待冷冻的冷冻输液材料达到的恒定目标温度的贮槽。要解冻的材料袋在放置在膜中之后被暴露（通过膜）到与贮槽中的流体相关联的静水力，使膜上的膜收缩，同时脉动喷嘴间接地冲击穿过膜的袋。以这种方式，随着袋解冻中的内容物，袋内的流体的循环发生，以更快速地实现袋内的流体的目标温度。

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