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1. 发明授权

US6146124A Freezing and thawing bag, mold, apparatus and method 失效
标题翻译：冷冻和解冻袋，模具，设备和方法
公开(公告)号：US6146124A
公开(公告)日：2000-11-14
申请号：US670368
申请日：1996-06-25
申请人： Philip Henry Coelho , Pablo Rubinstein
发明人： Philip Henry Coelho , Pablo Rubinstein
IPC分类号： B65D30/22 , A61J1/00 , A61J1/05 , A61J1/10 , A61J1/12 , A61J1/14 , A61J3/00 , A61M1/02 , B29C33/00 , F25C1/24 , B29C51/30
CPC分类号： A61J1/10 , A61M1/0277 , B29C65/04 , B29C66/1312 , B29C66/53262 , B29C66/54 , B29C66/543 , B29C66/7394 , F25C1/243 , A61J1/12 , B29C65/08 , B29C65/48 , B29C66/83221 , B29L2031/7148
摘要： A mold is disclosed for forming a freezable and thawable bag of uniform thickness, especially useful for cryopreservation of thermolabile substances. The mold features one or more recessed planar surfaces, including radiused peripheral walls about the recesses, a planar top surface, and means for conforming a blank sheet to the mold. Two mold halves combine to form a completed bag. The mold halves may be complimentary.
摘要翻译：公开了一种用于形成均匀厚度的可冷冻和可解冻袋的模具，特别适用于不可低温物质的低温保存。模具具有一个或多个凹陷的平坦表面，包括围绕凹槽的圆弧形周壁，平面顶表面和用于使坯料与模具一致的装置。两个半模组合成一个完整的袋子。半模可以是免费的。

2. 发明授权

US5928214A High concentration white cells, a method for agglomeration of the high concentration and a bag set for use in conjunction therewith 有权
标题翻译：高浓度白细胞，高浓度聚集方法和与之结合使用的袋装
公开(公告)号：US5928214A
公开(公告)日：1999-07-27
申请号：US128208
申请日：1998-08-03
申请人： Pablo Rubinstein , Philip Henry Coelho , Cladd E. Stevens
发明人： Pablo Rubinstein , Philip Henry Coelho , Cladd E. Stevens
IPC分类号： A01N1/02 , A61K35/14 , A61M1/02 , A61B19/00 , B01D33/15
CPC分类号： A01N1/0263 , A01N1/02 , A01N1/0221 , A61B5/150038 , A61B5/150229 , A61B5/150366 , A61B5/150755 , A61M1/0236 , A61M2202/0439 , A61M2202/0462 , Y10S206/828
摘要： A therapeutic product formed from a high concentration of white blood cells having a high degree of cell viability. The white blood cells are sequestered from their normal population presence in whole blood by placing the blood into a container and preventing coagulation of the blood, separating the blood into two components, one of which is extremely rich in white blood cells through the use of a reagent and centrifugation, sequestering the white cell concentration, and freezing the white cells.
摘要翻译：由具有高细胞存活能力的高浓度白细胞形成的治疗产品。通过将血液置于容器中并防止血液凝结，将血液分离成两部分，其中一种是通过使用试剂和离心，隔离白细胞浓度，并冷冻白细胞。

3. 外观设计

USD408527S Medical dispensing gun 失效
公开(公告)号：USD408527S
公开(公告)日：1999-04-20
申请号：US83019
申请日：1998-02-02
申请人： Philip Henry Coelho , Brian G. Malone , Pete Menke , Loren Stirling , John Gard
设计人： Philip Henry Coelho , Brian G. Malone , Pete Menke , Loren Stirling , John Gard

4. 发明授权

US07056722B1 Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby 有权
标题翻译：从其形成的血浆和凝血酶制备稳定的长期凝血酶的装置和方法
公开(公告)号：US07056722B1
公开(公告)日：2006-06-06
申请号：US09709237
申请日：2000-11-10
申请人： Philip Henry Coelho , Phil Kingsley , Jim Brausch , James H. Godsey , Gail Rock
发明人： Philip Henry Coelho , Phil Kingsley , Jim Brausch , James H. Godsey , Gail Rock
IPC分类号： C12N9/74 , C12Q1/56
CPC分类号： G01N33/86 , A61J3/002 , A61K35/16 , A61L24/108 , C12N9/6429 , C12Y304/21005 , G01N33/4905 , G01N2333/974
摘要： A sterile method for preparing stable thrombin component from a single donor's plasma in which the thrombin component is harvested simultaneously from the clotting and adhesive proteins component from the same donor plasma in less than one hour. The combined components provide an improved biological hemostatic agent and tissue sealant by virtue of its freedom from the risk of contaminating viruses or bacteria from allogenic human or bovine blood sources. The thrombin provides polymerization of the clotting and adhesive proteins in less than five seconds, and is sufficiently stable to provide that fast clotting over a six hour period. Further, the clotting times can be predictably lengthened by diluting the thrombin with saline.
摘要翻译：一种用于从单个供体血浆中制备稳定的凝血酶组分的无菌方法，其中凝血酶组分在不到一小时的时间内从同一供体血浆的凝血和粘附蛋白组分同时收获。组合的组分由于其免于污染来自同种异体人或牛血源的病毒或细菌的风险而提供改进的生物止血剂和组织密封剂。凝血酶在不到5秒内提供凝血和粘附蛋白的聚合，并且足够稳定，以便在6小时内提供快速凝血。此外，通过用盐水稀释凝血酶可以可预测地延长凝血时间。

5. 发明授权

US06491678B1 Freezer bag 有权
标题翻译：冷冻袋
公开(公告)号：US06491678B1
公开(公告)日：2002-12-10
申请号：US09313816
申请日：1999-05-18
申请人： Pablo Rubinstein , Philip Henry Coelho , Cladd E. Stevens
发明人： Pablo Rubinstein , Philip Henry Coelho , Cladd E. Stevens
IPC分类号： A61M3700
CPC分类号： A01N1/0263 , A01N1/02 , A01N1/0221 , A61B5/150038 , A61B5/150229 , A61B5/150366 , A61B5/150755 , A61M1/0236 , A61M2202/0439 , A61M2202/0462 , Y10S206/828 , A61M2202/0071
摘要： A therapeutic product formed from a high concentration of white blood cells having a high degree of cell viability. The white blood cells are sequestered from their normal population presence in whole blood by placing the blood into a container and preventing coagulation of the blood, separating the blood into two components, one of which is extremely rich in white blood cells through the use of a reagent and centrifugation, sequestering the white cell concentration, and freezing the white cells.
摘要翻译：由具有高细胞存活能力的高浓度白细胞形成的治疗产品。通过将血液置于容器中并防止血液凝结，将血液分离成两部分，其中一种是通过使用试剂和离心，隔离白细胞浓度，并冷冻白细胞。

6. 发明授权

US07182107B2 Biological adhesive loading station and method 有权
标题翻译：生物粘合剂装载站及方法
公开(公告)号：US07182107B2
公开(公告)日：2007-02-27
申请号：US10737066
申请日：2003-12-15
申请人： Eric Sommer , Philip Henry Coelho , Phil Kingsley
发明人： Eric Sommer , Philip Henry Coelho , Phil Kingsley
IPC分类号： B65B1/04
CPC分类号： A61B17/00491 , A61B2017/00495
摘要： A loading station having a dispensing manifold for loading syringe pairs with thrombin and adhesive and clotting proteins for use as a biological adhesive. The resulting loaded syringe pairs are compatible with a variety of biological adhesive dispensers and may be used in a surgical setting.
摘要翻译：具有用于将注射器对与凝血酶和粘合剂一起加载并用于生物粘合剂的凝血蛋白的分配歧管的装载站。所得到的装载的注射器对与各种生物粘合剂分配器兼容，并且可以用于手术设置。

7. 发明授权

US07169547B2 High concentration white blood cells as a therapeutic product 有权
标题翻译：高浓度白细胞作为治疗用品
公开(公告)号：US07169547B2
公开(公告)日：2007-01-30
申请号：US09855789
申请日：2001-05-15
申请人： Pablo Rubinstein , Philip Henry Coelho , Cladd E. Stevens
发明人： Pablo Rubinstein , Philip Henry Coelho , Cladd E. Stevens
IPC分类号： A01N1/02 , C12N5/00 , A61M37/00 , A61K35/16 , A61K35/14
CPC分类号： A61K35/14 , A01N1/02 , A01N1/0263 , A61J1/12 , A61M1/0209 , A61M1/0236 , A61M1/0272 , A61M1/0281 , A61M1/3693 , A61M2202/0439 , A61M2202/0462 , A61M2202/0071
摘要： A therapeutic product formed from a high concentration of white blood cells having a high degree of cell viability. The white blood cells are sequestered from their normal population presence in whole blood by placing the blood into a container and preventing coagulation of the blood, separating the blood into two components, one of which is extremely rich in white blood cells through the use of a reagent and centrifugation, sequestering the white cell concentration, and freezing the white cells.
摘要翻译：由具有高细胞存活能力的高浓度白细胞形成的治疗产品。通过将血液置于容器中并防止血液凝结，将血液分离成两部分，其中一种是通过使用试剂和离心，隔离白细胞浓度，并冷冻白细胞。

8. 发明授权

US6123696A Centrifugation bag with yieldable partitions 失效
标题翻译：离心袋与可屈服的隔板
公开(公告)号：US6123696A
公开(公告)日：2000-09-26
申请号：US118688
申请日：1998-07-16
申请人： Philip Henry Coelho , Pablo Rubinstein
发明人： Philip Henry Coelho , Pablo Rubinstein
IPC分类号： A61J1/00 , A61J1/05 , A61M1/02 , A61M1/36 , B04B7/18
CPC分类号： A61J1/10 , A61M1/0209 , A61M1/3693
摘要： A method and apparatus for the sequestration of components of a fluid by forcing heavier fractions of the fluid to pass beyond a yieldable partition integrally formed within a bag. Fluid fractions remain sequestered within bag compartments when forces driving the heavier fraction have been removed.
摘要翻译：一种用于通过迫使较重部分的流体超过在袋内整体形成的可屈服隔板的方法和装置来隔离流体的组分。当驱动较重部分的力已经被去除时，流体部分保留在袋隔室内。

9. 发明授权

US5789147A Method for concentrating white cells from whole blood by adding a red cell sedimentation reagent to whole anticoagulated blood 失效
标题翻译：通过向整个抗凝血中加入红细胞沉降试剂来浓缩全血白细胞的方法
公开(公告)号：US5789147A
公开(公告)日：1998-08-04
申请号：US349747
申请日：1994-12-05
申请人： Pablo Rubinstein , Philip Henry Coelho , Cladd E. Stevens
发明人： Pablo Rubinstein , Philip Henry Coelho , Cladd E. Stevens
IPC分类号： A01N1/02 , A61K35/14 , A61M1/02 , A01N63/00 , A61B19/00
CPC分类号： A01N1/0263 , A01N1/02 , A01N1/0221 , A61B5/150038 , A61B5/150229 , A61B5/150366 , A61B5/150755 , A61M1/0236 , A61M2202/0439 , A61M2202/0462 , Y10S206/828
摘要： A therapeutic product formed from a high concentration of white blood cells having a high degree of cell viability. The white blood cells are sequestered from their normal population presence in whole blood by placing the blood into a container and preventing coagulation of the blood, separating the blood into two components, one of which is extremely rich in white blood cells through the use of a reagent and centrifugation, sequestering the white cell concentration, and freezing the white cells.
摘要翻译：由具有高细胞存活能力的高浓度白细胞形成的治疗产品。通过将血液置于容器中并防止血液凝结，将血液分离成两部分，其中一种是通过使用试剂和离心，隔离白细胞浓度，并冷冻白细胞。

10. 发明授权

US06808675B1 Freezing and thawing bag, mold, apparatus and method 失效
标题翻译：冷冻和解冻袋，模具，设备和方法
公开(公告)号：US06808675B1
公开(公告)日：2004-10-26
申请号：US09672074
申请日：2000-09-28
申请人： Philip Henry Coelho , Pablo Rubinstein
发明人： Philip Henry Coelho , Pablo Rubinstein
IPC分类号： B29C4302
CPC分类号： A61J1/10 , A61J1/12 , A61M1/0277 , B29C65/04 , B29C65/08 , B29C65/48 , B29C66/1122 , B29C66/1312 , B29C66/53262 , B29C66/54 , B29C66/83221 , B29L2031/7148 , F25C1/243
摘要： A bag, method of manufacture and process are disclosed for the cryopreservation of thermolabile substances. The bag is characterized as having substantially uniform thickness throughout its length and height. The bag features a radiused peripheral edge wall for stress relief and to provide the constant cross-section. A peripheral flashing circumscribes the radiused edge wall and provides a suitable purchase area for sealing so that the thus formed bag is less susceptible to fracture particularly when exposed to cryogenic temperatures. The uniform thickness of the bag promulgates uniform heat transfer to and from the contents of the bag in relation to any surrounding medium at a different temperature. The bag affords more space for efficient storage and reduces heat invasion into the contents of the bag when a plurality of bags are placed with their larger planar surfaces in contact with each other.
摘要翻译：公开了一种袋，制造方法和方法，用于低温保存不耐热物质。该袋的特征在于其整个长度和高度具有基本均匀的厚度。该袋具有一个圆角的外围边缘壁，用于减轻应力，并提供恒定的横截面。外围闪光灯围绕圆角边缘壁并提供适当的密封采购区域，使得如此形成的袋子不易受到断裂的影响，特别是当暴露于低温时。袋子的均匀厚度相对于在不同温度下的任何周围介质，均匀地传送到袋子内部和从袋子的内容物传递。当多个袋子放置在其较大的平面彼此接触的位置时，袋子提供了更多的空间用于有效的储存并且减少热量侵入到袋子的内容物中。

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