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1. 发明授权

US08066515B2 Multiple graphics adapter connection systems 有权
标题翻译：多个图形适配器连接系统
公开(公告)号：US08066515B2
公开(公告)日：2011-11-29
申请号：US10991169
申请日：2004-11-17
申请人： Philip B. Johnson , Liping Yu , Ludger Mimberg , Ross F. Jatou
发明人： Philip B. Johnson , Liping Yu , Ludger Mimberg , Ross F. Jatou
IPC分类号： H01R12/00
CPC分类号： G06F1/186 , G06F1/184 , G06F1/185
摘要： A system provides a digital multi-bit connection between two or more graphics adapters. Each graphics adapter is manufactured as a printed circuit board including a finger-type edge connector. When two or more graphics adapters are installed in a system the edge connectors of each graphics adapter may be coupled to each other via a connection device that provides a portion of the digital multi-bit connection. The remainder of the digital multi-bit connection is provided by conductive traces coupling each finger of the edge connector to a graphics processing unit that is affixed to the graphics adapter. The connection device may be installed by an end-user as each additional graphics adapter is installed in the system.
摘要翻译：系统提供两个或多个图形适配器之间的数字多位连接。每个图形适配器被制造为包括手指式边缘连接器的印刷电路板。当系统中安装两个或多个图形适配器时，每个图形适配器的边缘连接器可以经由提供数字多位连接的一部分的连接装置彼此耦合。数字多位连接的其余部分由将边缘连接器的每个手指耦合到固定到图形适配器的图形处理单元的导电迹线提供。连接设备可以由最终用户安装，因为每个附加图形适配器被安装在系统中。

2. 发明申请

US20060274073A1 Multiple graphics adapter connection systems 有权
标题翻译：多个图形适配器连接系统
公开(公告)号：US20060274073A1
公开(公告)日：2006-12-07
申请号：US10991169
申请日：2004-11-17
申请人： Philip Johnson , Liping Yu , Ludger Mimberg , Ross Jatou
发明人： Philip Johnson , Liping Yu , Ludger Mimberg , Ross Jatou
IPC分类号： G09G5/39
CPC分类号： G06F1/186 , G06F1/184 , G06F1/185
摘要： A system provides a digital multi-bit connection between two or more graphics adapters. Each graphics adapter is manufactured as a printed circuit board including a finger-type edge connector. When two or more graphics adapters are installed in a system the edge connectors of each graphics adapter may be coupled to each other via a connection device that provides a portion of the digital multi-bit connection. The remainder of the digital multi-bit connection is provided by conductive traces coupling each finger of the edge connector to a graphics processing unit that is affixed to the graphics adapter. The connection device may be installed by an end-user as each additional graphics adapter is installed in the system.
摘要翻译：系统提供两个或多个图形适配器之间的数字多位连接。每个图形适配器被制造为包括手指式边缘连接器的印刷电路板。当系统中安装两个或多个图形适配器时，每个图形适配器的边缘连接器可以经由提供数字多位连接的一部分的连接装置彼此耦合。数字多位连接的其余部分由将边缘连接器的每个手指耦合到固定到图形适配器的图形处理单元的导电迹线提供。连接设备可以由最终用户安装，因为每个附加图形适配器被安装在系统中。

3. 发明授权

US07927561B2 Rapid particle detection assay 有权
标题翻译：快速粒子检测测定
公开(公告)号：US07927561B2
公开(公告)日：2011-04-19
申请号：US12316707
申请日：2008-12-15
申请人： Hrair Kirakossian , Liping Yu , Douglas A. Petry
发明人： Hrair Kirakossian , Liping Yu , Douglas A. Petry
IPC分类号： G01N21/75
CPC分类号： G01N21/6428 , B01L3/508 , B01L2200/0668 , B01L2300/0822 , B01L2400/043 , G01N33/54333
摘要： The present invention proves instruments and methods for detecting and/or quantitating an analyte in a fluid sample. The fluid sample is placed in a sample chamber having a small, shallow detection region. The analyte is magnetically labeled using magnetic particles coated with a binding reagent, and is detectably labeled using a fluorescent dye or other detection reagent. The magnetically labeled analyte is concentrated into the detection region using a focusing magnet positioned underneath the sample chamber detection region. Concentrated analyte is measured using excitation optics positioned on top of the sample chamber detection region, adapted to illuminate only the detection region, and detection optics positioned on top of the detection region, adapted to detect only light emitted from the detection region. In a preferred embodiment, the invention provides a simple, rapid assay for measuring the concentration of CD4+T cells in a whole blood sample.
摘要翻译：本发明证明用于检测和/或定量流体样品中的分析物的仪器和方法。将流体样品放置在具有小的浅检测区域的样品室中。使用涂覆有结合试剂的磁性颗粒将分析物磁性标记，并使用荧光染料或其他检测试剂可检测地标记。使用位于样品室检测区域下方的聚焦磁体将磁性标记的分析物浓缩到检测区域中。使用位于样品室检测区域顶部的激发光学器件来测量浓度分析物，其适于仅照射检测区域，以及位于检测区域顶部的检测光学元件，其仅检测从检测区域发射的光。在优选的实施方案中，本发明提供了用于测量全血样品中CD4 + T细胞浓度的简单快速测定。

4. 发明申请

US20130330739A1 Devices and Methods for Separating Magnetically Labeled Moieties in a Sample 有权
标题翻译：用于分离样品中的磁性标记部分的装置和方法
公开(公告)号：US20130330739A1
公开(公告)日：2013-12-12
申请号：US13984019
申请日：2012-04-05
申请人： Liping Yu
发明人： Liping Yu
IPC分类号： G01N1/34
CPC分类号： G01N1/34 , B03C1/0332 , B03C1/035 , B03C2201/18 , B03C2201/26
摘要： Devices for separating magnetically labeled moieties in a sample are provided. Aspects of the devices include a magnetic field source, a first magnetic field guide having a wedge-shaped portion with an apex edge, and a second magnetic field guide having a wedge-shaped portion with an apex edge. The apex edge of the first magnetic field guide is aligned substantially across from and parallel to the apex edge of the second magnetic field guide, and the device is configured to separate magnetically labeled moieties from non-magnetically labeled moieties in the sample. Also provided are methods of using the devices, as well as systems and kits configured for use with the devices and methods.
摘要翻译：提供了用于分离样品中磁性标记部分的装置。器件的方面包括磁场源，具有顶端边缘的楔形部分的第一磁场引导件和具有顶点边缘的楔形部分的第二磁场引导件。第一磁场引导件的顶点基本上跨过并平行于第二磁场引导件的顶点边缘，并且该装置被配置为将磁标记的部分与样品中的非磁性标记部分分离。还提供了使用设备的方法，以及被配置为与设备和方法一起使用的系统和套件。

5. 发明申请

US20130011860A1 METHODS FOR DETECTING INSULIN AUTOANTIBODY 有权
标题翻译：检测胰岛素自身抗体的方法
公开(公告)号：US20130011860A1
公开(公告)日：2013-01-10
申请号：US13521023
申请日：2011-01-06
申请人： George S. Eisenbarth , Liping Yu
发明人： George S. Eisenbarth , Liping Yu
IPC分类号： G01N33/566 , G01N21/76 , G01N21/66 , G01N21/64
CPC分类号： G01N33/6854 , G01N2800/24
摘要： The present invention provides methods for detecting insulin autoantibody. Such methods can be used, for example, to predict susceptibility of and/or diagnose the presence of Type 1 diabetes in a subject. Some aspects of the invention also provide kits adapted for use in such methods. In particular, some aspects of the invention use proinsulin to detect the presence of insulin autoantibody.
摘要翻译：本发明提供了检测胰岛素自身抗体的方法。这样的方法可以用于例如预测受试者中1型糖尿病的易感性和/或诊断1型糖尿病的存在。本发明的一些方面还提供适用于这种方法的试剂盒。特别地，本发明的一些方面使用胰岛素原来检测胰岛素自身抗体的存在。

6. 发明授权

US08263558B2 Methods of preparation of recombinant forms of human beta-amyloid protein and uses of these proteins 有权
标题翻译：人β-淀粉样蛋白重组形式的制备方法及其应用
公开(公告)号：US08263558B2
公开(公告)日：2012-09-11
申请号：US11574844
申请日：2006-11-30
申请人： Thomas F. Holzman , John E. Harlan , Rohinton P. Edalji , Edward T. Olejniczak , Ana Pereda-Lopez , Boris Labkovsky , Liping Yu , Heinz Hillen , Stefan Barghorn , Ulrich M. Ebert
发明人： Thomas F. Holzman , John E. Harlan , Rohinton P. Edalji , Edward T. Olejniczak , Ana Pereda-Lopez , Boris Labkovsky , Liping Yu , Heinz Hillen , Stefan Barghorn , Ulrich M. Ebert
IPC分类号： A61K38/16 , A61K39/00 , C07K14/435 , C07H21/00 , C12P21/06 , C12N15/09 , C12N15/12 , C12N15/63
CPC分类号： C07K14/4711 , A61K38/00 , C07K16/18
摘要： The subject invention relates to the cloning, expression and isolation of recombinant forms of beta-amyloid protein containing a N-terminal methionine (or one or more amino acids) as well as to methods of using this recombinant protein in the production of therapeutic antibodies, in the identification of therapeutic small molecules, and in the performance of diagnostic assays.
摘要翻译：本发明涉及含有N-末端甲硫氨酸（或一种或多种氨基酸）的重组形式的β-淀粉样蛋白的克隆，表达和分离以及在制备治疗性抗体中使用该重组蛋白的方法，在鉴定治疗性小分子时，以及在诊断测定中的表现。

7. 发明申请

US20110092445A1 Amyloid ß peptide analogues, oligomers thereof, processes for preparing and composi-tions comprising said analogues or oligomers, and their uses 审中-公开
标题翻译：淀粉样蛋白β肽类似物，其低聚物，包含所述类似物或寡聚物的制备和组合的方法及其用途
公开(公告)号：US20110092445A1
公开(公告)日：2011-04-21
申请号：US12509325
申请日：2009-07-24
申请人： Stefan Barghorn , Heinz Hillen , Rohinton Edalji , Leo Barrett , Paul Richardson , Liping Yu , Edward Olejniczak , John E. Harlan , Thomas Holzman
发明人： Stefan Barghorn , Heinz Hillen , Rohinton Edalji , Leo Barrett , Paul Richardson , Liping Yu , Edward Olejniczak , John E. Harlan , Thomas Holzman
IPC分类号： A61K38/12 , C07K4/00 , C07K14/00 , G01N33/68
CPC分类号： C07K14/4711 , A61K38/00 , C07K16/18 , C07K2319/00 , G01N2333/4709 , G01N2500/04 , G01N2800/2821
摘要： The present invention relates to an amyloid β peptide analogues comprising an amino acid sequence or a peptidomimetic thereof, wherein the sequence (i) forms a loop, (ii) has at least 66% identity to the amino acid sequence of native Aβ peptide or a portion thereof, (iii) comprises at least 6 contiguous amino acid residues and (iv) has at least 2 non-contiguous amino acid residues which are covalently linked with each other, oligomers comprising a plurality of said amyloid β peptide analogues, processes for preparing the amyloid β peptide analogues or oligomers, compositions comprising the amyloid β peptide analogues or oligomers, and uses of the amyloid β peptide analogues or oligomers such as their use for treating or preventing an amyloidosis (e.g. by active immunization), for diagnosing an amyloidosis, and for providing agents that are capable of binding to the amyloid β peptide analogues or oligomers. The subject invention also describes agents that are capable of binding to the amyloid β peptide analogues or oligomers, e.g. antibodies, compositions comprising the agents, and uses of the agents such as their use for treating or preventing an amyloidosis (e.g. by passive immunization) and for diagnosing an amyloidosis.
摘要翻译：本发明涉及淀粉样蛋白肽类似物，其包含氨基酸序列或其拟肽，其中所述序列（i）形成环，（ii）与天然A和Bgr的氨基酸序列具有至少66％的同一性; 肽或其一部分，（iii）包含至少6个连续氨基酸残基和（iv）具有彼此共价连接的至少2个不连续氨基酸残基，包含多个所述淀粉样蛋白和bgr的寡聚物; 肽类似物，制备淀粉样蛋白的方法肽类似物或寡聚物，包含淀粉样蛋白的组合物; 肽类似物或寡聚物，以及淀粉样蛋白和bgr的用途; 肽类似物或寡聚体，例如其用于治疗或预防淀粉样变性（例如通过主动免疫）用于诊断淀粉样变性的用途，以及用于提供能够结合淀粉样蛋白的药剂; 肽类似物或寡聚物。本发明还描述了能够结合淀粉样蛋白的药剂; 肽类似物或寡聚物，例如抗体，包含该试剂的组合物，以及该药剂的用途，例如其用于治疗或预防淀粉样变性（例如通过被动免疫）和用于诊断淀粉样变性的用途。

8. 发明授权

US09885642B2 Devices and methods for separating magnetically labeled moieties in a sample 有权
公开(公告)号：US09885642B2
公开(公告)日：2018-02-06
申请号：US13984019
申请日：2012-04-05
申请人： Liping Yu
发明人： Liping Yu
IPC分类号： G01N1/34 , B03C1/033 , B03C1/035
CPC分类号： G01N1/34 , B03C1/0332 , B03C1/035 , B03C2201/18 , B03C2201/26
摘要： Devices for separating magnetically labeled moieties in a sample are provided. Aspects of the devices include a magnetic field source, a first magnetic field guide having a wedge-shaped portion with an apex edge, and a second magnetic field guide having a wedge-shaped portion with an apex edge. The apex edge of the first magnetic field guide is aligned substantially across from and parallel to the apex edge of the second magnetic field guide, and the device is configured to separate magnetically labeled moieties from non-magnetically labeled moieties in the sample. Also provided are methods of using the devices, as well as systems and kits configured for use with the devices and methods.

9. 发明申请

US20090214515A1 METHODS OF PREPARATION OF RECOMBINANT FORMS OF HUMAN BETA-AMYLOID PROTEIN AND USES OF THESE PROTEINS 有权
标题翻译：人β-淀粉样蛋白重组体的制备方法和这些蛋白质的使用
公开(公告)号：US20090214515A1
公开(公告)日：2009-08-27
申请号：US11574844
申请日：2006-11-30
申请人： Thomas F. Holzman , John E. Harlan , Rohinton P. Edalji , Edward T. Olejniczak , Ana Pereda-Lopez , Boris Labkovsky , Liping Yu , Heinz Hillen , Stefan Barghorn , Ulrich M. Ebert
发明人： Thomas F. Holzman , John E. Harlan , Rohinton P. Edalji , Edward T. Olejniczak , Ana Pereda-Lopez , Boris Labkovsky , Liping Yu , Heinz Hillen , Stefan Barghorn , Ulrich M. Ebert
IPC分类号： A61K39/395 , C07K14/00 , C07H21/00 , C12N15/74 , C12N1/00 , C12P21/00 , C12N1/16 , C12N5/06 , C12N1/20 , C12N1/21 , C07K16/18 , C07K2/00 , G01N33/53 , A61K39/00 , A61P25/28
CPC分类号： C07K14/4711 , A61K38/00 , C07K16/18
摘要： The subject invention relates to the cloning, expression and isolation of recombinant forms of beta-amyloid protein containing a N-terminal methionine (or one or more amino acids) as well as to methods of using this recombinant protein in the production of therapeutic antibodies, in the identification of therapeutic small molecules, and in the performance of diagnostic assays.
摘要翻译：本发明涉及含有N-末端甲硫氨酸（或一种或多种氨基酸）的重组形式的β-淀粉样蛋白的克隆，表达和分离以及在制备治疗性抗体中使用该重组蛋白的方法，在鉴定治疗性小分子时，以及在诊断测定中的表现。

10. 发明授权

US09939448B2 Methods for detecting insulin autoantibody 有权
公开(公告)号：US09939448B2
公开(公告)日：2018-04-10
申请号：US13521023
申请日：2011-01-06
申请人： George S. Eisenbarth , Liping Yu
发明人： George S. Eisenbarth , Liping Yu
IPC分类号： G01N33/68
CPC分类号： G01N33/6854 , G01N2800/24
摘要： The present invention provides methods for detecting insulin autoantibody. Such methods can be used, for example, to predict susceptibility of and/or diagnose the presence of Type 1 diabetes in a subject. Some aspects of the invention also provide kits adapted for use in such methods. In particular, some aspects of the invention use proinsulin to detect the presence of insulin autoantibody.

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