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1. 发明申请

US20110092445A1 Amyloid ß peptide analogues, oligomers thereof, processes for preparing and composi-tions comprising said analogues or oligomers, and their uses 审中-公开
标题翻译：淀粉样蛋白β肽类似物，其低聚物，包含所述类似物或寡聚物的制备和组合的方法及其用途
公开(公告)号：US20110092445A1
公开(公告)日：2011-04-21
申请号：US12509325
申请日：2009-07-24
申请人： Stefan Barghorn , Heinz Hillen , Rohinton Edalji , Leo Barrett , Paul Richardson , Liping Yu , Edward Olejniczak , John E. Harlan , Thomas Holzman
发明人： Stefan Barghorn , Heinz Hillen , Rohinton Edalji , Leo Barrett , Paul Richardson , Liping Yu , Edward Olejniczak , John E. Harlan , Thomas Holzman
IPC分类号： A61K38/12 , C07K4/00 , C07K14/00 , G01N33/68
CPC分类号： C07K14/4711 , A61K38/00 , C07K16/18 , C07K2319/00 , G01N2333/4709 , G01N2500/04 , G01N2800/2821
摘要： The present invention relates to an amyloid β peptide analogues comprising an amino acid sequence or a peptidomimetic thereof, wherein the sequence (i) forms a loop, (ii) has at least 66% identity to the amino acid sequence of native Aβ peptide or a portion thereof, (iii) comprises at least 6 contiguous amino acid residues and (iv) has at least 2 non-contiguous amino acid residues which are covalently linked with each other, oligomers comprising a plurality of said amyloid β peptide analogues, processes for preparing the amyloid β peptide analogues or oligomers, compositions comprising the amyloid β peptide analogues or oligomers, and uses of the amyloid β peptide analogues or oligomers such as their use for treating or preventing an amyloidosis (e.g. by active immunization), for diagnosing an amyloidosis, and for providing agents that are capable of binding to the amyloid β peptide analogues or oligomers. The subject invention also describes agents that are capable of binding to the amyloid β peptide analogues or oligomers, e.g. antibodies, compositions comprising the agents, and uses of the agents such as their use for treating or preventing an amyloidosis (e.g. by passive immunization) and for diagnosing an amyloidosis.
摘要翻译：本发明涉及淀粉样蛋白肽类似物，其包含氨基酸序列或其拟肽，其中所述序列（i）形成环，（ii）与天然A和Bgr的氨基酸序列具有至少66％的同一性; 肽或其一部分，（iii）包含至少6个连续氨基酸残基和（iv）具有彼此共价连接的至少2个不连续氨基酸残基，包含多个所述淀粉样蛋白和bgr的寡聚物; 肽类似物，制备淀粉样蛋白的方法肽类似物或寡聚物，包含淀粉样蛋白的组合物; 肽类似物或寡聚物，以及淀粉样蛋白和bgr的用途; 肽类似物或寡聚体，例如其用于治疗或预防淀粉样变性（例如通过主动免疫）用于诊断淀粉样变性的用途，以及用于提供能够结合淀粉样蛋白的药剂; 肽类似物或寡聚物。本发明还描述了能够结合淀粉样蛋白的药剂; 肽类似物或寡聚物，例如抗体，包含该试剂的组合物，以及该药剂的用途，例如其用于治疗或预防淀粉样变性（例如通过被动免疫）和用于诊断淀粉样变性的用途。

2. 发明申请

US20050137943A1 Method and system for assisting a search for articles within a storage facility 审中-公开
标题翻译：用于帮助搜索存储设施内的物品的方法和系统
公开(公告)号：US20050137943A1
公开(公告)日：2005-06-23
申请号：US10738898
申请日：2003-12-17
申请人： Thomas Holzman
发明人： Thomas Holzman
IPC分类号： B65G1/137 , G06K17/00 , G06F17/60
CPC分类号： G06Q10/087
摘要： A system and method facilitate searching for an article kept within a storage enclosure. The system includes tag detectors, item tags, and appearance data. Selection of an article for searching by a user enables retrieval of appearance data corresponding to the selected article so that the user may be aware of the packaging of the article for the search. If the user requires more detailed information, the tag detectors may be activated to interrogate for an item identifier embodied in an item tag. The magnitude of the response signals are used to determine the location of the selected article so that it may be displayed with the appearance data.
摘要翻译：系统和方法便于搜索保存在存储外壳内的物品。该系统包括标签检测器，项目标签和外观数据。用户搜索的文章的选择使得能够检索与所选择的文章相对应的外观数据，使得用户可以知道用于搜索的文章的包装。如果用户需要更详细的信息，则可以激活标签检测器来询问项目标签中体现的物品标识符。响应信号的大小用于确定所选择的物品的位置，以便可以与外观数据一起显示。

3. 发明申请

US20110014632A1 ASSAYS FOR CLINICAL ASSESSMENTS OF RHEUMATOID ARTHRITIS 审中-公开
标题翻译：测定炎症性脑膜炎的临床评估
公开(公告)号：US20110014632A1
公开(公告)日：2011-01-20
申请号：US12537182
申请日：2009-08-06
申请人： Thomas Holzman , Winton Gibbons , Claude Lerner
发明人： Thomas Holzman , Winton Gibbons , Claude Lerner
IPC分类号： G01N33/53 , C07K7/08 , C07K7/06 , C07K7/64 , G01N33/564
CPC分类号： G01N33/564 , G01N2800/102
摘要： The disclosure provides methods of detecting autoantibodies present in the serum of subjects suffering from rheumatoid arthritis. The methods use capture probes and detection probes that can bind to the antifilaggrin autoantibodies or other epitope related autoantibodies. The presence, absence, and/or amount of the autoantibody complex may be detected, wherein the presence of the complex may indicate a positive diagnosis of rheumatoid arthritis.
摘要翻译：本公开提供了检测患有类风湿性关节炎的受试者血清中存在的自身抗体的方法。该方法使用捕获探针和检测探针，其可以结合抗缩蛋白自身抗体或其他表位相关的自身抗体。可以检测自身抗体复合物的存在，不存在和/或量，其中复合物的存在可以指示类风湿性关节炎的阳性诊断。

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