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1. 发明申请

US20080155705A1 Method For the Production of Multiple-Unsaturated Fatty Acids in Transgenic Organisms 有权
公开(公告)号：US20080155705A1
公开(公告)日：2008-06-26
申请号：US10566944
申请日：2004-07-16
申请人： Thorsten Zank , Jorg Bauer , Petra Cirpus , Amine Abbadi , Ernst Heinz , Xiao Qiu , Patricia Vrinten , Petra Sperling , Frederic Domergue , Astrid Meyer , Jelena Kirsch
发明人： Thorsten Zank , Jorg Bauer , Petra Cirpus , Amine Abbadi , Ernst Heinz , Xiao Qiu , Patricia Vrinten , Petra Sperling , Frederic Domergue , Astrid Meyer , Jelena Kirsch
IPC分类号： A01K67/00 , C12N15/82 , C07C51/00 , C12N15/11 , A01H5/00 , C12N15/00 , C12N1/20
CPC分类号： C12N15/8247 , A23D9/00 , A23D9/02 , A23L33/115 , A23V2002/00 , C11B1/00 , C12N9/0071 , C12N9/0083 , C12N9/0093 , C12N9/1029 , C12P7/6409 , C12P7/6427 , C12P7/6463 , C12P7/6472 , C12Y114/19 , C12Y114/19003 , C12Y203/01199 , Y02P20/52
摘要： The invention relates to a method for the production of multiply-unsaturated fatty acids in an organism, into which nucleic acids have been introduced, which code for polypeptides with Δ-5 elongase activity. Said nucleic acid sequences, optionally with further nucleic acid sequences, coding for polypeptides for the biosynthesis of fatty acids and lipid metabolism, are advantageously expressed in the organism. Nucleic acid sequences coding for a Δ-6 desaturase, a Δ-5 desaturase, Δ-4 desaturase and/or Δ-6 elongase activity are particularly advantageous and, advantageously, said saturases and elongases are derived from Thalassiosira, Euglena or Ostreococcus. The invention further relates to a method for the production of oils and/or triacylglycerides with an increased content of long-chain, multiply-unsaturated fatty acids. A particular embodiment of the invention is a method for the production of unsaturated ω-3 fatty acids and a method for the production of triglycerides with an increased content of unsaturated fatty acids, in particular, of Δ-3 fatty acids with more than three double bonds. Also disclosed is the production of a transgenic organism, preferably a transgenic plant, or a transgenic microorganism with increased content of ω-3 fatty acids, oils or lipids with ω-3 double bonds as a result of the expression of the elongases and desaturases employed in the above method, preferably in combination with ω-3 desaturases, for example a ω-3 desaturase from fungi of the family Pythiaceae such as the genus Phytophtora, for example, the genus and species Phytophtora infestans, or a ω-3 desaturase from algae such as the family Prasinophyceae, for example, the genus Ostreococcus and, particularly, the genus and species Ostreococcus tauri or diatomaceae such as the genus Thalassiosira and, particularly, the genus and species Thalassiosira pseudonana. The invention also relates to the nucleic acid sequences, nucleic acid constructs, vectors and organisms containing the nucleic acid sequences and/or the nucleic acid constructs and transgenic organisms containing said nucleic acid sequences, nucleic acid constructs and/or vectors. A further part of the invention relates to oils, lipids and/or fatty acids produced according to the above method and use thereof and, furthermore, unsaturated fatty acids and triglycerides with an increased content of unsaturated fatty acids and use thereof.

2. 发明申请

US20080076164A1 Method for Increasing the Content of Polyunsaturated Long-Chained Fatty Acids in Transgenic Organisms 有权
公开(公告)号：US20080076164A1
公开(公告)日：2008-03-27
申请号：US11632555
申请日：2005-07-15
申请人： Petra Cirpus , Jorg Bauer , Xiao Qiu , Patricia Vrinten
发明人： Petra Cirpus , Jorg Bauer , Xiao Qiu , Patricia Vrinten
IPC分类号： C12P7/64 , A01H5/00 , C07C51/00 , C07H21/04 , C12N15/82
CPC分类号： C12N9/0006 , C12N9/20 , C12N9/88 , C12N15/8247
摘要： The present invention relates to a method for increasing the content of polyunsaturated long-chain fatty acids in an organism by introducing into said organism nucleic acids coding for polypeptides or proteins exhibiting a phospholipase, ketoacyl-CoA reductase and/or dehydratase activity. Advantageously, said enzymes originate from Ostreococcus or Thraustochytrium. The present invention further relates to the nucleic acid sequences, nucleic acid constructs, vectors and organisms containing the nucleic acid sequences according to the present invention, vectors containing the nucleic acid sequences and/or the nucleic acid constructs as well as to transgenic organisms containing the above mentioned nucleic acid sequences, nucleic acid constructs and/or vectors. Advantageously, said previously mentioned nucleic acid sequences, nucleic acid constructs, vectors can optionally be expressed in the organism together with further nucleic acid sequences coding for polypeptides or proteins of the biosynthesis of the fatty acid or lipid metabolism. Particularly advantageous herein are those nucleic acid sequences of the fatty acid or lipid metabolism that code for a Δ-9 elongase, Δ-8 desaturase, Δ-6 desaturase, a Δ-5 desaturase, Δ-4 desaturase, Δ-12 desaturase, Δ-5 elongase and/or Δ-6 elongase activity. Advantageously, said desaturases and elongases originate from organisms like Thalassiosira, Euglena, Isochrysis, Physcomitrella, Thraustochytrium, Borago, Phytophthora, Crypthecodinium, Oncorhynchus, Primula, Xenopus, Ciona, Arabidopsis, Mortierella, Caenorhabditis, Phaeodactylum, Ceratodon or Ostreococcus. A further part of the present invention relates to oils, lipids and/or fatty acids produced according to the method of the present invention and the use thereof. Furthermore, the present invention relates to unsaturated fatty acids and triglycerides having an increased content of unsaturated fatty acids and the use thereof.

3. 发明申请

US20080076166A1 Method For Producing Polyunsaturated Fatty Acids In Transgenic Organisms 审中-公开
标题翻译：在转基因生物中产生多不饱和脂肪酸的方法
公开(公告)号：US20080076166A1
公开(公告)日：2008-03-27
申请号：US11794006
申请日：2005-12-21
申请人： Petra Cirpus , Jorg Bauer , Ernst Heinz , Frederic Domergue
发明人： Petra Cirpus , Jorg Bauer , Ernst Heinz , Frederic Domergue
IPC分类号： C12P7/64 , C07C51/00 , C07H21/04 , C07K2/00 , C12N15/82
CPC分类号： C12N9/0083 , C12N15/8247
摘要： The present invention relates to a process for the production of polyunsaturated fatty acids in an organism by introducing, into the organism, nucleic acids which encode polypeptides with Δ5-elongase, Δ6-desaturase, Δ5-desaturase, Δ4-desaturase, Δ12-desaturase and/or Δ6-elongase activity. These desaturases and elongases are advantageously derived from Ostreococcus. The invention furthermore relates to a process for the production of oils and/or triacylglycerides with an elevated content of long-chain polyunsaturated fatty acids. The invention furthermore relates to the nucleic acid sequences, nucleic acid constructs, vectors and organisms comprising the nucleic acid sequences according to the invention, to vectors comprising the nucleic acid sequences and/or the nucleic acid constructs and to transgenic organisms comprising the abovementioned nucleic acid sequences, nucleic acid constructs and/or vectors. A further part of the invention relates to oils, lipids and/or fatty acids produced by the process according to the invention and to their use. Moreover, the invention relates to unsaturated fatty acids and to triglycerides with an elevated content of unsaturated fatty acids and to their use.
摘要翻译：本发明涉及通过向生物体中引入用Δ5延伸酶，Δ6-去饱和酶，Δ5-去饱和酶，Δ4-去饱和酶，Δ12-去饱和酶和Δ1-去饱和酶和Δ5-去饱和酶将多肽不饱和脂肪酸生成多肽的方法 /或Δ6-延长酶活性。这些去饱和酶和延伸酶有利地来自Ostreococcus。本发明还涉及生产具有升高的多链多不饱和脂肪酸含量的油和/或三酰基甘油酯的方法。本发明还涉及包含本发明的核酸序列的核酸序列，核酸构建体，载体和生物体，包含核酸序列和/或核酸构建体的载体以及包含上述核酸的转基因生物序列，核酸构建体和/或载体。本发明的另一部分涉及通过根据本发明的方法生产的油，脂质和/或脂肪酸及其用途。此外，本发明涉及不饱和脂肪酸和具有升高的不饱和脂肪酸含量的甘油三酸酯及其用途。

4. 发明申请

US20090094707A1 Method for Producing Polyunsaturated Long-Chain Fatty Acids in Transgenic Organisms 有权
标题翻译：生物多不饱和长链脂肪酸在转基因生物中的应用
公开(公告)号：US20090094707A1
公开(公告)日：2009-04-09
申请号：US11793854
申请日：2005-12-20
申请人： Petra Cirpus , Jorg Bauer , Ernst Heinz , Amine Abbadi , Jelena Kirsch
发明人： Petra Cirpus , Jorg Bauer , Ernst Heinz , Amine Abbadi , Jelena Kirsch
IPC分类号： A01K67/027 , C12N15/11 , C12N9/12 , C12N15/00 , C11B1/00 , C12P7/64 , C12N1/21 , A01H5/00
CPC分类号： C12N9/1029
摘要： The invention relates to a method for producing polyunsaturated fatty acids in an organism, according to which nucleic acids coding for polypeptides with an acyl-CoA:lysophospholipid-acyltransferase activity am introduced into the organism. Advantageously, said nucleic acid sequences can be expressed in the transgenic organism optionally together with other nucleic acid sequences coding for polypeptides of the fatty acid or lipid metabolism. The invention also relates to the inventive nucleic acid sequences, nucleic acid constructs containing the inventive nucleic acid sequences, vectors containing the inventive nucleic acid sequences and/or the nucleic acid constructs, and transgenic organisms containing said nucleic acid sequences, nucleic acid constructs and/or vectors. The invention further relates to oils, lipids and/or fatty acids produced according to the inventive method, and to the use of the same.
摘要翻译：本发明涉及在生物体中生产多不饱和脂肪酸的方法，根据该方法将编码具有酰基-CoA：溶血磷脂酰基转移酶活性的多肽的核酸引入生物体中。有利地，所述核酸序列可以任选与编码脂肪酸或脂质代谢多肽的其它核酸序列一起在转基因生物体中表达。本发明还涉及本发明的核酸序列，含有本发明核酸序列的核酸构建体，含有本发明核酸序列和/或核酸构建体的载体，以及含有所述核酸序列，核酸构建体和/ 或向量。本发明还涉及根据本发明方法生产的油，脂和/或脂肪酸及其用途。

5. 发明申请

US20070224661A1 Method for Producing Unsaturated Omega-3-Fatty Acids in Transgenic Organisms 有权
标题翻译：在转基因生物中生产不饱和ω-3-脂肪酸的方法
公开(公告)号：US20070224661A1
公开(公告)日：2007-09-27
申请号：US10590958
申请日：2005-02-23
申请人： Petra Cirpus , Jorg Bauer , Thorsten Zank , Ernst Heinz
发明人： Petra Cirpus , Jorg Bauer , Thorsten Zank , Ernst Heinz
IPC分类号： C12P1/04
CPC分类号： C12N9/0071 , C12N9/0004 , C12N15/8247
摘要： The present invention relates to a process for production of unsaturated ω-3-fatty acids and to a process for production of triglycerides with an elevated content of unsaturated fatty acids, especially of ω-3-fatty acids having more than three double bonds. The invention relates to the production of a transgenic organism, preferably of a transgenic plant or of a transgenic microorganism, with an elevated content of unsaturated ω-3-fatty acids, oils or lipids having ω-3-double bonds as the result of the expression of an ω-3-desaturase from fungi of the family Pythiaceae such as the genus Phytophtora, for example of the genus and species Phytophtora infestans. The invention furthermore relates to the nucleic acid sequences, nucleic acid constructs, vectors and organisms comprising at least one nucleic acid sequence according to the invention, at least one vector comprising the nucleic acid sequence and/or the nucleic acid constructs, and transgenic organisms comprise the abovementioned nucleic acid sequences, nucleic acid constructs and/or vectors. A further part of the invention relates to oils, lipids and/or fatty acids produced by the process according to the invention, and to their use. The invention moreover relates to unsaturated fatty acids and triglycerides with an elevated content of unsaturated fatty acids and their use.
摘要翻译：本发明涉及一种生产不饱和ω-3-脂肪酸的方法，以及一种具有升高的不饱和脂肪酸含量，特别是具有三个以上双键的ω-3-脂肪酸含量的甘油三酯的制备方法。本发明涉及转基因生物，优选转基因植物或转基因微生物的生产，其具有升高的不饱和ω-3-脂肪酸含量，油或具有ω-3-双键的脂质作为来自真菌的真菌的ω-3-去饱和酶的表达，例如疫霉属（Phytophtora），例如属和种类疫霉属（Stytophtora infestans）。本发明还涉及包含至少一个根据本发明的核酸序列的核酸序列，核酸构建体，载体和生物体，至少一种包含核酸序列和/或核酸构建体的载体，以及转基因生物包括上述核酸序列，核酸构建体和/或载体。本发明的另一部分涉及通过根据本发明的方法生产的油，脂和/或脂肪酸及其用途。本发明还涉及不饱和脂肪酸和不饱和脂肪酸含量升高的甘油三酸酯及其用途。

6. 发明申请

US20080119630A1 Flame-Resistant, Low-Temperature Curing Cyanate-Based Resins with Improved Properties 审中-公开
标题翻译：具有改进性能的耐火，低温固化氰酸酯树脂
公开(公告)号：US20080119630A1
公开(公告)日：2008-05-22
申请号：US11747269
申请日：2007-05-11
申请人： Monika Bauer , Rajko Wurzel , Christoph Uhlig , Jorg Bauer
发明人： Monika Bauer , Rajko Wurzel , Christoph Uhlig , Jorg Bauer
IPC分类号： C08G18/00
CPC分类号： C08G73/0661 , C08L79/04
摘要： A prepolymer is prepared from a starting material a) of one or more bifunctional or polyfunctional organic cyanates; and a starting material b) of one or more bifunctional or polyfunctional aromatic alcohols and/or one or more bifunctional or polyfunctional aliphatic alcohols substituted in the aliphatic group with at least one fluorine atom, wherein the starting materials a) and b) are present in a weight ratio ensuring a molar ratio of the OCN groups to the OH groups between 95:5 and 70:30 in the starting materials a) and b). The prepolymer has a degree of crosslinking that is below the gel point of the prepolymer.
摘要翻译：预聚物由一种或多种双官能或多官能有机氰酸酯的原料a）制备; 和一种或多种双官能或多官能芳族醇和/或在脂族基团中被至少一个氟原子取代的一个或多个双官能或多官能脂族醇的原料b），其中原料a）和b）存在于在起始材料a）和b）中确保OCN基团与OH基团的摩尔比在95:5至70:30之间的重量比。预聚物的交联度低于预聚物的凝胶点。

7. 发明申请

US20060168684A1 Methods for increasing oil content in plants 失效
公开(公告)号：US20060168684A1
公开(公告)日：2006-07-27
申请号：US10513412
申请日：2003-05-06
申请人： Andreas Renz , Jorg Bauer , Marc Nigel , Rita Zrenner , Peter Geigenberger , Helene Vigeolas
发明人： Andreas Renz , Jorg Bauer , Marc Nigel , Rita Zrenner , Peter Geigenberger , Helene Vigeolas
IPC分类号： C12N15/82 , A01H5/00
CPC分类号： C12N9/0006 , C12N15/8247
摘要： The invention relates to methods for increasing the oil content in plants, preferably in the seeds of plants, by expression of glycerol-3-phosphatdehydrogenases (G3PDH) from yeast, preferably from Saccharomyces cerevisiae. The invention also relates to expression constructs for the expression of G3PDH yeast in plants, preferably in the seeds of plants, transgenic plants expressing G3PDH, and to the use of said transgenic plants in the production of foodstuffs, feed, seeds, pharmaceuticals or fine chemicals, especially in the production of oils.

8. 发明申请

US20090083882A1 METHOD FOR INCREASING THE TOTAL OIL CONTENT IN OIL PLANTS 审中-公开
标题翻译：增加油田总油含量的方法
公开(公告)号：US20090083882A1
公开(公告)日：2009-03-26
申请号：US12092603
申请日：2006-11-06
申请人： Thorsten Zank , Oliver Oswald , Jorg Bauer , Helene Vigeolas , Peter Geigenberger , Peter Waldeck , Mark Stitt
发明人： Thorsten Zank , Oliver Oswald , Jorg Bauer , Helene Vigeolas , Peter Geigenberger , Peter Waldeck , Mark Stitt
IPC分类号： C12N15/82 , A01H1/04
CPC分类号： C12N15/8247 , C12N9/0006
摘要： The invention relates to methods of increasing the total oil content and/or the glycerol 3-phosphate content in transgenic oil crop plants which comprise at least 20% by weight of oleic acid based on the total fatty acid content, preferably in plant seeds, by expressing glycerol 3-phosphate dehydrogenases (G3PDHs) from yeasts, preferably from Saccharomyces cerevisiae. The oil and/or the free fatty acids obtained in the process are advantageously added to polymers, foodstuffs, feedstuffs, cosmetics, pharmaceuticals or products with industrial applications.
摘要翻译：本发明涉及增加转基因油料作物植物中总油含量和/或甘油3-磷酸盐含量的方法，其中基于总脂肪酸含量，优选在植物种子中，包含至少20重量％的油酸，通过从酵母，优选来自酿酒酵母（Saccharomyces cerevisiae）表达甘油3-磷酸脱氢酶（G3PDH）。在该方法中获得的油和/或游离脂肪酸有利地加入到具有工业应用的聚合物，食品，饲料，化妆品，药物或产品中。

9. 发明申请

US20050260754A1 Constructs and methods for the regulation of gene expression 审中-公开
标题翻译：用于调节基因表达的构建体和方法
公开(公告)号：US20050260754A1
公开(公告)日：2005-11-24
申请号：US10508263
申请日：2003-03-17
申请人： Michael Kock , Jorg Bauer
发明人： Michael Kock , Jorg Bauer
IPC分类号： A61K38/00 , C12N15/11 , C12N15/29 , C12N15/82 , C12N15/85 , C07H21/02
CPC分类号： C12N15/111 , A61K38/00 , C07K2319/00 , C12N15/8218 , C12N15/8247 , C12N15/825 , C12N15/8251 , C12N15/8269 , C12N2310/14 , C12N2310/3519 , C12N2310/53 , C12N2330/30
摘要： The present invention relates to constructs and methods for regulating the gene expression of at least two endogenous target genes by introducing, into a eukaryotic cell or a eukaryotic organism, an at least partially double-stranded ribonucleic acid molecule, the ribonucleic acid molecule comprising at least two ribonucleotide sequence segments which are homologous to various genes of the eukaryotic cell.
摘要翻译：本发明涉及通过将至少部分双链核糖核酸分子引入真核细胞或真核生物体来调节至少两种内源性靶基因的基因表达的构建体和方法，所述核糖核酸分子至少包含与真核细胞的各种基因同源的两个核糖核苷酸序列片段。

10. 发明申请

US20050072083A1 Method and system for detachably fixing a surface component to a background 失效
标题翻译：将表面组件可拆卸地固定到背景的方法和系统
公开(公告)号：US20050072083A1
公开(公告)日：2005-04-07
申请号：US10380034
申请日：2001-09-14
申请人： Jorg Bauer
发明人： Jorg Bauer
IPC分类号： E04F13/08 , E04F15/02
CPC分类号： E04F15/02 , E04F13/088 , E04F15/02133 , E04F15/185 , Y10T442/3398
摘要： The invention relates to a system for detachably fixing a surface component (16) to a background (18), especially a tile to a wall or on a bottom, whereby projections connected to the surface component when secured to the background and/or recesses engage with recesses connected to the background and/or projections, said recesses and projections being correspondingly embodied in such a way that they have deformable undercuts in the direction of the distance of said component from the background, the projections and recesses connected to the background being embodied on a forming film (4). The projections and recesses embodied on the surface component (4) are formed by a hardenable bonding material (22) which is applied to the forming film (4) joined to the background (18, 26) and/or to the surface component before it is pressed onto the forming film, said material bonding with the surface component when hardened.
摘要翻译：本发明涉及一种用于将表面部件（16）可拆卸地固定到背景（18）的系统，特别是将瓦片固定到背景和/或凹部上的连接到表面部件的突起和/或凹部接合具有连接到背景和/或突起的凹部，所述凹部和突起相应地实现为使得它们在所述部件离开背景的距离的方向上具有可变形的底切部分，连接到背景的突起和凹陷被体现在成膜（4）上。实施在表面部件（4）上的突起和凹部由可硬化的接合材料（22）形成，该可粘合的粘合材料（22）施加到接合到背景（18,26）和/或其前面的表面部件的成形膜（4）被压在成形膜上，所述材料在硬化时与表面组分结合。

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