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1. 发明申请

US20070203532A1 Method and device for decoupling and/or desynchronizing neural brain activity 有权
标题翻译：用于去神经和/或去同步神经脑活动的方法和装置
公开(公告)号：US20070203532A1
公开(公告)日：2007-08-30
申请号：US11604284
申请日：2006-11-27
申请人： Peter Tass , Oleksandr Popovych , Christian Hauptmann , Valeril Krachkovskyi
发明人： Peter Tass , Oleksandr Popovych , Christian Hauptmann , Valeril Krachkovskyi
IPC分类号： A61N1/18
CPC分类号： A61N1/36082 , A61B5/0006 , A61B5/048 , A61B5/4082 , A61B5/7225 , A61B5/726 , A61N1/0551 , A61N1/06 , A61N1/36067 , A61N1/36135 , A61N1/36146
摘要： A device for decoupling and/or desynchronizing neural, pathologically synchronous brain activity, in which, the activities in a partial region of a brain area or a functionally associated brain area are stimulated by means of an electrode, resulting in decoupling and desynchronizing the affected neuron population from the pathological area and suppression of the symptoms in a patient. In an alternative embodiment of the device, the pathologically synchronous brain activity due to the disease is desynchronized which also leads to the symptoms being suppressed. The device has a stimulation electrode and at least one sensor which are driven by a control system in such a manner that they produce decoupling and/or desynchronization in their local environment.
摘要翻译：用于解耦和/或同步神经，病理同步脑活动的装置，其中通过电极刺激脑区域或功能相关的脑区域的部分区域中的活动，导致受影响的神经元的去耦和失同步病理区域的人群和患者症状的抑制。在该装置的替代实施方案中，由于疾病引起的病理同步脑活动是不同步的，这也导致症状被抑制。该装置具有刺激电极和由控制系统驱动的至少一个传感器，使得它们在其局部环境中产生解耦和/或去同步。

2. 发明授权

US08000796B2 Method and device for decoupling and/or desynchronizing neural brain activity 有权
标题翻译：用于去神经和/或去同步神经脑活动的方法和装置
公开(公告)号：US08000796B2
公开(公告)日：2011-08-16
申请号：US11604284
申请日：2006-11-27
申请人： Peter Tass , Oleksandr Popovych , Christian Hauptmann , Valerii Krachkovskyi
发明人： Peter Tass , Oleksandr Popovych , Christian Hauptmann , Valerii Krachkovskyi
IPC分类号： A61N1/372
CPC分类号： A61N1/36082 , A61B5/0006 , A61B5/048 , A61B5/4082 , A61B5/7225 , A61B5/726 , A61N1/0551 , A61N1/06 , A61N1/36067 , A61N1/36135 , A61N1/36146
摘要： A device for decoupling and/or desynchronizing neural, pathologically synchronous brain activity, in which, the activities in a partial region of a brain area or a functionally associated brain area are stimulated by means of an electrode, resulting in decoupling and desynchronizing the affected neuron population from the pathological area and suppression of the symptoms in a patient. In an alternative embodiment of the device, the pathologically synchronous brain activity due to the disease is desynchronized which also leads to the symptoms being suppressed. The device has a stimulation electrode and at least one sensor which are driven by a control system in such a manner that they produce decoupling and/or desynchronization in their local environment.
摘要翻译：用于解耦和/或同步神经，病理同步脑活动的装置，其中通过电极刺激脑区域或功能相关的脑区域的部分区域中的活动，导致受影响的神经元的去耦和失同步病理区域的人群和患者症状的抑制。在该装置的替代实施方案中，由于疾病引起的病理同步脑活动是不同步的，这也导致症状被抑制。该装置具有刺激电极和由控制系统驱动的至少一个传感器，使得它们在其局部环境中产生解耦和/或去同步。

3. 发明授权

US07974698B2 Method and apparatus for desynchronization of neural brain activity 有权
标题翻译：神经脑活动失步的方法和装置
公开(公告)号：US07974698B2
公开(公告)日：2011-07-05
申请号：US11441251
申请日：2006-05-26
申请人： Peter Tass , Oleksandr Popovych , Christian Hauptmann
发明人： Peter Tass , Oleksandr Popovych , Christian Hauptmann
IPC分类号： A61N1/36
CPC分类号： A61N1/36135 , A61N1/36082 , A61N1/36103
摘要： The invention relates to an apparatus for desynchronization of neural illness-synchronous brain activity in which the activities in at least two subareas of a brain area or at least two functionally associated brain areas are stimulated by means of at least two electrodes. In the case of a person with an illness, desynchronization therapy suppresses symptoms in the relevant neuron population. The feedback stimulation signal, that is to say the measured, time-delayed and process neural activity, is used as an individual stimulus. This results in self-regulated, demand control of the amplitude of the stimulation signal, thus minimizing the intensity of the stimulation stimuli automatically after successful desynchronization. The apparatus has at least two stimulation electrodes and at least one sensor, which are driven by a controller such that they result in desynchronization in their local environment.
摘要翻译：本发明涉及一种用于神经疾病同步脑活动的同步化的装置，其中通过至少两个电极刺激脑区域或至少两个功能相关的脑区域的至少两个子区域中的活动。在患有疾病的人的情况下，去同步治疗可抑制相关神经元群体的症状。反馈刺激信号，也就是说测量的，时间延迟的和过程的神经活动被用作个体刺激。这导致刺激信号的幅度的自我调节，需求控制，从而在成功的失步之后自动最小化刺激刺激的强度。该装置具有至少两个刺激电极和至少一个传感器，其由控制器驱动，使得它们导致其局部环境中的不同步。

4. 发明申请

US20060276853A1 Method and apparatus for desynchronization of neural brain activity 有权
标题翻译：神经脑活动失步的方法和装置
公开(公告)号：US20060276853A1
公开(公告)日：2006-12-07
申请号：US11441251
申请日：2006-05-26
申请人： Peter Tass , Oleksandr Popovych , Christian Hauptmann
发明人： Peter Tass , Oleksandr Popovych , Christian Hauptmann
IPC分类号： A61N1/36
CPC分类号： A61N1/36135 , A61N1/36082 , A61N1/36103
摘要： The invention relates to an apparatus for desynchronization of neural, illness-synchronous brain activity in which, according to the invention, the activities in at least two subareas of a brain area or at least two functionally associated brain areas are stimulated by means of at least two electrodes, on the basis of which, in the case of a person with an illness, desynchronization surprisingly occurs in the relevant neuron population and the symptoms are suppressed. The feedback stimulation signal, that is to say the measured, time-delayed and process neural activity, is used as an individual stimulus. In consequence, this results in demand control, which is self-regulating according to the invention, of the amplitude of the stimulation signal thus minimizing the intensity of the stimulation stimuli automatically after successful desynchronization. For successful operation, the apparatus requires neither complex calibration nor control of the stimulation parameters and, instead, these can preferably be adapted and optimized by the additional controller. The apparatus has at least two stimulation electrodes (2) and at least one sensor (3), which are driven by a controller such that they result in desynchronization in their local environment.
摘要翻译：本发明涉及一种用于神经，疾病同步脑活动的同步化的装置，其中根据本发明，通过至少刺激至少两个脑区域或至少两个功能相关的脑区域的至少两个子区域中的活动两个电极，在一个病人的情况下，在相关的神经元群体中出乎意料地发生了同步，并且抑制了症状。反馈刺激信号，也就是说测量的，时间延迟的和过程的神经活动被用作个体刺激。因此，这导致根据本发明自我调节的需求控制，刺激信号的幅度因此在成功去同步之后自动最小化刺激刺激的强度。为了成功运行，该装置既不需要复杂的校准也不需要对刺激参数的控制，相反，这些可以优选地由附加控制器进行调整和优化。该装置具有至少两个刺激电极（2）和至少一个传感器（3），其由控制器驱动，使得它们导致其局部环境中的不同步。

5. 发明申请

US20110009921A1 DEVICE AND METHOD FOR AUDITORY STIMULATION 有权
标题翻译：用于审核刺激的设备和方法
公开(公告)号：US20110009921A1
公开(公告)日：2011-01-13
申请号：US12884557
申请日：2010-09-17
申请人： Peter Tass , Hans-Joachim Freund , Oleksandr Popovych , Birgit Utako Barnikol , Joel Niederhauser , Jean-Christophe Roulet , Urban Schnell
发明人： Peter Tass , Hans-Joachim Freund , Oleksandr Popovych , Birgit Utako Barnikol , Joel Niederhauser , Jean-Christophe Roulet , Urban Schnell
IPC分类号： A61N1/36
CPC分类号： A61H23/00 , A61B5/486 , A61F11/00 , A61H1/00 , A61H2201/5005 , A61H2205/02 , A61M21/00 , A61M2021/0027
摘要： A device and method for desynchronizing a patient's neuronal brain activity involving a neuron population firing in a pathologically synchronized manner. The device includes a stimulation unit configured to generate an acoustic stimulation signal to stimulate the neuron population when the acoustic stimulation signal is aurally received by the patient. Furthermore, the acoustic stimulation signal has a first frequency and a second frequency, with the first frequency provided to reset the phase of the neuronal brain activity in a first sub-population of the stimulated neuron population, and the second frequency provided to reset the phase of the neuronal brain activity in a second sub-population of the stimulated neuron population.
摘要翻译：用于以病理同步的方式使涉及神经元群体的患者的神经元脑活动同步化的装置和方法。所述装置包括刺激单元，所述刺激单元经配置以在所述声刺激信号被所述患者听觉地接收时产生声刺激信号以刺激所述神经元群体。此外，声刺激信号具有第一频率和第二频率，其中提供第一频率以复位受刺激的神经元群体的第一子群体中的神经元脑活动的相位，并且提供的第二频率重置相位的神经元脑活动在受激神经元群体的第二个子群体中。

6. 发明授权

US08423144B2 Device and method for auditory stimulation 有权
标题翻译：用于听觉刺激的装置和方法
公开(公告)号：US08423144B2
公开(公告)日：2013-04-16
申请号：US12884557
申请日：2010-09-17
申请人： Peter Tass , Hans-Joachim Freund , Oleksandr Popovych , Birgit Utako Barnikol , Joel Niederhauser , Jean-Christophe Roulet , Urban Schnell
发明人： Peter Tass , Hans-Joachim Freund , Oleksandr Popovych , Birgit Utako Barnikol , Joel Niederhauser , Jean-Christophe Roulet , Urban Schnell
IPC分类号： A61N1/18 , A61N1/36
CPC分类号： A61H23/00 , A61B5/486 , A61F11/00 , A61H1/00 , A61H2201/5005 , A61H2205/02 , A61M21/00 , A61M2021/0027
摘要： A device and method for desynchronizing a patient's neuronal brain activity involving a neuron population firing in a pathologically synchronized manner. The device includes a stimulation unit configured to generate an acoustic stimulation signal to stimulate the neuron population when the acoustic stimulation signal is aurally received by the patient. Furthermore, the acoustic stimulation signal has a first frequency and a second frequency, with the first frequency provided to reset the phase of the neuronal brain activity in a first sub-population of the stimulated neuron population, and the second frequency provided to reset the phase of the neuronal brain activity in a second sub-population of the stimulated neuron population.
摘要翻译：用于以病理同步的方式使涉及神经元群体的患者的神经元脑活动同步化的装置和方法。所述装置包括刺激单元，所述刺激单元经配置以在所述声刺激信号被所述患者听觉地接收时产生声刺激信号以刺激所述神经元群体。此外，声刺激信号具有第一频率和第二频率，其中提供第一频率以复位受刺激的神经元群体的第一子群体中的神经元脑活动的相位，并且提供的第二频率重置相位的神经元脑活动在受激神经元群体的第二个子群体中。

7. 发明授权

US08538547B2 Apparatus for the stimulation of neural networks 有权
标题翻译：用于刺激神经网络的装置
公开(公告)号：US08538547B2
公开(公告)日：2013-09-17
申请号：US12739426
申请日：2008-10-28
申请人： Peter Tass , Christian Hauptmann
发明人： Peter Tass , Christian Hauptmann
IPC分类号： A61N1/36
CPC分类号： A61N1/326 , A61N1/0551 , A61N1/36003 , A61N1/36067 , A61N1/36167
摘要： An apparatus (100) is described which comprises at least one measuring unit (31-34) for recording test signals from neurons, a generator unit (10) for generating electrical stimulation signals in accordance with the test signals, and a plurality of stimulation units (11-14) that are connected to the generator unit (10). The stimulation units (11-14) stimulate a plurality of neural networks in a deferred manner by means of the stimulation signals and thus induce a deferred activity in the stimulated neural networks.
摘要翻译：描述了一种装置（100），其包括用于记录来自神经元的测试信号的至少一个测量单元（31-34），用于根据测试信号产生电刺激信号的发生器单元（10），以及多个刺激单元（11-14），其连接到所述发电机单元（10）。刺激单元（11-14）通过刺激信号以延迟的方式刺激多个神经网络，从而在受刺激的神经网络中诱导延迟的活动。

8. 发明申请

US20100222843A1 STIMULATION DEVICE 审中-公开
标题翻译：刺激装置
公开(公告)号：US20100222843A1
公开(公告)日：2010-09-02
申请号：US12597918
申请日：2008-05-06
申请人： Peter Tass , Volker Sturm
发明人： Peter Tass , Volker Sturm
IPC分类号： A61N1/36
CPC分类号： A61N1/36082
摘要： The invention refers to a device comprising a generator unit for generating stimulation signals and a stimulation unit connected to the generator unit, wherein the stimulation unit is designed to stimulate nerve cells in the nucleus accumbens and/or in the amygdaloid nucleus and/or in the fasciculus medialis telencephali and/or in pathways made of dopaminergic areas of the mesencephalon leading to the nucleus accumbens or the amygdaloid nucleus and/or in fiber bundles linking the nucleus accumbens and the amygdaloid nucleus using the stimulation signals.
摘要翻译：本发明涉及一种包括用于产生刺激信号的发生器单元和连接到发生器单元的刺激单元的装置，其中刺激单元被设计成刺激伏隔核和/或杏仁核中的神经细胞和/或在内侧中耳和/或由导致伏隔核或扁桃体核的中脑的多巴胺能区域和/或使用刺激信号连接伏隔核和杏仁核的纤维束形成的通路。

9. 发明申请

US20070135860A1 Device for treating patients by brain stimulation, electronic component and use of the device and electronic component in medicine and medical treatment method 审中-公开
标题翻译：用于通过脑刺激，电子元件治疗患者的装置以及医疗和医疗处理方法中的装置和电子部件的使用
公开(公告)号：US20070135860A1
公开(公告)日：2007-06-14
申请号：US11603293
申请日：2006-11-22
申请人： Peter Tass
发明人： Peter Tass
IPC分类号： A61N1/00
CPC分类号： A61N1/36067 , A61N1/36082
摘要： A device for treating patients by brain stimulation and related electronic component and use of the device and of the electronic component in a medical treatment method. To achieve the brain stimulation result, a device includes at least one electrode for stimulating a brain region, at least one sensor for measuring an electrical signal, a control system which can detect the occurrence of a pathological feature of the electrical signal which was measured by the sensor and, when the pathological feature occurs, delivers at least one component from a group of stimulus sequences (a) through (d): (a) a short high-frequency pulse train, (b) a resetting short high-frequency pulse train followed by a further desynchronizing short high-frequency pulse train, (c) a resetting low-frequency sequence of a high-frequency pulse train followed by a desynchronizing high-frequency pulse train, or (d) a resetting single pulse followed by a short desynchronizing high-frequency pulse train to the electrode.
摘要翻译：一种用于通过脑刺激和相关电子部件治疗患者的装置以及在医疗方法中使用该装置和电子部件。为了实现脑刺激结果，装置包括用于刺激脑区域的至少一个电极，用于测量电信号的至少一个传感器，可以检测电信号的病理特征的发生的控制系统，该控制系统由传感器，并且当发生病理特征时，从一组刺激序列（a）到（d）中递送至少一个分量：（a）短的高频脉冲串，（b）复位短的高频脉冲然后是进一步去同步的短高频脉冲串，（c）高频脉冲序列的复位低频序列，随后是去同步高频脉冲串，或（d）复位单脉冲，随后是短时间同步高频脉冲串到电极。

10. 发明申请

US20060212089A1 Device for the desynchronization of neuronal brain activity 有权
标题翻译：用于神经元脑活动失步的装置
公开(公告)号：US20060212089A1
公开(公告)日：2006-09-21
申请号：US10553679
申请日：2004-04-08
申请人： Peter Tass
发明人： Peter Tass
IPC分类号： A61N1/18
CPC分类号： A61N1/36064 , A61N1/36017 , A61N1/36067 , A61N1/36082 , A61N1/36135
摘要： The invention relates to a device for desynchronizing neuronal brain activity. According to the invention, the activity in at least two partial zones of a brain area or at least two functionally related brain areas is reset by means of two electrodes, surprisingly resulting in desynchronization in the targeted population of neurons of the patient and the symptoms being repressed. The inventive device comprises at least two stimulation electrodes (2) which are triggered by a control mechanism so as to cause synchronization in the local environment thereof. Preferably, the stimuli of the N electrodes are essentially out of phase by 1/N.
摘要翻译：本发明涉及一种用于使神经元脑活动失步的装置。根据本发明，脑区域或至少两个功能相关的脑区域的至少两个部分区域中的活性通过两个电极复位，令人惊奇地导致患者的目标群体的神经元的同步，症状为压抑本发明的装置包括由控制机构触发以在其局部环境中引起同步的至少两个刺激电极（2）。优选地，N个电极的刺激基本上异相1 / N。

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