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1. 发明申请

US20070203532A1 Method and device for decoupling and/or desynchronizing neural brain activity 有权
标题翻译：用于去神经和/或去同步神经脑活动的方法和装置
公开(公告)号：US20070203532A1
公开(公告)日：2007-08-30
申请号：US11604284
申请日：2006-11-27
申请人： Peter Tass , Oleksandr Popovych , Christian Hauptmann , Valeril Krachkovskyi
发明人： Peter Tass , Oleksandr Popovych , Christian Hauptmann , Valeril Krachkovskyi
IPC分类号： A61N1/18
CPC分类号： A61N1/36082 , A61B5/0006 , A61B5/048 , A61B5/4082 , A61B5/7225 , A61B5/726 , A61N1/0551 , A61N1/06 , A61N1/36067 , A61N1/36135 , A61N1/36146
摘要： A device for decoupling and/or desynchronizing neural, pathologically synchronous brain activity, in which, the activities in a partial region of a brain area or a functionally associated brain area are stimulated by means of an electrode, resulting in decoupling and desynchronizing the affected neuron population from the pathological area and suppression of the symptoms in a patient. In an alternative embodiment of the device, the pathologically synchronous brain activity due to the disease is desynchronized which also leads to the symptoms being suppressed. The device has a stimulation electrode and at least one sensor which are driven by a control system in such a manner that they produce decoupling and/or desynchronization in their local environment.
摘要翻译：用于解耦和/或同步神经，病理同步脑活动的装置，其中通过电极刺激脑区域或功能相关的脑区域的部分区域中的活动，导致受影响的神经元的去耦和失同步病理区域的人群和患者症状的抑制。在该装置的替代实施方案中，由于疾病引起的病理同步脑活动是不同步的，这也导致症状被抑制。该装置具有刺激电极和由控制系统驱动的至少一个传感器，使得它们在其局部环境中产生解耦和/或去同步。

2. 发明授权

US08538547B2 Apparatus for the stimulation of neural networks 有权
标题翻译：用于刺激神经网络的装置
公开(公告)号：US08538547B2
公开(公告)日：2013-09-17
申请号：US12739426
申请日：2008-10-28
申请人： Peter Tass , Christian Hauptmann
发明人： Peter Tass , Christian Hauptmann
IPC分类号： A61N1/36
CPC分类号： A61N1/326 , A61N1/0551 , A61N1/36003 , A61N1/36067 , A61N1/36167
摘要： An apparatus (100) is described which comprises at least one measuring unit (31-34) for recording test signals from neurons, a generator unit (10) for generating electrical stimulation signals in accordance with the test signals, and a plurality of stimulation units (11-14) that are connected to the generator unit (10). The stimulation units (11-14) stimulate a plurality of neural networks in a deferred manner by means of the stimulation signals and thus induce a deferred activity in the stimulated neural networks.
摘要翻译：描述了一种装置（100），其包括用于记录来自神经元的测试信号的至少一个测量单元（31-34），用于根据测试信号产生电刺激信号的发生器单元（10），以及多个刺激单元（11-14），其连接到所述发电机单元（10）。刺激单元（11-14）通过刺激信号以延迟的方式刺激多个神经网络，从而在受刺激的神经网络中诱导延迟的活动。

3. 发明申请

US20100331912A1 DEVICE AND METHOD FOR VISUAL STIMULATION 有权
标题翻译：用于视觉刺激的装置和方法
公开(公告)号：US20100331912A1
公开(公告)日：2010-12-30
申请号：US12875619
申请日：2010-09-03
申请人： Peter A. Tass , Birgit Utako Barnikol , Christian Hauptmann , Karim Haroud , Jean-Christophe Roulet , Urban Schnell
发明人： Peter A. Tass , Birgit Utako Barnikol , Christian Hauptmann , Karim Haroud , Jean-Christophe Roulet , Urban Schnell
IPC分类号： A61N1/18 , G02C11/04 , A61B5/00
CPC分类号： A61M21/00 , A61M2021/0044 , A61M2205/332 , A61M2205/3569 , A61M2230/10 , A61M2230/16 , A61M2230/30 , A61M2230/40 , A61M2230/60 , A61M2230/65 , A61N5/0618 , A61N5/0622 , A61N2005/0648 , A61N2005/073
摘要： A device and method for providing stimulation signals that reset the phase of the neuronal activity of neurons in a patient's brain. The device includes a control unit; and a stimulation unit that has a plurality of stimulation elements, and each stimulation element generates visual stimulation signals that reset the phase of the neuronal activity of the neurons when the signals are taken up via an eye of a patient and transmitted to neurons that are exhibiting a pathologically synchronous and oscillatory neuronal activity. The control unit is further capable of actuating the stimulation unit such that the stimulation elements generate the visual stimulation signals with a time offset in respect to one another and/or with differing phase and/or with differing polarity.
摘要翻译：一种用于提供刺激信号的装置和方法，所述刺激信号重置患者大脑中神经元的神经元活动的相位。该装置包括一个控制单元; 以及具有多个刺激元件的刺激单元，并且每个刺激元件产生视觉刺激信号，当信号经由患者的眼睛被摄取并且被传送到正在展现的神经元时，该视觉刺激信号重置神经元的神经元活动的相位病理同步和振荡的神经元活动。控制单元还能够致动刺激单元，使得刺激元件产生相对于彼此和/或具有不同相位和/或具有不同极性的时间偏移的视觉刺激信号。

4. 发明授权

US07974698B2 Method and apparatus for desynchronization of neural brain activity 有权
标题翻译：神经脑活动失步的方法和装置
公开(公告)号：US07974698B2
公开(公告)日：2011-07-05
申请号：US11441251
申请日：2006-05-26
申请人： Peter Tass , Oleksandr Popovych , Christian Hauptmann
发明人： Peter Tass , Oleksandr Popovych , Christian Hauptmann
IPC分类号： A61N1/36
CPC分类号： A61N1/36135 , A61N1/36082 , A61N1/36103
摘要： The invention relates to an apparatus for desynchronization of neural illness-synchronous brain activity in which the activities in at least two subareas of a brain area or at least two functionally associated brain areas are stimulated by means of at least two electrodes. In the case of a person with an illness, desynchronization therapy suppresses symptoms in the relevant neuron population. The feedback stimulation signal, that is to say the measured, time-delayed and process neural activity, is used as an individual stimulus. This results in self-regulated, demand control of the amplitude of the stimulation signal, thus minimizing the intensity of the stimulation stimuli automatically after successful desynchronization. The apparatus has at least two stimulation electrodes and at least one sensor, which are driven by a controller such that they result in desynchronization in their local environment.
摘要翻译：本发明涉及一种用于神经疾病同步脑活动的同步化的装置，其中通过至少两个电极刺激脑区域或至少两个功能相关的脑区域的至少两个子区域中的活动。在患有疾病的人的情况下，去同步治疗可抑制相关神经元群体的症状。反馈刺激信号，也就是说测量的，时间延迟的和过程的神经活动被用作个体刺激。这导致刺激信号的幅度的自我调节，需求控制，从而在成功的失步之后自动最小化刺激刺激的强度。该装置具有至少两个刺激电极和至少一个传感器，其由控制器驱动，使得它们导致其局部环境中的不同步。

5. 发明申请

US20060276853A1 Method and apparatus for desynchronization of neural brain activity 有权
标题翻译：神经脑活动失步的方法和装置
公开(公告)号：US20060276853A1
公开(公告)日：2006-12-07
申请号：US11441251
申请日：2006-05-26
申请人： Peter Tass , Oleksandr Popovych , Christian Hauptmann
发明人： Peter Tass , Oleksandr Popovych , Christian Hauptmann
IPC分类号： A61N1/36
CPC分类号： A61N1/36135 , A61N1/36082 , A61N1/36103
摘要： The invention relates to an apparatus for desynchronization of neural, illness-synchronous brain activity in which, according to the invention, the activities in at least two subareas of a brain area or at least two functionally associated brain areas are stimulated by means of at least two electrodes, on the basis of which, in the case of a person with an illness, desynchronization surprisingly occurs in the relevant neuron population and the symptoms are suppressed. The feedback stimulation signal, that is to say the measured, time-delayed and process neural activity, is used as an individual stimulus. In consequence, this results in demand control, which is self-regulating according to the invention, of the amplitude of the stimulation signal thus minimizing the intensity of the stimulation stimuli automatically after successful desynchronization. For successful operation, the apparatus requires neither complex calibration nor control of the stimulation parameters and, instead, these can preferably be adapted and optimized by the additional controller. The apparatus has at least two stimulation electrodes (2) and at least one sensor (3), which are driven by a controller such that they result in desynchronization in their local environment.
摘要翻译：本发明涉及一种用于神经，疾病同步脑活动的同步化的装置，其中根据本发明，通过至少刺激至少两个脑区域或至少两个功能相关的脑区域的至少两个子区域中的活动两个电极，在一个病人的情况下，在相关的神经元群体中出乎意料地发生了同步，并且抑制了症状。反馈刺激信号，也就是说测量的，时间延迟的和过程的神经活动被用作个体刺激。因此，这导致根据本发明自我调节的需求控制，刺激信号的幅度因此在成功去同步之后自动最小化刺激刺激的强度。为了成功运行，该装置既不需要复杂的校准也不需要对刺激参数的控制，相反，这些可以优选地由附加控制器进行调整和优化。该装置具有至少两个刺激电极（2）和至少一个传感器（3），其由控制器驱动，使得它们导致其局部环境中的不同步。

6. 发明授权

US09302069B2 Device and method for visual stimulation 有权
标题翻译：视觉刺激的装置和方法
公开(公告)号：US09302069B2
公开(公告)日：2016-04-05
申请号：US12875619
申请日：2010-09-03
申请人： Peter A. Tass , Birgit Utako Barnikol , Christian Hauptmann , Karim Haroud , Jean-Christophe Roulet , Urban Schnell
发明人： Peter A. Tass , Birgit Utako Barnikol , Christian Hauptmann , Karim Haroud , Jean-Christophe Roulet , Urban Schnell
IPC分类号： A61N1/18 , A61M21/00 , A61N5/06 , A61N5/073
CPC分类号： A61M21/00 , A61M2021/0044 , A61M2205/332 , A61M2205/3569 , A61M2230/10 , A61M2230/16 , A61M2230/30 , A61M2230/40 , A61M2230/60 , A61M2230/65 , A61N5/0618 , A61N5/0622 , A61N2005/0648 , A61N2005/073
摘要： A device and method for providing stimulation signals that reset the phase of the neuronal activity of neurons in a patient's brain. The device includes a control unit; and a stimulation unit that has a plurality of stimulation elements, and each stimulation element generates visual stimulation signals that reset the phase of the neuronal activity of the neurons when the signals are taken up via an eye of a patient and transmitted to neurons that are exhibiting a pathologically synchronous and oscillatory neuronal activity. The control unit is further capable of actuating the stimulation unit such that the stimulation elements generate the visual stimulation signals with a time offset in respect to one another and/or with differing phase and/or with differing polarity.
摘要翻译：一种用于提供刺激信号的装置和方法，所述刺激信号重置患者大脑中神经元的神经元活动的相位。该装置包括一个控制单元; 以及具有多个刺激元件的刺激单元，并且每个刺激元件产生视觉刺激信号，当信号经由患者的眼睛被摄取并且被传送到正在展现的神经元时，该视觉刺激信号重置神经元的神经元活动的相位病理同步和振荡的神经元活动。控制单元还能够致动刺激单元，使得刺激元件产生具有相对于彼此和/或具有不同相位和/或具有不同极性的时间偏移的视觉刺激信号。

7. 发明授权

US08000796B2 Method and device for decoupling and/or desynchronizing neural brain activity 有权
标题翻译：用于去神经和/或去同步神经脑活动的方法和装置
公开(公告)号：US08000796B2
公开(公告)日：2011-08-16
申请号：US11604284
申请日：2006-11-27
申请人： Peter Tass , Oleksandr Popovych , Christian Hauptmann , Valerii Krachkovskyi
发明人： Peter Tass , Oleksandr Popovych , Christian Hauptmann , Valerii Krachkovskyi
IPC分类号： A61N1/372
CPC分类号： A61N1/36082 , A61B5/0006 , A61B5/048 , A61B5/4082 , A61B5/7225 , A61B5/726 , A61N1/0551 , A61N1/06 , A61N1/36067 , A61N1/36135 , A61N1/36146
摘要： A device for decoupling and/or desynchronizing neural, pathologically synchronous brain activity, in which, the activities in a partial region of a brain area or a functionally associated brain area are stimulated by means of an electrode, resulting in decoupling and desynchronizing the affected neuron population from the pathological area and suppression of the symptoms in a patient. In an alternative embodiment of the device, the pathologically synchronous brain activity due to the disease is desynchronized which also leads to the symptoms being suppressed. The device has a stimulation electrode and at least one sensor which are driven by a control system in such a manner that they produce decoupling and/or desynchronization in their local environment.
摘要翻译：用于解耦和/或同步神经，病理同步脑活动的装置，其中通过电极刺激脑区域或功能相关的脑区域的部分区域中的活动，导致受影响的神经元的去耦和失同步病理区域的人群和患者症状的抑制。在该装置的替代实施方案中，由于疾病引起的病理同步脑活动是不同步的，这也导致症状被抑制。该装置具有刺激电极和由控制系统驱动的至少一个传感器，使得它们在其局部环境中产生解耦和/或去同步。

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