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1. 发明申请

US20080102192A1 Masking Method for Coating a Microneedle Array 有权
标题翻译：用于涂覆微针阵列的掩模方法
公开(公告)号：US20080102192A1
公开(公告)日：2008-05-01
申请号：US11718737
申请日：2005-11-18
申请人： Peter R. Johnson , Maria R. Emery , James T. Wolter , Jennifer E. Raeder-Devens , Daniel c. Duan , Moses M. David , Hye-Ok Choi
发明人： Peter R. Johnson , Maria R. Emery , James T. Wolter , Jennifer E. Raeder-Devens , Daniel c. Duan , Moses M. David , Hye-Ok Choi
IPC分类号： A61L33/00
CPC分类号： A61K9/0021 , A61M37/0015 , A61M2037/0046 , A61M2037/0053
摘要： A method of coating a microneedle array comprising: providing a microneedle array having a substrate and at least one needle; providing a removable masking layer on the microneedle array such that the substrate is at least partially covered by the masking layer and the at least one needle remains at least partially exposed; and applying a coating material to at least a portion of the exposed portion of the microneedle array.
摘要翻译：一种涂覆微针阵列的方法，包括：提供具有基底和至少一个针的微针阵列; 在所述微针阵列上提供可移除的掩模层，使得所述基底至少部分地被所述掩蔽层覆盖，并且所述至少一个针保持至少部分地暴露; 以及将涂层材料施加到所述微针阵列的暴露部分的至少一部分。

2. 发明授权

US07846488B2 Masking method for coating a microneedle array 有权
标题翻译：用于涂布微针阵列的掩模方法
公开(公告)号：US07846488B2
公开(公告)日：2010-12-07
申请号：US11718737
申请日：2005-11-18
申请人： Peter R. Johnson , Marla R. Emery , James T. Wolter , Jennifer E. Raeder-Devens , Daniel C. Duan , Moses M. David , Hye-Ok Choi
发明人： Peter R. Johnson , Marla R. Emery , James T. Wolter , Jennifer E. Raeder-Devens , Daniel C. Duan , Moses M. David , Hye-Ok Choi
IPC分类号： A61L33/00
CPC分类号： A61K9/0021 , A61M37/0015 , A61M2037/0046 , A61M2037/0053
摘要： A method of coating a microneedle array comprising: providing a microneedle array having a substrate and at least one needle; providing a removable masking layer on the microneedle array such that the substrate is at least partially covered by the masking layer and the at least one needle remains at least partially exposed; and applying a coating material to at least a portion of the exposed portion of the microneedle array.
摘要翻译：一种涂覆微针阵列的方法，包括：提供具有基底和至少一个针的微针阵列; 在所述微针阵列上提供可移除的掩模层，使得所述基底至少部分地被所述掩蔽层覆盖，并且所述至少一个针保持至少部分地暴露; 以及将涂层材料施加到所述微针阵列的暴露部分的至少一部分。

3. 发明申请

US20080294116A1 Coatable Compositions, Coatings Derived Therefrom and Microarrays Having Such Coatings 有权
标题翻译：可涂覆组合物，衍生自其的涂层和具有这种涂层的微阵列
公开(公告)号：US20080294116A1
公开(公告)日：2008-11-27
申请号：US12092733
申请日：2006-11-17
申请人： James T. Wolter , John K. Simons , Peter R. Johnson
发明人： James T. Wolter , John K. Simons , Peter R. Johnson
IPC分类号： A61M5/32 , A61K39/00
CPC分类号： A61K9/0021 , A61K47/12 , A61K47/26 , A61K47/32 , A61M37/0015 , A61M2037/0023 , A61M2037/0046
摘要： Coatable compositions and coatings derived from the coatable compositions, and microarrays comprising such coatings are described. In one aspect, the invention provides a microarray comprising: a plurality of microneedles extending from a support substrate; a coating deposited on at least one of the plurality of microneedles, the coating comprising an active agent and a biological salt. In another aspect, the invention provides a coatable composition, comprising: active agent; a biological salt; and solvent. In still another aspect, the invention provides a dried coating coated on a microneedle, the coating comprising: an active agent; and a biological salt.
摘要翻译：描述了可涂覆组合物和衍生自可涂覆组合物的涂层，以及包含这种涂层的微阵列。一方面，本发明提供了一种微阵列，包括：多个从支撑基板延伸的微针; 沉积在所述多个微针中的至少一个上的涂层，所述涂层包含活性剂和生物盐。另一方面，本发明提供一种可涂覆组合物，其包含：活性剂; 生物盐; 和溶剂。另一方面，本发明提供涂覆在微针上的干燥涂层，所述涂层包含：活性剂; 和生物盐。

4. 发明授权

US08900180B2 Coatable compositions, coatings derived therefrom and microarrays having such coatings 有权
标题翻译：可涂覆组合物，由其衍生的涂层和具有这种涂层的微阵列
公开(公告)号：US08900180B2
公开(公告)日：2014-12-02
申请号：US12092733
申请日：2006-11-17
申请人： James T. Wolter , John K. Simons , Peter R. Johnson
发明人： James T. Wolter , John K. Simons , Peter R. Johnson
IPC分类号： A61B17/20 , A61K9/00 , A61M37/00 , A61K47/26 , A61K47/32 , A61K47/12
CPC分类号： A61K9/0021 , A61K47/12 , A61K47/26 , A61K47/32 , A61M37/0015 , A61M2037/0023 , A61M2037/0046
摘要： Coatable compositions and coatings derived from the coatable compositions, and microarrays comprising such coatings are described. In one aspect, the invention provides a microarray comprising: a plurality of microneedles extending from a support substrate; a coating deposited on at least one of the plurality of microneedles, the coating comprising an active agent and a biological salt. In another aspect, the invention provides a coatable composition, comprising: active agent; a biological salt; and solvent. In still another aspect, the invention provides a dried coating coated on a microneedle, the coating comprising: an active agent; and a biological salt.
摘要翻译：描述了可涂覆组合物和衍生自可涂覆组合物的涂层，以及包含这种涂层的微阵列。一方面，本发明提供了一种微阵列，包括：多个从支撑基板延伸的微针; 沉积在所述多个微针中的至少一个上的涂层，所述涂层包含活性剂和生物盐。另一方面，本发明提供一种可涂覆组合物，其包含：活性剂; 生物盐; 和溶剂。另一方面，本发明提供涂覆在微针上的干燥涂层，所述涂层包含：活性剂; 和生物盐。

5. 发明授权

US08039528B2 Method for the manufacture of pressure sensitive adhesives 有权
标题翻译：制造压敏粘合剂的方法
公开(公告)号：US08039528B2
公开(公告)日：2011-10-18
申请号：US11576931
申请日：2005-10-13
申请人： Dong-Wei Zhu , Cheryl L. Moore , James T. Wolter
发明人： Dong-Wei Zhu , Cheryl L. Moore , James T. Wolter
IPC分类号： C08F2/00 , C09B67/00
CPC分类号： C08F6/006 , C08L2205/02 , C08L2666/04 , C09J133/04
摘要： A method for the manufacture of an adhesive id described, comprising: (A) Providing an initial reaction product of a solution polymerization reaction, the initial reaction product comprising polymer, unreacted polymerizable reactant, non-polymerizable material, and solvent; and (B) Purifying the initial reaction product by adding an oxidizing agent and a reducing agent to the initial reaction product and allowing the unreacted polymerizable reactant in the initial reaction product to further react, thereby providing a second reaction product comprising additional polymer and a lower level of unreacted polymerizable reactant than was present in the initial reaction product. Optionally, the method of the invention may further comprise: Precipitating the polymer from the second reaction product to provide a precipitated polymer, and separating the precipitated polymer from the remainder of the second reaction product, the precipitated polymer comprising a lower level of non-polymerizable material or unreacted polymerizable reactant or both non-polymerizable material and unreacted polymerizable reactant than was present in the second reaction product.
摘要翻译：一种制造所述粘合剂的方法，包括：（A）提供溶液聚合反应的初始反应产物，包含聚合物的初始反应产物，未反应的可聚合反应物，不可聚合材料和溶剂; 和（B）通过向初始反应产物中加入氧化剂和还原剂并使初始反应产物中的未反应的可聚合反应物进一步反应来纯化初始反应产物，由此提供第二反应产物，其包含另外的聚合物和较低的未反应的可聚合反应物的水平比初始反应产物中存在的水平高。任选地，本发明的方法还可以包括：从第二反应产物中沉淀聚合物以提供沉淀的聚合物，并将沉淀的聚合物与第二反应产物的其余部分分离，沉淀的聚合物包含较低水平的不可聚合材料或未反应的可聚合反应物或两种不可聚合材料和未反应的可聚合反应物。

6. 发明授权

US08961477B2 Delivery of immune response modifier compounds 有权
标题翻译：递送免疫反应调节剂化合物
公开(公告)号：US08961477B2
公开(公告)日：2015-02-24
申请号：US10595073
申请日：2004-08-25
申请人： James T. Wolter , Ross M. Kedl
发明人： James T. Wolter , Ross M. Kedl
IPC分类号： A61M25/00 , A61K9/00 , A61K31/4745 , A61M37/00
CPC分类号： A61K9/0021 , A61K31/4745 , A61M37/0015 , A61M2037/0046
摘要： Delivery of one or more immune response modifiers (IRMs) across a biological barrier by the use of a microneedle device.
摘要翻译：通过使用微针装置在生物屏障上传递一种或多种免疫应答调节剂（IRM）。

7. 发明申请

US20090018274A1 METHOD FOR THE MANUFACTURE OF PRESSURE SENSITIVE ADHESIVES 有权
标题翻译：压力敏感性粘合剂的制造方法
公开(公告)号：US20090018274A1
公开(公告)日：2009-01-15
申请号：US11576931
申请日：2006-09-21
申请人： Dong-Wei Zhu , Cheryl L. Moore , James T. Wolter
发明人： Dong-Wei Zhu , Cheryl L. Moore , James T. Wolter
IPC分类号： C08F8/06
CPC分类号： C08F6/006 , C08L2205/02 , C08L2666/04 , C09J133/04
摘要： A method for the manufacture of an adhesive id described, comprising: (A) Providing an initial reaction product of a solution polymerization reaction, the initial reaction product comprising polymer, unreacted polymerizable reactant, non-poly-merizable material, and solvent; and (B) Purifying the initial reaction product by adding an oxidizing agent and a reducing agent to the initial reaction product and allowing the unreacted polymerizable reactant in the initial reaction product to further react, thereby providing a second reaction product comprising additional polymer and a lower level of unreacted polymerizable reactant than was present in the initial reaction product. Optionally, the method of the invention may further comprise: Precipitating the polymer from the second reaction product to provide a precipitated polymer, and separating the precipitated polymer from the remainder of the second reaction product, the precipitated polymer comprising a lower level of non-polymerizable material or unreacted polymerizable reactant or both non-polymerizable material and unreacted polymerizable reactant than was present in the second reaction product.
摘要翻译：一种制造所述粘合剂的方法，包括：（A）提供溶液聚合反应的初始反应产物，包含聚合物的初始反应产物，未反应的可聚合反应物，非可聚合物质和溶剂; 和（B）通过向初始反应产物中加入氧化剂和还原剂并使初始反应产物中的未反应的可聚合反应物进一步反应来纯化初始反应产物，由此提供第二反应产物，其包含另外的聚合物和较低的未反应的可聚合反应物的水平比初始反应产物中存在的水平高。任选地，本发明的方法还可以包括：从第二反应产物中沉淀聚合物以提供沉淀的聚合物，并将沉淀的聚合物与第二反应产物的其余部分分离，沉淀的聚合物包含较低水平的不可聚合材料或未反应的可聚合反应物或两种不可聚合材料和未反应的可聚合反应物。

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