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1. 发明授权

US07858655B2 Drug preparation comprising α-lipoic acid, ambroxol and/or inhibitors of the angiotensin-converting enzyme (ACE) and its use for the treatment of neurodegenerative diseases 失效
标题翻译：包含α-硫辛酸，氨溴索和/或血管紧张素转化酶（ACE）抑制剂及其用于治疗神经变性疾病的药物制剂
公开(公告)号：US07858655B2
公开(公告)日：2010-12-28
申请号：US10764676
申请日：2004-01-26
申请人： Peter Röhnert , Frank Striggow , Klaus Reymann , Siegfried Ansorge , Michael Täger , Ulrich Schröder
发明人： Peter Röhnert , Frank Striggow , Klaus Reymann , Siegfried Ansorge , Michael Täger , Ulrich Schröder
IPC分类号： A61K31/40
CPC分类号： A61K45/06
摘要： The present invention concerns the use of Provided is a drug composition and a method for using the composition for the prevention and the therapy of neurodegenerative diseases. The combination comprises at least two of the following substances: α-lipoic acid; ambroxol and one or several inhibitor(s) of the angiotension-converting enzyme (ACE).
摘要翻译：本发明涉及使用本发明提供的药物组合物和使用该组合物预防和治疗神经变性疾病的方法。该组合物包含至少两种以下物质：α-硫辛酸; 氨溴索和血管紧张素转换酶（ACE）的一种或几种抑制剂。

2. 发明申请

US20070037785A1 Novel dipeptidyl peptidase IV inhibitors used for functionally influencing different cells and treating immunological, infammatory, neuronal, and other diseases 审中-公开
标题翻译：用于功能影响不同细胞和治疗免疫，炎症，神经元和其他疾病的新型二肽基肽酶IV抑制剂
公开(公告)号：US20070037785A1
公开(公告)日：2007-02-15
申请号：US10575883
申请日：2004-10-15
申请人： Siegfried Ansorge , Ute Bank , Karsten Nordhoff , Michael Taeger , Frank Striggow
发明人： Siegfried Ansorge , Ute Bank , Karsten Nordhoff , Michael Taeger , Frank Striggow
IPC分类号： A61K31/55 , A61K31/397 , A61K31/519 , A61K31/538 , A61K31/5377 , A61K31/497 , A61K31/506 , A61K31/4745 , A61K31/473 , A61K31/165
CPC分类号： C07C235/56 , C04B35/632 , C07C229/34 , C07C243/28 , C07C251/80 , C07C251/86 , C07C255/61 , C07C259/14 , C07C271/28 , C07C311/08 , C07C311/19 , C07C311/29 , C07C323/60 , C07C327/48 , C07C2601/10 , C07C2603/74 , C07D205/08 , C07D213/82 , C07D225/02 , C07D401/12 , C07D405/12 , C07D417/12 , C07F9/6506
摘要： The present invention relates to substances capable of specifically inhibiting Gly-Pro-p-nitroanilide cleaving peptidases, for a use in the medical field. Furthermore, the invention relates to the use of at least one of such substances or of at least one pharmaceutical or cosmetic composition containing at least one such substance for a prophylaxis or a therapy of diseases, particularly for a prophylaxis and a therapy of diseases accompanied by an excessive immune response (autoimmune diseases, allergies, transplant rejections), of other chronic-inflammatory diseases, of neuronal diseases and cerebral damage, of skin diseases (inter alia acne, psoriasis), of tumor diseases and of specific virus infections (inter alia SARS).
摘要翻译：本发明涉及能够特异性抑制Gly-Pro-对硝基苯胺裂解肽酶的物质，用于医疗领域。此外，本发明涉及至少一种这样的物质或至少一种含有至少一种这样的物质的药物或化妆品组合物用于预防或治疗疾病，特别是用于预防和治疗伴随着其他慢性炎性疾病，神经元疾病和脑损伤，皮肤病（尤其是痤疮，牛皮癣），肿瘤疾病和特定病毒感染（特别是其他疾病）的过度免疫应答（自身免疫疾病，过敏，移植排斥） SARS）。

3. 发明申请

US20120258960A1 NOVEL MULTIFUNCTIONAL PEPTIDASE INHIBITORS, ESPECIALLY FOR MEDICAL USE 审中-公开
标题翻译：新型多功能肽抑制剂，特别适用于医疗用途
公开(公告)号：US20120258960A1
公开(公告)日：2012-10-11
申请号：US13393748
申请日：2010-08-26
申请人： Siegfried Ansorge , Ute Bank , Karsten Nordhoff , Peter Roehnert , Sofia Stefin , Frank Striggow , Michael Taeger
发明人： Siegfried Ansorge , Ute Bank , Karsten Nordhoff , Peter Roehnert , Sofia Stefin , Frank Striggow , Michael Taeger
IPC分类号： A61K31/165 , C07D295/192 , A61K31/495 , C07D277/04 , A61K31/426 , C07D243/08 , A61K31/551 , A61K8/42 , A61K8/49 , A61P37/00 , A61P9/10 , A61P25/00 , A61P17/00 , A61P35/00 , A61P37/06 , A61P31/12 , A61P3/10 , C07C237/20
CPC分类号： C07C237/20 , C07C237/22 , C07C271/20 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D213/56 , C07D239/26 , C07D263/24 , C07D277/04 , C07D295/192 , C07D333/24
摘要： The invention relates to compounds of the general formula (1) or the acid addition salts thereof with organic and/or inorganic acids; as well as to the use of the compounds of the general formula (1) in medicine.
摘要翻译：本发明涉及通式（1）的化合物或其与有机和/或无机酸的酸加成盐; 以及在药物中使用通式（1）的化合物。

4. 发明申请

US20070078130A1 Dual alanyl aminopeptidase and dipeptidyl peptidase iv inhibitors for functionally influencing different cells and for treating immunological inflammatory, neuronal and other diseases 失效
标题翻译：双丙氨酰氨基肽酶和二肽基肽酶iv抑制剂功能影响不同细胞和治疗免疫炎症，神经元和其他疾病
公开(公告)号：US20070078130A1
公开(公告)日：2007-04-05
申请号：US10575878
申请日：2004-10-15
申请人： Siegfried Ansorge , Ute Bank , Michael Taeger , Frank Striggow
发明人： Siegfried Ansorge , Ute Bank , Michael Taeger , Frank Striggow
IPC分类号： A61K31/5377 , A61K31/452 , C07D413/02 , C07D405/02
CPC分类号： C07C327/48 , C07C233/83 , C07C251/86 , C07D317/60 , C07D401/14 , C07D403/06 , C07D409/14 , C07D413/06 , C07D413/14
摘要： The present invention relates to substances capable of specifically inhibiting Ala-p-nitroanilide-cleaving peptidases and Gly-Pro-p-nitroanilide-cleaving peptidases as well, for a use in the medical field. Furthermore, the invention relates to the use of at least one of such substances or of at least one pharmaceutical or cosmetic composition containing at least one such substance for a prophylaxis or a therapy of diseases, particularly for a prophylaxis and a therapy of diseases accompanied by an excessive immune response (autoimmune diseases, allergies, transplant rejections), of other chronic-inflammatory diseases, of neuronal diseases and cerebral damage, of skin diseases (inter alia acne, psoriasis), of tumor diseases and of specific virus infections (inter alia SARS).
摘要翻译：本发明涉及能够特异性抑制丙氨酸对硝基苯胺切割肽酶和Gly-Pro-对硝基苯胺切割肽酶的物质，用于医疗领域。此外，本发明涉及至少一种这样的物质或至少一种含有至少一种这样的物质的药物或化妆品组合物用于预防或治疗疾病，特别是用于预防和治疗伴随着其他慢性炎性疾病，神经元疾病和脑损伤，皮肤病（尤其是痤疮，牛皮癣），肿瘤疾病和特定病毒感染（特别是其他疾病）的过度免疫应答（自身免疫疾病，过敏，移植排斥） SARS）。

5. 发明申请

US20070037752A1 Novel alanyl-amino peptidase inhibitors for functionally influencing different cells and treating immunological, inflammatory, neuronal, and other diseases 审中-公开
标题翻译：用于功能影响不同细胞和治疗免疫，炎症，神经元和其他疾病的新型丙氨酰 - 氨基肽酶抑制剂
公开(公告)号：US20070037752A1
公开(公告)日：2007-02-15
申请号：US10575882
申请日：2004-10-15
申请人： Siegfried Ansorge , Ute Bank , Karsten Nordhoff , Michael Taeger , Frank Striggow
发明人： Siegfried Ansorge , Ute Bank , Karsten Nordhoff , Michael Taeger , Frank Striggow
IPC分类号： A61K38/06 , A61K31/655 , A61K31/55 , A61K31/5415 , A61K31/5377 , A61K31/53 , A61K31/522 , A61K31/407 , A61K31/4439 , A61K31/4152
CPC分类号： C07C327/48 , C07C259/06 , C07C317/44 , C07C325/02 , C07C2601/10 , C07C2601/14 , C07D207/46 , C07D221/14 , C07D233/90 , C07D241/52 , C07D253/06 , C07D257/04 , C07D261/20 , C07D307/46 , C07D323/00 , C07D333/36 , C07D339/08 , C07D405/06 , C07D405/12 , C07D413/12 , C07D413/14 , C07D487/04 , C07D513/04 , C07F9/5333
摘要： The invention relates to substances which specifically inhibit peptidases splitting ala-p-nitroanilide for use in medicine. The invention further relates to the use of at least one such substance or of a pharmaceutical or cosmetic composition containing at least one such substance for the prophylaxis and therapy of diseases, in particular the prophylaxis and therapy of diseases with an overshooting immune response (autoimmune diseases, allergies and transplant rejections), of other chronic inflammatory diseases, neuronal diseases and brain damages, skin diseases (acne and psoriasis, among others), tumor diseases and special virus infections (including SARS).
摘要翻译：本发明涉及特异性抑制肽酶裂解α-对硝基苯胺以用于药物的物质。本发明还涉及至少一种此类物质或含有至少一种此类物质的药物或化妆品组合物用于预防和治疗疾病，特别是预防和治疗具有过度免疫应答的疾病（自身免疫性疾病，过敏和移植排斥），其他慢性炎性疾病，神经元疾病和脑损伤，皮肤疾病（痤疮和牛皮癣等），肿瘤疾病和特殊病毒感染（包括SARS）。

6. 发明授权

US08263636B2 Dual alanyl aminopeptidase and dipeptidyl peptidase iv inhibitors for functionally influencing different cells and for treating immunological inflammatory, neuronal and other diseases 失效
标题翻译：双丙氨酰氨基肽酶和二肽基肽酶iv抑制剂功能影响不同细胞和治疗免疫炎症，神经元和其他疾病
公开(公告)号：US08263636B2
公开(公告)日：2012-09-11
申请号：US10575878
申请日：2004-10-15
申请人： Siegfried Ansorge , Ute Bank , Karsten Nordhoff , Michael Taeger , Frank Striggow
发明人： Siegfried Ansorge , Ute Bank , Karsten Nordhoff , Michael Taeger , Frank Striggow
IPC分类号： A61K31/4045 , C07D209/08
CPC分类号： C07C327/48 , C07C233/83 , C07C251/86 , C07D317/60 , C07D401/14 , C07D403/06 , C07D409/14 , C07D413/06 , C07D413/14
摘要： The present invention relates to substances capable of specifically inhibiting Ala-p-nitroanilide-cleaving peptidases and Gly-Pro-p-nitroanilide-cleaving peptidases as well, for a use in the medical field. Furthermore, the invention relates to the use of at least one of such substances or of at least one pharmaceutical or cosmetic composition containing at least one such substance for a prophylaxis or a therapy of diseases, particularly for a prophylaxis and a therapy of diseases accompanied by an excessive immune response (autoimmune diseases, allergies, transplant rejections), of other chronic-inflammatory diseases, of neuronal diseases and cerebral damage, of skin diseases (inter alia acne, psoriasis), of tumor diseases and of specific virus infections (inter alia SARS).
摘要翻译：本发明涉及能够特异性抑制丙氨酸对硝基苯胺切割肽酶和Gly-Pro-对硝基苯胺切割肽酶的物质，用于医疗领域。此外，本发明涉及至少一种这样的物质或至少一种含有至少一种这样的物质的药物或化妆品组合物用于预防或治疗疾病，特别是用于预防和治疗伴随着其他慢性炎性疾病，神经元疾病和脑损伤，皮肤病（尤其是痤疮，牛皮癣），肿瘤疾病和特定病毒感染（特别是其他疾病）的过度免疫应答（自身免疫疾病，过敏，移植排斥） SARS）。

7. 发明申请

US20070005169A1 Device and method for automatically carrying out laboratory procedure steps 审中-公开
标题翻译：自动执行实验室程序步骤的装置和方法
公开(公告)号：US20070005169A1
公开(公告)日：2007-01-04
申请号：US10573448
申请日：2004-09-24
申请人： Peter Röhnert , Frank Striggow
发明人： Peter Röhnert , Frank Striggow
IPC分类号： G06F19/00
CPC分类号： G01N35/028 , G01N1/31 , G01N35/0099 , G01N2035/00326 , G01N2035/0422 , G01N2035/0467
摘要： The present invention relates to a device for automatically carrying out laboratory operations on cell or tissue samples, which comprises a plurality of modular stations, each of which carries out at least one operation in a total sequence of operations, and at least one support unit for transporting sample containers to and between the stations, the device having at least one station for automatically changing liquid media in the sample containers.
摘要翻译：本发明涉及一种用于自动执行细胞或组织样本的实验室操作的装置，其包括多个模块化站，每个模块站在整个操作序列中执行至少一个操作，以及至少一个支撑单元，用于将样品容器运送到工位之间和之间，该装置具有至少一个用于在样品容器中自动改变液体介质的工位。

8. 发明授权

US09527894B2 Polymutant tau protein variants and their use for recapitulating human tauopathies 有权
标题翻译： Polymutant tau蛋白变体及其用于重述人类tau蛋白病的用途
公开(公告)号：US09527894B2
公开(公告)日：2016-12-27
申请号：US14114036
申请日：2011-04-28
申请人： Andrea Robitzki , Heinz-Georg Jahnke , Dana Krinke , Frank Striggow , Till Mack
发明人： Andrea Robitzki , Heinz-Georg Jahnke , Dana Krinke , Frank Striggow , Till Mack
IPC分类号： C07K14/47
CPC分类号： C07K14/47 , C07K14/4711
摘要： Disclosed herein are methods for identifying an agent for treating or preventing neurogenerative disease and to methods for recapitulating tauopathies using a tau protein that includes at least four different mutations that cause the condition frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), and to nucleic acids encoding the tau protein.
摘要翻译：本文公开了用于鉴定用于治疗或预防神经生殖疾病的药剂的方法和使用tau蛋白重复tau蛋白病的方法，所述tau蛋白包括引起与染色体17（FTDP-17）相关的额颞痴呆和帕金森综合征的至少四种不同突变，以及涉及编码tau蛋白的核酸。

9. 发明申请

US20080118475A1 Model System for Testing the Efficacy of Pharmaceutical Preparation on Inflammatory Processes in the Nervous System 审中-公开
标题翻译：用于测试药物制剂对炎症过程在神经系统中的功效的模型系统
公开(公告)号：US20080118475A1
公开(公告)日：2008-05-22
申请号：US11664584
申请日：2005-09-22
申请人： Frank Striggow , Till Mack , Peter Roehnert
发明人： Frank Striggow , Till Mack , Peter Roehnert
IPC分类号： A61K35/30 , C12N5/06 , C12N5/08
CPC分类号： C12N5/0622 , C12N2503/02
摘要： Live cells obtained from a mammalian tissue or organ. The cells are maintained ex vivo on a porous membrane having a pore size of ≧0.02 μm at a physiologically acceptable pH, in the presence of a culture gas, in culture and in a culture medium. The inter-neighbour relationships and the signal transduction between the cells are retained.
摘要翻译：从哺乳动物组织或器官获得的活细胞。在生理学上可接受的pH下，在培养气体存在下，在培养基和培养基中，将细胞离体维持在孔径>0.02μm的多孔膜上。保持细胞间的邻居关系和信号转导。

10. 发明授权

US07645461B2 Method of treating cerebral ischemia with hydrogenation products of frankincense extracts 失效
标题翻译：用乳香提取物氢化产物治疗脑缺血的方法
公开(公告)号：US07645461B2
公开(公告)日：2010-01-12
申请号：US10549323
申请日：2004-03-18
申请人： Frank Striggow , Werner Schmidt , Till Mack
发明人： Frank Striggow , Werner Schmidt , Till Mack
IPC分类号： A61K36/00 , A61K31/00 , A01K26/00 , A01N61/00
CPC分类号： A61K31/19 , A61K36/324
摘要： The invention relates to the use of the hydrogenation products of frankincense (olibanum), its hydrogenated ingredients as well as physiologically acceptable salts and derivatives thereof and hydrogenated frankincense extracts for the production of a medicament for the prophylactic and/or therapeutic treatment of cerebral ischemia, cranial/brain trauma and/or Alzheimer's disease. The use of frankincense, frankincense extract, substances contained in frankincense, their physiologically acceptable salts, their derivatives and the physiological salts thereof, pure boswellic acids, tirucallic acids or other triterpenes, their physiologically acceptable salts, derivatives of the salts thereof for the production of a medicament for the prophylactic and/or therapeutic treatment of cerebral ischemia and/or cranial/brain trauma is also provided according to the invention.
摘要翻译：本发明涉及乳香（olibanum）的氢化产物，其氢化成分及其生理上可接受的盐和衍生物以及氢化乳香提取物在制备用于预防和/或治疗性脑缺血的药物中的用途，颅脑/脑创伤和/或阿尔茨海默氏病。使用乳香，乳香提取物，乳香中含有的物质，其生理学上可接受的盐，其衍生物及其生理盐，纯的保乳酸，铁金属酸或其他三萜烯，其生理学上可接受的盐，其盐的衍生物，用于生产根据本发明还提供了用于预防和/或治疗脑缺血和/或颅/脑创伤的药物。

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