专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09527894B2 Polymutant tau protein variants and their use for recapitulating human tauopathies 有权
标题翻译： Polymutant tau蛋白变体及其用于重述人类tau蛋白病的用途
公开(公告)号：US09527894B2
公开(公告)日：2016-12-27
申请号：US14114036
申请日：2011-04-28
申请人： Andrea Robitzki , Heinz-Georg Jahnke , Dana Krinke , Frank Striggow , Till Mack
发明人： Andrea Robitzki , Heinz-Georg Jahnke , Dana Krinke , Frank Striggow , Till Mack
IPC分类号： C07K14/47
CPC分类号： C07K14/47 , C07K14/4711
摘要： Disclosed herein are methods for identifying an agent for treating or preventing neurogenerative disease and to methods for recapitulating tauopathies using a tau protein that includes at least four different mutations that cause the condition frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), and to nucleic acids encoding the tau protein.
摘要翻译：本文公开了用于鉴定用于治疗或预防神经生殖疾病的药剂的方法和使用tau蛋白重复tau蛋白病的方法，所述tau蛋白包括引起与染色体17（FTDP-17）相关的额颞痴呆和帕金森综合征的至少四种不同突变，以及涉及编码tau蛋白的核酸。

2. 发明申请

US20140162306A1 POLYMUTANT TAU PROTEIN VARIANTS AND THEIR USE FOR RECAPITULATING HUMAN TAUOPATHIES 有权
标题翻译：聚合酶蛋白变异体及其用于记录人类胎盘血症的用途
公开(公告)号：US20140162306A1
公开(公告)日：2014-06-12
申请号：US14114036
申请日：2011-04-28
申请人： Andrea Robitzki , Heinz-Georg Jahnke , Dana Krinke , Frank Striggow , Till Mack
发明人： Andrea Robitzki , Heinz-Georg Jahnke , Dana Krinke , Frank Striggow , Till Mack
IPC分类号： C07K14/47
CPC分类号： C07K14/47 , C07K14/4711
摘要： The present invention relates to a tau protein comprising at least four different mutations selected from group consisting of mutations which cause the condition frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), and to nucleic acids encoding said tau protein. The invention further pertains to methods for identifying an agent for treating or preventing neurogenerative disease, and to methods for recapitulating tauopathies.
摘要翻译：本发明涉及包含至少四种不同突变的tau蛋白，所述突变选自引起与染色体17（FTDP-17）相关的额颞叶痴呆和帕金森综合征的突变，以及编码所述tau蛋白的核酸。本发明还涉及用于鉴定用于治疗或预防神经生殖疾病的药物的方法，以及用于重述tau蛋白病的方法。

3. 发明申请

US20140346058A1 DEVICE AND METHOD FOR PARALLEL RECORDING OF IMPEDANCE SPECTRA AND FIELD POTENTIAL 有权
标题翻译：阻抗谱和场势平行记录的装置和方法
公开(公告)号：US20140346058A1
公开(公告)日：2014-11-27
申请号：US14351777
申请日：2012-08-13
申请人： Andrea Robitzki , Heinz-Georg Jahnke , Ronny Azendorf
发明人： Andrea Robitzki , Heinz-Georg Jahnke , Ronny Azendorf
IPC分类号： G01N27/327
CPC分类号： G01N27/327 , G01N33/4836 , G01N33/48707 , G01N33/48728
摘要： The present invention relates to a device and a method for parallel recording of impedance spectra and field potential of cells in vitro.
摘要翻译：本发明涉及用于在体外并行记录细胞的阻抗谱和场电位的装置和方法。

4. 发明授权

US09551681B2 Device and method for parallel recording of impedance spectra and field potential 有权
标题翻译：并联记录阻抗谱和场电位的装置和方法
公开(公告)号：US09551681B2
公开(公告)日：2017-01-24
申请号：US14351777
申请日：2012-08-13
申请人： Andrea Robitzki , Heinz-Georg Jahnke , Ronny Azendorf
发明人： Andrea Robitzki , Heinz-Georg Jahnke , Ronny Azendorf
IPC分类号： G01N27/327 , G01N33/487 , G01N33/483
CPC分类号： G01N27/327 , G01N33/4836 , G01N33/48707 , G01N33/48728
摘要： The present invention relates to a device and a method for parallel recording of impedance spectra and field potential of cells in vitro.
摘要翻译：本发明涉及在体外并行记录细胞的阻抗谱和场电位的装置和方法。

5. 发明授权

US07709246B2 Device and method for detecting bioelectric signals from electrophysiologically active regions in spheroids 失效
标题翻译：用于检测球状体中电生理活性区域的生物电信号的装置和方法
公开(公告)号：US07709246B2
公开(公告)日：2010-05-04
申请号：US10487711
申请日：2002-08-20
申请人： Hagen Thielecke , Andrea Robitzki
发明人： Hagen Thielecke , Andrea Robitzki
IPC分类号： C12M1/34 , C12Q1/00
CPC分类号： G01N15/1475 , C12M41/46 , G01N15/1227 , G01N2015/1254 , G01N2015/1263
摘要： Disclosed is a device for detecting bioelectric signals from spheroids comprising a measuring chamber having a measuring chamber wall which encloses a volume, which is open at least at one side, is composed of an electrically non-conducting material, and has, in at least one measuring region, an inner cross section, which corresponds as far as possible to the largest cross section of a spheroid, comprising at least a number of electrodes which are disposed in a common plane inside said measuring chamber wall and each electrode has a freely accessible electrode surface which is oriented towards the measuring region, and comprising an impedance measuring arrangement which is connected to the electrodes. The device and the method can be used to test substances in 3D biological in-vitro (three-dimensional) cell aggregates.
摘要翻译：公开了一种用于检测来自球体的生物电信号的装置，包括具有测量室壁的测量室，所述测量室围绕至少在一侧开放的体积，该体积由不导电材料构成，并且在至少一个测量区域，尽可能对应于球状体的最大横截面的内部横截面，包括至少多个电极，所述至少一些电极设置在所述测量室壁内部的公共平面中，并且每个电极具有可自由访问的电极表面朝向测量区域定向，并且包括连接到电极的阻抗测量装置。该装置和方法可用于测试3D生物体外（三维）细胞聚集体中的物质。

6. 发明申请

US20130217064A1 Integrated cultivation and measurement device for label-free detection and classification of cellular alterations, in particular for generation and characterisation of cell-spheroids, components and uses thereof 审中-公开
标题翻译：用于无标记检测和细胞变异分类的综合培养和测量装置，特别是用于细胞球体的产生和表征，其组分和用途
公开(公告)号：US20130217064A1
公开(公告)日：2013-08-22
申请号：US13576957
申请日：2011-02-02
申请人： Andrea Robitzki , Randy Kurz
发明人： Andrea Robitzki , Randy Kurz
IPC分类号： G01N33/50
CPC分类号： G01N33/5088 , B01F11/0014 , B01L3/5027 , C12M23/12 , C12M25/08 , C12M33/08 , C12M41/46 , G01N33/48735
摘要： The invention relates to an integrated cultivation and measurement device for label-free detection and classification of cellular alterations, in particular for generation and characterisation of cell-spheroids and monitoring the condition of the cell-spheroids in real time, comprising a) a mounting device for a cultivation chamber plate, b) an amplifier board linked with the contacts for the microelectrodes in the mounting device, c) a rotary shaker, on which the amplifier board and the mounting device for the cultivation chamber plate are placed, and d) a control unit, that is linked with the amplifier board and the rotary shaker, wherein the control unit allows recording, analyzing of data and controlling of the movement of the rotary shaker. The cultivation chamber plate has several culture reservoirs, wherein the bottom of each culture reservoir forms a microcavity and each microcavity features microelectrodes on the microcavity walls. The mounting device has contacts for the microelectrodes. The invention advantageously allows the automated generation, cultivation and characterisation of spheroids, as well as the cultivation and characterisation of tissue probes.
摘要翻译：本发明涉及用于无标记检测和细胞变异分类的综合培养和测量装置，特别是用于细胞球体的产生和表征并实时监测细胞 - 球体的状况，包括：a）安装装置对于培养室板，b）与安装装置中用于微电极的触头相连的放大器板，c）旋转振动器，放大器板和用于培养室板的安装装置放置在其上，d）控制单元，其与放大器板和旋转振动器连接，其中控制单元允许记录，分析数据和控制旋转振动器的运动。培养室板有几个培养池，其中每个培养储存器的底部形成微腔，每个微腔在微腔壁上具有微电极。安装装置具有用于微电极的触点。本发明有利地允许球体的自动生成，培养和表征，以及组织探针的培养和表征。

7. 发明申请

US20060199173A1 Device and method for characterizing spheroids 审中-公开
标题翻译：用于表征球体的装置和方法
公开(公告)号：US20060199173A1
公开(公告)日：2006-09-07
申请号：US11401894
申请日：2006-04-12
申请人： Hagen Thielecke , Andrea Robitzki
发明人： Hagen Thielecke , Andrea Robitzki
IPC分类号： C12Q1/00
CPC分类号： G01N15/12 , G01N15/1218
摘要： The present invention relates to a device and a method for characterizing spheroids. The to-be-characterized spheroid is introduced into a tube of an electrically insulating material and with an inner diameter which is smaller than the diameter of the to-be-characterized spheroid in such a manner that the latter is in mechanical contact over the entire circumference with the inner wall of the electrically insulated tube. Electrodes are disposed on both sides of the spheroid in the tube. By means of these electrodes, a current flow can be generated through the spheroid and the resulting drop in voltage at the spheroid can be measured. The invented arrangement and the corresponding method permits producing an impedance spectrum of spheroids with high sensitivity, thereby realizing rapid and nondestructive characterization of spheroids.
摘要翻译：本发明涉及一种用于表征球体的装置和方法。要被表征的球体被引入电绝缘材料的管中，其内径小于被表征的球体的直径，使得后者在整个机械接触圆周与电绝缘管的内壁。电极设置在管中球状体的两侧。通过这些电极，可以通过球体产生电流，并且可以测量所得到的球状电压下降。本发明的装置和相应的方法允许以高灵敏度产生球体的阻抗谱，从而实现球体的快速和非破坏性表征。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式