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1. 发明授权

US07259142B2 Redox-stable, non-phosphorylated cyclic peptide inhibitors of SH2 domain binding to target protein, conjugates thereof, compositions and methods of synthesis and use 有权
标题翻译：与靶蛋白结合的SH2结构域的氧化还原稳定的非磷酸化环肽抑制剂，其结合物，组合物和合成和使用方法
公开(公告)号：US07259142B2
公开(公告)日：2007-08-21
申请号：US11224819
申请日：2005-09-13
申请人： Peter P Roller , Ya-Qui Long , Feng-Di T. Lung , C. Richter King , Dajun Yang , Johannes H. Voigt
发明人： Peter P Roller , Ya-Qui Long , Feng-Di T. Lung , C. Richter King , Dajun Yang , Johannes H. Voigt
IPC分类号： A61K38/12
CPC分类号： C07K7/06 , A61K38/00 , C07K7/56
摘要： A compound of formula: in which (i) aa1 is Adi and aa4 is Glu or (ii) each of aa1 and aa4 is Adi, L is sulfur, sulfoxide, oxygen or methylene, which compound (and its conjugates) bind to an SH2 domain in a protein comprising an SH2 domain, is non-phosphorylated, is redox-stable in vivo, is characterized by an IC50 in vivo of less than about 4.0 μM with respect to the SH2 domain in Grb2, and, upon binding to the SH2 domain of Grb2, has a turn conformation. A conjugate comprising a compound as described above and a carrier agent, a composition comprising (i) a compound or a conjugate as described above and (ii) a carrier, a method of inhibiting binding of an SH2 domain in a protein comprising an SH2 domain to a target protein in an animal, wherein the SH2 domain is contacted with a target protein-binding inhibiting effective amount of a compound or a conjugate as described above, and a method of synthesizing such conjugates.
摘要翻译：下式化合物：其中（i）aa 1是Adi，aa 4是Glu或（ii）aa 1和a a各自独立地选自 Ad1，L是硫，亚砜，氧或亚甲基，该化合物（及其缀合物）与包含SH2结构域的蛋白质中的SH2结构域结合，未被磷酸化，是氧化还原稳定的在体内，相对于Grb2中的SH2结构域，其体内IC 50小于约4.0μM，并且在结合到Grb2的SH2结构域时具有转向构象。包含如上所述的化合物和载体的缀合物，包含（i）如上所述的化合物或缀合物和（ii）载体的组合物，抑制包含SH2结构域的蛋白质中SH2结构域结合的方法涉及一种动物中的靶蛋白，其中SH2结构域与靶蛋白结合抑制有效量的上述化合物或结合物接触，以及合成这种缀合物的方法。

2. 发明授权

US06951915B2 Redox-stable, non-phosphorylated cyclic peptide inhibitors of SH2 domain binding to target protein, conjugates thereof, compositions and methods of synthesis and use 有权
标题翻译：与靶蛋白结合的SH2结构域的氧化还原稳定的非磷酸化环肽抑制剂，其结合物，组合物和合成和使用方法
公开(公告)号：US06951915B2
公开(公告)日：2005-10-04
申请号：US09998350
申请日：2001-11-30
申请人： Peter P. Roller , Ya-Qiu Long , Feng-Di T. Lung , C. Richter King , Dajun Yang
发明人： Peter P. Roller , Ya-Qiu Long , Feng-Di T. Lung , C. Richter King , Dajun Yang
IPC分类号： A61K38/00 , C07K7/06 , C07K7/56 , C07K7/00 , A61K31/00 , C07K7/50
CPC分类号： C07K7/06 , A61K38/00 , C07K7/56
摘要： A compound of formula: in which L is sulfur, sulfoxide, oxygen or methylene, and a compound of formula: in which (i) aa1 is Adi and aa4 is Glu or (ii) each of aa1 and aa4 is Adi, L is sulfur, sulfoxide, oxygen or methylene, which compounds (and their conjugates) bind to an SH2 domain in a protein comprising an SH2 domain, are non-phosphorylated, are redox-stable in vivo, are characterized by an IC50 in vivo of less than about 4.0 μM with respect to the SH2 domain in Grb2, and, upon binding to the SH2 domain of Grb2, have a turn conformation. A conjugate comprising a compound as described above and a carrier agent, a composition comprising (i) a compound or a conjugate as described above and (ii) a carrier, a method of inhibiting binding of an SH2 domain in a protein comprising an SH2 domain to a target protein in an animal, wherein the SH2 domain is contacted with a target protein-binding inhibiting effective amount of a compound or a conjugate as described above, and a method of synthesizing such conjugates.
摘要翻译：下式的化合物：其中L是硫，亚砜，氧或亚甲基，以及下式的化合物：其中（i）aa 1是Adi和aa 4是 Glu或（ii）aa 1和a 4中的每一个为Adi，L为硫，亚砜，氧或亚甲基，该化合物（及其共轭物）与SH2结合包含SH2结构域的未被磷酸化，在体内氧化还原稳定的蛋白质的结构域的特征在于体内相对于Grb2中的SH2结构域的小于约4.0μM的IC 50 并且在与Grb2的SH2结构域结合时具有转向构象。包含如上所述的化合物和载体的缀合物，包含（i）如上所述的化合物或缀合物和（ii）载体的组合物，抑制包含SH2结构域的蛋白质中SH2结构域结合的方法涉及一种动物中的靶蛋白，其中SH2结构域与靶蛋白结合抑制有效量的上述化合物或结合物接触，以及合成这种缀合物的方法。

3. 发明申请

US20080031812A1 REDOX-STABLE, NON-PHOSPHORYLATED CYCLIC PEPTIDE INHIBITORS OF SH2 DOMAIN BINDING TO TARGET PROTEIN, CONJUGATES, THEREOF, COMPOSITIONS AND METHODS OF SYNTHESIS AND USE 审中-公开
标题翻译：抗氧化稳定性，SH2结合蛋白的非磷酸化循环肽抑制剂与靶向蛋白质，其结合物，组合物及其合成和使用方法
公开(公告)号：US20080031812A1
公开(公告)日：2008-02-07
申请号：US11838427
申请日：2007-08-14
申请人： Peter Roller , Ya-Qiu Long , Feng-Di T. Lung , C. Richter King , Dajun Yang , Johannes Voigt
发明人： Peter Roller , Ya-Qiu Long , Feng-Di T. Lung , C. Richter King , Dajun Yang , Johannes Voigt
IPC分类号： A61K38/12 , A61K51/00 , A61P35/00
CPC分类号： C07K7/56 , A61K38/00 , A61K47/64 , C07K7/06
摘要： A compound of formula: in which (i) aa1 is Adi and aa4 is Glu or (ii) each of aa1 and aa4 is Adi, L is sulfur, sulfoxide, oxygen or methylene, which compound (and its conjugates) bind to an SH2 domain in a protein comprising an SH2 domain, is non-phosphorylated, is redox-stable in vivo, is characterized by an IC50 in vivo of less than about 4.0 μM with respect to the SH2 domain in Grb2, and, upon binding to the SH2 domain of Grb2, has a turn conformation. A conjugate comprising a compound as described above and a carrier agent, a composition comprising (i) a compound or a conjugate as described above and (ii) a carrier, a method of inhibiting binding of an SH2 domain in a protein comprising an SH2 domain to a target protein in an animal, wherein the SH2 domain is contacted with a target protein-binding inhibiting effective amount of a compound or a conjugate as described above, and a method of synthesizing such conjugates.
摘要翻译：下式化合物：其中（i）aa 1是Adi，aa 4是Glu或（ii）aa 1和a a各自独立地选自 Ad1，L是硫，亚砜，氧或亚甲基，该化合物（及其缀合物）与包含SH2结构域的蛋白质中的SH2结构域结合，未被磷酸化，是氧化还原稳定的在体内，相对于Grb2中的SH2结构域，其体内IC 50小于约4.0μM，并且在结合到Grb2的SH2结构域时具有转向构象。包含如上所述的化合物和载体的缀合物，包含（i）如上所述的化合物或缀合物和（ii）载体的组合物，抑制包含SH2结构域的蛋白质中SH2结构域结合的方法涉及一种动物中的靶蛋白，其中SH2结构域与靶蛋白结合抑制有效量的上述化合物或结合物接触，以及合成这种缀合物的方法。

4. 发明申请

US20080233650A1 Method for propagating adenoviral vectors encoding inhibitory gene products 审中-公开
标题翻译：繁殖编码抑制性基因产物的腺病毒载体的方法
公开(公告)号：US20080233650A1
公开(公告)日：2008-09-25
申请号：US12118008
申请日：2008-05-09
申请人： Jason G. D. Gall , Douglas E. Brough , C. Richter King
发明人： Jason G. D. Gall , Douglas E. Brough , C. Richter King
IPC分类号： C12N15/87 , C12N5/06
CPC分类号： C12N15/635 , C12N7/00 , C12N15/86 , C12N2710/10343 , C12N2710/10352 , C12N2830/006
摘要： The invention provides a method of propagating an adenoviral vector. The method comprises (a) providing a cell comprising a cellular genome comprising a nucleic acid sequence encoding a tetracycline operon repressor protein (tetR), and (b) contacting the cell with an adenoviral vector comprising a heterologous nucleic acid sequence encoding a toxic protein. The heterologous nucleic acid sequence is operably linked to a promoter and one or more tetracycline operon operator sequences (tetO), and expression of the heterologous nucleic acid sequence is inhibited in the presence of tetR, such that the adenoviral vector is propagated. The invention also provides a system comprising the aforementioned cell and adenoviral vector.
摘要翻译：本发明提供了一种繁殖腺病毒载体的方法。该方法包括（a）提供包含细胞基因组的细胞，所述细胞基因组包含编码四环素操纵子阻遏蛋白（tetR）的核酸序列，和（b）使细胞与包含编码毒性蛋白质的异源核酸序列的腺病毒载体接触。异源核酸序列可操作地连接到启动子和一个或多个四环素操纵子操纵子序列（tetO），并且异源核酸序列的表达在tetR存在下被抑制，使得腺病毒载体被繁殖。本发明还提供了包含上述细胞和腺病毒载体的系统。

5. 发明授权

US06653084B1 Anti-erbB-2 antibodies to human receptor related to but distinct from EGF receptor 失效
标题翻译：与人类受体的抗erbB-2抗体相关但不同于EGF受体
公开(公告)号：US06653084B1
公开(公告)日：2003-11-25
申请号：US08472114
申请日：1995-06-07
申请人： C. Richter King , Matthias H. Kraus , Stuart A. Aaronson
发明人： C. Richter King , Matthias H. Kraus , Stuart A. Aaronson
IPC分类号： A61K39395
CPC分类号： C07K14/71 , A61K38/00 , G01N33/566 , G01N33/57484 , G01N33/68 , G01N2333/82 , Y02A50/473 , Y10S435/805 , Y10S435/81 , Y10S436/813
摘要： The isolation, cloning and characterization of a human gene related to but distinct from the EGF receptor gene has been described. Nucleotide sequence of the gene and amino acid sequence of the polypeptide encoded by the gene have been determined. The use of the nucleic acid probes and antibodies having specific binding affinity with said polypeptide for diagnostic and therapeutic purposes has also been described.
摘要翻译：已经描述了与EGF受体基因相关但与EGF受体基因不同的人基因的分离，克隆和表征。已经确定了由该基因编码的多肽的基因和氨基酸序列的核苷酸序列。已经描述了使用与所述多肽具有特异性结合亲和力的核酸探针和抗体用于诊断和治疗目的。

6. 发明授权

US06579522B1 Replication deficient adenoviral TNF vector 失效
标题翻译：复制缺陷型腺病毒TNF载体
公开(公告)号：US06579522B1
公开(公告)日：2003-06-17
申请号：US09604694
申请日：2000-06-27
申请人： Douglas E. Brough , C. Richter King , Imre Kovesdi , Jasper J. Schaible
发明人： Douglas E. Brough , C. Richter King , Imre Kovesdi , Jasper J. Schaible
IPC分类号： A01N6300
CPC分类号： C12N15/86 , A61K38/191 , A61K48/00 , C12N2710/10343 , C12N2810/40
摘要： An adenoviral vector comprising (a) an adenoviral genome deficient in the E4 region of the adenoviral genome, (b) a nucleic acid sequence coding for TNF, and (c) a radiation inducible promoter operably linked to the nucleic acid sequence coding for TNF. This invention also provides an adenoviral vector comprising (a) an adenoviral genome deficient in the E4 region of the adenoviral genome, (b) a nucleic acid sequence coding for TNF, and (c) a spacer element of at least 15 base pairs in the E4 region of the adenoviral genome. A method of producing an adenoviral vector and a method of treating a tumor or cancer in a host comprising administering an anti-cancer or anti-tumor effective amount of the adenoviral vector of the present invention also is provided.
摘要翻译：一种腺病毒载体，其包含（a）在腺病毒基因组的E4区域缺失的腺病毒基因组，（b）编码TNF的核酸序列，和（c）与编码TNF的核酸序列可操作地连接的放射诱导型启动子。本发明还提供了一种腺病毒载体，其包含（a）在腺病毒基因组的E4区域缺失的腺病毒基因组，（b）编码TNF的核酸序列，和（c）至少15个碱基对的间隔元件， E4区域的腺病毒基因组。本发明提供了生产腺病毒载体的方法和治疗宿主中的肿瘤或癌症的方法，包括给予抗癌或抗肿瘤有效量的本发明的腺病毒载体。

7. 发明授权

US5985553A erbB-2 gene segments, probes, recombinant DNA and kits for detection 失效
标题翻译： erbB-2基因片段，探针，重组DNA和检测试剂盒
公开(公告)号：US5985553A
公开(公告)日：1999-11-16
申请号：US475035
申请日：1995-06-07
申请人： C. Richter King , Matthias H. Kraus , Stuart A. Aaronson
发明人： C. Richter King , Matthias H. Kraus , Stuart A. Aaronson
IPC分类号： A61K38/00 , C07K14/71 , G01N33/566 , G01N33/574 , G01N33/68 , C12Q1/68
CPC分类号： C07K14/71 , G01N33/566 , G01N33/57484 , G01N33/68 , A61K38/00 , G01N2333/82 , Y10S435/805 , Y10S435/81 , Y10S436/813
摘要： The isolation, cloning and characterization of a human gene related to but distinct from the EGF receptor gene has been described. Nucleotide sequence of the gene and amino acid sequence of the polypeptide encoded by the gene have been determined. The use of the nucleic acid probes and antibodies having specific binding affinity with said polypeptide for diagnostic and therapeutic purposes has also been described.
摘要翻译：已经描述了与EGF受体基因相关但与EGF受体基因不同的人基因的分离，克隆和表征。已经确定了由该基因编码的多肽的基因和氨基酸序列的核苷酸序列。已经描述了使用与所述多肽具有特异性结合亲和力的核酸探针和抗体用于诊断和治疗目的。

8. 发明申请

US20140314809A1 MALARIA ANTIGEN SCREENING METHOD 审中-公开
标题翻译： MALARIA抗原筛选方法
公开(公告)号：US20140314809A1
公开(公告)日：2014-10-23
申请号：US13866116
申请日：2013-04-19
申请人： Joseph T. Bruder , Imre Kovesdi , Duncan L. McVey , Douglas E. Brough , C. Richter King , Denise Louise Doolan , Joao Carlos Aguair , Daniel John Carucci , Martha Sedegah , Walter R. Weiss , Keith Limbach
发明人： Joseph T. Bruder , Imre Kovesdi , Duncan L. McVey , Douglas E. Brough , C. Richter King , Denise Louise Doolan , Joao Carlos Aguair , Daniel John Carucci , Martha Sedegah , Walter R. Weiss , Keith Limbach
IPC分类号： G01N33/50
CPC分类号： G01N33/505
摘要： The invention provides a method of identifying an antigen from a pathogen or a disease antigen comprising the use of an adenoviral vector array comprising two or more different adenoviral vectors, wherein each adenoviral vector comprises a nucleic acid sequence encoding a different antigen of a pathogen. The adenoviral vectors are administered to antigen presenting cells (APCs) in vitro or to an animal in vivo. The immunogenicity of the antigen is measured by screening for an immune response from effector T lymphocytes in vitro and by screening for the absence of pathogen-induced disease onset in vivo.
摘要翻译：本发明提供了鉴定来自病原体或疾病抗原的抗原的方法，其包括使用包含两种或多种不同腺病毒载体的腺病毒载体阵列，其中每个腺病毒载体包含编码病原体的不同抗原的核酸序列。腺病毒载体在体外或动物体内施用于抗原呈递细胞（APC）。通过体外筛选来自效应T淋巴细胞的免疫应答并通过筛选在体内不存在病原体诱发的疾病来测量抗原的免疫原性。

9. 发明授权

US08454972B2 Method for inducing a multiclade immune response against HIV utilizing a multigene and multiclade immunogen 失效
标题翻译：使用多基因和多重免疫原诱导针对HIV的多重免疫应答的方法
公开(公告)号：US08454972B2
公开(公告)日：2013-06-04
申请号：US13010141
申请日：2011-01-20
申请人： Gary J. Nabel , Ling Xu , Bimal Chakrabarti , Lan Wu , Zhi-yong Yang , Jason G. D. Gall , C. Richter King , Zengguang Wang
发明人： Gary J. Nabel , Yue Huang , Ling Xu , Bimal Chakrabarti , Lan Wu , Zhi-yong Yang , Jason G. D. Gall , C. Richter King
IPC分类号： A61K39/21 , A61K39/295 , C07H21/04
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/57 , A61K2039/70 , C07K14/005 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12N2740/16222 , C12N2740/16234 , C12N2740/16271 , C12N2740/16322 , C12N2740/16334 , C12N2740/16371
摘要： The present disclosure provides compositions for eliciting an immune response, including a prophylactic immune response, against human immunodeficiency virus. The composition includes nucleic acid constructs encoding HIV antigenic polypeptides of multiple clades or strains. Methods for eliciting an immune response by administering the composition to a subject are also provided.
摘要翻译：本公开提供了针对人类免疫缺陷病毒引发免疫应答（包括预防性免疫应答）的组合物。该组合物包括编码多个进化枝或菌株的HIV抗原多肽的核酸构建体。还提供了通过将受试者施用组合物引起免疫应答的方法。

10. 发明申请

US20120302627A1 METHOD OF USING ADENOVIRAL VECTORS TO INDUCE AN IMMUNE RESPONSE 审中-公开
标题翻译：使用腺病毒载体诱导免疫应答的方法
公开(公告)号：US20120302627A1
公开(公告)日：2012-11-29
申请号：US13568239
申请日：2012-08-07
申请人： Gary J. Nabel , Cheng Cheng , Wing-Pui Kong , Jason G.D. Gall , C. Richter King
发明人： Gary J. Nabel , Cheng Cheng , Wing-Pui Kong , Jason G.D. Gall , C. Richter King
IPC分类号： A61K31/7088 , A61P37/02
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/57 , C12N7/00 , C12N15/86 , C12N2710/10343 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234
摘要： The invention provides a method of inducing an immune response against a human immunodeficiency virus (HIV) in a mammal. The method comprises administering to the mammal an adenoviral vector composition comprising one or more adenoviral vectors encoding two or more different HIV antigens, the production of which induces an immune response against HIV in the mammal. The invention also provides an adenoviral vector composition comprising four adenoviral vectors encoding an HIV clade A Env protein, an HIV clade B Env protein, an HIV clade C Env protein, and a fusion protein comprising an HIV clade B Gag protein and Pol protein, respectively.
摘要翻译：本发明提供一种在哺乳动物中诱导针对人类免疫缺陷病毒（HIV）的免疫应答的方法。该方法包括向哺乳动物施用腺病毒载体组合物，其包含编码两种或更多种不同HIV抗原的一种或多种腺病毒载体，其产生在哺乳动物中诱导针对HIV的免疫应答。本发明还提供一种腺病毒载体组合物，其包含分别编码HIV进化枝A Env蛋白，HIV进化枝B Env蛋白，HIV进化枝C Env蛋白和包含HIV进化枝B Gag蛋白和Pol蛋白的融合蛋白的四种腺病毒载体。

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