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1. 发明申请

US20100093728A1 NOVEL SUBSTITUTED BIPYRIDINE DERIVATIVES AND THEIR USE AS ADENOSINE RECEPTOR LIGANDS 失效
标题翻译：新的替代苄嘧啶衍生物及其作为腺苷受体配体使用
公开(公告)号：US20100093728A1
公开(公告)日：2010-04-15
申请号：US12440423
申请日：2007-08-30
申请人： Peter Nell , Walter Hübsch , Barbara Albrecht-Küpper , Joerg Keldenich , Andreas Knorr
发明人： Peter Nell , Walter Hübsch , Barbara Albrecht-Küpper , Joerg Keldenich , Andreas Knorr
IPC分类号： A61K31/5377 , A61K31/495 , A61K31/506 , A61K31/4436 , C07D413/14 , C07D401/14 , C07D417/14 , A61P3/10 , A61P9/04
CPC分类号： C07D417/14 , A61K31/444 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/85 , C07D401/14 , C07D409/14 , C07D413/14
摘要： The present invention relates to novel substituted 2,4′- and 3,4′-bipyridine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.
摘要翻译：本发明涉及新的取代的2,4'-和3,4'-联吡啶衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备治疗用药物和 /或预防疾病，优选用于治疗和/或预防高血压和其它心血管疾病。

2. 发明授权

US08653109B2 Substituted bipyridine derivatives and their use as adenosine receptor ligands 失效
标题翻译：取代的联吡啶衍生物及其作为腺苷受体配体的用途
公开(公告)号：US08653109B2
公开(公告)日：2014-02-18
申请号：US12440423
申请日：2007-08-30
申请人： Peter Nell , Walter Hübsch , Barbara Albrecht-Küpper , Joerg Keldenich , Andreas Knorr
发明人： Peter Nell , Walter Hübsch , Barbara Albrecht-Küpper , Joerg Keldenich , Andreas Knorr
IPC分类号： A61K31/444 , C07D211/60
CPC分类号： C07D417/14 , A61K31/444 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/85 , C07D401/14 , C07D409/14 , C07D413/14
摘要： The present invention relates to novel substituted 2,4′- and 3,4′-bipyridine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.
摘要翻译：本发明涉及新的取代的2,4'-和3,4'-联吡啶衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备治疗用药物和 /或预防疾病，优选用于治疗和/或预防高血压和其它心血管疾病。

3. 发明授权

US08691850B2 Substituted phenylaminothiazoles and use thereof 失效
标题翻译：取代的苯基氨基噻唑及其用途
公开(公告)号：US08691850B2
公开(公告)日：2014-04-08
申请号：US11661820
申请日：2005-08-30
申请人： Jens-Kerim Ergüden , Gunter Karig , Ulrich Rosentreter , Barbara Albrecht , Kerstin Henninger , Joachim Hütter , Nicole Diedrichs , Peter Nell , Sabine Arndt , Walter Hübsch , Andreas Knorr , Karl-Heinz Schlemmer , Dirk Brohm
发明人： Jens-Kerim Ergüden , Gunter Karig , Ulrich Rosentreter , Barbara Albrecht , Kerstin Henninger , Joachim Hütter , Nicole Diedrichs , Peter Nell , Sabine Arndt , Walter Hübsch , Andreas Knorr , Karl-Heinz Schlemmer , Dirk Brohm
IPC分类号： A61K31/4436 , C07D417/12
CPC分类号： C07D417/12
摘要： The present application relates to novel phenylaminothiazole derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.
摘要翻译：本申请涉及新的苯基氨基噻唑衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗和/ 或预防高血压和其他心血管疾病。

4. 发明授权

US09040566B2 Adenosine A1 agonists for the treatment of glaucoma and ocular hypertension 有权
标题翻译：腺苷A1激动剂治疗青光眼和高眼压症
公开(公告)号：US09040566B2
公开(公告)日：2015-05-26
申请号：US13819790
申请日：2011-08-29
申请人： Jürgen Klar , Georges Von Degenfeld , Hans-Georg Lerchen , Barbara Albrecht-Küpper , Andreas Knorr , Peter Sandner , Daniel Meibom
发明人： Jürgen Klar , Georges Von Degenfeld , Hans-Georg Lerchen , Barbara Albrecht-Küpper , Andreas Knorr , Peter Sandner , Daniel Meibom
IPC分类号： A01N43/40 , A61K31/44 , C07D409/00 , C07D411/00 , C07D405/00 , C07D417/12 , A61K9/00 , A61K9/08 , A61K31/4439 , A61K45/06 , C07D413/12 , C07D417/14
CPC分类号： A61K31/4439 , A61K9/0048 , A61K9/08 , A61K38/05 , A61K45/06 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention relates to the use of selective adenosine A1 agonists, in particular the dicyanopyridines of formula (I), for the treatment and/or prophylaxis of glaucoma and ocular hypertension as well as the their use for the production of a medicament for the treatment and/or prophylaxis of glaucoma and ocular hypertension.
摘要翻译：本发明涉及选择性腺苷A1激动剂，特别是式（I）的二氰基吡啶用于治疗和/或预防青光眼和高眼压症及其用于生产治疗药物的用途的用途和/或预防青光眼和高眼压症。

5. 发明申请

US20130210797A1 ADENOSINE A1 AGONISTS FOR THE TREATMENT OF GLAUCOMA AND OCULAR HYPERTENSION 有权
公开(公告)号：US20130210797A1
公开(公告)日：2013-08-15
申请号：US13819790
申请日：2011-08-29
申请人： Jürgen Klar , Georges Von Degenfeld , Hans-Georg Lerchen , Barbara Albrecht-Küpper , Andreas Knorr , Peter Sandner , Daniel Meiibom
发明人： Jürgen Klar , Georges Von Degenfeld , Hans-Georg Lerchen , Barbara Albrecht-Küpper , Andreas Knorr , Peter Sandner , Daniel Meiibom
IPC分类号： C07D417/12 , A61K45/06 , C07D417/14 , A61K31/4439 , C07D413/12
CPC分类号： A61K31/4439 , A61K9/0048 , A61K9/08 , A61K38/05 , A61K45/06 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention relates to the use of selective adenosine A1 agonists, in particular the dicyanopyridines of formula (I), for the treatment and/or prophylaxis of glaucoma and ocular hypertension as well as the their use for the production of a medicament for the treatment and/or prophylaxis of glaucoma and ocular hypertension.

6. 发明申请

US20080269300A1 Substituted Phenylaminothiazoles and Use Thereof 失效
标题翻译：取代的苯基氨基噻唑及其用途
公开(公告)号：US20080269300A1
公开(公告)日：2008-10-30
申请号：US11661820
申请日：2005-08-30
申请人： Jens-Kerim Erguden , Gunter Karig , Ulrich Rosentreter , Barbara Albrecht , Kerstin Henninger , Joachim Hutter , Nicole Diedrichs , Peter Nell , Sabine Arndt , Walter Hubsch , Andreas Knorr , Karl-Heinz Schlemmer , Dirk Brohm
发明人： Jens-Kerim Erguden , Gunter Karig , Ulrich Rosentreter , Barbara Albrecht , Kerstin Henninger , Joachim Hutter , Nicole Diedrichs , Peter Nell , Sabine Arndt , Walter Hubsch , Andreas Knorr , Karl-Heinz Schlemmer , Dirk Brohm
IPC分类号： A61K31/4439 , C07D417/12 , A61P9/12
CPC分类号： C07D417/12
摘要： The present application relates to novel phenylaminothiazole derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.
摘要翻译：本申请涉及新的苯基氨基噻唑衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗和/ 或预防高血压和其他心血管疾病。

7. 发明授权

US10189856B2 Use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) 有权
公开(公告)号：US10189856B2
公开(公告)日：2019-01-29
申请号：US13816020
申请日：2011-05-24
申请人： Claudia Hirth-Dietrich , Peter Sandner , Johannes-Peter Stasch , Andreas Knorr , Georges Von Degenfeld , Michael Hahn , Markus Follmann
发明人： Claudia Hirth-Dietrich , Peter Sandner , Johannes-Peter Stasch , Andreas Knorr , Georges Von Degenfeld , Michael Hahn , Markus Follmann
IPC分类号： A61K31/437 , A61K31/197 , A61K31/427 , A61K31/4439 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D495/04 , C07D471/04 , A61K31/426 , C07C229/38 , C07D261/10 , C07D277/30 , C07D333/34 , C07D401/04 , C07D417/06 , C07D487/04
摘要： The use of sGC stimulators, sGC activators alone, or in combination with PDE5 inhibitors for the prevention and treatment of fibrotic diseases, such as systemic sclerosis, scleroderma, and the concomitant fibrosis of internal organs.

8. 发明授权

US09257325B2 Semiconductor structures and methods for forming isolation between Fin structures of FinFET devices 有权
标题翻译：用于在FinFET器件的Fin结构之间形成隔离的半导体结构和方法
公开(公告)号：US09257325B2
公开(公告)日：2016-02-09
申请号：US12562849
申请日：2009-09-18
申请人： Andreas Knorr , Frank Scott Johnson
发明人： Andreas Knorr , Frank Scott Johnson
IPC分类号： H01L29/06 , H01L21/762 , H01L29/66 , H01L29/78
CPC分类号： H01L21/76229 , H01L29/66795 , H01L29/7851
摘要： Semiconductor structures and methods for forming isolation between fin structures formed from a bulk silicon wafer are provided. A bulk silicon wafer is provided having one or more fin structures formed therefrom. Forming of the fin structures defines isolation trenches between the one or more fin structures. Each of the fin structures has vertical sidewalls. An oxide layer is deposited in the isolation trenches and on the vertical sidewalls using HDPCVD in about a 4:1 ratio or greater. The oxide layer is isotropically etched to remove the oxide layer from the vertical sidewalls and a portion of the oxide layer from the bottom of the isolation trenches. A substantially uniformly thick isolating oxide layer is formed on the bottom of the isolation trench to isolate the one or more fin structures and substantially reduce fin height variability.
摘要翻译：提供了用于形成由体硅晶片形成的翅片结构之间的隔离的半导体结构和方法。提供具有由其形成的一个或多个翅片结构的体硅晶片。翅片结构的形成限定了一个或多个翅片结构之间的隔离沟槽。每个翅片结构都具有垂直侧壁。使用HDPCVD以大约4:1的比例或更大的比例在隔离沟槽和垂直侧壁上沉积氧化物层。氧化层被各向同性蚀刻以从隔离沟底部的垂直侧壁和氧化物层的一部分去除氧化物层。在隔离沟槽的底部上形成基本上均匀的厚的隔离氧化物层，以隔离一个或多个翅片结构，并显着降低翅片高度的可变性。

9. 发明申请

US20140148433A1 BICYCLIC AZA HETEROCYCLES, AND USE THEREOF 有权
标题翻译： BICYCLIC AZA HETEROCYCLES，及其使用
公开(公告)号：US20140148433A1
公开(公告)日：2014-05-29
申请号：US13819337
申请日：2011-08-31
申请人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Jens Ackerstaff , Nils Griebenow , Andreas Knorr , Frank Wunder , Volkhart Min-Jian Li , Lars Bärfacker , Stefan Weigand
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Jens Ackerstaff , Nils Griebenow , Andreas Knorr , Frank Wunder , Volkhart Min-Jian Li , Lars Bärfacker , Stefan Weigand
IPC分类号： C07D471/04 , A61K31/522 , A61K31/517 , C07D495/04 , A61K31/519 , A61K45/06 , C07D498/04 , C07D487/04 , A61K31/551 , C07D475/06 , A61K31/5377 , C07D473/28 , C07D513/04
CPC分类号： C07D471/04 , A61K31/517 , A61K31/519 , A61K31/522 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D473/28 , C07D475/06 , C07D487/04 , C07D495/04 , C07D498/04 , C07D513/04 , C07D519/00
摘要： The present application relates to novel bicyclic azaheterocycles, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译：本申请涉及新型双环氮杂环，其制备方法，单独或组合用于治疗和/或预防疾病及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/或预防心血管疾病。

10. 发明申请

US20140038956A1 Use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc). 审中-公开
标题翻译：使用sGC刺激剂，sGC激活剂，单独使用和与PDE5抑制剂的组合治疗系统性硬化症（SSc）。
公开(公告)号：US20140038956A1
公开(公告)日：2014-02-06
申请号：US13816020
申请日：2011-05-24
申请人： Claudia Hirth-Dietrich , Peter Sandner , Johannes-Peter Stasch , Andreas Knorr , Georges Von Degenfeld , Michael Hahn , Markus Follmann
发明人： Claudia Hirth-Dietrich , Peter Sandner , Johannes-Peter Stasch , Andreas Knorr , Georges Von Degenfeld , Michael Hahn , Markus Follmann
IPC分类号： C07D495/04 , C07C229/38 , C07D333/34 , C07D261/10 , C07D401/04 , C07D417/06 , C07D277/30 , C07D487/04 , A61K31/5377 , A61K31/506 , A61K31/197 , A61K31/4439 , A61K31/427 , A61K31/426 , A61K31/519 , A61K45/06 , C07D471/04
CPC分类号： C07D495/04 , A61K31/197 , A61K31/426 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07C229/38 , C07D261/10 , C07D277/30 , C07D333/34 , C07D401/04 , C07D417/06 , C07D471/04 , C07D487/04 , A61K2300/00
摘要： The use of sGC stimulators, sGC activators alone, or in combination with PDE5 inhibitors for the prevention and treatment of fibrotic diseases, such as systemic sclerosis, scleroderma, and the concomitant fibrosis of internal organs.
摘要翻译：单独使用sGC刺激剂，sGC激活剂或与PDE5抑制剂联合用于预防和治疗纤维化疾病，如系统性硬化症，硬皮病和伴随的内脏纤维化。

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