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1. 发明申请

US20080275659A1 APPARATUS AND METHOD FOR FULLY AUTOMATED CLOSED SYSTEM QUALITY CONTROL OF A SUBSTANCE 有权
标题翻译：一种物质完全自动关闭系统质量控制的装置和方法
公开(公告)号：US20080275659A1
公开(公告)日：2008-11-06
申请号：US11743288
申请日：2007-05-02
申请人： Peter Miller , Jan Henrik Ardenkjaer-Larsen , Martin John Bradney , Andrew Michael Leach , Per Christian Sontum , Eric John Telfeyan , David Brandon Whitt , Jan Wolber
发明人： Peter Miller , Jan Henrik Ardenkjaer-Larsen , Martin John Bradney , Andrew Michael Leach , Per Christian Sontum , Eric John Telfeyan , David Brandon Whitt , Jan Wolber
IPC分类号： G01N21/01
CPC分类号： G01N21/33 , G01N21/21 , G01N21/35 , G01N21/3577 , G01N2021/8416 , G01R33/282 , G01R33/60
摘要： The present invention provides an apparatus and method for automated quality control of a substance comprising a compartment wherein a substance is located, a monitoring device coupled to the compartment and configured to monitor at least one quality control parameter prior to an end-use of the substance, and a processor coupled to the monitoring device, wherein the monitoring device is configured to communicate data to the processor for comparing at least one quality control parameter to an end-use value, and wherein the processor is further configured to control the release of the substance from the compartment to its end-use.
摘要翻译：本发明提供了一种用于对物质进行自动质量控制的装置和方法，所述物质包括物质位于其中的隔间，耦合到隔室的监测装置，并且被配置为在物质的最终使用之前监测至少一个质量控制参数以及耦合到所述监视设备的处理器，其中所述监视设备被配置为将数据传送到所述处理器，用于将至少一个质量控制参数与最终使用值进行比较，并且其中所述处理器还被配置为控制所述处理器的释放物质从隔间到最终用途。

2. 发明授权

US07519492B2 Apparatus and method for fully automated closed system quality control of a substance 有权
标题翻译：物质全自动封闭系统质量控制的装置和方法
公开(公告)号：US07519492B2
公开(公告)日：2009-04-14
申请号：US11743288
申请日：2007-05-02
申请人： Peter Miller , Jan Henrik Ardenkjaer-Larsen , Martin John Bradney , Andrew Michael Leach , Per Christian Sontum , Eric John Telfeyan , David Brandon Whitt , Jan Wolber
发明人： Peter Miller , Jan Henrik Ardenkjaer-Larsen , Martin John Bradney , Andrew Michael Leach , Per Christian Sontum , Eric John Telfeyan , David Brandon Whitt , Jan Wolber
IPC分类号： G01N37/00 , G06F11/00
CPC分类号： G01N21/33 , G01N21/21 , G01N21/35 , G01N21/3577 , G01N2021/8416 , G01R33/282 , G01R33/60
摘要： The present invention provides an apparatus and method for automated quality control of a substance comprising a compartment wherein a substance is located, a monitoring device coupled to the compartment and configured to monitor at least one quality control parameter prior to an end-use of the substance, and a processor coupled to the monitoring device, wherein the monitoring device is configured to communicate data to the processor for comparing at least one quality control parameter to an end-use value, and wherein the processor is further configured to control the release of the substance from the compartment to its end-use.
摘要翻译：本发明提供了一种用于对物质进行自动质量控制的装置和方法，所述物质包括物质位于其中的隔间，耦合到隔室的监测装置，并且被配置为在物质的最终使用之前监测至少一个质量控制参数以及耦合到所述监视设备的处理器，其中所述监视设备被配置为将数据传送到所述处理器，用于将至少一个质量控制参数与最终使用值进行比较，并且其中所述处理器还被配置为控制所述处理器的释放物质从隔间到最终用途。

3. 发明申请

US20120117985A1 FLUID PATH SYSTEM FOR DISSOLUTION AND TRANSPORT OF A HYPERPOLARIZED MATERIAL 有权
标题翻译：用于溶解和运输超高分子材料的流体路径系统
公开(公告)号：US20120117985A1
公开(公告)日：2012-05-17
申请号：US13350189
申请日：2012-01-13
申请人： John Arthur Urbahn , Jan Henrik Ardenkjaer-Larsen , Andrew Michael Leach , Eric John Telfeyan , David Key Dietrich , David Brandon Whitt , Peter Miller , Ernst Wolfgang Stautner
发明人： John Arthur Urbahn , Jan Henrik Ardenkjaer-Larsen , Andrew Michael Leach , Eric John Telfeyan , David Key Dietrich , David Brandon Whitt , Peter Miller , Ernst Wolfgang Stautner
IPC分类号： F17C3/00 , B23P21/00 , F15D1/00
CPC分类号： G01N13/00 , G01N33/15 , G01N2013/006 , G01R33/282 , Y10T29/49826 , Y10T137/8593 , Y10T436/24 , Y10T436/25
摘要： A fluid path system includes a vial containing a pharmaceutical product therein. A dissolution fluid path is also included in the fluid path system, the dissolution fluid path having an output end in fluid communication with the vial and an input end attached to a pressure vessel containing a dissolution medium. A delivery fluid path is also included in the system having a first end hermetically attached to the vial to transport therefrom a mixture of dissolved pharmaceutical product and dissolution medium and a second end connected to a receiving vessel to receive the mixture. A dissolution fluid path valve is positioned between the pressure vessel and the dissolution fluid path to control flow of the dissolution medium, and a delivery fluid path valve is also included in the fluid path system to control flow of the mixture from the delivery fluid path to the receiving vessel.
摘要翻译：流体路径系统包括其中含有药物产品的小瓶。溶解流体路径也包括在流体路径系统中，溶解流体路径具有与小瓶流体连通的输出端和连接到包含溶解介质的压力容器的输入端。输送流体路径还包括在系统中，其具有气密地附接到小瓶以从其中输送溶解的药物产物和溶出介质的混合物的第一端和连接到接收容器的第二端以接收混合物。溶解流体通道阀定位在压力容器和溶解流体路径之间以控制溶解介质的流动，并且输送流体通道阀也包括在流体路径系统中以控制混合物从输送流体路径到接收船。

4. 发明授权

US08731640B2 Fluid path system for dissolution and transport of a hyperpolarized material 有权
标题翻译：用于溶解和运输超极化材料的流体路径系统
公开(公告)号：US08731640B2
公开(公告)日：2014-05-20
申请号：US13350189
申请日：2012-01-13
申请人： John Arthur Urbahn , Jan Henrik Ardenkjaer-Larsen , Andrew Michael Leach , Eric John Telfeyan , David Key Dietrich , David Brandon Whitt , Peter Miller , Ernst Wolfgang Stautner
发明人： John Arthur Urbahn , Jan Henrik Ardenkjaer-Larsen , Andrew Michael Leach , Eric John Telfeyan , David Key Dietrich , David Brandon Whitt , Peter Miller , Ernst Wolfgang Stautner
IPC分类号： A61B5/055
CPC分类号： G01N13/00 , G01N33/15 , G01N2013/006 , G01R33/282 , Y10T29/49826 , Y10T137/8593 , Y10T436/24 , Y10T436/25
摘要： A fluid path system includes a vial containing a pharmaceutical product therein. A dissolution fluid path is also included in the fluid path system, the dissolution fluid path having an output end in fluid communication with the vial and an input end attached to a pressure vessel containing a dissolution medium. A delivery fluid path is also included in the system having a first end hermetically attached to the vial to transport therefrom a mixture of dissolved pharmaceutical product and dissolution medium and a second end connected to a receiving vessel to receive the mixture. A dissolution fluid path valve is positioned between the pressure vessel and the dissolution fluid path to control flow of the dissolution medium, and a delivery fluid path valve is also included in the fluid path system to control flow of the mixture from the delivery fluid path to the receiving vessel.
摘要翻译：流体路径系统包括其中含有药物产品的小瓶。溶解流体路径也包括在流体路径系统中，溶解流体路径具有与小瓶流体连通的输出端和连接到包含溶解介质的压力容器的输入端。输送流体路径还包括在系统中，其具有气密地附接到小瓶以从其中输送溶解的药物产物和溶出介质的混合物的第一端和连接到接收容器的第二端以接收混合物。溶解流体通道阀定位在压力容器和溶解流体路径之间以控制溶解介质的流动，并且输送流体通道阀也包括在流体路径系统中以控制混合物从输送流体路径到接收船。

5. 发明申请

US20120053364A1 METHODS FOR DYNAMIC FILTRATION OF PHARMACEUTICAL PRODUCTS 有权
标题翻译：药用植物动态过滤方法
公开(公告)号：US20120053364A1
公开(公告)日：2012-03-01
申请号：US13292468
申请日：2011-11-09
申请人： Andrew Michael Leach , Peter Miller , Eric John Telfeyan , David Brandon Whitt
发明人： Andrew Michael Leach , Peter Miller , Eric John Telfeyan , David Brandon Whitt
IPC分类号： C07C51/487
CPC分类号： B01J20/261 , A61M5/165 , B01D15/00 , B01D15/322 , B01D15/327 , B01J20/103 , B01J20/3204 , B01J20/3242 , B01J47/15
摘要： A method for dynamic filtration of a pharmaceutical product is provided. The method includes using an unconditioned resin configured to selectively retain one or more components from a mixture having the pharmaceutical product and where the unconditioned resin is configured to be activated by a medium of the mixture. The method further includes the use of at least one positioning material disposed adjacent to the unconditioned resin, where the positioning material is configured to provide mechanical support to the resin to at least partially retain the resin in position.
摘要翻译：提供了药物动态过滤的方法。该方法包括使用非条件树脂，其构造成从具有药物产品的混合物中选择性地保留一种或多种组分，并且其中未条件化的树脂被配置为由混合物的介质活化。该方法还包括使用邻近未条件化树脂设置的至少一个定位材料，其中定位材料构造成为树脂提供机械支撑以至少部分地将树脂保持在适当位置。

6. 发明授权

US09227173B2 Methods for dynamic filtration of pharmaceutical products 有权
标题翻译：药品动态过滤方法
公开(公告)号：US09227173B2
公开(公告)日：2016-01-05
申请号：US13292468
申请日：2011-11-09
申请人： Andrew Michael Leach , Peter Miller , Eric John Telfeyan , David Brandon Whitt
发明人： Andrew Michael Leach , Peter Miller , Eric John Telfeyan , David Brandon Whitt
IPC分类号： C07C51/487 , B01J20/26 , B01D15/00 , B01J20/10 , B01J20/32 , B01J47/14 , A61M5/165 , B01D15/32
CPC分类号： B01J20/261 , A61M5/165 , B01D15/00 , B01D15/322 , B01D15/327 , B01J20/103 , B01J20/3204 , B01J20/3242 , B01J47/15
摘要： A method for dynamic filtration of a pharmaceutical product is provided. The method includes using an unconditioned resin configured to selectively retain one or more components from a mixture having the pharmaceutical product and where the unconditioned resin is configured to be activated by a medium of the mixture. The method further includes the use of at least one positioning material disposed adjacent to the unconditioned resin, where the positioning material is configured to provide mechanical support to the resin to at least partially retain the resin in position.
摘要翻译：提供了药物动态过滤的方法。该方法包括使用非条件树脂，其构造成从具有药物产品的混合物中选择性地保留一种或多种组分，并且其中未条件化的树脂被配置为由混合物的介质活化。该方法还包括使用邻近未条件化树脂设置的至少一个定位材料，其中定位材料构造成为树脂提供机械支撑以至少部分地将树脂保持在适当位置。

7. 发明授权

US08763410B2 Method and apparatus for the dissolution and filtration of a hyperpolarized agent with a neutral dissolution media 有权
标题翻译：用中性溶出介质溶解和过滤超极化剂的方法和装置
公开(公告)号：US08763410B2
公开(公告)日：2014-07-01
申请号：US12106570
申请日：2008-04-21
申请人： David Brandon Whitt , Andrew Michael Leach , Peter Miller , Eric Telfeyan
发明人： David Brandon Whitt , Andrew Michael Leach , Peter Miller , Eric Telfeyan
IPC分类号： F25B19/00 , A61B5/055
CPC分类号： G01R33/30 , G01R33/282 , G01R33/62
摘要： Methods and apparatuses that facilitate dissolving a hyperpolarized agent within a polarizer and transporting it to a receiver is provided. The methods include delivering water to a hyperpolarized agent contained within a polarizer, forming a hyperpolarized aqueous solution, transporting the aqueous solution through a fluid path system out of the polarizer, filtering the aqueous solution through a partical size exclusion filter to a receiver, and modifying the pH of the filtered hyperpolarized aquous solution with a dissolution medium contained in the receiver. Also disclosed herein are apparatuses for dissolving a hyperpolarized agent comprising a vial for containing a hyperpolarized imaging agent therein, a dissolution fluid path, a delivery fluid path, a particle size exclusion filter, and a receiver connected to the particle size exclusion filter and positioned to receive the filtered aqueous solution of the hyperpolarized imaging agent.
摘要翻译：提供了有助于将偏振器内的超极化剂溶解并将其输送到接收器的方法和装置。所述方法包括将水输送到偏振器内所含的超极化剂，形成超极化水溶液，将水溶液通过流体路径系统输送出偏振器，将水溶液通过部分尺寸排阻滤器过滤到接受器，并修改过滤的超极化水溶液的pH值，其中溶解介质包含在接收器中。本文还公开了用于溶解超极化剂的装置，其包含其中含有超极化成像剂的小瓶，溶解流体路径，输送流体路径，粒度排阻过滤器和连接到粒度排阻过滤器的接收器，并且定位成接收过滤的超极化成像剂的水溶液。

8. 发明申请

US20090263325A1 METHOD AND APPARATUS FOR THE DISSOLUTION AND FILTRATION OF A HYPERPOLARIZED AGENT WITH A NEUTRAL DISSOLUTION MEDIA 有权
标题翻译：用于中性溶解介质的高分子化合物的溶解和过滤的方法和装置
公开(公告)号：US20090263325A1
公开(公告)日：2009-10-22
申请号：US12106570
申请日：2008-04-21
申请人： David Brandon Whitt , Andrew Michael Leach , Peter Miller , Eric Telfeyan
发明人： David Brandon Whitt , Andrew Michael Leach , Peter Miller , Eric Telfeyan
IPC分类号： A61K49/10 , B01J19/00
CPC分类号： G01R33/30 , G01R33/282 , G01R33/62
摘要： Methods and apparatuses that facilitate dissolving a hyperpolarized agent within a polarizer and transporting it to a receiver is provided. The methods include delivering water to a hyperpolarized agent contained within a polarizer, forming a hyperpolarized aqueous solution, transporting the aqueous solution through a fluid path system out of the polarizer, filtering the aqueous solution through a partical size exclusion filter to a receiver, and modifying the pH of the filtered hyperpolarized aquous solution with a dissolution medium contained in the receiver. Also disclosed herein are apparatuses for dissolving a hyperpolarized agent comprising a vial for containing a hyperpolarized imaging agent therein, a dissolution fluid path, a delivery fluid path, a particle size exclusion filter, and a receiver connected to the particle size exclusion filter and positioned to receive the filtered aqueous solution of the hyperpolarized imaging agent.
摘要翻译：提供了有助于将偏振器内的超极化剂溶解并将其输送到接收器的方法和装置。所述方法包括将水输送到偏振器内所含的超极化剂，形成超极化水溶液，将水溶液通过流体路径系统输送出偏振器，将水溶液通过部分尺寸排阻滤器过滤到接受器，并修改过滤的超极化水溶液的pH值，其中溶解介质包含在接收器中。本文还公开了用于溶解超极化剂的装置，其包含其中含有超极化成像剂的小瓶，溶解流体路径，输送流体路径，粒度排阻过滤器和连接到粒度排阻过滤器的接收器，并且定位成接收过滤的超极化成像剂的水溶液。

9. 发明申请

US20110180482A1 METHODS AND DEVICES FOR DYNAMIC FILTRATION OF PHARMACEUTICAL PRODUCTS 审中-公开
标题翻译：用于动态过滤药物产品的方法和装置
公开(公告)号：US20110180482A1
公开(公告)日：2011-07-28
申请号：US13081572
申请日：2011-04-07
申请人： Andrew Michael Leach , Peter Miller , Eric Telfeyan , David Brandon Whitt
发明人： Andrew Michael Leach , Peter Miller , Eric Telfeyan , David Brandon Whitt
IPC分类号： B01J47/00
CPC分类号： A61M5/165 , B01D15/00 , B01D15/08 , B01D15/322 , B01D15/327 , B01J20/103 , B01J20/26 , B01J20/3242
摘要： A device for dynamic filtration of a pharmaceutical product is provided. The device includes a resin configured to selectively retain one or more components from a mixture having the pharmaceutical product, where the resin is configured to be activated by a medium of the mixture. The device further includes at least one positioning material disposed adjacent to the resin, where the positioning material is configured to provide mechanical support to the resin to at least partially retain the resin in position. In certain embodiments, the device does not require conditioning immediately prior to filtration.
摘要翻译：提供了用于药物动力过滤的装置。该装置包括被配置为从具有药物产品的混合物中选择性地保持一种或多种组分的树脂，其中树脂被配置为由混合物的介质活化。该装置还包括邻近树脂设置的至少一个定位材料，其中定位材料构造成为树脂提供机械支撑以至少部分地将树脂保持在适当位置。在某些实施方案中，该装置在过滤之前不需要立即进行调节。

10. 发明申请

US20080314836A1 METHODS AND DEVICES FOR DYNAMIC FILTRATION OF PHARMACEUTICAL PRODUCTS 审中-公开
标题翻译：用于动态过滤药物产品的方法和装置
公开(公告)号：US20080314836A1
公开(公告)日：2008-12-25
申请号：US11766881
申请日：2007-06-22
申请人： Andrew Michael Leach , Peter Miller , Eric Telfeyan , David Brandon Whitt
发明人： Andrew Michael Leach , Peter Miller , Eric Telfeyan , David Brandon Whitt
IPC分类号： B01J47/00 , B01D15/00 , B01D15/36 , B01J45/00
CPC分类号： A61M5/165 , B01D15/00 , B01D15/08 , B01D15/322 , B01D15/327 , B01J20/103 , B01J20/26 , B01J20/3242
摘要： A device for dynamic filtration of a pharmaceutical product is provided. The device includes a resin configured to selectively retain one or more components from a mixture having the pharmaceutical product, where the resin is configured to be activated by a medium of the mixture. The device further includes at least one positioning material disposed adjacent to the resin, where the positioning material is configured to provide mechanical support to the resin to at least partially retain the resin in position. In certain embodiments, the device does not require conditioning immediately prior to filtration.
摘要翻译：提供了用于药物动力过滤的装置。该装置包括被配置为从具有药物产品的混合物中选择性地保持一种或多种组分的树脂，其中树脂被配置为由混合物的介质活化。该装置还包括邻近树脂设置的至少一个定位材料，其中定位材料构造成为树脂提供机械支撑以至少部分地将树脂保持在适当位置。在某些实施方案中，该装置在过滤之前不需要立即进行调节。

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