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1. 发明授权

US07803320B2 Apparatus for quality control analysis of an on-site prepared pharmaceutical product 有权
标题翻译：用于现场制备的药物产品的质量控制分析的装置
公开(公告)号：US07803320B2
公开(公告)日：2010-09-28
申请号：US11747769
申请日：2007-05-11
申请人： Peter Miller , Andrew M. Leach , Eric Telfeyan , David B. Whitt
发明人： Peter Miller , Andrew M. Leach , Eric Telfeyan , David B. Whitt
IPC分类号： G01N21/00 , G01N31/00
CPC分类号： G01N13/00 , G01N35/00663 , G01N35/00712 , G01N2013/006
摘要： A quality control system for measuring parameters in a pharmaceutical product includes a receiver vessel to receive a pharmaceutical product therein. The quality control system also includes a sample tube having a first end attached to the receiver vessel to remove pharmaceutical product from the receiver vessel and an appendage connected to a second end of the sample tube. The appendage includes at least one chamber therein to receive a quantity of pharmaceutical product from the receiver vessel. A valve positioned within the sample tube controls flow of the pharmaceutical product to the appendage and prevents flow of the pharmaceutical product from the appendage back into the receiver vessel. The system also includes a quality control device configured to measure at least one parameter of the pharmaceutical product in at least one of the receiver vessel and the appendage.
摘要翻译：用于测量药物产品中的参数的质量控制系统包括用于在其中接收药物产品的接收器容器。质量控制系统还包括样品管，其具有附接到接收器容器的第一端以从接收器容器中除去药物产品，以及连接到样品管的第二端的附件。附件包括至少一个室，以从接收器容器接收一定数量的药品。定位在样品管内的阀将药物产品的流动控制到附件，并防止药物从附属物流向接收容器。该系统还包括质量控制装置，该质量控制装置被配置成在接收器容器和附件中的至少一个中测量药品的至少一个参数。

2. 发明申请

US20080279723A1 APPARATUS FOR QUALITY CONTROL ANALYSIS OF AN ON-SITE PREPARED PHARMACEUTICAL PRODUCT 有权
标题翻译：现场制备药品的质量控制分析装置
公开(公告)号：US20080279723A1
公开(公告)日：2008-11-13
申请号：US11747769
申请日：2007-05-11
申请人： Peter Miller , Andrew M. Leach , Eric Telfeyan , David B. Whitt
发明人： Peter Miller , Andrew M. Leach , Eric Telfeyan , David B. Whitt
IPC分类号： G01N33/15 , B65D83/14
CPC分类号： G01N13/00 , G01N35/00663 , G01N35/00712 , G01N2013/006
摘要： A quality control system for measuring parameters in a pharmaceutical product includes a receiver vessel to receive a pharmaceutical product therein. The quality control system also includes a sample tube having a first end attached to the receiver vessel to remove pharmaceutical product from the receiver vessel and an appendage connected to a second end of the sample tube. The appendage includes at least one chamber therein to receive a quantity of pharmaceutical product from the receiver vessel. A valve positioned within the sample tube controls flow of the pharmaceutical product to the appendage and prevents flow of the pharmaceutical product from the appendage back into the receiver vessel. The system also includes a quality control device configured to measure at least one parameter of the pharmaceutical product in at least one of the receiver vessel and the appendage.
摘要翻译：用于测量药物产品中的参数的质量控制系统包括用于在其中接收药物产品的接收器容器。质量控制系统还包括样品管，其具有附接到接收器容器的第一端以从接收器容器中除去药物产品，以及连接到样品管的第二端的附属物。附件包括至少一个室，以从接收器容器接收一定数量的药品。定位在样品管内的阀将药物产品的流动控制到附件，并防止药物从附属物流向接收容器。该系统还包括质量控制装置，该质量控制装置被配置成在接收器容器和附件中的至少一个中测量药品的至少一个参数。

3. 发明申请

US20080240998A1 FLUID PATH SYSTEM FOR DISSOLUTION AND TRANSPORT OF A HYPERPOLARIZED MATERIAL 审中-公开
标题翻译：用于溶解和运输超高分子材料的流体路径系统
公开(公告)号：US20080240998A1
公开(公告)日：2008-10-02
申请号：US11692642
申请日：2007-03-28
申请人： John A. Urbahn , Jan Ardenkjaer-Larsen , Andrew M. Leach , Eric Telfeyan , David K. Dietrich , David B. Whitt , Peter Miller , Ernst W. Stautner
发明人： John A. Urbahn , Jan Ardenkjaer-Larsen , Andrew M. Leach , Eric Telfeyan , David K. Dietrich , David B. Whitt , Peter Miller , Ernst W. Stautner
IPC分类号： B01L11/00 , B21D39/00
CPC分类号： G01N13/00 , G01N33/15 , G01N2013/006 , G01R33/282 , G01R33/307 , Y10T29/49826
摘要： A fluid path system includes a vial containing a frozen pharmaceutical product therein. A dissolution fluid path is also included in the fluid path system, the dissolution fluid path having an output end in fluid communication with the vial and an input end attached to a pressure vessel containing a dissolution medium. A delivery fluid path is also included in the system having a first end hermetically attached to the vial to transport therefrom a mixture of dissolved pharmaceutical product and dissolution medium and a second end connected to a receiving vessel to receive the mixture. A dissolution fluid path valve is positioned between the pressure vessel and the dissolution fluid path to control flow of the dissolution medium, and a delivery fluid path valve is also included in the fluid path system to control flow of the mixture from the delivery fluid path to the receiving vessel.
摘要翻译：流体路径系统包括其中含有冷冻药品的小瓶。溶解流体路径也包括在流体路径系统中，溶解流体路径具有与小瓶流体连通的输出端和连接到包含溶解介质的压力容器的输入端。输送流体路径还包括在系统中，其具有气密地附接到小瓶以从其中输送溶解的药物产物和溶出介质的混合物的第一端和连接到接收容器的第二端以接收混合物。溶解流体通道阀定位在压力容器和溶解流体路径之间以控制溶解介质的流动，并且输送流体通道阀也包括在流体路径系统中以控制混合物从输送流体路径到接收船。

4. 发明申请

US20110036453A1 NOZZLE FOR DNP POLARIZER 审中-公开
标题翻译： DNP极化剂喷嘴
公开(公告)号：US20110036453A1
公开(公告)日：2011-02-17
申请号：US12675815
申请日：2008-08-27
申请人： Jan Henrik Ardenkjaer-larsen , David Dietrich , Karl Andreas Gram , Andrew M. Leach , Peter Miller , Eric J. Telfeyan , Mikkel Thaning , David B. Whitt
发明人： Jan Henrik Ardenkjaer-larsen , David Dietrich , Karl Andreas Gram , Andrew M. Leach , Peter Miller , Eric J. Telfeyan , Mikkel Thaning , David B. Whitt
IPC分类号： B65B1/04 , B05B1/00
CPC分类号： G01R33/307 , B01F1/0022 , B01L3/0293 , G01N1/38 , G01N2001/1025 , G01N2001/383 , G01R33/282 , G01R33/62
摘要： DNP polarizer comprising a housing receiving a free end of a tubular fluid conduit positioned in fluid communication with a nozzle supported by said housing, said nozzle including an input port, a dispense port and a tapering inner surface or a stepped inner surface defining a nozzle flowpath extending in fluid communication between said input port and said dispense port.
摘要翻译： DNP偏振器包括壳体，其容纳与由所述壳体支撑的喷嘴流体连通的管状流体导管的自由端，所述喷嘴包括输入端口，分配端口和锥形内表面或限定喷嘴流径的阶梯式内表面在所述输入端口和所述分配端口之间流体连通地延伸。

5. 发明申请

US20110180482A1 METHODS AND DEVICES FOR DYNAMIC FILTRATION OF PHARMACEUTICAL PRODUCTS 审中-公开
标题翻译：用于动态过滤药物产品的方法和装置
公开(公告)号：US20110180482A1
公开(公告)日：2011-07-28
申请号：US13081572
申请日：2011-04-07
申请人： Andrew Michael Leach , Peter Miller , Eric Telfeyan , David Brandon Whitt
发明人： Andrew Michael Leach , Peter Miller , Eric Telfeyan , David Brandon Whitt
IPC分类号： B01J47/00
CPC分类号： A61M5/165 , B01D15/00 , B01D15/08 , B01D15/322 , B01D15/327 , B01J20/103 , B01J20/26 , B01J20/3242
摘要： A device for dynamic filtration of a pharmaceutical product is provided. The device includes a resin configured to selectively retain one or more components from a mixture having the pharmaceutical product, where the resin is configured to be activated by a medium of the mixture. The device further includes at least one positioning material disposed adjacent to the resin, where the positioning material is configured to provide mechanical support to the resin to at least partially retain the resin in position. In certain embodiments, the device does not require conditioning immediately prior to filtration.
摘要翻译：提供了用于药物动力过滤的装置。该装置包括被配置为从具有药物产品的混合物中选择性地保持一种或多种组分的树脂，其中树脂被配置为由混合物的介质活化。该装置还包括邻近树脂设置的至少一个定位材料，其中定位材料构造成为树脂提供机械支撑以至少部分地将树脂保持在适当位置。在某些实施方案中，该装置在过滤之前不需要立即进行调节。

6. 发明申请

US20080314836A1 METHODS AND DEVICES FOR DYNAMIC FILTRATION OF PHARMACEUTICAL PRODUCTS 审中-公开
标题翻译：用于动态过滤药物产品的方法和装置
公开(公告)号：US20080314836A1
公开(公告)日：2008-12-25
申请号：US11766881
申请日：2007-06-22
申请人： Andrew Michael Leach , Peter Miller , Eric Telfeyan , David Brandon Whitt
发明人： Andrew Michael Leach , Peter Miller , Eric Telfeyan , David Brandon Whitt
IPC分类号： B01J47/00 , B01D15/00 , B01D15/36 , B01J45/00
CPC分类号： A61M5/165 , B01D15/00 , B01D15/08 , B01D15/322 , B01D15/327 , B01J20/103 , B01J20/26 , B01J20/3242
摘要： A device for dynamic filtration of a pharmaceutical product is provided. The device includes a resin configured to selectively retain one or more components from a mixture having the pharmaceutical product, where the resin is configured to be activated by a medium of the mixture. The device further includes at least one positioning material disposed adjacent to the resin, where the positioning material is configured to provide mechanical support to the resin to at least partially retain the resin in position. In certain embodiments, the device does not require conditioning immediately prior to filtration.
摘要翻译：提供了用于药物动力过滤的装置。该装置包括被配置为从具有药物产品的混合物中选择性地保持一种或多种组分的树脂，其中树脂被配置为由混合物的介质活化。该装置还包括邻近树脂设置的至少一个定位材料，其中定位材料构造成为树脂提供机械支撑以至少部分地将树脂保持在适当位置。在某些实施方案中，该装置在过滤之前不需要立即进行调节。

7. 发明授权

US08763410B2 Method and apparatus for the dissolution and filtration of a hyperpolarized agent with a neutral dissolution media 有权
标题翻译：用中性溶出介质溶解和过滤超极化剂的方法和装置
公开(公告)号：US08763410B2
公开(公告)日：2014-07-01
申请号：US12106570
申请日：2008-04-21
申请人： David Brandon Whitt , Andrew Michael Leach , Peter Miller , Eric Telfeyan
发明人： David Brandon Whitt , Andrew Michael Leach , Peter Miller , Eric Telfeyan
IPC分类号： F25B19/00 , A61B5/055
CPC分类号： G01R33/30 , G01R33/282 , G01R33/62
摘要： Methods and apparatuses that facilitate dissolving a hyperpolarized agent within a polarizer and transporting it to a receiver is provided. The methods include delivering water to a hyperpolarized agent contained within a polarizer, forming a hyperpolarized aqueous solution, transporting the aqueous solution through a fluid path system out of the polarizer, filtering the aqueous solution through a partical size exclusion filter to a receiver, and modifying the pH of the filtered hyperpolarized aquous solution with a dissolution medium contained in the receiver. Also disclosed herein are apparatuses for dissolving a hyperpolarized agent comprising a vial for containing a hyperpolarized imaging agent therein, a dissolution fluid path, a delivery fluid path, a particle size exclusion filter, and a receiver connected to the particle size exclusion filter and positioned to receive the filtered aqueous solution of the hyperpolarized imaging agent.
摘要翻译：提供了有助于将偏振器内的超极化剂溶解并将其输送到接收器的方法和装置。所述方法包括将水输送到偏振器内所含的超极化剂，形成超极化水溶液，将水溶液通过流体路径系统输送出偏振器，将水溶液通过部分尺寸排阻滤器过滤到接受器，并修改过滤的超极化水溶液的pH值，其中溶解介质包含在接收器中。本文还公开了用于溶解超极化剂的装置，其包含其中含有超极化成像剂的小瓶，溶解流体路径，输送流体路径，粒度排阻过滤器和连接到粒度排阻过滤器的接收器，并且定位成接收过滤的超极化成像剂的水溶液。

8. 发明申请

US20090263325A1 METHOD AND APPARATUS FOR THE DISSOLUTION AND FILTRATION OF A HYPERPOLARIZED AGENT WITH A NEUTRAL DISSOLUTION MEDIA 有权
标题翻译：用于中性溶解介质的高分子化合物的溶解和过滤的方法和装置
公开(公告)号：US20090263325A1
公开(公告)日：2009-10-22
申请号：US12106570
申请日：2008-04-21
申请人： David Brandon Whitt , Andrew Michael Leach , Peter Miller , Eric Telfeyan
发明人： David Brandon Whitt , Andrew Michael Leach , Peter Miller , Eric Telfeyan
IPC分类号： A61K49/10 , B01J19/00
CPC分类号： G01R33/30 , G01R33/282 , G01R33/62
摘要： Methods and apparatuses that facilitate dissolving a hyperpolarized agent within a polarizer and transporting it to a receiver is provided. The methods include delivering water to a hyperpolarized agent contained within a polarizer, forming a hyperpolarized aqueous solution, transporting the aqueous solution through a fluid path system out of the polarizer, filtering the aqueous solution through a partical size exclusion filter to a receiver, and modifying the pH of the filtered hyperpolarized aquous solution with a dissolution medium contained in the receiver. Also disclosed herein are apparatuses for dissolving a hyperpolarized agent comprising a vial for containing a hyperpolarized imaging agent therein, a dissolution fluid path, a delivery fluid path, a particle size exclusion filter, and a receiver connected to the particle size exclusion filter and positioned to receive the filtered aqueous solution of the hyperpolarized imaging agent.
摘要翻译：提供了有助于将偏振器内的超极化剂溶解并将其输送到接收器的方法和装置。所述方法包括将水输送到偏振器内所含的超极化剂，形成超极化水溶液，将水溶液通过流体路径系统输送出偏振器，将水溶液通过部分尺寸排阻滤器过滤到接受器，并修改过滤的超极化水溶液的pH值，其中溶解介质包含在接收器中。本文还公开了用于溶解超极化剂的装置，其包含其中含有超极化成像剂的小瓶，溶解流体路径，输送流体路径，粒度排阻过滤器和连接到粒度排阻过滤器的接收器，并且定位成接收过滤的超极化成像剂的水溶液。

9. 发明申请

US20120117985A1 FLUID PATH SYSTEM FOR DISSOLUTION AND TRANSPORT OF A HYPERPOLARIZED MATERIAL 有权
标题翻译：用于溶解和运输超高分子材料的流体路径系统
公开(公告)号：US20120117985A1
公开(公告)日：2012-05-17
申请号：US13350189
申请日：2012-01-13
申请人： John Arthur Urbahn , Jan Henrik Ardenkjaer-Larsen , Andrew Michael Leach , Eric John Telfeyan , David Key Dietrich , David Brandon Whitt , Peter Miller , Ernst Wolfgang Stautner
发明人： John Arthur Urbahn , Jan Henrik Ardenkjaer-Larsen , Andrew Michael Leach , Eric John Telfeyan , David Key Dietrich , David Brandon Whitt , Peter Miller , Ernst Wolfgang Stautner
IPC分类号： F17C3/00 , B23P21/00 , F15D1/00
CPC分类号： G01N13/00 , G01N33/15 , G01N2013/006 , G01R33/282 , Y10T29/49826 , Y10T137/8593 , Y10T436/24 , Y10T436/25
摘要： A fluid path system includes a vial containing a pharmaceutical product therein. A dissolution fluid path is also included in the fluid path system, the dissolution fluid path having an output end in fluid communication with the vial and an input end attached to a pressure vessel containing a dissolution medium. A delivery fluid path is also included in the system having a first end hermetically attached to the vial to transport therefrom a mixture of dissolved pharmaceutical product and dissolution medium and a second end connected to a receiving vessel to receive the mixture. A dissolution fluid path valve is positioned between the pressure vessel and the dissolution fluid path to control flow of the dissolution medium, and a delivery fluid path valve is also included in the fluid path system to control flow of the mixture from the delivery fluid path to the receiving vessel.
摘要翻译：流体路径系统包括其中含有药物产品的小瓶。溶解流体路径也包括在流体路径系统中，溶解流体路径具有与小瓶流体连通的输出端和连接到包含溶解介质的压力容器的输入端。输送流体路径还包括在系统中，其具有气密地附接到小瓶以从其中输送溶解的药物产物和溶出介质的混合物的第一端和连接到接收容器的第二端以接收混合物。溶解流体通道阀定位在压力容器和溶解流体路径之间以控制溶解介质的流动，并且输送流体通道阀也包括在流体路径系统中以控制混合物从输送流体路径到接收船。

10. 发明申请

US20120096702A1 AUTOMATED CONSTRUCTION SYSTEM 审中-公开
标题翻译：自动化施工系统
公开(公告)号：US20120096702A1
公开(公告)日：2012-04-26
申请号：US12558470
申请日：2009-09-11
申请人： Alan Kingsley , Larry Bertelsen , Peter Miller , Richard Alan Roen
发明人： Alan Kingsley , Larry Bertelsen , Peter Miller , Richard Alan Roen
IPC分类号： B23P23/00 , B23Q7/00
CPC分类号： E04H7/06 , B23P23/04 , E04B1/35 , Y10T29/5122 , Y10T29/5143 , Y10T29/5152
摘要： An automated construction system is described. Embodiments of the automated construction system comprise an inner work station having at least one working level, and an outer work station having at least one working level, with industrial robots disposed on the outer or inner work station. The outer work station typically surrounds the inner work station, with a shaft disposed between the two work stations. A lift or hoist is provided for raising and lowering a work piece in the shaft. Embodiments of the present invention further comprise a carousel adapted to forming work piece sections from metal plate.
摘要翻译：描述了一种自动化施工系统。自动化施工系统的实施例包括具有至少一个工作水平的内部工作站和具有至少一个工作水平的外部工作站，工作机器人设置在外部或内部工作站上。外部工作站通常围绕内部工作站，其中轴设置在两个工作站之间。提供升降机或升降机，用于升高和降低轴上的工件。本发明的实施例还包括适于从金属板形成工件部分的转盘。

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