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    • 1. 发明申请
    • Methods for identifying modulators of kinesin activity
    • 识别驱动蛋白活性调节剂的方法
    • US20070134660A1
    • 2007-06-14
    • US10558463
    • 2004-05-28
    • Mao MaoPeter LinsleyCarolyn BuserChristopher Marshall
    • Mao MaoPeter LinsleyCarolyn BuserChristopher Marshall
    • C12Q1/68G01N33/574A61K31/175
    • G01N33/5011A61K31/175A61K38/00C12Q1/34G01N33/573G01N33/57415
    • In a first aspect, the invention provides methods for screening for modulators of a target protein, comprising the steps of contacting a target protein with a candidate agent and determining whether the candidate agent modulates the activity of the target protein, wherein the target protein comprises a sequence that has more than 80% amino acid sequence identity to KIF14 (SEQ ID NO:2) or the KIF14 motor domain (SEQ ID NO:3). In a second aspect, the invention provides methods for modulating cell proliferation comprising administering to a cell an effective amount of a modulator of the activity of a target protein. Some embodiments of this aspect provide methods for treating a subject with a cellular hyperproliferation disorder, such as cancer. In a third aspect, the invention provides methods for identifying candidate subjects for treatment with an inhibitor of the activity of a target protein.
    • 在第一方面,本发明提供了筛选靶蛋白的调节剂的方法,包括以下步骤:使靶蛋白与候选试剂接触并确定候选试剂是否调节靶蛋白的活性,其中靶蛋白包含 与KIF14(SEQ ID NO:2)或KIF14运动结构域(SEQ ID NO:3)具有80%以上氨基酸序列同一性的序列。 在第二方面,本发明提供了调节细胞增殖的方法,包括向细胞施用有效量的靶蛋白活性的调节剂。 该方面的一些实施方案提供了用细胞过度增殖病症如癌症治疗受试者的方法。 在第三方面,本发明提供用于鉴定候选受试者用靶蛋白活性抑制剂治疗的方法。