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1. 发明授权

US06357163B1 Use of nucleic acid analogues in diagnostics and analytical procedures 失效
标题翻译：在诊断和分析程序中使用核酸类似物
公开(公告)号：US06357163B1
公开(公告)日：2002-03-19
申请号：US08150156
申请日：1994-05-04
申请人： Ole Buchardt , Michael Egholm , Peter E. Nielsen , Rolf H. Berg
发明人： Ole Buchardt , Michael Egholm , Peter E. Nielsen , Rolf H. Berg
IPC分类号： C12Q168
CPC分类号： C07H21/00 , A61K38/00 , C07K5/06026 , C07K5/06139 , C07K7/06 , C07K7/08 , C07K14/003 , C12Q1/68 , C12Q1/6813 , C12Q1/6832 , C12Q1/6869 , C12Q2535/107 , C12Q2525/107
摘要： Methods of capture, recognition, detection, identification or quantitation of nucleic acids and diagnostics uses generally are described in which are used: (a) a peptide nucleic acid (PNA) comprising a polyamide backbone bearing a plurality of ligands at respective spaced locations along said backbone, said ligands being each independently naturally occurring nucleobases, non-naturally occurring nucleobases or nucleobase-binding groups, each said ligand being bound directly or indirectly to a nitrogen atom in said backbone, and said ligand bearing nitrogen atoms mainly being separated from one another in said backbone by from 4 to 8 intervening atoms; or (b) a nucleic acid analogue capable of hybridizing to a nucleic acid of complementary sequence to form a hybrid which is more stable against denaturation by heat than a hybrid between the conventional deoxyribonucleotide corresponding to said analogue and said nucleic acid; or (c) a nucleic acid analogue capable of hybridizing to a double stranded nucleic acid in which one strand has a sequence complementary to said analogue, so as to displace the other strand from said one strand.
摘要翻译：通常描述了核酸和诊断用途的捕获，识别，检测，鉴定或定量的方法，其中使用：（a）肽核酸（PNA），其包含聚酰胺主链，所述聚酰胺主链在所述所述配体各自独立地是天然存在的核碱基，非天然存在的核碱基或核碱基结合基团，每个所述配体直接或间接地结合到所述主链中的氮原子，并且所述配位体氮原子主要彼此分离在所述骨架中通过4至8个插入的原子; 或（b）能够与互补序列核酸杂交的核酸类似物，以形成与对应于所述类似物的所述类似物和所述核酸的常规脱氧核糖核苷酸之间的杂交体相比，通过加热变性更稳定的杂交体; 或（c）能够与双链核酸杂交的核酸类似物，其中一条链具有与所述类似物互补的序列，以便从所述一条链取代另一条链。

2. 发明授权

US5641625A Cleaving double-stranded DNA with peptide nucleic acids 失效
标题翻译：用肽核酸切割双链DNA
公开(公告)号：US5641625A
公开(公告)日：1997-06-24
申请号：US88658
申请日：1993-07-02
申请人： David J. Ecker , Ole Buchardt , Michael Egholm , Peter E. Nielsen , Rolf H. Berg , Niels E. Mollegaard
发明人： David J. Ecker , Ole Buchardt , Michael Egholm , Peter E. Nielsen , Rolf H. Berg , Niels E. Mollegaard
IPC分类号： C12N15/09 , A61K31/00 , A61K31/52 , A61K31/522 , A61K31/70 , A61K31/7088 , A61K31/7125 , A61K38/00 , A61K48/00 , A61P31/00 , A61P31/12 , A61P35/00 , A61P35/02 , A61P43/00 , C07C233/46 , C07C237/22 , C07D239/24 , C07D239/54 , C07D473/18 , C07D473/34 , C07H21/00 , C07H21/02 , C07H21/04 , C07K7/06 , C07K7/08 , C07K14/00 , C08G69/00 , C08G69/08 , C12N15/113 , C12Q1/68
CPC分类号： C12Q1/6813 , B82Y5/00 , C07H21/00 , C07K14/003 , C12N15/113 , A61K38/00 , C12N2310/15 , C12N2310/3181
摘要： Peptide nucleic acids and analogues of peptide nucleic acids are used to form duplex, triplex, and other structures with nucleic acids and to modify nucleic acids. The peptide nucleic acids and analogues thereof also are used to modulate protein activity through, for example, transcription arrest, transcription initiation, and site specific cleavage of nucleic acids.
摘要翻译：肽核酸和肽核酸的类似物用于与核酸形成双链体，三链体和其他结构并修饰核酸。肽核酸及其类似物也用于通过例如核酸的转录停止，转录起始和位点特异性切割来调节蛋白质活性。

3. 发明授权

US06770738B1 Higher order structure and binding of peptide nucleic acids 失效
标题翻译：高级结构和肽核酸的结合
公开(公告)号：US06770738B1
公开(公告)日：2004-08-03
申请号：US09442054
申请日：1999-11-16
申请人： David J. Ecker , Ole Buchardt , Michael Egholm , Peter E. Nielsen , Rolf H. Berg , Niels E. Mollegaard
发明人： David J. Ecker , Ole Buchardt , Michael Egholm , Peter E. Nielsen , Rolf H. Berg , Niels E. Mollegaard
IPC分类号： A61K3800
CPC分类号： C12N15/113 , A61K38/00 , B82Y5/00 , C07H21/00 , C07K14/003 , C12N2310/15 , C12N2310/3181 , C12Q1/6813 , C12Q2525/107 , C12Q2537/119
摘要： Peptide nucleic acids and analogues of peptide nucleic acids are used to form duplex, triplex, and other structures with nucleic acids and to modify nucleic acids. The peptide nucleic acids and analogues thereof also are used to modulate protein activity through, for example, transcription arrest, transcription initiation, and site specific cleavage of nucleic acids.
摘要翻译：肽核酸和肽核酸的类似物用于与核酸形成双链体，三链体和其他结构并修饰核酸。肽核酸及其类似物也用于通过例如核酸的转录停止，转录起始和位点特异性切割来调节蛋白质活性。

4. 发明授权

US5539082A Peptide nucleic acids 失效
公开(公告)号：US5539082A
公开(公告)日：1996-07-23
申请号：US54363
申请日：1993-04-26
申请人： Peter E. Nielsen , Ole Buchardt , Michael Egholm , Rolf H. Berg
发明人： Peter E. Nielsen , Ole Buchardt , Michael Egholm , Rolf H. Berg
IPC分类号： C12N15/09 , A61K31/00 , A61K31/52 , A61K31/522 , A61K31/70 , A61K31/7088 , A61K38/00 , A61K48/00 , A61P31/00 , A61P31/12 , A61P35/00 , C07C233/46 , C07C237/22 , C07D239/24 , C07D239/54 , C07D473/18 , C07D473/34 , C07H21/00 , C07K5/06 , C07K7/06 , C07K7/08 , C07K14/00 , C08G69/08 , C12N15/113 , C12Q1/68 , C07K7/00 , C07D239/00 , C07H5/04 , C07H21/04
CPC分类号： C12N15/113 , B82Y5/00 , C07H21/00 , C07K14/003 , C07K5/06026 , C07K7/06 , C07K7/08 , C12Q1/68 , C12Q1/6813 , C12Q1/6869 , A61K38/00 , C12N2310/15 , C12N2310/3181
摘要： A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.

5. 发明授权

US6107470A Histidine-containing peptide nucleic acids 失效
标题翻译：含组氨酸的肽核酸
公开(公告)号：US6107470A
公开(公告)日：2000-08-22
申请号：US225146
申请日：1999-01-04
申请人： Peter E. Nielsen , Ole Buchardt, deceased , Rolf H. Berg , Michael Egholm
发明人： Peter E. Nielsen , Ole Buchardt, deceased , Rolf H. Berg , Michael Egholm
IPC分类号： C07K14/00 , C07H21/02 , C07H19/00 , C07H21/04 , C12Q1/68
CPC分类号： C07K14/003
摘要： Peptide nucleic acids containing histidine moieties are provided. These compounds have applications including diagnostics, research and potential therapeutics.
摘要翻译：提供含有组氨酸部分的肽核酸。这些化合物具有诊断，研究和潜在治疗的应用。

6. 发明申请

US20120115136A1 PNA DIAGNOSTIC USE 审中-公开
标题翻译： PNA诊断用途
公开(公告)号：US20120115136A1
公开(公告)日：2012-05-10
申请号：US13190164
申请日：2011-07-25
申请人： Ole Buchardt , Michael Egholm , Peter E. Nielsen , Rolf H. Berg
发明人： Ole Buchardt , Michael Egholm , Peter E. Nielsen , Rolf H. Berg
IPC分类号： C12Q1/68 , C07K17/02 , C12N9/96 , C07K2/00
CPC分类号： C07H21/00 , A61K38/00 , C07K5/06026 , C07K5/06139 , C07K7/06 , C07K7/08 , C07K14/003 , C12Q1/68 , C12Q1/6813 , C12Q1/6832 , C12Q1/6869 , C12Q2535/107 , C12Q2525/107
摘要： The present invention pertains to certain nucleic acid analogs and related kits that are useful for the capture, recognition, detection, identification, or quantification of certain chemical or biological entities.
摘要翻译：本发明涉及可用于某些化学或生物实体的捕获，识别，检测，鉴定或定量的某些核酸类似物和相关试剂盒。

7. 发明授权

US06710164B1 Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility 失效
标题翻译：肽核酸
公开(公告)号：US06710164B1
公开(公告)日：2004-03-23
申请号：US09230088
申请日：1999-03-10
申请人： Peter E. Nielsen , Michael Egholm , Rolf H. Berg , Ole Buchardt
发明人： Peter E. Nielsen , Michael Egholm , Rolf H. Berg , Ole Buchardt
IPC分类号： A61K3800
CPC分类号： C07K5/06139 , C07K14/003 , C12Q1/68
摘要： A novel class of compounds known as peptide nucleic acids, bind complementary DNA and RNA strands, and generally do so more strongly than the corresponding DNA or RNA strands while exhibiting increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases, including 2,6-diaminopurine, attached to a polyamide backbone, and contain alkyl amine side chains.
摘要翻译：被称为肽核酸的新一类化合物结合互补DNA和RNA链，并且通常比相应的DNA或RNA链更强烈地显示出增加的序列特异性和溶解性。肽核酸包含选自天然存在的核碱基和非天然存在的核碱基的配体，包括连接到聚酰胺主链上的2,6-二氨基嘌呤，并且含有烷基胺侧链。

8. 发明授权

US5986053A Peptide nucleic acids complexes of two peptide nucleic acid strands and one nucleic acid strand 失效
标题翻译：两个肽核酸链和一个核酸链的肽核酸复合物
公开(公告)号：US5986053A
公开(公告)日：1999-11-16
申请号：US471907
申请日：1995-06-07
申请人： David J. Ecker , Ole Buchardt , Michael Egholm , Peter E. Nielsen , Rolf H. Berg , Niels E. Mollegaard
发明人： David J. Ecker , Ole Buchardt , Michael Egholm , Peter E. Nielsen , Rolf H. Berg , Niels E. Mollegaard
IPC分类号： C12N15/09 , A61K31/00 , A61K31/52 , A61K31/522 , A61K31/70 , A61K31/7088 , A61K31/7125 , A61K38/00 , A61K48/00 , A61P31/00 , A61P31/12 , A61P35/00 , A61P35/02 , A61P43/00 , C07C233/46 , C07C237/22 , C07D239/24 , C07D239/54 , C07D473/18 , C07D473/34 , C07H21/00 , C07H21/02 , C07H21/04 , C07K7/06 , C07K7/08 , C07K14/00 , C08G69/00 , C08G69/08 , C12N15/113 , C12Q1/68 , C07K2/00
CPC分类号： C12Q1/6813 , B82Y5/00 , C07H21/00 , C07K14/003 , C12N15/113 , A61K38/00 , C12N2310/15 , C12N2310/3181
摘要： Peptide nucleic acids and analogues of peptide nucleic acids are used to form duplex, triplex, and other structures with nucleic acids and to modify nucleic acids. The peptide nucleic acids and analogues thereof also are used to modulate protein activity through, for example, transcription arrest, transcription initiation, and site specific cleavage of nucleic acids.
摘要翻译：肽核酸和肽核酸的类似物用于与核酸形成双链体，三链体和其他结构并修饰核酸。肽核酸及其类似物也用于通过例如核酸的转录停止，转录起始和位点特异性切割来调节蛋白质活性。

9. 发明授权

US5773571A Peptide nucleic acids 失效
公开(公告)号：US5773571A
公开(公告)日：1998-06-30
申请号：US595387
申请日：1996-02-01
申请人： Peter E. Nielsen , Ole Buchardt , Michael Egholm , Rolf H. Berg
发明人： Peter E. Nielsen , Ole Buchardt , Michael Egholm , Rolf H. Berg
IPC分类号： C12N15/09 , A61K31/00 , A61K31/52 , A61K31/522 , A61K31/70 , A61K31/7088 , A61K38/00 , A61K48/00 , A61P31/00 , A61P31/12 , A61P35/00 , C07C233/46 , C07C237/22 , C07D239/24 , C07D239/54 , C07D473/18 , C07D473/34 , C07H21/00 , C07K5/06 , C07K7/06 , C07K7/08 , C07K14/00 , C08G69/08 , C12N15/113 , C12Q1/68 , C07K5/00
CPC分类号： C12N15/113 , B82Y5/00 , C07H21/00 , C07K14/003 , C07K5/06026 , C07K7/06 , C07K7/08 , C12Q1/68 , C12Q1/6813 , C12Q1/6869 , A61K38/00 , C12N2310/15 , C12N2310/3181
摘要： A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.

10. 发明授权

US06610650B1 Modulation of cellular transcription factor activity 失效
标题翻译：调节细胞转录因子活性
公开(公告)号：US06610650B1
公开(公告)日：2003-08-26
申请号：US09610264
申请日：2000-07-06
申请人： Benget Norden , Pernilla Wittung , Ole Buchardt , Michael Egholm , Peter E. Nielsen , Rolf Berg
发明人： Benget Norden , Pernilla Wittung , Ole Buchardt , Michael Egholm , Peter E. Nielsen , Rolf Berg
IPC分类号： A01N3718
CPC分类号： C12N15/113 , A61K38/00 , B82Y5/00 , C07H21/00 , C07K14/003 , C12N15/1132 , C12N15/1135 , C12N2310/13 , C12N2310/15 , C12N2310/3181 , C12N2310/3513 , C12Q1/6813 , C12Q2525/107 , C12Q2537/119
摘要： A novel class of compounds, known as peptide nucleic acids, form double-stranded structures with one another and with ssDNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
摘要翻译：一类新的化合物，称为肽核酸，形成双链结构，并与ssDNA形成双链结构。肽核酸通常包含配体，例如通过合适的接头连接到肽主链上的天然存在的DNA碱基。

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