专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5786215A Method for culturing animal cells 失效
标题翻译：培养动物细胞的方法
公开(公告)号：US5786215A
公开(公告)日：1998-07-28
申请号：US436648
申请日：1995-05-08
申请人： Peter C. Brown , Mark T. Wininger , Robert V. Oakley
发明人： Peter C. Brown , Mark T. Wininger , Robert V. Oakley
IPC分类号： C12M3/06 , C12N5/00
CPC分类号： C12M23/24 , C12M23/06 , C12M23/34
摘要： An apparatus and method for the in vitro culturing of animal cells, e.g., mammalian cells, to attain mass growth of the cells per se and/or to recover cell-secreted products of interest therefrom, in which an integral culture and gassing element is formed from spirally-wound or concentricallywrapped lengths of a liquid-impermeable, oxygen-permeable membrane envelope such that narrow cell culture spaces are formed between adjacent windings or wrapping of the envelope. Cells in the culture spaces, which spaces may optionally contain cell substrate material, are cultured in contact with a culture medium introduced into the spaces from an end of the element, and in contact with oxygen-containing gas supplied to the membrane envelope for diffusion across its oxygen-permeable walls into the culture spaces.
摘要翻译：用于体外培养动物细胞（例如哺乳动物细胞）的装置和方法，以实现细胞本身的大规模生长和/或回收其中形成整合培养物和放气元件的感兴趣的细胞分泌产物从不透液体的透氧薄膜包膜的螺旋卷绕或同心包裹的长度，使得相邻绕组之间形成狭窄的细胞培养空间或包封。将培养空间中的细胞任选地含有细胞底物材料的细胞与从元件末端引入到空间中的培养基接触培养，并与供应到膜包膜的含氧气体接触以扩散跨越其透氧壁渗入培养空间。

2. 发明授权

US07901934B2 Probe connector assembly and method of use 有权
标题翻译：探头连接器组件及使用方法
公开(公告)号：US07901934B2
公开(公告)日：2011-03-08
申请号：US12116050
申请日：2008-05-06
申请人： Kurt T. Kunas , Robert V. Oakley , Fauad F. Hasan , Michael E. Goodwin , Jeremy K. Larsen , Nephi D. Jones
发明人： Kurt T. Kunas , Robert V. Oakley , Fauad F. Hasan , Michael E. Goodwin , Jeremy K. Larsen , Nephi D. Jones
IPC分类号： C12M1/00 , C12M3/00
CPC分类号： C12M23/14 , B01F7/001 , B01F7/1695 , B01F7/22 , B01F15/00006 , B01F15/00831 , B01F15/0085 , B01F2215/0073 , C12M23/00 , C12M23/06 , C12M23/26 , C12M23/28 , C12M27/02 , C12M29/06 , Y10T29/49826
摘要： A probe assembly includes a tubular sleeve having a passage extending between a first end and an opposing second end. The tubular sleeve is movable between an extended position wherein the first end and the opposing second end are spaced apart and a collapsed position wherein the first end and the opposing second end are moved closer together. A connector is secured to the second end of the tubular sleeve, the connector having an opening extending therethrough that communicates with the passage of the tubular sleeve, a sealing layer removably covering the opening of the connector. An elongated probe has a first end and an opposing second end, the second end of the probe being positioned within the passage of the tubular sleeve, the second end of the probe being configured to pass through the opening of the connector when the sealing layer is removed therefrom.
摘要翻译：探针组件包括具有在第一端和相对的第二端之间延伸的通道的管状套管。管状套管可以在其中第一端和相对的第二端间隔开的延伸位置和折叠位置之间移动，其中第一端和相对的第二端更靠近地一起移动。连接器被固定到管状套筒的第二端，连接器具有穿过其中的开口，其与管状套管的通道相通，密封层可拆卸地覆盖连接器的开口。细长的探针具有第一端和相对的第二端，探针的第二端定位在管状套筒的通道内，探针的第二端构造成当密封层是通过时穿过连接器的开口从中移除。

3. 发明授权

US5017490A Method for in vitro reproduction and growth of cells in culture medium 失效
标题翻译：培养基中细胞体外繁殖和生长的方法
公开(公告)号：US5017490A
公开(公告)日：1991-05-21
申请号：US321765
申请日：1989-03-10
申请人： Van Taiariol , Robert V. Oakley , Peter Ventura
发明人： Van Taiariol , Robert V. Oakley , Peter Ventura
IPC分类号： C12M3/00 , C12M1/00 , C12M3/06 , C12N5/02
CPC分类号： C12M23/34 , C12M23/14 , C12M23/24
摘要： Method and apparatus for in vitro culture of cells in culture medium to produce a viable cell mass of cell number greater than the initial cell number, wherein a cell mass of particular cell number is cultured in a first oxygen-permeable culture sub-compartment to an increased cell number, and then aseptically transferred directly from the first sub-compartment to a next serial culture sub-compartment providing additional medium and/or culture space for further growth and reproduction to produce a viable cell mass of still higher cell number. Continued transfers are made, if necessary, to successive serial culture sub-compartment until a viable cell mass of desired cell number is attained, particularly one useful for seeding of a production-scale culture system.
摘要翻译：在培养基中体外培养细胞以产生大于初始细胞数的细胞数的活细胞块的方法和装置，其中特定细胞数量的细胞群在第一透氧培养子室中培养至增加的细胞数量，然后直接从第一子室直接转移到下一个连续培养子室，提供用于进一步生长和繁殖的另外的培养和/或培养空间以产生更高细胞数的活细胞块。如果需要，连续转移到连续的培养子室，直至获得所需细胞数的活细胞块，特别是用于种植生产规模培养系统的细胞块。

4. 发明授权

US4999307A Apparatus and method for periodic aseptic withdrawal of liquid samples from a sterile liquid source 失效
标题翻译：从无菌液体源定期无菌取出液体样品的装置和方法
公开(公告)号：US4999307A
公开(公告)日：1991-03-12
申请号：US310539
申请日：1989-02-13
申请人： Robert V. Oakley
发明人： Robert V. Oakley
IPC分类号： G01N1/00 , C12M1/32 , G01N1/10 , G01N1/18 , G01N1/20
CPC分类号： C12M33/06 , C12M37/00 , G01N1/18 , Y10S435/80 , Y10T436/2575
摘要： A liquid sampling device is provided for periodic aseptic removal of samples of a source liquid to be analyzed, comprised of a primary liquid conduit tube closed at one end and, at the other end, adapted to be in liquid communication with a principal or secondary flow line through which the source liquid flows or is arranged to flow, and a plurality of separate sample conduit tubes emanating from and in liquid communication with the primary liquid conduit tube, one end of each sample conduit tube being adapted to withdraw therethrough a sample of the source liquid. The device is configured such that, after a sample is taken through a particular sample conduit tube, that tube can be isolated or removed from the system, and subsequent samples are taken successively from remaining sample conduit tubes in the same manner.
摘要翻译：提供一种液体取样装置，用于对要分析的源液体的样品进行周期性的无菌去除，包括在一端封闭的主要液体导管，另一端适于与主流体或二次流体液体连通源液体通过其流动或被布置成流动的管线，以及从主液体导管发出并与液体连通的多个单独的样品导管，每个样品管道的一端适于从其中抽出样品源液体。该装置被配置成使样品通过特定的样品导管后，该管可以从系统中分离或除去，并且以相同的方式连续地从剩余的样品导管中取出随后的样品。

5. 发明申请

US20120218855A1 STIRRED TANK REACTOR SYSTEMS AND METHODS OF USE 有权
标题翻译：搅拌罐反应器系统和使用方法
公开(公告)号：US20120218855A1
公开(公告)日：2012-08-30
申请号：US13443391
申请日：2012-04-10
申请人： Kurt T. Kunas , Robert V. Oakley , Fauad F. Hasan , Michael E. Goodwin , Jeremy K. Larsen , Nephi D. Jones
发明人： Kurt T. Kunas , Robert V. Oakley , Fauad F. Hasan , Michael E. Goodwin , Jeremy K. Larsen , Nephi D. Jones
IPC分类号： C12M1/02 , B01F15/02
CPC分类号： C12M23/14 , B01F7/001 , B01F7/1695 , B01F7/22 , B01F15/00006 , B01F15/00831 , B01F15/0085 , B01F2215/0073 , C12M23/00 , C12M23/06 , C12M23/26 , C12M23/28 , C12M27/02 , C12M29/06 , Y10T29/49826
摘要： A reactor system includes a flexible bag having an interior surface bounding a compartment. An elongated tubular connector is disposed within the compartment of the flexible bag, the tubular connector having a first end and an opposing second end, the first end of the tubular connector being coupled with the flexible bag. An impeller is disposed within the compartment of the flexible bag and is secured to the tubular connector. A drive shaft is removably received within the tubular connector such that rotation of the drive shaft facilitates rotation of the impeller.
摘要翻译：反应器系统包括具有包围隔室的内表面的柔性袋。细长的管状连接器设置在柔性袋的隔室内，管状连接器具有第一端和相对的第二端，管状连接器的第一端与柔性袋结合。叶轮设置在柔性袋的隔室内并固定到管状连接器。驱动轴可移除地容纳在管状连接器内，使得驱动轴的旋转有利于叶轮的旋转。

6. 发明授权

US08187867B2 Probe connector assembly and method of use 有权
标题翻译：探头连接器组件及使用方法
公开(公告)号：US08187867B2
公开(公告)日：2012-05-29
申请号：US13014575
申请日：2011-01-26
申请人： Kurt T. Kunas , Robert V. Oakley , Fauad F. Hasan , Michael E. Goodwin , Jeremy K. Larsen , Nephi D. Jones
发明人： Kurt T. Kunas , Robert V. Oakley , Fauad F. Hasan , Michael E. Goodwin , Jeremy K. Larsen , Nephi D. Jones
IPC分类号： C12M1/00 , C12M3/00
CPC分类号： C12M23/14 , B01F7/001 , B01F7/1695 , B01F7/22 , B01F15/00006 , B01F15/00831 , B01F15/0085 , B01F2215/0073 , C12M23/00 , C12M23/06 , C12M23/26 , C12M23/28 , C12M27/02 , C12M29/06 , Y10T29/49826
摘要： A probe assembly includes a tubular sleeve having a passage extending between a first end and an opposing second end. The tubular sleeve is movable between an extended position wherein the first end and the opposing second end are spaced apart and a collapsed position wherein the first end and the opposing second end are moved closer together. A connector is secured to the second end of the tubular sleeve, the connector having an opening extending therethrough that communicates with the passage of the tubular sleeve, a sealing layer removably covering the opening of the connector. An elongated probe has a first end and an opposing second end, the second end of the probe being positioned within the passage of the tubular sleeve, the second end of the probe being configured to pass through the opening of the connector when the sealing layer is removed therefrom.
摘要翻译：探针组件包括具有在第一端和相对的第二端之间延伸的通道的管状套管。管状套筒可以在其中第一端和相对的第二端间隔开的延伸位置和折叠位置之间移动，其中第一端和相对的第二端更靠近地一起移动。连接器被固定到管状套筒的第二端，连接器具有穿过其中的开口，其与管状套管的通道相通，密封层可拆卸地覆盖连接器的开口。细长的探针具有第一端和相对的第二端，探针的第二端定位在管状套筒的通道内，探针的第二端构造成当密封层是通过时穿过连接器的开口从中移除。

7. 发明申请

US20080206847A1 PROBE CONNECTOR ASSEMBLY AND METHOD OF USE 有权
标题翻译：探头连接器总成及使用方法
公开(公告)号：US20080206847A1
公开(公告)日：2008-08-28
申请号：US12116050
申请日：2008-05-06
申请人： Kurt T. Kunas , Robert V. Oakley , Fauad F. Hasan , Michael E. Goodwin , Jeremy K. Larson , Nephi D. Jones
发明人： Kurt T. Kunas , Robert V. Oakley , Fauad F. Hasan , Michael E. Goodwin , Jeremy K. Larson , Nephi D. Jones
IPC分类号： C12M1/00 , B23P11/00
CPC分类号： C12M23/14 , B01F7/001 , B01F7/1695 , B01F7/22 , B01F15/00006 , B01F15/00831 , B01F15/0085 , B01F2215/0073 , C12M23/00 , C12M23/06 , C12M23/26 , C12M23/28 , C12M27/02 , C12M29/06 , Y10T29/49826
摘要： A probe assembly includes a tubular sleeve having a passage extending between a first end and an opposing second end. The tubular sleeve is movable between an extended position wherein the first end and the opposing second end are spaced apart and a collapsed position wherein the first end and the opposing second end are moved closer together. A connector is secured to the second end of the tubular sleeve, the connector having an opening extending therethrough that communicates with the passage of the tubular sleeve, a sealing layer removably covering the opening of the connector. An elongated probe has a first end and an opposing second end, the second end of the probe being positioned within the passage of the tubular sleeve, the second end of the probe being configured to pass through the opening of the connector when the sealing layer is removed therefrom.
摘要翻译：探针组件包括具有在第一端和相对的第二端之间延伸的通道的管状套管。管状套管可以在其中第一端和相对的第二端间隔开的延伸位置和折叠位置之间移动，其中第一端和相对的第二端更靠近地一起移动。连接器被固定到管状套筒的第二端，连接器具有穿过其中的开口，其与管状套管的通道相通，密封层可拆卸地覆盖连接器的开口。细长的探针具有第一端和相对的第二端，探针的第二端定位在管状套筒的通道内，探针的第二端构造成当密封层是通过时穿过连接器的开口从中移除。

8. 发明申请

US20110117594A1 PROBE CONNECTOR ASSEMBLY AND MEHTOD OF USE 有权
标题翻译：探头连接器总成和使用手段
公开(公告)号：US20110117594A1
公开(公告)日：2011-05-19
申请号：US13014575
申请日：2011-01-26
申请人： Kurt T. Kunas , Robert V. Oakley , Fauad F. Hasan , Michael E. Goodwin , Jeremy K. Larsen , Nephi D. Jones
发明人： Kurt T. Kunas , Robert V. Oakley , Fauad F. Hasan , Michael E. Goodwin , Jeremy K. Larsen , Nephi D. Jones
IPC分类号： C12Q1/02
CPC分类号： C12M23/14 , B01F7/001 , B01F7/1695 , B01F7/22 , B01F15/00006 , B01F15/00831 , B01F15/0085 , B01F2215/0073 , C12M23/00 , C12M23/06 , C12M23/26 , C12M23/28 , C12M27/02 , C12M29/06 , Y10T29/49826
摘要： A probe assembly includes a tubular sleeve having a passage extending between a first end and an opposing second end. The tubular sleeve is movable between an extended position wherein the first end and the opposing second end are spaced apart and a collapsed position wherein the first end and the opposing second end are moved closer together. A connector is secured to the second end of the tubular sleeve, the connector having an opening extending therethrough that communicates with the passage of the tubular sleeve, a sealing layer removably covering the opening of the connector. An elongated probe has a first end and an opposing second end, the second end of the probe being positioned within the passage of the tubular sleeve, the second end of the probe being configured to pass through the opening of the connector when the sealing layer is removed therefrom.
摘要翻译：探针组件包括具有在第一端和相对的第二端之间延伸的通道的管状套管。管状套管可以在其中第一端和相对的第二端间隔开的延伸位置和折叠位置之间移动，其中第一端和相对的第二端更靠近地一起移动。连接器被固定到管状套筒的第二端，连接器具有穿过其中的开口，其与管状套管的通道相通，密封层可拆卸地覆盖连接器的开口。细长的探针具有第一端和相对的第二端，探针的第二端定位在管状套筒的通道内，探针的第二端构造成当密封层是通过时穿过连接器的开口从中移除。

9. 发明授权

US07682067B2 Mixing systems and related mixers 有权
标题翻译：混合系统和相关混合器
公开(公告)号：US07682067B2
公开(公告)日：2010-03-23
申请号：US11379535
申请日：2006-04-20
申请人： Derik R. West , Whitt F. Woods , Jeremy K. Larsen , Nephi D. Jones , Robert V. Oakley , Kurt Thomas Kunas , Fauad F. Hasan
发明人： Derik R. West , Whitt F. Woods , Jeremy K. Larsen , Nephi D. Jones , Robert V. Oakley , Kurt Thomas Kunas , Fauad F. Hasan
IPC分类号： B01F7/16
CPC分类号： B01F7/00691 , B01F7/001 , B01F7/00341 , B01F7/00725 , B01F15/00006 , B01F15/00831 , B01F15/00837 , B01F15/0085 , B01F2215/0032 , B01F2215/0073
摘要： A mixing system includes a housing and a motor mount disposed on the housing and having a passage extending therethrough. A dive motor is coupled with the motor mount for selectively rotating the motor mount relative to the housing. A rotational assembly includes a hub having a passageway extending therethrough and a casing at least partially encircling the hub, the hub being rotatable to the casing. The rotational assembly is removably coupled to the housing so that the passageway of the hub aligns with the passage of the motor mount.
摘要翻译：混合系统包括壳体和设置在壳体上并具有延伸通过其的通道的马达座。潜水电动机与电动机支架联接，用于相对于壳体选择性地旋转电动机支架。旋转组件包括具有延伸穿过其中的通道的轮毂和至少部分地环绕轮毂的壳体，所述轮毂可旋转到壳体。旋转组件可移除地联接到壳体，使得毂的通道与电动机支架的通道对准。

10. 发明授权

US5102790A Method for culturing animal cells 失效
标题翻译：培养动物细胞的方法
公开(公告)号：US5102790A
公开(公告)日：1992-04-07
申请号：US286756
申请日：1988-12-19
申请人： Rudolf F. Bliem , Robert V. Oakley , Van C. Taiariol
发明人： Rudolf F. Bliem , Robert V. Oakley , Van C. Taiariol
IPC分类号： C12M3/02 , C12M3/00 , C12N5/02
CPC分类号： C12M29/04 , C12M23/34 , C12M25/16
摘要： A method of using an apparatus for the in vitro cultrue of animal cells to recover secreted proteins of interest therefrom, affording the capability of being readily and predictably scaled up or down to desired protein productin rates, comprised of a housed arrangement of culture subunits containing a packed bed of carrier particles, each subunit being fed in parallel from a common culture medium source, and the spent culture fluid from each subunit being directed to a common spent fluid conduit within the housed arrangement. Scale-up or scale-down is effected by addition or subtraction of culture subunits and/or by increase or decrease in carrier particle volume within a subunit while maintaining substantially constant packed bed height.
摘要翻译：使用用于体外培养动物细胞以从其中回收分泌的目的蛋白质的装置的方法，提供容易且可预测地按比例放大或缩小至所需蛋白质产生速率的能力，其包含含有载体颗粒的填充床，每个亚单位从普通培养基来源平行进料，并且来自每个子单元的废培养液被引导到所容纳的布置中的共用废流体导管。通过加入或减去培养物单位和/或通过增加或减少亚单位内的载体颗粒体积同时保持基本上恒定的填充床高度来实现放大或缩小。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式