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1. 发明申请

US20070184847A1 Method and a system for safe pairing of wireless communication devices 审中-公开
标题翻译：无线通信设备安全配对的方法和系统
公开(公告)号：US20070184847A1
公开(公告)日：2007-08-09
申请号：US11508355
申请日：2006-08-23
申请人： Per Hansen , Per Holm , Morten Stribek
发明人： Per Hansen , Per Holm , Morten Stribek
IPC分类号： H04Q7/20
CPC分类号： H04W48/18 , A61B5/0022 , A61B5/14532 , G16H40/67 , H04W48/14 , H04W84/18
摘要： The present invention relates to a method and a system for safe pairing of wireless communication medical devices in a situation when multiple servers are within the reach of a client by determining and indicating the number of wireless medical devices responding to a node query broadcast and accordingly establishing a connection with the appropriate medical device.
摘要翻译：本发明涉及一种在通过确定和指示响应节点查询广播的无线医疗设备的数量并因此建立多个服务器在客户端范围内的情况下无线通信医疗设备的安全配对的方法和系统与适当的医疗设备的连接。

2. 发明申请

US20070061674A1 Transmission data packet construction for better header authentication 审中-公开
标题翻译：传输数据包构建，更好的头认证
公开(公告)号：US20070061674A1
公开(公告)日：2007-03-15
申请号：US11513085
申请日：2006-08-30
申请人： Per Hansen , Per Holm
发明人： Per Hansen , Per Holm
IPC分类号： H03M13/00
CPC分类号： H04L63/0428 , H04L63/123
摘要： The invention relates to a packet format for data being transmitted in a packet switched network. The packet as constructed in accordance with the invention enables the detection of data tampering and alteration of the data payload part as well as header part. The invention uses check code and encryption for constructing a secure packet but does not encrypt the header part of the transmission data packet.
摘要翻译：本发明涉及用于在分组交换网络中传输的数据的分组格式。根据本发明构造的分组能够检测数据篡改和数据有效载荷部分的改变以及报头部分。本发明使用校验码和加密来构建安全分组，但不对发送数据分组的报头部分进行加密。

3. 发明申请

US20070186130A1 Reduced size transmission data packet header format for a medical device 审中-公开
标题翻译：减小医疗设备的传输数据包头数据格式
公开(公告)号：US20070186130A1
公开(公告)日：2007-08-09
申请号：US11522831
申请日：2006-09-18
申请人： Per Holm , Per Hansen , Morten Stribaek
发明人： Per Holm , Per Hansen , Morten Stribaek
IPC分类号： G06F11/00
CPC分类号： H04L1/0083 , H04L1/0041 , H04L1/0045 , H04L1/0061 , H04L1/0072
摘要： The present invention relates to a reduced size format for transmission packet header wherein a source address is encoded together with a check code in a medical device. The packet header thus contains one single field now in place of two i.e. the check code and source address. At the receiving end, the receiver looks up the sender address from the session descriptor table, calculates the check code and then performs the same encoding with the address and the check code, thus authenticating and validating the packet.
摘要翻译：本发明涉及用于传输分组报头的缩小尺寸格式，其中源地址与医疗设备中的校验码一起被编码。因此，分组报头包含现在代替两个单个字段，即检查码和源地址。在接收端，接收端从会话描述符表中查找发送方地址，计算校验码，然后用地址和校验码执行相同的编码，从而对数据包进行认证和验证。

4. 发明授权

US08664239B2 Tacrolimus for improved treatment of transplant patients 有权
公开(公告)号：US08664239B2
公开(公告)日：2014-03-04
申请号：US13167420
申请日：2011-06-23
申请人： Robert D. Gordon , Per Holm , Anne-Marie Lademann , Tomas Norling
发明人： Robert D. Gordon , Per Holm , Anne-Marie Lademann , Tomas Norling
IPC分类号： A61K31/44 , A61K31/436
CPC分类号： A61K31/436 , A61K9/0053 , A61K9/1617 , A61K9/1641 , A61K9/1652 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2077 , A61K9/284 , A61K9/2846 , A61K9/4891 , A61K47/10 , Y10S514/885
摘要： An extended release oral dosage form comprising as active substance tacrolimus or a pharmaceutically active analogue thereof for a once daily immunosuppressive treatment of a patient in need thereof, preferable a kidney or liver transplant patient. The dosage form releases the active substance over an extended period of time. It also provides improved pharmacokinetic parameters due to an extended and constant in vivo release including substantial decreased peak concentrations, despite increased bioavailability, substantial extended times for maximal concentration, and higher minimal concentrations when compared with conventional immediate release dosage forms and a recent modified release tacrolimus dosage form.

5. 发明授权

US08591946B2 Modified release compositions comprising tacrolimus 有权
公开(公告)号：US08591946B2
公开(公告)日：2013-11-26
申请号：US10569862
申请日：2004-08-30
申请人： Per Holm
发明人： Per Holm
IPC分类号： A61K9/14
CPC分类号： A61K9/0053 , A61K9/10 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/1641 , A61K9/1652 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2077 , A61K9/2095 , A61K9/2846 , A61K9/2893 , A61K31/00 , A61K31/436 , A61K31/439 , A61K31/4745 , Y10S514/885
摘要： A modified release composition comprising tacrolimus releases less than 20% w/w of the active ingredient within 0.5 hours when subjected to an in vitro dissolution test using USP Paddle method and using 0.1 N HCl as dissolution medium and has increased bioavailability by effectively reducing or even avoiding the effects of CYP3A4 metabolism. The modified composition may be coated with an enteric coating; and/or may comprise a solid dispersion or a solid solution of tacrolimus in a hydrophilic or water-miscible vehicle and one or more modifying release agents; and/or may comprise a solid dispersion or a solid solution of tacrolimus in an amphiphilic or hydrophobic vehicle and optionally one or more modifying release agents.

6. 发明申请

US20100323008A1 SOLID DOSAGE FORM COMPRISING A FIBRATE 有权
标题翻译：固体剂型包含纤维素
公开(公告)号：US20100323008A1
公开(公告)日：2010-12-23
申请号：US12642563
申请日：2009-12-18
申请人： Per Holm , Tomas Norling
发明人： Per Holm , Tomas Norling
IPC分类号： A61K9/32 , A61K31/216 , A61P3/00
CPC分类号： A61K9/20 , A61K9/2013 , A61K9/2018 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/22 , A61K31/40 , A61K45/06 , A61K2300/00
摘要： The invention provides stable, solid dosage forms and pharmaceutical compositions in particulate form comprising a fibrate, for example fenofibrate, dissolved in an non-aqueous vehicle in order to ensure improved bioavailability of the active ingredient upon oral administration relative to known fibrate formulations.
摘要翻译：本发明提供稳定的固体剂型和药物组合物，其包含溶解在非水载体中的贝特类，例如非诺贝特，以确保相对于已知的贝特类制剂口服给药时活性成分的生物利用度得到改善。

7. 发明授权

US07772273B2 Stabilized atorvastatin 失效
标题翻译：稳定阿托伐他汀
公开(公告)号：US07772273B2
公开(公告)日：2010-08-10
申请号：US11673270
申请日：2007-02-09
申请人： Per Holm
发明人： Per Holm
IPC分类号： A01N43/36
CPC分类号： A61K9/209 , A61K9/1617 , A61K9/1623 , A61K9/1652 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K9/2077 , A61K9/2846 , A61K9/2866 , A61K31/138 , A61K31/40 , A61K31/401 , A61K2300/00
摘要： A stable pharmaceutical composition for oral administration comprising atorvastatin and an amount of a pharmaceutically acceptable organic alkalizing compound capable of establishing a microenvironment for atorvastatin having a pH of at least about 5, for example 2-amino-2-(hydroxymethyl)-1,3-propanediol (trometamol).
摘要翻译：一种用于口服给药的稳定药物组合物，其包含阿托伐他汀和一定量的药学上可接受的有机碱化化合物，其能够建立pH至少约为5的阿托伐他汀的微环境，例如2-氨基-2-（羟甲基） - 丙二醇（氨丁三醇）。

8. 发明申请

US20090186081A1 Disintegrating Loadable Tablets 审中-公开
标题翻译：崩解性可装载片剂
公开(公告)号：US20090186081A1
公开(公告)日：2009-07-23
申请号：US12087392
申请日：2007-01-05
申请人： Per Holm , Lillian Slot
发明人： Per Holm , Lillian Slot
IPC分类号： A61K9/20 , A61K47/02
CPC分类号： A61K9/2095 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/205 , A61K9/2054
摘要： A disintegrating loadable tablet product in compressed form comprising i) at least 60% w/w of a sorbent material having a specific surface area (BET surface area) of at least 50 m2/g as measured by gas adsorption or mixtures of such sorbent materials, and ii) a disintegrant or a mixture of disintegrants wherein the tablet in compressed form has a) a porosity of 45% v/v or more, b) a hardness of at least 20 Newton, and c) a loading capacity of at least 30% of a liquid. The tablet is suitable for the preparation of a tablet containing an active substance by e.g. immersing the tablet in a liquid containing the active substance. The invention thus provides a safe and reproducible new method of preparing pharmaceutical tablets.
摘要翻译：一种压缩形式的崩解性可装载片剂，其包含：i）通过气体吸附测定的至少60％w / w的具有至少50m 2 / g的比表面积（BET表面积）的吸附剂材料或这些吸附剂材料的混合物，和ii）崩解剂或崩解剂的混合物，其中压缩形式的片剂具有a）45％v / v以上的孔隙率，b）至少20牛顿的硬度，和c）至少负载能力 30％的液体。片剂适用于制备含有活性物质的片剂。将片剂浸入含有活性物质的液体中。因此，本发明提供了制备药物片剂的安全和可重现的新方法。

9. 发明申请

US20080070308A1 Portous Article For Delivering Chemical Substances 审中-公开
标题翻译：波多尔文章提供化学物质
公开(公告)号：US20080070308A1
公开(公告)日：2008-03-20
申请号：US11597786
申请日：2005-06-27
申请人： Thomas Ruhland , Per Holm
发明人： Thomas Ruhland , Per Holm
IPC分类号： G01N37/00
CPC分类号： B01J19/0046 , A61K9/2009 , A61K9/2095 , B01J2219/00351 , B01J2219/00454 , B01J2219/00459 , B01J2219/0054 , B01J2219/00599 , B01J2219/0072 , B01L3/0293 , B01L2200/16 , B01L2300/069 , C40B50/08 , C40B50/14 , C40B60/14 , C40B70/00 , Y02P20/582 , Y10T436/10
摘要： A reagent delivering article capable of retaining liquid reagents, a method of pre-paring said articles and the use of said articles for loading liquid reagents is provided. Furthermore a reagent delivering article loaded with at least one liquid reagent, a method of preparing same and the use of said loaded article in solution phase chemistry, where said loaded reagent is released from said article into the solution is provided.
摘要翻译：提供了能够保留液体试剂的试剂递送制品，预先制备所述制品的方法和所述制品用于装载液体试剂的用途。此外，提供了装载有至少一种液体试剂的试剂递送制品，其制备方法以及所述加载的试剂在溶液相化学中的用途，其中所述加载的试剂从所述制品释放到溶液中。

10. 发明申请

US20070105912A1 Pharmaceutical compositions comprising lercanidipine 审中-公开
标题翻译：包含氯卡地平的药物组合物
公开(公告)号：US20070105912A1
公开(公告)日：2007-05-10
申请号：US10581128
申请日：2004-12-01
申请人： Per Holm , Tomas Norling
发明人： Per Holm , Tomas Norling
IPC分类号： A61K31/455
CPC分类号： A61K31/44 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/1641 , A61K9/1652 , A61K9/2018 , A61K9/2031 , A61K9/2054 , A61K9/4858 , A61K31/4418
摘要： A controlled release pharmaceutical composition comprising lercanidipine dissolved or dispersed in a solid vehicle at ambient temperature, thus forming a solid dispersion, achieves delayed release of lercanidipine over an extended period of time, reduced food effect and increased bioavailability compared to commercially available lercanidipine containing products.
摘要翻译：一种控释药物组合物，其包含在环境温度下溶解或分散在固体载体中的氯卡地平，从而形成固体分散体，与市售的含有乐卡西地平的产品相比，在延长的时间段内实现延迟释放莱卡西平，降低的食物效应和增加的生物利用度。

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