专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20060258561A1 Novel NPH insulin preparations 审中-公开
标题翻译：新型NPH胰岛素制剂
公开(公告)号：US20060258561A1
公开(公告)日：2006-11-16
申请号：US11226870
申请日：2005-09-09
申请人： Per Balschmidt , Helle Olsen , Niels Kaarsholm , Peter Madsen , Palle Jakobsen , Svend Ludvigsen , Gerd Schluckebier , Dorte Steensgaard , Anders Petersen
发明人： Per Balschmidt , Helle Olsen , Niels Kaarsholm , Peter Madsen , Palle Jakobsen , Svend Ludvigsen , Gerd Schluckebier , Dorte Steensgaard , Anders Petersen
IPC分类号： A61K38/28 , A61K31/522 , A61K31/513 , A61K31/426 , A61K31/4196 , A61K31/4184 , A61K31/4166 , A61K33/32
CPC分类号： A61K31/4166 , A61K31/4184 , A61K31/4196 , A61K31/426 , A61K31/513 , A61K31/522 , A61K33/30 , A61K38/28 , A61K45/06
摘要： This invention relates to NPH-insulin (crystalline preparations) that are prepared in the presence of certain high-affinity ligands for the HisB10 Zn2+-sites of the R-state insulin hexamer. Preparation of NPH-insulin in the presence of high-affinity ligand results in crystalline NPH-insulin suspensions that are absorbed more slowly from subcutis than regular NPH-insulin. Hence the resulting action profile is longer and the spike is less pronounced than observed with regular NPH-insulin
摘要翻译：本发明涉及在R状态胰岛素六聚体的HisB10 Zn 2+ 2+的某些高亲和力配体存在下制备的NPH-胰岛素（结晶制剂）。在高亲和力配体的存在下制备NPH-胰岛素导致结晶NPH-胰岛素悬浮液比皮下组织比常规NPH-胰岛素更慢吸收。因此，所得到的作用谱更长，并且峰值不如用常规NPH-胰岛素观察到的

2. 发明授权

US09260502B2 Protease-stabilized insulin analogues 有权
标题翻译：蛋白酶稳定的胰岛素类似物
公开(公告)号：US09260502B2
公开(公告)日：2016-02-16
申请号：US12922106
申请日：2009-03-13
申请人： Peter Kresten Nielsen , Frantisek Hubalek , Inger Lautrup-Larsen , Per Balschmidt , Svend Ludvigsen , Thomas Børglum Kjeldsen
发明人： Peter Kresten Nielsen , Frantisek Hubalek , Inger Lautrup-Larsen , Per Balschmidt , Svend Ludvigsen , Thomas Børglum Kjeldsen
IPC分类号： A61K38/16 , C07K14/00 , C07K14/62 , A61K38/00
CPC分类号： C07K14/62 , A61K38/00
摘要： The present invention relates to novel insulin analogs comprising mutations at position A14 in the A chain and at positions B27, B28, B29 and B30 in the B chain and exhibiting resistance towards protease; a method for the preparation of such insulin analogs; insulin preparations containing the insulin analogs of the invention; and, a method of treating diabetes mellitus using these insulin analogs.
摘要翻译：本发明涉及新的胰岛素类似物，其包含A链A14位和B链位置B27，B28，B29和B30处的突变，并表现出对蛋白酶的抗性; 一种制备这种胰岛素类似物的方法; 含有本发明胰岛素类似物的胰岛素制剂; 以及使用这些胰岛素类似物治疗糖尿病的方法。

3. 发明授权

US09018161B2 Protease resistant insulin analogues 有权
标题翻译：蛋白酶抗性胰岛素类似物
公开(公告)号：US09018161B2
公开(公告)日：2015-04-28
申请号：US12442190
申请日：2007-09-20
申请人： Peter Kresten Nielsen , Frantisek Hubalek , Inger Lautrup-Larsen , Svend Ludvigsen , Ulla Ribel-Madsen , Per Balschmidt , Per Nørgaard , Svend Havelund
发明人： Peter Kresten Nielsen , Frantisek Hubalek , Inger Lautrup-Larsen , Svend Ludvigsen , Ulla Ribel-Madsen , Per Balschmidt , Per Nørgaard , Svend Havelund
IPC分类号： A61K38/28 , C07K14/62 , A61K38/00
CPC分类号： C07K14/62 , A61K38/00
摘要： The present invention relates to novel insulin analogues exhibiting resistance towards protease, wherein at least two amino acids are substituted and/or deleted relative to the parent insulin molecule. A method for the preparation of such insulin analogues, insulin preparations containing the insulin analogues of the invention and a method of treating diabetes mellitus using these insulin analogues is also provided.
摘要翻译：本发明涉及对蛋白酶表现出抗性的新型胰岛素类似物，其中至少两个氨基酸相对于母体胰岛素分子被取代和/或缺失。还提供了制备这种胰岛素类似物的方法，含有本发明的胰岛素类似物的胰岛素制剂和使用这些胰岛素类似物治疗糖尿病的方法。

4. 发明申请

US20110092419A1 PROTEASE-STABILIZED INSULIN ANALOGUES 有权
标题翻译：蛋白稳定的胰岛素类似物
公开(公告)号：US20110092419A1
公开(公告)日：2011-04-21
申请号：US12922106
申请日：2009-03-19
申请人： Peter Kresten Nielsen , Frantisek Hubalek , Inger Lautrup-Larsen , Per Balschmidt , Svend Ludvigsen , Thomas Børglum Kjeldsen
发明人： Peter Kresten Nielsen , Frantisek Hubalek , Inger Lautrup-Larsen , Per Balschmidt , Svend Ludvigsen , Thomas Børglum Kjeldsen
IPC分类号： C07K14/62 , A61K38/28 , A61P3/10
CPC分类号： C07K14/62 , A61K38/00
摘要： The present invention relates to novel insulin analogues comprising mutations at position A14 in the A chain and at positions B27, B28, B29 and B30 in the B chain and exhibiting resistance towards protease; a method for the preparation of such insulin analogues; insulin preparations containing the insulin analogues of the invention; and, a method of treating diabetes mellitus using these insulin analogues.
摘要翻译：本发明涉及新的胰岛素类似物，其包含A链A14位和B链位置B27，B28，B29和B30的突变，并表现出对蛋白酶的抗性; 一种制备这种胰岛素类似物的方法; 含有本发明胰岛素类似物的胰岛素制剂; 以及使用这些胰岛素类似物治疗糖尿病的方法。

5. 发明申请

US20100009898A1 PROTEASE RESISTANT INSULIN ANALOGUES 有权
标题翻译：抗蛋白酶胰蛋白酶类似物
公开(公告)号：US20100009898A1
公开(公告)日：2010-01-14
申请号：US12442190
申请日：2007-09-20
申请人： Peter Kresten Nielsen , Frantisek Hubalek , Inger Lautrup-Larsen , Svend Ludvigsen , Ulla Ribel-Madsen , Per Balschmidt , Per Norgaard , Svend Havelund
发明人： Peter Kresten Nielsen , Frantisek Hubalek , Inger Lautrup-Larsen , Svend Ludvigsen , Ulla Ribel-Madsen , Per Balschmidt , Per Norgaard , Svend Havelund
IPC分类号： A61K38/28 , C07K14/62 , C12N15/11
CPC分类号： C07K14/62 , A61K38/00
摘要： The present invention relates to novel insulin analogues exhibiting resistance towards protease, wherein at least two amino acids are substituted and/or deleted relative to the parent insulin molecule. A method for the preparation of such insulin analogues, insulin preparations containing the insulin analogues of the invention and a method of treating diabetes mellitus using these insulin analogues is also provided.
摘要翻译：本发明涉及对蛋白酶表现出抗性的新型胰岛素类似物，其中至少两个氨基酸相对于母体胰岛素分子被取代和/或缺失。还提供了制备这种胰岛素类似物的方法，含有本发明的胰岛素类似物的胰岛素制剂和使用这些胰岛素类似物治疗糖尿病的方法。

6. 发明申请

US20140315797A1 Novel N-Terminally Modified Insulin Derivatives 审中-公开
标题翻译：新型N-末端修饰的胰岛素衍生物
公开(公告)号：US20140315797A1
公开(公告)日：2014-10-23
申请号：US13823952
申请日：2011-10-14
申请人： Peter Madsen , Per Balschmidt , Svend Havelund , Thomas Hoeg-Jensen , Thomas Boerglum Kjeldsen , Charlotte Harkjaer Fynbo
发明人： Peter Madsen , Per Balschmidt , Svend Havelund , Thomas Hoeg-Jensen , Thomas Boerglum Kjeldsen , Charlotte Harkjaer Fynbo
IPC分类号： C07K14/62
CPC分类号： C07K14/62
摘要： The invention is related to novel N-terminally modified insulin derivatives, pharmaceutical compositions comprising such and methods of making such.
摘要翻译：本发明涉及新型N-末端修饰的胰岛素衍生物，包含其的药物组合物及其制备方法。

7. 发明申请

US20110021423A1 Rapid Acting Insulin Analogues 有权
标题翻译：快速作用胰岛素类似物
公开(公告)号：US20110021423A1
公开(公告)日：2011-01-27
申请号：US12673226
申请日：2008-08-12
申请人： Helle Birk Olsen , Thomas Børglum Kjeldsen , Per Balschmidt , Tine Glendorf , Svend Havelund
发明人： Helle Birk Olsen , Thomas Børglum Kjeldsen , Per Balschmidt , Tine Glendorf , Svend Havelund
IPC分类号： A61K38/28 , C07K14/62 , A61P3/10
CPC分类号： C07K14/62 , A61K38/00
摘要： The invention is related to fast acting insulin analogues which can form soluble mix-tures (pre-mixed or self-mixed) with long acting insulin analogues. The fast action is achieved through monomerizing substitutions/deletions in the C-terminus of the B-chain of human insulin and the mixability with long acting insulin analogues is achieved through a substitution of the Zn-binding His in position B10 of human insulin with a Gln amino acid residue. In one embodiment the invention is related to fast acting insulin analogues in which at least one of the natural amino acid residues in position B22-B30 in the human B-chain has been substituted with another amino acid residue having the effect of promoting formation of the monomeric form of insulin, the His amino acid residue in position 10 in the B-chain is substituted with a Gln and wherein further one or more of the amino acid residues in position B22-B30 optionally have been deleted.
摘要翻译：本发明涉及可与长效胰岛素类似物形成可溶性混合物（预混合或自混合）的快速作用胰岛素类似物。快速作用通过在人胰岛素的B链的C末端进行单体取代/缺失实现，并且通过用人胰岛素B10位置上的Zn结合His取代长效胰岛素类似物的混合性来实现 Gln氨基酸残基。在一个实施方案中，本发明涉及快速作用的胰岛素类似物，其中人B链中位置B22-B30中的至少一个天然氨基酸残基已经被另一个氨基酸残基取代，其具有促进形成单体形式的胰岛素，B链中10位的His氨基酸残基被Gln取代，并且其中位置B22-B30中的一个或多个氨基酸残基任选地被缺失。

8. 发明申请

US20100055738A1 Method for Making Acylated Polypeptides 有权
标题翻译：制备酰化多肽的方法
公开(公告)号：US20100055738A1
公开(公告)日：2010-03-04
申请号：US12543027
申请日：2009-08-18
申请人： Ib Jonassen , Michi Egel- Mitani , Per Balschmidt , Jan Markussen , Ivan Diers , Thomas Borglum Kjeldsen
发明人： Ib Jonassen , Michi Egel- Mitani , Per Balschmidt , Jan Markussen , Ivan Diers , Thomas Borglum Kjeldsen
IPC分类号： C12P21/06 , C07K4/00
CPC分类号： C07K1/006 , C07K1/1077
摘要： The present invention related to a method of producing polypeptides in transformed host cells by expressing a precursor molecule of the desired polypeptide which are to be acylated in a subsequent in vitro step. The invention is also related to DNA-sequences, vectors and transformed host cells for use in the claimed method. Further, the present invention is related to certain precursors of the desired polypeptides and certain acylation methods. The invention provides a method for making polypeptides being preferentially acylated in certain lysine ε-amino groups.
摘要翻译：本发明涉及通过在随后的体外步骤中表达待酰化的所需多肽的前体分子，在转化的宿主细胞中产生多肽的方法。本发明还涉及用于所要求保护的方法的DNA序列，载体和转化的宿主细胞。此外，本发明涉及所需多肽的某些前体和某些酰化方法。本发明提供了在某些赖氨酸和氨基中优先酰化多肽的方法。

9. 发明授权

US07316999B2 Glucose dependent release of insulin from glucose sensing insulin derivatives 有权
标题翻译：从葡萄糖感测胰岛素衍生物中葡萄糖依赖性释放胰岛素
公开(公告)号：US07316999B2
公开(公告)日：2008-01-08
申请号：US09870884
申请日：2001-05-31
申请人： Thomas Hoeg-Jensen , Svend Havelund , Jan Markussen , Soren Ostergaard , Signe Ridderberg , Per Balschmidt , Lauge Schaffer , Ib Jonassen
发明人： Thomas Hoeg-Jensen , Svend Havelund , Jan Markussen , Soren Ostergaard , Signe Ridderberg , Per Balschmidt , Lauge Schaffer , Ib Jonassen
IPC分类号： A61K38/28 , C07K14/62
CPC分类号： C07K14/62
摘要： Insulin derivatives having a built-in glucose sensor, capable of delivering insulin from a depot as a function of the glucose concentration in the surrounding medium (e.g. tissue), such that the rate of insulin release from the depot increases with an increased glucose concentration and decreases with a decreased glucose concentration.
摘要翻译：具有内置葡萄糖传感器的胰岛素衍生物，其能够将来自贮库的胰岛素作为周围介质（例如组织）中的葡萄糖浓度的函数，使得从贮库中释放的胰岛素的速率随着葡萄糖浓度的增加而增加，并且葡萄糖浓度降低。

10. 发明授权

US5430016A Insulin compounds and compositions 失效
标题翻译：胰岛素化合物和组合物
公开(公告)号：US5430016A
公开(公告)日：1995-07-04
申请号：US495798
申请日：1990-03-19
申请人： Per Balschmidt , Finn B. Hansen
发明人： Per Balschmidt , Finn B. Hansen
IPC分类号： C12P21/02 , A61K38/00 , A61K38/28 , C07K20060101 , C07K14/575 , C07K14/62 , C12P21/04 , C12P21/06
CPC分类号： C07K14/62 , A61K38/00
摘要： Novel insulin compounds having a desirably protracted insulin action and/or antigenicity are provided.The novel insulin compounds are represented by the formula II: ##STR1## wherein E individually represents Glu or a neutral amino acid residue which can be coded for by nucleotide sequences, N represents an amino acid residue which can be coded for by nucleotide sequences,T represents Thr or Arg,X represents Thr, Ser, Ala or OH, andY represents OR or NR.sup.1 R.sup.2, where R, R.sup.1 and R.sup.2 individually represents hydrogen or lower alkyl, but is not present when X represents OH.
摘要翻译：提供了具有理想的长时间胰岛素作用和/或抗原性的新型胰岛素化合物。新颖的胰岛素化合物由式II表示：其中E分别表示Glu或可由核苷酸序列编码的中性氨基酸残基，N表示可编码的氨基酸残基对于核苷酸序列，T表示Thr或Arg，X表示Thr，Ser，Ala或OH，Y表示OR或NR1R2，其中R，R1和R2各自表示氢或低级烷基，但当X表示OH时不存在。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式