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1. 发明申请

US20100055738A1 Method for Making Acylated Polypeptides 有权
标题翻译：制备酰化多肽的方法
公开(公告)号：US20100055738A1
公开(公告)日：2010-03-04
申请号：US12543027
申请日：2009-08-18
申请人： Ib Jonassen , Michi Egel- Mitani , Per Balschmidt , Jan Markussen , Ivan Diers , Thomas Borglum Kjeldsen
发明人： Ib Jonassen , Michi Egel- Mitani , Per Balschmidt , Jan Markussen , Ivan Diers , Thomas Borglum Kjeldsen
IPC分类号： C12P21/06 , C07K4/00
CPC分类号： C07K1/006 , C07K1/1077
摘要： The present invention related to a method of producing polypeptides in transformed host cells by expressing a precursor molecule of the desired polypeptide which are to be acylated in a subsequent in vitro step. The invention is also related to DNA-sequences, vectors and transformed host cells for use in the claimed method. Further, the present invention is related to certain precursors of the desired polypeptides and certain acylation methods. The invention provides a method for making polypeptides being preferentially acylated in certain lysine ε-amino groups.
摘要翻译：本发明涉及通过在随后的体外步骤中表达待酰化的所需多肽的前体分子，在转化的宿主细胞中产生多肽的方法。本发明还涉及用于所要求保护的方法的DNA序列，载体和转化的宿主细胞。此外，本发明涉及所需多肽的某些前体和某些酰化方法。本发明提供了在某些赖氨酸和氨基中优先酰化多肽的方法。

2. 发明授权

US08835132B2 Method for making acylated polypeptides 有权
标题翻译：制备酰化多肽的方法
公开(公告)号：US08835132B2
公开(公告)日：2014-09-16
申请号：US12543027
申请日：2009-08-18
申请人： Ib Jonassen , Michi Egel-Mitani , Per Balschmidt , Jan Markussen , Ivan Diers , Thomas Borglum Kjeldsen
发明人： Ib Jonassen , Michi Egel-Mitani , Per Balschmidt , Jan Markussen , Ivan Diers , Thomas Borglum Kjeldsen
IPC分类号： C07K1/00 , C07K1/107
CPC分类号： C07K1/006 , C07K1/1077
摘要： The present invention related to a method of producing polypeptides in transformed host cells by expressing a precursor molecule of the desired polypeptide which are to be acylated in a subsequent in vitro step. The invention is also related to DNA-sequences, vectors and transformed host cells for use in the claimed method. Further, the present invention is related to certain precursors of the desired polypeptides and certain acylation methods. The invention provides a method for making polypeptides being preferentially acylated in certain lysine ε-amino groups.
摘要翻译：本发明涉及通过在随后的体外步骤中表达待酰化的所需多肽的前体分子，在转化的宿主细胞中产生多肽的方法。本发明还涉及用于所要求保护的方法的DNA序列，载体和转化的宿主细胞。此外，本发明涉及所需多肽的某些前体和某些酰化方法。本发明提供了在某些赖氨酸和氨基中优先酰化多肽的方法。

3. 发明授权

US07595172B2 Method for making acylated polypeptides 失效
公开(公告)号：US07595172B2
公开(公告)日：2009-09-29
申请号：US10205110
申请日：2002-07-24
申请人： Ib Jonassen , Michi Egel-Mitani , Per Balschmidt , Jan Markussen , Ivan Diers , Thomas Borglum Kjeldsen
发明人： Ib Jonassen , Michi Egel-Mitani , Per Balschmidt , Jan Markussen , Ivan Diers , Thomas Borglum Kjeldsen
IPC分类号： A61K38/00
CPC分类号： C07K1/006 , C07K1/1077
摘要： The present invention related to a method of producing polypeptides in transformed host cells by expressing a precursor molecule of the desired polypeptide which are to be acylated in a subsequent in vitro step. The invention is also related to DNA-sequences, vectors and transformed host cells for use in the claimed method. Further, the present invention is related to certain precursors of the desired polypeptides and certain acylation methods. The invention provides a method for making polypeptides being preferentially acylated in certain lysine ε-amino groups.

4. 发明申请

US20050272125A1 Method for making acylated polypeptides 有权
标题翻译：制备酰化多肽的方法
公开(公告)号：US20050272125A1
公开(公告)日：2005-12-08
申请号：US11191574
申请日：2005-07-28
申请人： Thomas Hoeg-Jensen , Michi Egel-Mitani , Per Balschmidt , Jan Markussen , Ivan Diers
发明人： Thomas Hoeg-Jensen , Michi Egel-Mitani , Per Balschmidt , Jan Markussen , Ivan Diers
IPC分类号： C07K1/00 , C07K1/107 , C07K14/605 , C12P21/06 , C07H21/04
CPC分类号： C07K1/1077 , C07K1/006 , C07K14/605
摘要： The present invention related to a method of producing polypeptides in transformed host cells by expressing a precursor molecule of the desired polypeptide which are to be acylated in a subsequent in vitro step. The invention is also related to DNA-sequences, vectors and transformed host cells for use in the claimed method. Further, the present invention is related to certain precursors of the desired polypeptides and certain acylation methods. The invention provides a method for making polypeptides being preferentially acylated in certain lysine ε-amino groups.
摘要翻译：本发明涉及通过在随后的体外步骤中表达待酰化的所需多肽的前体分子，在转化的宿主细胞中产生多肽的方法。本发明还涉及用于所要求保护的方法的DNA序列，载体和转化的宿主细胞。此外，本发明涉及所需多肽的某些前体和某些酰化方法。本发明提供了在某些赖氨酸ε-氨基中制备优先酰化多肽的方法。

5. 发明授权

US07572884B2 Method for making acylated polypeptides 有权
标题翻译：制备酰化多肽的方法
公开(公告)号：US07572884B2
公开(公告)日：2009-08-11
申请号：US11191574
申请日：2005-07-28
申请人： Thomas Hoeg-Jensen , Michi Egel-Mitani , Per Balschmidt , Jan Markussen , Ivan Diers
发明人： Thomas Hoeg-Jensen , Michi Egel-Mitani , Per Balschmidt , Jan Markussen , Ivan Diers
IPC分类号： A61K38/00 , A61K38/04
CPC分类号： C07K1/1077 , C07K1/006 , C07K14/605
摘要： The present invention related to a method of producing polypeptides in transformed host cells by expressing a precursor molecule of the desired polypeptide which are to be acylated in a subsequent in vitro step. The invention is also related to DNA-sequences, vectors and transformed host cells for use in the claimed method. Further, the present invention is related to certain precursors of the desired polypeptides and certain acylation methods. The invention provides a method for making polypeptides being preferentially acylated in certain lysine ε-amino groups.
摘要翻译：本发明涉及通过在随后的体外步骤中表达待酰化的所需多肽的前体分子，在转化的宿主细胞中产生多肽的方法。本发明还涉及用于所要求保护的方法的DNA序列，载体和转化的宿主细胞。此外，本发明涉及所需多肽的某些前体和某些酰化方法。本发明提供了在某些赖氨酸ε-氨基中制备优先酰化多肽的方法。

6. 发明授权

US07316999B2 Glucose dependent release of insulin from glucose sensing insulin derivatives 有权
标题翻译：从葡萄糖感测胰岛素衍生物中葡萄糖依赖性释放胰岛素
公开(公告)号：US07316999B2
公开(公告)日：2008-01-08
申请号：US09870884
申请日：2001-05-31
申请人： Thomas Hoeg-Jensen , Svend Havelund , Jan Markussen , Soren Ostergaard , Signe Ridderberg , Per Balschmidt , Lauge Schaffer , Ib Jonassen
发明人： Thomas Hoeg-Jensen , Svend Havelund , Jan Markussen , Soren Ostergaard , Signe Ridderberg , Per Balschmidt , Lauge Schaffer , Ib Jonassen
IPC分类号： A61K38/28 , C07K14/62
CPC分类号： C07K14/62
摘要： Insulin derivatives having a built-in glucose sensor, capable of delivering insulin from a depot as a function of the glucose concentration in the surrounding medium (e.g. tissue), such that the rate of insulin release from the depot increases with an increased glucose concentration and decreases with a decreased glucose concentration.
摘要翻译：具有内置葡萄糖传感器的胰岛素衍生物，其能够将来自贮库的胰岛素作为周围介质（例如组织）中的葡萄糖浓度的函数，使得从贮库中释放的胰岛素的速率随着葡萄糖浓度的增加而增加，并且葡萄糖浓度降低。

7. 发明申请

US20060030518A1 Acylated insulin 审中-公开
标题翻译：酰化胰岛素
公开(公告)号：US20060030518A1
公开(公告)日：2006-02-09
申请号：US11169100
申请日：2005-06-28
申请人： Svend Havelund , John Halstrom , Ib Jonassen , Asser Andersen , Jan Markussen
发明人： Svend Havelund , John Halstrom , Ib Jonassen , Asser Andersen , Jan Markussen
IPC分类号： A61K38/28 , C07K14/62
CPC分类号： C07K14/62 , A61K38/00 , Y10S514/866
摘要： The present invention relates to protracted human insulin derivatives in which the A21 and the B3 amino acid residues are, independently, any amino acid residue which can be coded for by the genetic code except Lys, Arg and Cys; PheB1 may be deleted; the B30 amino acid residue is (a) a non-codable, lipophilic amino acid having from 10 to 24 carbon atoms, in which case an acyl group of a carboxylic acid with up to 5 carbon atoms is bound to the ε-amino group of LysB29; or (b) the B30 amino acid residue is deleted or is any amino acid residue which can be coded for by the genetic code except Lys, Arg and Cys, in any of which cases the C-amino group of LysB29 has a lipophilic substituent; and any Zn2+ complexes thereof with the proviso that when B30 is Thr or Ala and A21 and B3 are both Asn, and PheB1 is present, then the insulin derivative is always present as a Zn2+ complex.
摘要翻译：本发明涉及延长的人胰岛素衍生物，其中A21和B3氨基酸残基独立地是可由遗传密码编码的除Lys，Arg和Cys之外的任何氨基酸残基; Phe 可以被删除; B30氨基酸残基是（a）具有10-24个碳原子的不可编码的亲脂性氨基酸，在这种情况下，具有至多5个碳原子的羧酸的酰基与ε-氨基的ε-氨基结合 B29 或（b）B30氨基酸残基被缺失，或者是任何氨基酸残基，其可以通过除Lys，Arg和Cys之外的遗传密码进行编码，在任何情况下，Lys B29的C-氨基， / SUP>具有亲油取代基; 和其任何Zn 2+ 2 +配合物，条件是当B30是Thr或Ala，A21和B3都是Asn和Phe B1时，则胰岛素衍生物是总是作为Zn 2+复合物存在。

8. 发明授权

US07229964B2 Insulin derivatives 有权
标题翻译：胰岛素衍生物
公开(公告)号：US07229964B2
公开(公告)日：2007-06-12
申请号：US10620651
申请日：2003-07-16
申请人： Jan Markussen , Ib Jonassen , Svend Havelund , Jakob Brandt , Peter Kurtzhals , Per Hertz Hansen , Niels Christian Kaarsholm
发明人： Jan Markussen , Ib Jonassen , Svend Havelund , Jakob Brandt , Peter Kurtzhals , Per Hertz Hansen , Niels Christian Kaarsholm
IPC分类号： A61K38/28
CPC分类号： C07K14/62 , Y10S514/866
摘要： The present invention relates to insulin derivatives in which a lipophilic group having from 12 to 40 carbon atoms is attached to the α-amino group of the N-terminal amino acid in the B-chain or to the carboxy group of the C-terminal amino acid in the B-chain have a protracted profile of action.
摘要翻译：本发明涉及其中具有12至40个碳原子的亲脂基团连接到B链中的N-末端氨基酸的α-氨基或C末端氨基的羧基的胰岛素衍生物 B链中的酸具有延长的作用。

9. 发明授权

US5750497A Acylated insulin 失效
标题翻译：酰化胰岛素
公开(公告)号：US5750497A
公开(公告)日：1998-05-12
申请号：US400256
申请日：1995-03-08
申请人： Svend Havelund , John Halstr.o slashed.m , Ib Jonassen , Asser Sloth Andersen , Jan Markussen
发明人： Svend Havelund , John Halstr.o slashed.m , Ib Jonassen , Asser Sloth Andersen , Jan Markussen
IPC分类号： C12N15/09 , A61K38/00 , A61K38/28 , A61P3/08 , A61P3/10 , C07K14/62 , C12N1/19 , C12N1/21 , C12P21/02 , C12R1/19 , C12R1/865
CPC分类号： C07K14/62 , A61K38/00 , Y10S514/866
摘要： The present invention relates to human insulin derivatives having a protracted profile of action in which the A21 and B3 amino acid residues are, independently, any amino acid residue which can be coded for by the genetic code except Lys, Arg and Cys; Phe.sup.B1 may be deleted; the B30 amino acid residue is (a) a non-codable, lipophilic amino acid having from 10 to 24 carbon atoms in which case an acyl group of a carboxylic acid with up to 5 carbon atoms is bound to the E-amino group of Lys.sup.B29 ; (b) any amino acid residue which can be coded by the genetic code except Lys, Arg and Cys, in which case a lipophilic substituent is bound to the E-amino group of Lys.sup.B29 ; or (c) deleted, in which case a lipophilic substituent is bound to the E-amino group of LyS.sup.B29 ; and any Zn.sup.2+ complexes thereof; provided that when the B30 amino acid residue is Thr or Ala, the A21 and B3 amino acid residues are both Asn and Phe.sup.B1 is present, then the insulin derivative is a Zn.sup.2 + complex.
摘要翻译：本发明涉及具有延长的作用曲线的人胰岛素衍生物，其中A21和B3氨基酸残基独立地是可由除Lys，Arg和Cys之外的遗传密码编码的任何氨基酸残基; PheB1可能被删除; B30氨基酸残基是（a）具有10-24个碳原子的非可编码的亲脂性氨基酸，在这种情况下，具有至多5个碳原子的羧酸的酰基与LysB29的E-氨基结合 ; （b）除了Lys，Arg和Cys之外可以通过遗传密码编码的任何氨基酸残基，在这种情况下，亲油性取代基与LysB29的E氨基结合; 或（c）缺失，在这种情况下，亲油取代基与LySB29的E氨基结合; 及其任何Zn2 +配合物; 条件是当B30氨基酸残基是Thr或Ala时，A21和B3氨基酸残基都是Asn和PheB1，则胰岛素衍生物是Zn 2+络合物。

10. 发明授权

US06251856B1 Insulin derivatives 失效
标题翻译：胰岛素衍生物
公开(公告)号：US06251856B1
公开(公告)日：2001-06-26
申请号：US08932082
申请日：1997-09-17
申请人： Jan Markussen , Ib Jonassen , Svend Havelund , Jakob Brandt , Peter Kurtzhals , Per Hertz Hansen , Niels Christian Kaarsholm
发明人： Jan Markussen , Ib Jonassen , Svend Havelund , Jakob Brandt , Peter Kurtzhals , Per Hertz Hansen , Niels Christian Kaarsholm
IPC分类号： C07K1462
CPC分类号： C07K14/62 , Y10S514/866
摘要： The present invention relates to insulin derivatives in which a lipophilic group having from 12 to 40 carbon atoms is attached to the &agr;-amino group of the N-terminal amino acid in the B-chain or to the carboxy group of the C-terminal amino acid in the B-chain have a protracted profile of action.
摘要翻译：本发明涉及其中具有12至40个碳原子的亲脂基团连接到B链中的N-末端氨基酸的α-氨基或C末端氨基的羧基的胰岛素衍生物 B链中的酸具有延长的作用。

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