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1. 发明授权

US08785477B2 Hexahydropyrrolo[3,4-b]pyrrole derivatives, preparation methods and pharmaceutical uses thereof 有权
标题翻译：六氢吡咯并[3,4-b]吡咯衍生物，其制备方法和药物用途
公开(公告)号：US08785477B2
公开(公告)日：2014-07-22
申请号：US13685454
申请日：2012-11-26
申请人： Peng Lu , Rui Zhang , Wansong Yu , Mingjie Zhu , Yilang Chen
发明人： Peng Lu , Rui Zhang , Wansong Yu , Mingjie Zhu , Yilang Chen
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： Hexahydropyrrolo[3,4-b]pyrrole derivatives, preparation methods and pharmaceutical uses thereof are provided. Specifically, dipeptidyl peptidase IV inhibitors presented by following formula (I) are provided. Such compounds can be used for treating or preventing the diseases associated with dipeptidyl peptidase IV, such as diabetes, obesity and hyperlipemia. The compounds presented by formula (I) and pharmaceutically acceptable salts thereof, a method for preparing a pharmaceutical composition thereof and their uses in the manufacture of medicaments for treating or preventing the disease associated with dipeptidyl peptidase IV are provided.
摘要翻译：提供了六氢吡咯并[3,4-b]吡咯衍生物，其制备方法和药物用途。具体地，提供了由下式（I）表示的二肽基肽酶IV抑制剂。这些化合物可用于治疗或预防与二肽基肽酶IV相关的疾病，如糖尿病，肥胖症和高脂血症。提供式（I）化合物及其药学上可接受的盐，其药物组合物的制备方法及其在制备用于治疗或预防与二肽基肽酶IV相关的疾病的药物中的用途。

2. 发明申请

US20130178500A1 HEXAHYDROPYRROLO[3,4-b]PYRROLE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF 有权
标题翻译：十氢吡咯并[3,4-b]吡咯烷酮衍生物，其制备方法及其药物用途
公开(公告)号：US20130178500A1
公开(公告)日：2013-07-11
申请号：US13685454
申请日：2012-11-26
申请人： Peng Lu , Rui Zhang , Wansong Yu , Mingjie Zhu , Yilang Chen
发明人： Peng Lu , Rui Zhang , Wansong Yu , Mingjie Zhu , Yilang Chen
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： Hexahydropyrrolo[3,4-b]pyrrole derivatives, preparation methods and pharmaceutical uses thereof are provided. Specifically, dipeptidyl peptidase IV inhibitors presented by following formula (I) are provided. Such compounds can be used for treating or preventing the diseases associated with dipeptidyl peptidase IV, such as diabetes, obesity and hyperlipemia. The compounds presented by formula (I) and pharmaceutically acceptable salts thereof, a method for preparing a pharmaceutical composition thereof and their uses in the manufacture of medicaments for treating or preventing the disease associated with dipeptidyl peptidase IV are provided.
摘要翻译：提供了六氢吡咯并[3,4-b]吡咯衍生物，其制备方法和药物用途。具体地，提供了由下式（I）表示的二肽基肽酶IV抑制剂。这些化合物可用于治疗或预防与二肽基肽酶IV相关的疾病，如糖尿病，肥胖症和高脂血症。提供式（I）化合物及其药学上可接受的盐，其药物组合物的制备方法及其在制备用于治疗或预防与二肽基肽酶IV相关的疾病的药物中的用途。

3. 发明授权

US11028398B2 Fusion proteins having mutated immunoglobulin hinge region 有权
公开(公告)号：US11028398B2
公开(公告)日：2021-06-08
申请号：US13275205
申请日：2011-10-17
申请人： Haitao Wang , Yong Du , Rui Zhang , Jing Xu , Longbin Liu
发明人： Haitao Wang , Yong Du , Rui Zhang , Jing Xu , Longbin Liu
IPC分类号： C07K1/00 , A61K45/00 , A61K39/00 , C12N15/62 , A61K47/68 , C07K16/00
摘要： A fusion protein having a non-immunoglobulin polypeptide having a cysteine residue proximal to the C terminal thereof, and an immunoglobulin component with a mutated hinge region is provided. The mutation comprises a point mutated site corresponding in position to the position in a native hinge region of the cysteine residue located nearest the cysteine residue of the non-Ig component. The distance from the cysteine residue of the non-immunoglobulin polypeptide and any remaining cysteine residues of the mutated hinge region is sufficient to prevent the formation of a disulphide bond therebetween.

4. 发明申请

US20170034330A1 Method and Device to Operate Phone with a Single Key 审中-公开
标题翻译：用单键操作手机的方法和设备
公开(公告)号：US20170034330A1
公开(公告)日：2017-02-02
申请号：US15283455
申请日：2015-03-30
申请人： Rui Zhang
发明人： Yimin Zhang , Rui Zhang
IPC分类号： H04M1/725 , H04M1/2745 , H04M7/12 , H04M3/44
CPC分类号： H04M1/7258 , G06F3/0233 , H04M1/274533 , H04M1/72541 , H04M3/44 , H04M7/1295 , H04M2250/70
摘要： The present invention discloses a method to operate phone using a single key, first provide method to form ‘key value’: (1) When the key is just closed, plus 1 to the ‘key value’, (2) When the key closing time is greater than time t1, form ‘closing key value’, (3) When the key closing time is smaller than t1 and the immediate key releasing time is greater than t2, store the key value as ‘releasing key value’, (4) When the key closing time is smaller than t1 and the immediate key releasing time is smaller than t2, skip to step (1). The ‘releasing key values’ can be used to represent the numerical and alphabetical keys on typical keypad of phone, while the ‘closing key values’ can be used to represent the function key on typical keypad of phone, so that the complete function of a typical phone keypad can be realized using only one key. Therefore, a phone can be made very small, which can be especially useful when installed on small Bluetooth device that connects to phone, since not only can it answer incoming phone calls, but also making outgoing phone calls.
摘要翻译：本发明公开了一种使用单一键操作电话的方法，首先提供形成“键值”的方法：（1）当键刚刚关闭时，加上1键到“键值”，（2）当键关闭时时间大于时间t1，形成“关闭键值”，（3）当键关闭时间小于t1，即时键释放时间大于t2时，将键值存储为“释放键值”，（4））当钥匙闭合时间小于t1且紧急钥匙释放时间小于t2时，请跳到步骤（1）。 “释放键值”可用于表示电话典型键盘上的数字和字母键，而“关闭键值”可用于表示电话典型键盘上的功能键，从而完成典型的电话键盘只能用一个键来实现。因此，手机可以做得非常小，当安装在连接到手机的小型蓝牙设备上时，这可能特别有用，因为它不仅可以应答来电，而且拨出电话。

5. 发明申请

US20170010166A1 PRESSURE SENSING DEVICE 有权
标题翻译：压力传感装置
公开(公告)号：US20170010166A1
公开(公告)日：2017-01-12
申请号：US15011456
申请日：2016-01-29
申请人： Jinyu Zhang , Rui Zhang
发明人： Jinyu Zhang , Rui Zhang
IPC分类号： G01L9/00 , G06F3/041
CPC分类号： G01L19/0084 , G01L9/0044
摘要： A pressure sensing device is disclosed in the present disclosure. The pressure sensing device includes a bottom plate, a flexible shell and a MEMS pressure sensor. The flexible shell covers the bottom plate for forming a hermetical cavity, and the MEMS pressure sensor is accommodated in the hermetical cavity. Air in the hermetical cavity is compressed when the flexible shell is pressed, the MEMS pressure sensor is configured for detecting variation of an air pressure within the hermetical cavity when the flexible shell is pressed, and convert the variation of the air pressure into an electric signal.
摘要翻译：在本公开中公开了压力感测装置。压力感测装置包括底板，柔性壳和MEMS压力传感器。柔性壳覆盖用于形成密封腔的底板，并且MEMS压力传感器容纳在密封腔中。当压缩弹性壳体时，气密腔中的空气被压缩，MEMS压力传感器构造成用于在柔性壳体被按压时检测气密腔内的空气压力的变化，并将空气压力的变化转换为电信号。

6. 发明授权

US09260668B2 Method for revamping an HF or sulphuric acid alkylation unit and method for the production of alkylate 有权
标题翻译：用于改造HF或硫酸烷基化单元的方法和用于生产烷基化物的方法
公开(公告)号：US09260668B2
公开(公告)日：2016-02-16
申请号：US13388499
申请日：2010-07-09
申请人： Zhichang Liu , Chunming Xu , Rui Zhang , Xianghai Meng , Ana Cecilia Patroni , Peter Anton August Klusener , Albertus Vincentius Petrus Van Den Bosch
发明人： Zhichang Liu , Chunming Xu , Rui Zhang , Xianghai Meng , Ana Cecilia Patroni , Peter Anton August Klusener , Albertus Vincentius Petrus Van Den Bosch
IPC分类号： C07C2/74 , C10G29/20 , C07C2/60
CPC分类号： C10G29/205 , C07C2/60 , C07C2527/053 , C07C2527/055 , C07C2527/06 , C07C2527/122 , C07C2527/128 , C07C2527/135 , C07C2527/138 , C07C2527/25 , C07C2531/02 , C10G2300/1081 , C10G2300/1092 , C10G2300/70 , Y02P20/584 , Y10T29/49716
摘要： The present invention provides a method for revamping an HF or sulphuric acid alkylation unit to an ionic liquid alkylation unit, wherein the HF or sulphuric acid alkylation unit comprise at least: —a reactor unit for contacting catalyst and hydrocarbon reactants; —a separator unit for separating a reactor effluent into a catalyst phase and an alkylate-comprising hydrocarbon phase; —a fractionator unit for fractionating the alkylate-comprising hydrocarbon phase into at least one stream comprising alkylate; —a catalyst phase recycle means to recycle at least part of the catalyst phase from the separator unit to the reactor unit; which method includes: —adapting the catalyst phase recycle means by providing a means for acid injection and/or a means for halohydrocarbon injection into the catalyst recycle means. The invention further provides a method for the production of alkylate.
摘要翻译：本发明提供了将HF或硫酸烷基化单元改性为离子液体烷基化单元的方法，其中HF或硫酸烷基化单元至少包括： - 用于使催化剂和烃反应物接触的反应器单元; - 用于将反应器流出物分离成催化剂相的分离器单元和包含烷基化物的烃相; - 用于将含烷基化物烃相分级成至少一种包含烷基化物的流的分馏器单元; - 催化剂相再循环装置，用于将至少部分催化剂相从分离器单元再循环到反应器单元; 该方法包括： - 通过提供酸注入的方法和/或将卤代烃注入到催化剂再循环装置中的手段，来适应催化剂相循环装置。本发明还提供了一种生产烷基化物的方法。

7. 发明授权

US09247650B2 Method for making conductive wires 有权
标题翻译：制作导线的方法
公开(公告)号：US09247650B2
公开(公告)日：2016-01-26
申请号：US12589459
申请日：2009-10-22
申请人： Yao-Wen Bai , Rui Zhang , Cheng-Hsien Lin
发明人： Yao-Wen Bai , Rui Zhang , Cheng-Hsien Lin
IPC分类号： H05K3/24 , C23C18/18 , B82Y10/00 , H05K3/12
CPC分类号： H05K3/246 , B82Y10/00 , C23C18/18 , H05K3/125 , H05K2201/026 , H05K2201/0323 , H05K2201/0347 , H05K2203/013 , H05K2203/072
摘要： A method for making conductive wires is provided. Firstly, an ink having carbon nanotubes is provided. Secondly, a baseline is formed using the ink on a substrate. Thirdly, the baseline is electroless plated.
摘要翻译：提供制造导线的方法。首先，提供具有碳纳米管的油墨。其次，使用基板上的墨形成基线。第三，基线是无电镀。

8. 发明申请

US20150336991A1 NOVEL GLUCOKINASE ACTIVATOR COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS, AND METHODS OF TREATMENT 有权
标题翻译：新型GLUCOKINASE激活剂化合物，包含这些化合物的组合物和处理方法
公开(公告)号：US20150336991A1
公开(公告)日：2015-11-26
申请号：US14652883
申请日：2013-12-12
申请人： Emma R. PARMEE , Songnian LIN , Brian CAMPBELL , Sunita V. DEWNANI , Roman KATS-KAGAN , Jiayi XU , Libo XU , Rui ZHANG , MERCK SHARP & DOHME CORP.
发明人： Songnian Lin , Rui Zhang , Brian Campbell , Sunita V. Dewnani , Jiayi Xu , Libo Xu , Emma R. Parmee , Roman Kats-Kagan
IPC分类号： C07F9/6539 , A61K31/4439 , C07D401/04 , A61K31/444 , C07D471/04 , A61K31/427 , C07F9/58 , A61K31/675 , C07D403/14 , A61K31/497 , C07D417/14 , C07D401/14 , A61K31/437
CPC分类号： C07F9/6539 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/675 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D417/14 , C07D471/04 , C07F7/0812 , C07F9/58 , C07F9/65583
摘要： Novel pyridine-2-carboxamide derivatives of formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are effective as glucokinase activating agents. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译：公开了式I的新型吡啶-2-甲酰胺衍生物及其药学上可接受的盐可用于治疗或预防2型糖尿病和类似病症。这些化合物作为葡萄糖激酶活化剂是有效的。还包括药物组合物和治疗方法。

9. 发明授权

US08633346B2 Process for preparing an alkylate 有权
标题翻译：制备烷基化物的方法
公开(公告)号：US08633346B2
公开(公告)日：2014-01-21
申请号：US13388491
申请日：2010-08-05
申请人： Zhichang Liu , Chunming Xu , Rui Zhang , Xianghai Meng , Ana Cecilia Patroni , Peter Anton August Klusener , Albertus Vincentius Petrus Van Den Bosch
发明人： Zhichang Liu , Chunming Xu , Rui Zhang , Xianghai Meng , Ana Cecilia Patroni , Peter Anton August Klusener , Albertus Vincentius Petrus Van Den Bosch
IPC分类号： C07C2/56
CPC分类号： B01J31/40 , B01J31/0278 , B01J31/0284 , B01J31/26 , B01J31/30 , B01J2231/32 , C07C2/58 , C07C2527/10 , C10G29/205 , C10G2300/1081 , C10G2300/1088 , C10G2300/4081 , Y02P20/584 , C07C9/16
摘要： The present invention provides process for preparing an alkylate comprising contacting in a reaction zone a hydrocarbon mixture comprising at least an isoparaffin and an olefin with an acidic ionic liquid catalyst under alkylation conditions to obtain an alkylate-comprising effluent, in which process: —solids are formed in the reaction zone; —a solids-comprising effluent comprising hydrocarbons and acidic ionic liquid is withdrawn from the reaction zone; and—at least part of the solids-comprising effluent is treated to remove at least part of the solids to obtain a solids-depleted effluent. The invention further provides a process for treating an acidic ionic liquid comprising at least 0.1 wt % of solids based on the total weight of the acidic ionic liquid, wherein at least part of the solids are removed.
摘要翻译：本发明提供了制备烷基化物的方法，其包括在烷基化条件下使反应区中含有至少异链烷烃和烯烃的烃混合物与酸性离子液体催化剂接触以获得含烷基化物的流出物，其中： - 固体为在反应区形成; - 包含烃和酸性离子液体的包含固体的流出物从反应区域排出; 并且处理至少部分含固体的流出物以除去至少部分固体以获得固体贫化的流出物。本发明还提供了一种处理酸性离子液体的方法，其包含基于酸性离子液体的总重量至少0.1重量％的固体，其中至少部分固体被除去。

10. 发明申请

US20130226856A1 PERFORMANCE-EFFICIENT SYSTEM FOR PREDICTING USER ACTIVITIES BASED ON TIME-RELATED FEATURES 有权
标题翻译：基于时间相关特征预测用户活动的性能有效系统
公开(公告)号：US20130226856A1
公开(公告)日：2013-08-29
申请号：US13403129
申请日：2012-02-23
申请人： Rui Zhang , Kurt E. Partridge , James M. A. Begole , Robert R. Price
发明人： Rui Zhang , Kurt E. Partridge , James M. A. Begole , Robert R. Price
IPC分类号： G06N5/02
CPC分类号： G06N5/02 , G06N7/005 , G06Q30/02 , G06Q30/0255 , G06Q30/0261
摘要： A recommender system uses an activity decision tree to model the changes in a user's behavior according to a plurality of time-related features. The system determines historical activities for the user, and generates a decision tree for the user's historical activities. Each leaf node of the decision tree is associated with an activity-prediction model that computes a probability for a corresponding activity. The system selects a path of the decision tree from a root node to a leaf node of the decision tree based on a target time. The selected path traverses two or more non-leaf nodes that are each associated with a temporal decision model that compares the target time against a temporal classifier. The system then determines a probability for a user activity based on an activity-prediction model of the selected path.
摘要翻译：推荐系统使用活动决策树来根据多个时间相关特征对用户行为的变化进行建模。系统确定用户的历史活动，并为用户的历史活动生成决策树。决策树的每个叶节点与计算相应活动概率的活动预测模型相关联。系统基于目标时间从决策树的根节点到叶节点选择决策树的路径。所选择的路径遍历两个或多个非叶节点，每个非叶节点与时间决策模型相关联，时间决策模型将目标时间与时间分类器进行比较。然后，系统基于所选路径的活动预测模型来确定用户活动的概率。

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