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1. 发明授权

US07524935B2 Sequences characteristic of hypoxia-regulated gene transcription 有权
标题翻译：缺氧调控基因转录特征的序列
公开(公告)号：US07524935B2
公开(公告)日：2009-04-28
申请号：US11440016
申请日：2006-05-25
申请人： Paz Einat , Rami Skaliter , Elena Feinstein , Aviv Regev , Hagar Kalinski
发明人： Paz Einat , Rami Skaliter , Elena Feinstein , Aviv Regev , Hagar Kalinski
IPC分类号： C07K16/00
CPC分类号： C12Q1/6883 , A61K38/00 , A61K48/00 , C07K14/47 , C07K14/4702 , C07K14/4747 , C12N9/0004 , C12Q2600/158 , C12Y114/11004
摘要： There are provided polynucleotides that are modulated by hypoxic conditions. The disclosure includes such genes and proteins as well as analogs, salts and functional derivatives of such proteins, and DNA encoding such analogs, and methods of use. Methods for treating the effects of stroke, hypoxia and/or ischemia by regulating such genes or proteins are also disclosed. The presence of hypoxia or a hypoxia-associated pathology may be diagnosed by screening for the presence of at least one polynucleotide having the nucleic acid sequence according to the present invention. Methods of regulating hypoxia associated pathologies are also provided.
摘要翻译：提供了由缺氧条件调节的多核苷酸。本公开包括此类基因和蛋白质以及此类蛋白质的类似物，盐和功能性衍生物，以及编码此类类似物的DNA及其使用方法。还公开了通过调节这些基因或蛋白质治疗中风，缺氧和/或缺血的作用的方法。可以通过筛选至少一种具有本发明的核酸序列的多核苷酸的存在来诊断缺氧或缺氧相关病理的存在。还提供了调节缺氧相关病变的方法。

2. 发明授权

US07074895B2 Sequences characteristic of hypoxia-regulated gene transcription 有权
公开(公告)号：US07074895B2
公开(公告)日：2006-07-11
申请号：US09802472
申请日：2001-03-09
申请人： Paz Einat , Rami Skaliter , Elena Feinstein , Aviv Regev
发明人： Paz Einat , Rami Skaliter , Elena Feinstein , Aviv Regev
IPC分类号： C07K1/00 , C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6883 , A61K38/00 , A61K48/00 , C07K14/47 , C07K14/4702 , C07K14/4747 , C12N9/0004 , C12Q2600/158 , C12Y114/11004
摘要： There are provided polynucleotides which are modulated by hypoxic conditions. The disclosure includes such genes and proteins as well as analogs, salts and functional derivatives of such proteins, and DNA encoding such analogs, and methods of use. Methods for treating the effects of stroke, hypoxia and/or ischemia by regulating such genes or proteins are also disclosed. The presence of hypoxia or a hypoxia-associated pathology may be diagnosed by screening for the presence of at least one polynucleotide having the nucleic acid sequence according to the present invention. Methods of regulating hypoxia associated pathologies are also provided.

3. 发明申请

US20060241290A1 Sequences characteristic of hypoxia-regulated gene transcription 有权
公开(公告)号：US20060241290A1
公开(公告)日：2006-10-26
申请号：US11440016
申请日：2006-05-25
申请人： Paz Einat , Rami Skaliter , Elena Feinstein , Aviv Regev
发明人： Paz Einat , Rami Skaliter , Elena Feinstein , Aviv Regev
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： C12Q1/6883 , A61K38/00 , A61K48/00 , C07K14/47 , C07K14/4702 , C07K14/4747 , C12N9/0004 , C12Q2600/158 , C12Y114/11004
摘要： There are provided polynucleotides that are modulated by hypoxic conditions. The disclosure includes such genes and proteins as well as analogs, salts and functional derivatives of such proteins, and DNA encoding such analogs, and methods of use. Methods for treating the effects of stroke, hypoxia and/or ischemia by regulating such genes or proteins are also disclosed. The presence of hypoxia or a hypoxia-associated pathology may be diagnosed by screening for the presence of at least one polynucleotide having the nucleic acid sequence according to the present invention. Methods of regulating hypoxia associated pathologies are also provided.

4. 发明授权

US07259253B2 Genes associated with mechanical stress, expression products therefrom, and uses thereof 失效
标题翻译：与机械应力相关的基因，表达产物及其用途
公开(公告)号：US07259253B2
公开(公告)日：2007-08-21
申请号：US10454351
申请日：2003-06-04
申请人： Paz Einat , Orit Segev , Rami Skaliter , Elena Feinstein , Alexander Faerman , Aviva Samach
发明人： Paz Einat , Orit Segev , Rami Skaliter , Elena Feinstein , Alexander Faerman , Aviva Samach
IPC分类号： C07H21/02 , C07H21/04 , C12Q1/68
CPC分类号： C07H21/04 , C07K14/47 , C07K16/18
摘要： The disclosure relates to human and mechanical stress induced genes, in particular gene 608, and functional equivalents, probes therefor, tests to identify such genes, polypeptide expression products of such genes, antibodies to the polypeptides, uses for such genes, expression products and antibodies, e.g., in diagnosis (for instance risk determination), treatment, prevention, or control, of osteoporosis or fractures; and to diagnostic, treatment, prevention, or control methods or processes, as well as compositions therefor and methods or processes for making and using such compositions, and receptors therefor and methods or processes for obtaining and using such receptors.
摘要翻译：本公开涉及人和机械应激诱导的基因，特别是基因608和功能等同物，其探针，鉴定这些基因的测试，这些基因的多肽表达产物，对多肽的抗体，用于这些基因，表达产物和抗体，例如骨质疏松症或骨折的诊断（例如风险确定），治疗，预防或控制; 以及诊断，治疗，预防或控制方法或过程，以及其组合物以及用于制备和使用这些组合物及其受体的方法或方法以及用于获得和使用此类受体的方法或方法。

5. 发明申请

US20050004065A1 Hypoxia regulated genes 审中-公开
标题翻译：缺氧调节基因
公开(公告)号：US20050004065A1
公开(公告)日：2005-01-06
申请号：US10857942
申请日：2004-06-02
申请人： Elena Feinstein , Paz Einat , Rami Skaliter
发明人： Elena Feinstein , Paz Einat , Rami Skaliter
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C12N15/85 , C12P19/12
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00
摘要： The polynucleotide sequence of the 2-2-83 gene encodes the 2-2-83 protein. Hypoxic-associated pathologies may be regulated by administering an effective amount of a polynucleotide or protein of the present invention, or a direct or indirect biologically active product of enzymatic activity of the protein. Tumorigenesis may be inhibited by inhibiting the enzymatic activity of the protein of the present invention. The presence of a hypoxia-associated pathology may be diagnosed by screening for the reduced expression of the 2-2-83 gene.
摘要翻译： 2-2-83基因的多核苷酸序列编码2-2-83蛋白。可以通过施用有效量的本发明的多核苷酸或蛋白质或蛋白质的酶活性的直接或间接的生物活性产物来调节低氧相关病理学。通过抑制本发明的蛋白质的酶活性可以抑制肿瘤发生。通过筛选2-2-83基因的表达降低可以诊断缺氧相关病理学的存在。

6. 发明授权

US06555667B1 Hypoxia-regulated genes 有权
标题翻译：低氧调控基因
公开(公告)号：US06555667B1
公开(公告)日：2003-04-29
申请号：US09604728
申请日：2000-06-28
申请人： Paz Einat , Rami Skaliter
发明人： Paz Einat , Rami Skaliter
IPC分类号： C07H2104
CPC分类号： C07K14/4747 , A61K38/00 , A61K48/00 , C07K14/47 , C07K14/4702
摘要： Neuroleukin (SEQ ID NO:8) has been discovered to be hypoxia regulated. Furthermore, it serves as an astrocyte motility factor. Astrocyte motility can be inhibited by a neuroleukin inhibitor.
摘要翻译：已经发现神经白细胞介素（SEQ ID NO：8）是缺氧调节的。此外，它作为星形胶质细胞运动因子。星形胶质细胞运动能被神经白细胞介素抑制剂抑制。

7. 发明申请

US20090036662A1 Hypoxia-regulated genes 有权
标题翻译：低氧调控基因
公开(公告)号：US20090036662A1
公开(公告)日：2009-02-05
申请号：US12157821
申请日：2008-06-13
申请人： Paz Einat , Rami Skaliter , Sylvie Luria
发明人： Paz Einat , Rami Skaliter , Sylvie Luria
IPC分类号： C07H21/02
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , C07K14/4702 , C07K14/4747
摘要： According to the present invention, purified, isolated and cloned nucleic acid polynucleotide encoding hypoxia-regulating genes and the proteins thereof and antibodies directed against the proteins which have sequences as set forth in SEQ ID No:1, SEQ ID No:2, SEQ ID No:3, SEQ ID No:4, SEQ ID No:5 and SEQ ID No:6 are provided. The present invention further provides transgenic animals and cell lines as well as knock-out organisms of these sequences. The present invention further provides methods of regulating angiogenesis or apoptosis or regulating response to hypoxic conditions in a patient in need of such treatment. The present invention also provides a method of diagnosing the presence of ischemia in a patient including the steps of analyzing a bodily fluid or tissue sample from the patient for the presence or gene product of at least one expressed gene (up-regulated) as set forth in the group comprising SEQ ID No:2; SEQ ID No:3; SEQ ID No:4; SEQ ID No:5; and SEQ ID No:6 and where ischemia is determined if the up-regulated gene or gene product is ascertained.
摘要翻译：根据本发明，编码缺氧调节基因及其蛋白质的纯化，分离和克隆的核酸多核苷酸和针对具有SEQ ID No：1，SEQ ID No：2，SEQ ID NO：2所示序列的蛋白质的抗体提供了No.3，SEQ ID No：4，SEQ ID No：5和SEQ ID No：6。本发明进一步提供这些序列的转基因动物和细胞系以及敲除生物体。本发明还提供了在需要这种治疗的患者中调节血管发生或凋亡或调节对缺氧条件的反应的方法。本发明还提供了一种诊断患者局部缺血的方法，包括以下步骤：从患者体内分析至少一种表达基因（上调）的存在或基因产物，如上所述在包含SEQ ID No：2的组中; SEQ ID No：3; SEQ ID No：4; SEQ ID No：5; 和SEQ ID No：6，如果确定上调基因或基因产物，则确定缺血。

8. 发明授权

US6013437A Method for identifying translationally regulated genes 失效
标题翻译：识别翻译调控基因的方法
公开(公告)号：US6013437A
公开(公告)日：2000-01-11
申请号：US748130
申请日：1996-11-12
申请人： Sylvie Luria , Paz Einat , Nicholas Harris , Rami Skaliter , Zehava Grosman
发明人： Sylvie Luria , Paz Einat , Nicholas Harris , Rami Skaliter , Zehava Grosman
IPC分类号： C12N15/10 , C12Q1/68
CPC分类号： C12N15/1034 , C12Q1/6809
摘要： A method for identifying translationally regulated genes includes selectively stimulating translation of an unknown target mRNA with a stress inducing element wherein the target mRNA is part of a larger sample of mRNA. The mRNA sample is divided into pools of translated and untranslated mRNA which are differentially analyzed to identify genes that are translationally regulated by the stress inducing element. A method for identifying gene sequences coding for internal ribosome entry sites includes inhibiting 5' cap-dependant mRNA translation in a cell, collecting a pool of mRNA from the cells, and differentially analyzing the pool of mRNA to identify genes with sequences coding for internal ribosome entry sites.
摘要翻译：用于鉴定翻译调节基因的方法包括用应激诱导元件选择性刺激未知靶mRNA的翻译，其中靶mRNA是mRNA的较大样本的一部分。将mRNA样品分成翻译的和非翻译的mRNA的mRNA，其进行差异分析以鉴定由应激诱导元件翻译调节的基因。用于鉴定编码内部核糖体进入位点的基因序列的方法包括抑制细胞中的5'帽依赖性mRNA翻译，从细胞中收集mRNA库，并差异分析mRNA库以鉴定编码内部核糖体的序列的基因进入网站。

9. 发明授权

US07973156B2 Hypoxia-regulated genes 有权
标题翻译：低氧调控基因
公开(公告)号：US07973156B2
公开(公告)日：2011-07-05
申请号：US12157821
申请日：2008-06-13
申请人： Paz Einat , Rami Skaliter , Sylvie Luria
发明人： Paz Einat , Rami Skaliter , Sylvie Luria
IPC分类号： C07H21/04 , A61K48/00 , C12Q1/68
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , C07K14/4702 , C07K14/4747
摘要： According to the present invention, purified, isolated and cloned nucleic acid polynucleotide encoding hypoxia-regulating genes and the proteins thereof and antibodies directed against the proteins which have sequences as set forth in SEQ ID No:1, SEQ ID No:2, SEQ ID No:3, SEQ ID No:4, SEQ ID No:5 and SEQ ID No:6 are provided. The present invention further provides transgenic animals and cell lines as well as knock-out organisms of these sequences. The present invention further provides methods of regulating angiogenesis or apoptosis or regulating response to hypoxic conditions in a patient in need of such treatment. The present invention also provides a method of diagnosing the presence of ischemia in a patient including the steps of analyzing a bodily fluid or tissue sample from the patient for the presence or gene product of at least one expressed gene (up-regulated) as set forth in the group comprising SEQ ID No:2; SEQ ID No:3; SEQ ID No:4; SEQ ID No:5; and SEQ ID No:6 and where ischemia is determined if the up-regulated gene or gene product is ascertained.
摘要翻译：根据本发明，编码缺氧调节基因及其蛋白质的纯化，分离和克隆的核酸多核苷酸和针对具有SEQ ID No：1，SEQ ID No：2，SEQ ID NO：2所示序列的蛋白质的抗体提供了No.3，SEQ ID No：4，SEQ ID No：5和SEQ ID No：6。本发明进一步提供这些序列的转基因动物和细胞系以及敲除生物体。本发明还提供了在需要这种治疗的患者中调节血管发生或凋亡或调节对缺氧条件的反应的方法。本发明还提供了一种诊断患者局部缺血的方法，包括以下步骤：从患者体内分析至少一种表达基因（上调）的存在或基因产物，如上所述在包含SEQ ID No：2的组中; SEQ ID No：3; SEQ ID No：4; SEQ ID No：5; 和SEQ ID No：6，如果确定上调基因或基因产物，则确定缺血。

10. 发明授权

US06455674B1 Hypoxia-regulated genes 有权
标题翻译：低氧调控基因
公开(公告)号：US06455674B1
公开(公告)日：2002-09-24
申请号：US09604978
申请日：2000-06-28
申请人： Paz Einat , Rami Skaliter
发明人： Paz Einat , Rami Skaliter
IPC分类号： C07K1400
CPC分类号： C07K14/4747 , A61K38/00 , A61K48/00 , C07K14/47 , C07K14/4702
摘要： Isolated hypoxia-regulated polypeptides have sequences as set forth in SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:7 and SEQ ID NO:11. Antibodies directed against such polypeptides may be prepared.
摘要翻译：分离的缺氧调节多肽具有SEQ ID NO：9，SEQ ID NO：10，SEQ ID NO：7和SEQ ID NO：11所示的序列。可以制备针对这种多肽的抗体。

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