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1. 发明申请

US20070191400A1 Pharmaceutical compositions comprising anti-inflammatory quinazolinecarboxamide derivatives 审中-公开
标题翻译：包含抗炎喹唑啉羧酰胺衍生物的药物组合物
公开(公告)号：US20070191400A1
公开(公告)日：2007-08-16
申请号：US10594081
申请日：2005-03-24
申请人： Paul Gregor , Nicholas Harris , Juraj Koppel , Regina Zhuk
发明人： Paul Gregor , Nicholas Harris , Juraj Koppel , Regina Zhuk
IPC分类号： A61K31/517
CPC分类号： A61K31/517
摘要： The present invention provides pharmaceutical compositions comprising quinazolinecarboxamide derivative, and certain novel quinazolinecarboxamide derivatives capable of inhibiting heparan sulfate-glycosaminoglycan (HS-GAGs) interactions with L-selectin, and useful in the prevention or treatment of various diseases, disorders and conditions mediated by HS-GAGs, particularly inflammatory and autoimmune diseases, viral diseases, cancer, and amyloid disorders.
摘要翻译：本发明提供了包含喹唑啉甲酰胺衍生物的药物组合物，以及能够抑制硫酸乙酰肝素 - 糖胺聚糖（HS-GAG）与L-选择蛋白相互作用的某些新型喹唑啉甲酰胺衍生物，可用于预防或治疗由HS介导的各种疾病，病症和病症 -GAGs，特别是炎性和自身免疫性疾病，病毒性疾病，癌症和淀粉样蛋白病症。

2. 发明申请

US20060275214A1 Methods of screening for anti-inflammatory drugs and use thereof 审中-公开
标题翻译：筛选抗炎药物的方法及其用途
公开(公告)号：US20060275214A1
公开(公告)日：2006-12-07
申请号：US10541099
申请日：2003-12-30
申请人： Paul Gregor , Nicholas Harris , Juraj Koppel
发明人： Paul Gregor , Nicholas Harris , Juraj Koppel
IPC分类号： A61K51/00 , G01N33/53 , G01N33/574 , A61K38/16 , A61K31/737 , A61K31/727 , A61K39/395 , C07K16/30
CPC分类号： C07K16/2854 , G01N33/5011 , G01N33/57488 , G01N2333/70546 , G01N2333/7056 , G01N2333/78 , G01N2400/40
摘要： The present invention relates to methods for screening small organic compounds capable of inhibiting the interactions of glycosaminoglycans with effector cell adhesion molecules. Specifically, the present invention provides a method for screening of small organic compounds, the compounds inhibit the interaction of heparin with L-selectin or P-selectin. The compounds identified by the methods of the invention are useful for treating inflammatory disorders, autoimmune diseases and cancer.
摘要翻译：本发明涉及筛选能够抑制糖胺聚糖与效应细胞粘附分子相互作用的小有机化合物的方法。具体地说，本发明提供了筛选小有机化合物的方法，该化合物抑制肝素与L-选择蛋白或P-选择蛋白的相互作用。通过本发明的方法鉴定的化合物可用于治疗炎性疾病，自身免疫性疾病和癌症。

3. 发明申请

US20050170043A1 Method and apparatus for malting 审中-公开
标题翻译：麦芽的方法和装置
公开(公告)号：US20050170043A1
公开(公告)日：2005-08-04
申请号：US10504781
申请日：2003-02-14
申请人： Nicholas Harris
发明人： Nicholas Harris
IPC分类号： B02B5/02 , C12C1/15 , A23L1/10
CPC分类号： C12C1/073 , C12C1/15
摘要： A method and apparatus for carrying out a malting process comprising means for efficiently turning over the grain mass in a bottom to top fashion by directing grain from adjacent to the bottom of the vessel to the centre of the bottom of the vessel from where it is elevated above the grain mass and redistributed back on top of the grain mass. The apparatus can be used for any stage of the malting process.
摘要翻译：一种用于进行麦芽过程的方法和装置，包括用于通过将颗粒从相邻的容器的底部引导到容器的底部的中心，从而从顶部到顶部有效地翻转谷物的装置，高于谷物质量并重新分布在谷物的顶部。该设备可用于任何阶段的麦芽过程。

4. 发明授权

US4281190A Process for preparing N-[2-(p-hydroxyphenyl)-ethyl]-p-chlorobenzamide 失效
标题翻译：制备N- [2-（对羟基苯基） - 乙基] - 对氯苯甲酰胺的方法
公开(公告)号：US4281190A
公开(公告)日：1981-07-28
申请号：US177906
申请日：1980-08-14
申请人： Nicholas Harris
发明人： Nicholas Harris
IPC分类号： C07C67/00 , C07C231/00 , C07C231/12 , C07C231/14 , C07C233/73 , C07D263/42 , C07C103/78
CPC分类号： C07D263/42
摘要： A process for preparing N-[2-(p-hydroxyphenyl)ethyl]-p-chlorobenzamide, a penultimate precursor for bezafibrate, is described.
摘要翻译：描述了制备N- [2-（对 - 羟基苯基）乙基] - 对氯苯甲酰胺的方法，其是吩噻嗪酸的倒数第二个前体。

5. 发明授权

US08703911B2 Cytokine receptor peptides, compositions thereof and methods thereof 有权
标题翻译：细胞因子受体肽及其组合物及其方法
公开(公告)号：US08703911B2
公开(公告)日：2014-04-22
申请号：US12225122
申请日：2007-03-18
申请人： Chai Ezerzer , Nicholas Harris
发明人： Chai Ezerzer , Nicholas Harris
IPC分类号： A61K38/04 , A61K38/00
CPC分类号： A61K38/195 , A61K9/0019 , A61K38/00 , A61K38/177 , A61K38/1793 , A61K38/19 , A61K38/2053 , C07K7/06 , C07K14/7158
摘要： The invention provides a pharmaceutical composition including a peptide comprising at least a portion of a chemokine receptor or a G-protein coupled receptor and optionally a cytokine. The pharmaceutical composition of the invention may be used for altering immune system functioning, for example, to treat an immune system disorder, such as an autoimmune disease, multiple sclerosis, transplant rejection, psoriasis and asthma. The invention also provides peptides that may be used in the pharmaceutical composition and a method for preparing the pharmaceutical composition of the invention. The invention further provides a method for to treating an immune system disorder, such as an autoimmune disease, multiple sclerosis, transplant rejection, and psoriasis asthma.
摘要翻译：本发明提供一种药物组合物，其包含包含至少一部分趋化因子受体或G-蛋白偶联受体和任选的细胞因子的肽。本发明的药物组合物可用于改变免疫系统功能，例如治疗免疫系统疾病，例如自身免疫性疾病，多发性硬化，移植排斥，牛皮癣和哮喘。本发明还提供可用于药物组合物中的肽以及制备本发明药物组合物的方法。本发明还提供了治疗免疫系统疾病如自身免疫疾病，多发性硬化，移植排斥和牛皮癣哮喘的方法。

6. 发明申请

US20100034771A1 Combination Of Cytokine And Cytokine Receptor For Altering Immune System Functioning 有权
标题翻译：细胞因子和细胞因子受体的组合改变免疫系统功能
公开(公告)号：US20100034771A1
公开(公告)日：2010-02-11
申请号：US12225122
申请日：2007-03-18
申请人： Chai Ezerzer , Nicholas Harris
发明人： Chai Ezerzer , Nicholas Harris
IPC分类号： A61K38/20 , A61K38/16 , C07K7/06 , A61P37/00 , A61P37/06 , A61P17/06 , A61P11/06
CPC分类号： A61K38/195 , A61K9/0019 , A61K38/00 , A61K38/177 , A61K38/1793 , A61K38/19 , A61K38/2053 , C07K7/06 , C07K14/7158
摘要： The invention provides a pharmaceutical composition including a cytokine and a peptide comprising at least a portion of a chemokine receptor or a c_protein coupled receptor. The pharmaceutical composition of the invention may be used for altering immune system functioning, for example, to treat an immune system disorder, such as an autoimmune disease, multiple sclerosis, transplant rejection, psoriasis and asthma. The invention also provides peptides that may be used in the pharmaceutical composition and a method for preparing the pharmaceutical composition of the invention. The invention further provides a method for to treating an immune system disorder, such as an autoimmune disease, multiple sclerosis, transplant rejection, and psoriasis asthma.
摘要翻译：本发明提供包含细胞因子和包含趋化因子受体或c_蛋白偶联受体的至少一部分的肽的药物组合物。本发明的药物组合物可用于改变免疫系统功能，例如治疗免疫系统疾病，例如自身免疫性疾病，多发性硬化，移植排斥，牛皮癣和哮喘。本发明还提供可用于药物组合物中的肽以及制备本发明药物组合物的方法。本发明还提供了治疗免疫系统疾病如自身免疫疾病，多发性硬化，移植排斥和牛皮癣哮喘的方法。

7. 发明申请

US20070007827A1 Electromagnetic device for converting mechinal vibrational energy into electrical energy, and manufacture thereof 有权
标题翻译：用于将机械振动能转换为电能的电磁装置及其制造
公开(公告)号：US20070007827A1
公开(公告)日：2007-01-11
申请号：US10569631
申请日：2004-08-13
申请人： Nicholas Harris , Michael Tudor , Neil White , Stephen Beeby , Peter Glynne-Jones
发明人： Nicholas Harris , Michael Tudor , Neil White , Stephen Beeby , Peter Glynne-Jones
IPC分类号： H02K7/18 , H02K35/00
CPC分类号： H02K35/04
摘要： An electromagnetic generator comprising a multilayer assembly of a first layer carrying at least one magnet, a second layer carrying at least one coil, and a third layer carrying at least one magnet, the at least one magnet of the first and third layers being configured to define therebetween a region of magnetic flux in which the at least one coil is disposed, at least one of the layers being shaped to define a respective displaceable portion thereof which is displaceable by vibration of the electromagnetic generator thereby to cause relative movement between the coil and the magnets and generate an electrical current in the coil.
摘要翻译：一种电磁发生器，包括承载至少一个磁体的第一层的多层组件，承载至少一个线圈的第二层和承载至少一个磁体的第三层，所述第一层和第三层的至少一个磁体被配置为在其间限定出一个磁通区域，其中至少一个线圈被设置在其中，至少一个层被成形为限定其可相应的位移部分，其可由电磁发生器的振动移位，从而引起线圈和磁体并在线圈中产生电流。

8. 发明授权

US06211020B1 Process for fabricating a common source region in memory devices 有权
标题翻译：用于在存储器件中制造公共源极区的工艺
公开(公告)号：US06211020B1
公开(公告)日：2001-04-03
申请号：US09177294
申请日：1998-10-22
申请人： Nicholas Harris Tripsas , Mark T. Ramsbey
发明人： Nicholas Harris Tripsas , Mark T. Ramsbey
IPC分类号： H01L21336
CPC分类号： H01L27/11521 , H01L27/115
摘要： A method for manufacturing a non-volatile memory device includes forming a memory device on the semiconductor substrate by forming isolation regions in said substrate, forming gate stacks on the substrate between respective ones of said isolation regions, with each stack having at least an active region adjacent thereto, and forming common source regions for the plurality of gate stacks through a plasma implant of an impurity. A memory device having a plurality of memory transistors is also provided. The device generally comprises a semiconductor substrate having a generally planar surface. Field oxide regions are formed in the semiconductor substrate to a depth below the substrate surface. The common bus region is provided which is exposed to the substrate, the common bus region including at least a first recessed portion of the substrate wherein areas of the field oxide regions have been removed so that said recessed portion has a depth below the surface of the substrate. An impurity region forming the common bus is formed in the common bus region, with the impurity region having a junction depth which is generally uniform within the recessed portion.
摘要翻译：一种用于制造非易失性存储器件的方法包括通过在所述衬底中形成隔离区域在所述半导体衬底上形成存储器件，在所述隔离区域的相应区域之间的所述衬底上形成栅叠层，每个叠层至少具有有源区并且通过杂质的等离子体注入形成用于多个栅极叠层的公共源区。还提供了具有多个存储晶体管的存储器件。该器件通常包括具有大致平坦表面的半导体衬底。半导体衬底中的场氧化物区域形成在衬底表面下方的深度。提供公共总线区域，其暴露于衬底，公共总线区域至少包括衬底的第一凹陷部分，其中场氧化物区域的区域已被去除，使得所述凹陷部分的深度低于基质。形成公共总线的杂质区域形成在公共总线区域中，杂质区域具有在凹部内大致均匀的结深度。

9. 发明授权

US6015717A Method for monitoring rapid thermal process integrity 失效
标题翻译：监测快速热过程完整性的方法
公开(公告)号：US6015717A
公开(公告)日：2000-01-18
申请号：US42331
申请日：1998-03-13
申请人： Nicholas Harris Tripsas
发明人： Nicholas Harris Tripsas
IPC分类号： H01L21/66 , H01L23/544 , G01R31/26
CPC分类号： H01L22/20 , H01L22/34
摘要： A method for determining the integrity of a rapid thermal process device which is sensitive to atmospheric leaks. The method includes the steps of providing a wafer having a susceptibility to oxidation-enhanced diffusion into the device. The wafer is then annealed in an inert ambient, and the oxide thickness and sheet resistance of the wafer are then measured. In a further aspect of the invention, a control wafer is simultaneously processed or sequentially processed in the chamber. The control wafer is not sensitive to temperature variation. Following the theories of statistical process control, the analysis of the oxide thickness, sheet resistance and temperature control wafer will allow a determination of whether the ambient leaks have occurred in the system.
摘要翻译：一种确定对大气泄漏敏感的快速热处理装置的完整性的方法。该方法包括提供具有对氧化增强扩散的敏感性的晶片到设备中的步骤。然后将晶片在惰性环境中退火，然后测量晶片的氧化物厚度和薄层电阻。在本发明的另一方面，控制晶片在腔室中被同时处理或顺序处理。控制晶片对温度变化不敏感。根据统计过程控制的理论，氧化物厚度，薄层电阻和温度控制晶片的分析将允许确定系统中是否发生了环境泄漏。

10. 发明授权

US6013437A Method for identifying translationally regulated genes 失效
标题翻译：识别翻译调控基因的方法
公开(公告)号：US6013437A
公开(公告)日：2000-01-11
申请号：US748130
申请日：1996-11-12
申请人： Sylvie Luria , Paz Einat , Nicholas Harris , Rami Skaliter , Zehava Grosman
发明人： Sylvie Luria , Paz Einat , Nicholas Harris , Rami Skaliter , Zehava Grosman
IPC分类号： C12N15/10 , C12Q1/68
CPC分类号： C12N15/1034 , C12Q1/6809
摘要： A method for identifying translationally regulated genes includes selectively stimulating translation of an unknown target mRNA with a stress inducing element wherein the target mRNA is part of a larger sample of mRNA. The mRNA sample is divided into pools of translated and untranslated mRNA which are differentially analyzed to identify genes that are translationally regulated by the stress inducing element. A method for identifying gene sequences coding for internal ribosome entry sites includes inhibiting 5' cap-dependant mRNA translation in a cell, collecting a pool of mRNA from the cells, and differentially analyzing the pool of mRNA to identify genes with sequences coding for internal ribosome entry sites.
摘要翻译：用于鉴定翻译调节基因的方法包括用应激诱导元件选择性刺激未知靶mRNA的翻译，其中靶mRNA是mRNA的较大样本的一部分。将mRNA样品分成翻译的和非翻译的mRNA的mRNA，其进行差异分析以鉴定由应激诱导元件翻译调节的基因。用于鉴定编码内部核糖体进入位点的基因序列的方法包括抑制细胞中的5'帽依赖性mRNA翻译，从细胞中收集mRNA库，并差异分析mRNA库以鉴定编码内部核糖体的序列的基因进入网站。

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