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    • 1. 发明授权
    • Meso- and microfluidic continuous flow and stopped flow electroösmotic mixer
    • 介质和微流体连续流动和停止流动电渗流混合器
    • US06482306B1
    • 2002-11-19
    • US09404454
    • 1999-09-22
    • Paul YagerMark R. HollAndrew KamholzCatherine CabreraKaterina Macounova
    • Paul YagerMark R. HollAndrew KamholzCatherine CabreraKaterina Macounova
    • B01F1300
    • B01F13/0076B01F13/0001B01F13/0005B01F13/0077B01L3/5027Y10T137/2087Y10T137/2191
    • An electroösmotic mixing device and a method for mixing one or more fluids for use in meso- or microfluidic device applications. The mixing device provides batch or continuous mixing of one or more fluids in meso- or microfluidic channels. An electric field is generated in the channel in substantial contact with chargeable surfaces therein. No alterations of the geometry of existing flow paths need be made, and the degree of mixing in the device can be controlled by the length of the electrodes, the flow rate past the electrodes, and the voltage applied to those electrodes. The degree of mixing is affected by choice of materials for the chargeable surface (in some cases by the selection of materials or coatings for channel walls) and the ionic strength of the fluids and the type and concentration of ions in the fluids. The ionic strength of fluids to be mixed is sufficiently low to allow electroosmotic flow. The method and device of this invention is preferably applied to fluids to having low ionic strength less than or equal to about 1 mM.
    • 一种电渗混合装置和用于混合用于中等或微流体装置应用的一种或多种流体的方法。 混合装置在中等或微流体通道中提供一种或多种流体的间歇或连续混合。 在通道中产生与其中的可充电表面实质接触的电场。 不需要改变现有流路的几何形状,并且可以通过电极的长度,通过电极的流速和施加到这些电极的电压来控制装置中的混合程度。 混合的程度受到可充电表面的材料选择(在某些情况下通过选择通道壁的材料或涂层)以及流体的离子强度以及流体中离子的类型和浓度的影响。 要混合的流体的离子强度足够低以允许电渗流。 本发明的方法和装置优选应用于具有小于或等于约1mM的低离子强度的流体。