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1. 发明授权

US07479541B2 Human and murine Mus81 proteins 有权
标题翻译：人和鼠Mus81蛋白
公开(公告)号：US07479541B2
公开(公告)日：2009-01-20
申请号：US11800929
申请日：2007-05-08
申请人： Paul R. Russell , Jorge E. Vialard , Michael N. Boddy , Paul A. Shanahan , Antonia Lopez-Girona , Cecile-Marie D. D. Denis , Clare H. McGowan
发明人： Paul R. Russell , Jorge E. Vialard , Michael N. Boddy , Paul A. Shanahan , Antonia Lopez-Girona , Cecile-Marie D. D. Denis , Clare H. McGowan
IPC分类号： C07K14/00
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4738 , C12N9/22
摘要： The present invention encompasses novel mammalian cell cycle checkpoint genes/DNA repair genes, cDNA or genomic DNA, isolated nucleic acids corresponding thereto, proteins encoded thereby, expression vectors comprising said nucleic acids, host cells transformed with said expression vectors, and methods for treating a cell using such nucleic acids or proteins.
摘要翻译：本发明包括新的哺乳动物细胞周期检查点基因/ DNA修复基因，cDNA或基因组DNA，与其相对应的分离的核酸，由此编码的蛋白质，包含所述核酸的表达载体，用所述表达载体转化的宿主细胞，以及治疗使用这种核酸或蛋白质的细胞。

2. 发明授权

US07214790B2 Genes and proteins encoded thereby 有权
标题翻译：由此编码的基因和蛋白质
公开(公告)号：US07214790B2
公开(公告)日：2007-05-08
申请号：US10229355
申请日：2002-08-27
申请人： Paul R. Russell , Jorge E. Vialard , Michael N. Boddy , Paul A. Shanahan , Antonia Lopez-Girona , Cecile-Marie D. D. Denis , Clare H. McGowan
发明人： Paul R. Russell , Jorge E. Vialard , Michael N. Boddy , Paul A. Shanahan , Antonia Lopez-Girona , Cecile-Marie D. D. Denis , Clare H. McGowan
IPC分类号： C07H21/04 , C07H21/02 , A61K48/00
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4738 , C12N9/22
摘要： The present invention encompasses novel mammalian cell cycle checkpoint genes/DNA repair genes, cDNA or genomic DNA, isolated nucleic acids corresponding thereto, expression vectors comprising said nucleic acids, host cells transformed with said expression vectors, pharmaceutical compositions and the formulation of such compositions comprising said nucleic acids or proteins expressed therefrom, methods for treating a cell using such nucleic acids, proteins or pharmaceutical compositions, and the use of such nucleic acids or proteins in formulating a pharmaceutical preparation.
摘要翻译：本发明包括新的哺乳动物细胞周期检查点基因/ DNA修复基因，cDNA或基因组DNA，与其相对应的分离的核酸，包含所述核酸的表达载体，用所述表达载体转化的宿主细胞，药物组合物和这些组合物的制剂，其包含由此表达的核酸或蛋白质，使用这种核酸，蛋白质或药物组合物治疗细胞的方法，以及这些核酸或蛋白质在配制药物制剂中的用途。

3. 发明授权

US07396669B2 Mammalian endonucleases and methods of use 失效
标题翻译：哺乳动物内切核酸酶和使用方法
公开(公告)号：US07396669B2
公开(公告)日：2008-07-08
申请号：US10880881
申请日：2004-06-30
申请人： Michael N. Boddy , Veronique Blais , Xiao-Bo Chen , Clare H. McGowan , Pierre-Henri L. Gaillard , Paul R. Russell
发明人： Michael N. Boddy , Veronique Blais , Xiao-Bo Chen , Clare H. McGowan , Pierre-Henri L. Gaillard , Paul R. Russell
IPC分类号： C12N9/16 , C07K14/00 , C12Q1/44 , C12P21/06 , C12N15/00 , C12N5/10 , C12N1/21 , C07H21/04
CPC分类号： C12N9/22
摘要： Isolated mammalian Mus81-Eme endonuclease complexes comprise an Mus81 protein portion and an Eme protein portion. A method of identifying a chemical compound that modulates mammalian cellular response to DNA damage comprises contacting a chemical compound to be tested with a biochemical mixture containing an isolated mammalian Mus81-Eme1 endonuclease complex, a source of magnesium ion, and a suitable DNA substrate; measuring the activity level of mammalian Mus81-Eme endonuclease complex in the mixture; comparing the measured activity level to the activity level of a substantially similar mixture of isolated Mus81-Eme1 endonuclease, magnesium ion, and DNA substrate in the absence of the chemical compound to be tested; and selecting a chemical compound that increases or decreases the endonuclease activity. Isolated mammalian Eme1 and Eme2 proteins derived from humans and murine species and isolated nucleic acids encoding the proteins are also described.
摘要翻译：分离的哺乳动物Mus81-Eme内切核酸酶复合物包含Mus81蛋白质部分和Eme蛋白质部分。鉴定调节哺乳动物细胞对DNA损伤的反应的化合物的方法包括将待测试的化合物与含有分离的哺乳动物Mus81-Eme1内切核酸酶复合物，镁离子源和合适的DNA底物的生化混合物接触; 测量混合物中哺乳动物Mus81-Eme核酸内切酶复合物的活性水平; 将测量的活性水平与不存在待测化学化合物的分离的Mus81-Eme1内切核酸酶，镁离子和DNA底物的基本相似的混合物的活性水平进行比较; 并选择增加或减少核酸内切酶活性的化合物。还描述了衍生自人和鼠类物种的分离的哺乳动物Eme1和Eme2蛋白以及编码蛋白质的分离的核酸。

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