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1. 发明授权

US07396669B2 Mammalian endonucleases and methods of use 失效
标题翻译：哺乳动物内切核酸酶和使用方法
公开(公告)号：US07396669B2
公开(公告)日：2008-07-08
申请号：US10880881
申请日：2004-06-30
申请人： Michael N. Boddy , Veronique Blais , Xiao-Bo Chen , Clare H. McGowan , Pierre-Henri L. Gaillard , Paul R. Russell
发明人： Michael N. Boddy , Veronique Blais , Xiao-Bo Chen , Clare H. McGowan , Pierre-Henri L. Gaillard , Paul R. Russell
IPC分类号： C12N9/16 , C07K14/00 , C12Q1/44 , C12P21/06 , C12N15/00 , C12N5/10 , C12N1/21 , C07H21/04
CPC分类号： C12N9/22
摘要： Isolated mammalian Mus81-Eme endonuclease complexes comprise an Mus81 protein portion and an Eme protein portion. A method of identifying a chemical compound that modulates mammalian cellular response to DNA damage comprises contacting a chemical compound to be tested with a biochemical mixture containing an isolated mammalian Mus81-Eme1 endonuclease complex, a source of magnesium ion, and a suitable DNA substrate; measuring the activity level of mammalian Mus81-Eme endonuclease complex in the mixture; comparing the measured activity level to the activity level of a substantially similar mixture of isolated Mus81-Eme1 endonuclease, magnesium ion, and DNA substrate in the absence of the chemical compound to be tested; and selecting a chemical compound that increases or decreases the endonuclease activity. Isolated mammalian Eme1 and Eme2 proteins derived from humans and murine species and isolated nucleic acids encoding the proteins are also described.
摘要翻译：分离的哺乳动物Mus81-Eme内切核酸酶复合物包含Mus81蛋白质部分和Eme蛋白质部分。鉴定调节哺乳动物细胞对DNA损伤的反应的化合物的方法包括将待测试的化合物与含有分离的哺乳动物Mus81-Eme1内切核酸酶复合物，镁离子源和合适的DNA底物的生化混合物接触; 测量混合物中哺乳动物Mus81-Eme核酸内切酶复合物的活性水平; 将测量的活性水平与不存在待测化学化合物的分离的Mus81-Eme1内切核酸酶，镁离子和DNA底物的基本相似的混合物的活性水平进行比较; 并选择增加或减少核酸内切酶活性的化合物。还描述了衍生自人和鼠类物种的分离的哺乳动物Eme1和Eme2蛋白以及编码蛋白质的分离的核酸。

2. 发明授权

US07479541B2 Human and murine Mus81 proteins 有权
标题翻译：人和鼠Mus81蛋白
公开(公告)号：US07479541B2
公开(公告)日：2009-01-20
申请号：US11800929
申请日：2007-05-08
申请人： Paul R. Russell , Jorge E. Vialard , Michael N. Boddy , Paul A. Shanahan , Antonia Lopez-Girona , Cecile-Marie D. D. Denis , Clare H. McGowan
发明人： Paul R. Russell , Jorge E. Vialard , Michael N. Boddy , Paul A. Shanahan , Antonia Lopez-Girona , Cecile-Marie D. D. Denis , Clare H. McGowan
IPC分类号： C07K14/00
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4738 , C12N9/22
摘要： The present invention encompasses novel mammalian cell cycle checkpoint genes/DNA repair genes, cDNA or genomic DNA, isolated nucleic acids corresponding thereto, proteins encoded thereby, expression vectors comprising said nucleic acids, host cells transformed with said expression vectors, and methods for treating a cell using such nucleic acids or proteins.
摘要翻译：本发明包括新的哺乳动物细胞周期检查点基因/ DNA修复基因，cDNA或基因组DNA，与其相对应的分离的核酸，由此编码的蛋白质，包含所述核酸的表达载体，用所述表达载体转化的宿主细胞，以及治疗使用这种核酸或蛋白质的细胞。

3. 发明授权

US07214790B2 Genes and proteins encoded thereby 有权
标题翻译：由此编码的基因和蛋白质
公开(公告)号：US07214790B2
公开(公告)日：2007-05-08
申请号：US10229355
申请日：2002-08-27
申请人： Paul R. Russell , Jorge E. Vialard , Michael N. Boddy , Paul A. Shanahan , Antonia Lopez-Girona , Cecile-Marie D. D. Denis , Clare H. McGowan
发明人： Paul R. Russell , Jorge E. Vialard , Michael N. Boddy , Paul A. Shanahan , Antonia Lopez-Girona , Cecile-Marie D. D. Denis , Clare H. McGowan
IPC分类号： C07H21/04 , C07H21/02 , A61K48/00
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4738 , C12N9/22
摘要： The present invention encompasses novel mammalian cell cycle checkpoint genes/DNA repair genes, cDNA or genomic DNA, isolated nucleic acids corresponding thereto, expression vectors comprising said nucleic acids, host cells transformed with said expression vectors, pharmaceutical compositions and the formulation of such compositions comprising said nucleic acids or proteins expressed therefrom, methods for treating a cell using such nucleic acids, proteins or pharmaceutical compositions, and the use of such nucleic acids or proteins in formulating a pharmaceutical preparation.
摘要翻译：本发明包括新的哺乳动物细胞周期检查点基因/ DNA修复基因，cDNA或基因组DNA，与其相对应的分离的核酸，包含所述核酸的表达载体，用所述表达载体转化的宿主细胞，药物组合物和这些组合物的制剂，其包含由此表达的核酸或蛋白质，使用这种核酸，蛋白质或药物组合物治疗细胞的方法，以及这些核酸或蛋白质在配制药物制剂中的用途。

4. 发明授权

US06440732B1 Genes and proteins encoded thereby 有权
标题翻译：由此编码的基因和蛋白质
公开(公告)号：US06440732B1
公开(公告)日：2002-08-27
申请号：US09661711
申请日：2000-09-14
申请人： Paul R. Russell , Jorge E. Vialard , Michael N. Boddy , Paul A. Shanahan , Antonia Lopez-Girona , Cecile-Marie D. D. Denis
发明人： Paul R. Russell , Jorge E. Vialard , Michael N. Boddy , Paul A. Shanahan , Antonia Lopez-Girona , Cecile-Marie D. D. Denis
IPC分类号： C07H1700
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4738 , C12N9/22
摘要： The present invention encompasses novel mammalian cell cycle checkpoint genes/DNA repair genes, cDNA or genomic DNA, isolated nucleic acids corresponding thereto, expression vectors comprising said nucleic acids, host cells transformed with said expression vectors, pharmaceutical compositions and the formulation of such compositions comprising said nucleic acids or proteins expressed therefrom, methods for treating a cell using such nucleic acids, proteins or pharmaceutical compositions, and the use of such nucleic acids or proteins in formulating a pharmaceutical preparation.
摘要翻译：本发明包括新的哺乳动物细胞周期检查点基因/ DNA修复基因，cDNA或基因组DNA，与其相对应的分离的核酸，包含所述核酸的表达载体，用所述表达载体转化的宿主细胞，药物组合物和这些组合物的制剂，其包含由此表达的核酸或蛋白质，使用这种核酸，蛋白质或药物组合物治疗细胞的方法，以及这些核酸或蛋白质在配制药物制剂中的用途。

5. 发明授权

US4991631A Lead straightening and trimming apparatus 失效
标题翻译：铅矫正和修边装置
公开(公告)号：US4991631A
公开(公告)日：1991-02-12
申请号：US403940
申请日：1989-09-07
申请人： Robert J. Eminger , Bueford Ebert , Paul R. Russell , Donald L. Van Gilder
发明人： Robert J. Eminger , Bueford Ebert , Paul R. Russell , Donald L. Van Gilder
IPC分类号： H02K15/04 , H02K15/00
CPC分类号： H02K15/0056 , H02K15/0075
摘要： A lead straightening and trimming apparatus for the leads of electrical components such as stators. The apparatus includes a pallet having positioning posts which position the stators on the pallet and also position coils within the stator. The apparatus also includes a rotating helical pick-up tool which is movable between a retracted position and an extended position adjacent to a component supporting pallet having lead retaining posts. The pick-up tool operates to capture the free ends of leads extending from posts provided by the pallets. Upon retraction, the pick-up tool moves the associated free ends of the leads to a partially straightened gripping position. The apparatus also includes a combined gripper straightening and cutting apparatus which grips the associated lead adjacent to the pallet post with a force insufficient to cut the lead. Retraction of the gripper straightens the portion of the lead extending from the retaining post of the pallet. The gripper is then released to release tension in the lead. The straightener cutter then cuts the lead along the straightened portion at a predetermined distance from the post.

6. 发明授权

US07467179B2 Backplane architecture for a data server 有权
标题翻译：数据服务器的背板架构
公开(公告)号：US07467179B2
公开(公告)日：2008-12-16
申请号：US10153665
申请日：2002-05-24
申请人： Andrew M. Fussell , Paul R. Russell
发明人： Andrew M. Fussell , Paul R. Russell
IPC分类号： G06F15/16
CPC分类号： G06F13/4095
摘要： A media server for use in networks where media are transmitted in packet form comprises at least one card shelf containing at least one bus controller card, at least one other card such as a media processor card, and a backplane. The backplane includes a media bus group. Each packet has a routing header added to it. The data is optionally sent over a single media bus to a single card, or to a plurality of different cards. Framing information and clock pulse strings are passed to each card over the backplane. Each card is assigned an address, so that data sent from each card has a source address which is identified each time that card wishes to send data elsewhere. Also, data that is being addressed to each card will include the respective destination address of that card in its routing header. A failed card or bus can be sensed and isolated by the bus controller card, and packets will continue to be transmitted to the remaining cards over the remaining buses. In the case where a redundant bus controller is present, the redundant bus controller can detect errors, and take the active bus controller card out of service, and then become the active bus controller itself.
摘要翻译：用于以分组形式传送媒体的网络中的媒体服务器包括至少一个包含至少一个总线控制器卡，至少一个其他卡，例如媒体处理器卡和背板的卡架。背板包括一个媒体总线组。每个数据包都有一个路由头添加到它。数据可选地通过单个媒体总线发送到单个卡或多个不同的卡。帧信息和时钟脉冲串通过背板传递到每个卡。每个卡被分配一个地址，使得从每个卡发送的数据具有源卡地址，每当该卡希望在其他地方发送数据时，该地址被识别。此外，正在寻址到每个卡的数据将包括该卡在其路由头中的相应目的地址。故障卡或总线可以被总线控制卡检测和隔离，并且数据包将继续通过其余总线传输到剩余的卡。在存在冗余总线控制器的情况下，冗余总线控制器可以检测错误，并使有效总线控制器卡停止工作，然后成为主动总线控制器本身。

7. 发明授权

US4800646A Transfer tooling for wire coils 失效
标题翻译：线圈转移工具
公开(公告)号：US4800646A
公开(公告)日：1989-01-31
申请号：US100611
申请日：1987-09-24
申请人： Paul R. Russell
发明人： Paul R. Russell
IPC分类号： H02K15/06
CPC分类号： H02K15/068 , Y10T29/49009 , Y10T29/49073 , Y10T29/53161
摘要： Transfer and inserter tooling for receiving coil windings from a coil winder such as a shed winder, and for inserting the coils into a dynamoelectric component such as a motor stator. The tooling includes a transfer tool molded of plastic and providing a cylindrical array of cantilever-supported fingers. The coils formed on the winder are positioned in a predetermined arrangement within the spaces between the fingers. Also included is an inserter tool having a cylindrical array of cantilever-mounted fingers and operable to insert coils positioned within the spaces between the fingers into the slots of a stator and the like. The transfer tool and inserter tool fingers are provided with interfitting alignment and guide means which properly position associated fingers of the two tools when the tools are assembled for transfer of the coils from the transfer tool to the inserter tool. The alignment and guide means operate to accurately align associated fingers even when the fingers of the transfer tool are displaced from their proper aligned positions by the windings carried therebetween.
摘要翻译：用于从线圈卷绕机（例如梭形绕线机）接收线圈绕组并用于将线圈插入诸如电动机定子的电动部件中的传送和插入器工具。工具包括由塑料模制的转移工具，并提供悬臂支撑的手指的圆柱形阵列。形成在卷绕机上的线圈以预定的布置定位在指状物之间的空间内。还包括具有悬臂安装的指状物的圆柱形阵列的插入器工具，并且可操作以将定位在指状物之间的空间内的线圈插入定子等的槽中。转移工具和插入器工具指状物设置有配合对准和引导装置，当工具被组装用于将线圈从转移工具传送到插入器工具时，适当地定位两个工具的相关联的手指。即使当传送工具的指状物被它们之间承载的绕组从其适当的对准位置偏移时，对准和引导装置也可以精确对准相关的手指。

8. 外观设计

USD353425S Triangular game playing arena 失效
公开(公告)号：USD353425S
公开(公告)日：1994-12-13
申请号：US000233
申请日：1992-10-08
申请人： Paul R. Russell , Alysn Hassenforder
设计人： Paul R. Russell , Alysn Hassenforder

9. 发明授权

US5271627A Real encounter game for balancing the body, mind and spirit 失效
标题翻译：真正的相遇游戏，平衡身体，心灵和精神
公开(公告)号：US5271627A
公开(公告)日：1993-12-21
申请号：US880183
申请日：1992-05-07
申请人： Paul R. Russell , Alysn Hassenforder
发明人： Paul R. Russell , Alysn Hassenforder
IPC分类号： A63B69/00 , A63B71/04 , A63B71/06
CPC分类号： A63B69/0053
摘要： A multidimensional equilateral angular game playing apparatus and method include electronically controlled, life-sized obelisk "opponents" in the vertex of each angle. A sound generator and multiple lighted targets are mounted upon variously angled surfaces of each obelisk so that a target becomes momentarily active when its light is illuminated and a sound generator mounted upon the obelisk holding the target is actuated. The sequence of targets presented to a player and the time duration of each activation may be selected in a random manner by electronic controls. A single player strikes activated targets using thrusting and sweeping motions of a double-sided, padded playing staff. Upon successfully striking a target, the sound generator upon which obelisk the target is mounted emits a tone verifying the success of the strike, a point is added to a total sum of successful strikes, the target is deactivated and the next target is immediately presented to the player. Therefore, the speed of the game changes according to the reaction time of each individual player. A score of successful target strikes and total number of targets presented are displayed to the player. Physical agility and stamina, mental concentration and an indomitable spirit are tested and cultivated by the game.
摘要翻译：多维等角角度游戏装置和方法包括在每个角度的顶点中的电子控制的，终身尺寸的方尖碑“对手”。声发生器和多个发光目标安装在每个方尖角的不同角度的表面上，使得当其照明时，目标变得瞬间有效，并且安装在保持目标的方尖碑上的声音发生器被致动。呈现给玩家的目标序列和每次激活的持续时间可以通过电子控制随机选择。一名单身球员使用双面，填充玩具的工作人员的推动和清扫动作打击激活的目标。当成功地击中目标时，安装目标的声音发生器发出一个验证罢工成功的音调，一个点被添加到成功击打的总和中，目标被停用，并且下一个目标被立即呈现给玩家。因此，游戏速度根据每个玩家的反应时间而变化。成功的目标罢工和所提出的目标总数的得分将显示给玩家。身体敏捷和耐力，精神集中和不屈不挠的精神都是通过游戏进行测试和培育的。

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