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1. 发明授权

US5112298A Apheresis method and device 失效
标题翻译：分离方法和装置
公开(公告)号：US5112298A
公开(公告)日：1992-05-12
申请号：US542846
申请日：1990-06-25
申请人： Paul R. Prince , William Miller , Grant S. Benjamin
发明人： Paul R. Prince , William Miller , Grant S. Benjamin
IPC分类号： A61M1/02 , A61M1/30 , A61M1/34
CPC分类号： A61M1/30 , A61M1/303 , A61M1/308 , A61M1/341 , A61M2205/3393
摘要： A simplified fluid separation method and device usable for various apheresis procedures, including plasmapheresis. At least one pump is utilized to draw a first fluid (e.g. whole blood) into a separation device. The separation device then operates to separate the fluid (e.g. whole blood) into first and second fluid fractions (e.g. a cell concentrate and blood plasma). The first and second fluid fractions are pumped from the separation device to separate first and second fluid fraction containers, both of which are positioned on a single weighing device, such as an electronic load cell. At least one of the fluid fractions is subsequently removed from its fluid fraction container and returned to the human subject or other fluid source. Weights recorded by the single weighing device are then utilized to calculate the actual weights of fluid and/or fluid fractions pumped by at least one pump during the procedure. Such actual weights of fluid and/or fluid fractions are then utilized to calculate new pump flow constants, thereby enabling the calibration of the pump(s) to be corrected, on the basis of such new pump flow constants, prior to subsequent utilization of the pump(s) for pumping the fluid and/or fluid fractions. The single weighing device may also be utilized to monitor the weight change or rate of weight change occurring as the fluid fractions are pumped into and/or out of the fluid fraction containers, thereby providing a means for monitoring and verifying the pressures and flow rates within the system.
摘要翻译：一种简化的流体分离方法和装置，可用于各种分离程序，包括血浆置换术。使用至少一个泵将第一流体（例如全血）吸入分离装置。分离装置然后操作以将流体（例如全血）分离成第一和第二流体部分（例如细胞浓缩物和血浆）。第一和第二流体馏分从分离装置泵送以分离第一和第二流体分馏容器，它们都位于单个称重装置上，例如电子称重传感器。随后从其流体馏分容器中除去至少一种流体馏分并返回到人类受试者或其他流体源。然后使用单个称重装置记录的重量来计算在该过程期间由至少一个泵泵送的流体和/或流体部分的实际重量。然后使用流体和/或流体部分的这种实际重量来计算新的泵流量常数，从而在随后利用所述泵流量常数之前，基于这种新的泵流量常数对泵的校准进行校正用于泵送流体和/或流体部分的泵。单个称重装置还可以用于监测当流体部分被泵入和/或流出流体部分容器时发生的重量变化或重量变化率，从而提供用于监测和验证内部压力和流速的装置系统。

2. 发明授权

US08485194B2 Oral airway 失效
标题翻译：口腔气道
公开(公告)号：US08485194B2
公开(公告)日：2013-07-16
申请号：US13550666
申请日：2012-07-17
申请人： Phillip Benjamin Guerra , Paul R. Prince
发明人： Phillip Benjamin Guerra , Paul R. Prince
IPC分类号： A61M11/00
CPC分类号： A61M16/0463 , A61M16/0486 , A61M16/0488 , A61M16/0493 , A61M16/0495 , A61M16/0666 , A61M16/0672 , A61M16/0816
摘要： An oral airway for insertion into a mouth and pharynx of a patient to provide a breathing pathway and for cooperating with either an anesthesia breathing connector, a suction tube, or a nasal cannula. The oral airway includes a first tubular member, a second tubular member disposed within the first tubular member, and a connector configured to securely attach to both the first tubular member and the second tubular member. The connector includes a first portion in fluid communication with the first tubular member and a second portion in fluid communication with the second tubular member.
摘要翻译：用于插入患者口腔和咽部以提供呼吸通路并用于与麻醉呼吸连接器，抽吸管或鼻插管配合的口腔气道。所述口腔气道包括第一管状构件，设置在所述第一管状构件内的第二管状构件和被构造成牢固地附接到所述第一管状构件和所述第二管状构件的连接器。连接器包括与第一管状构件流体连通的第一部分和与第二管状构件流体连通的第二部分。

3. 外观设计

USD680642S1 Oral airway 有权
标题翻译：口腔气道
公开(公告)号：USD680642S1
公开(公告)日：2013-04-23
申请号：US29415724
申请日：2012-03-13
申请人： Phillip B. Guerra , Paul R. Prince
设计人： Phillip B. Guerra , Paul R. Prince

4. 发明授权

US06568938B1 Drawing aid 失效
标题翻译：绘图辅助
公开(公告)号：US06568938B1
公开(公告)日：2003-05-27
申请号：US09717586
申请日：2000-11-21
申请人： Paul R. Prince , Mary Von Lortz
发明人： Paul R. Prince , Mary Von Lortz
IPC分类号： G09B1100
CPC分类号： G09B11/06 , G09B11/04
摘要： A system for sketching, illustrating, drawing or painting likeness compositions such as canvas oil paintings from source images includes a set of increasing size reusable overlayable source image grids with image composition frames used with corresponding destination canvas grid patterns, allowing a consistent grid pattern for all canvas sizes by using predetermined grid dimensions for each canvas size. The image grid patterns may be affixed to clear plastic sheets or may be software-generated patterns. This combination greatly simplifies the use of grids in artwork and provides low-cost timesaving methods to draw accurate perspective. The system includes a unique canvas grid ruler for simplifying generation of canvas grid lines and in some embodiments canvases are pre-printed or backside-shadowed with appropriate canvas grid patterns and labels.
摘要翻译：用于从源图像中绘制，绘制或绘制诸如帆布油画的相似组合的系统包括一组增加尺寸的可重复使用的可叠加源图像网格，其具有与相应的目的地画布网格图案一起使用的图像合成框架，从而允许所有的网格图案一致通过使用每个画布大小的预定网格尺寸来绘制画布大小。图像网格图案可以被固定到透明塑料片上，或者可以是软件生成的图案。这种组合大大简化了艺术品中网格的使用，并提供了低成本的节省时间的方法来绘制准确的视角。该系统包括用于简化画布网格线的生成的独特的画布网格标尺，并且在一些实施例中，使用适当的画布网格图案和标签预先打印或背面阴影画布。

5. 发明授权

US5178603A Blood extraction and reinfusion flow control system and method 失效
标题翻译：血液提取和再灌注流量控制系统及方法
公开(公告)号：US5178603A
公开(公告)日：1993-01-12
申请号：US556778
申请日：1990-07-24
申请人： Paul R. Prince
发明人： Paul R. Prince
IPC分类号： A61M1/02 , A61M1/26 , A61M1/30 , A61M1/36
CPC分类号： A61M1/30 , A61M1/262 , A61M1/303 , A61M1/308 , A61M1/3621 , A61M1/3639 , A61M1/3656 , A61M1/3643 , A61M2205/3344 , A61M2205/3351 , A61M2205/3355 , A61M2205/702 , A61M2205/705
摘要： A method and system for adaptively controlled withdrawal/infusion of a fluid, such as blood, to or from a fluid source, such as a blood vessel. An adaptive flow rate limit is established and periodically adjusted during the course of withdrawal/infusion so as to maximize and optimize the withdrawal/infusion rate while, at the same time, providing for rapid corrective adjustments in flow rate responsive to early indications of flow disruption, such as occlusion or collapse of the blood vessel during blood withdrawal. The method and system of the invention is particularly applicable to automated apheresis systems.
摘要翻译：用于自适应控制地将流体（例如血液）排出/输注到流体源（例如血管）或从流体源（例如血管）输入的方法和系统。在抽出/输注过程中建立适应性流量限制并进行周期性调整，以便最大限度地提高和优化提取/输注速率，同时提供响应早期流量中断的快速流量校正调整，例如在抽血期间血管的闭塞或塌陷。本发明的方法和系统特别适用于自动取样系统。

6. 发明授权

US4062070A Toilet urine deflector 失效
标题翻译：厕所尿液导流板
公开(公告)号：US4062070A
公开(公告)日：1977-12-13
申请号：US728874
申请日：1976-10-01
申请人： Paul R. Prince
发明人： Paul R. Prince
IPC分类号： E03D9/00 , E03D11/00
CPC分类号： E03D9/00
摘要： A toilet bowl system with a floating and self-rinsing deflector for receiving and noiselessly dispersing urine into the water located in the bottom of said toilet bowl.
摘要翻译：一种具有漂浮和自漂洗偏转器的马桶系统，用于接收并无噪声地将尿液分散在位于所述马桶的底部的水中。

7. 发明申请

US20130014754A1 Oral Airway 失效
标题翻译：口腔气道
公开(公告)号：US20130014754A1
公开(公告)日：2013-01-17
申请号：US13550666
申请日：2012-07-17
申请人： Phillip Guerra , Paul R. Prince
发明人： Phillip Guerra , Paul R. Prince
IPC分类号： A61M16/04 , A61M1/00 , A61M16/01
CPC分类号： A61M16/0463 , A61M16/0486 , A61M16/0488 , A61M16/0493 , A61M16/0495 , A61M16/0666 , A61M16/0672 , A61M16/0816
摘要： An oral airway for insertion into a mouth and pharynx of a patient to provide a breathing pathway and for cooperating with either an anesthesia breathing connector, a suction tube, or a nasal cannula. The oral airway includes a first tubular member, a second tubular member disposed within the first tubular member, and a connector configured to securely attach to both the first tubular member and the second tubular member. The connector includes a first portion in fluid communication with the first tubular member and a second portion in fluid communication with the second tubular member.
摘要翻译：用于插入患者口腔和咽部以提供呼吸通路并用于与麻醉呼吸连接器，抽吸管或鼻插管配合的口腔气道。所述口腔气道包括第一管状构件，设置在所述第一管状构件内的第二管状构件和被构造成牢固地附接到所述第一管状构件和所述第二管状构件的连接器。连接器包括与第一管状构件流体连通的第一部分和与第二管状构件流体连通的第二部分。

8. 发明授权

US5200090A Multiple fluid source isolation, metering and alarm system and method 失效
标题翻译：多流体源隔离，计量和报警系统及方法
公开(公告)号：US5200090A
公开(公告)日：1993-04-06
申请号：US769335
申请日：1991-10-01
申请人： Michael G. Ford , Paul R. Prince
发明人： Michael G. Ford , Paul R. Prince
IPC分类号： A61M1/34 , A61M5/168 , G01G17/04
CPC分类号： A61M1/3441 , A61M1/3451 , A61M5/16809 , G01G17/04 , A61M2205/3393 , A61M5/16845 , Y10S210/929
摘要： A system is provided for weighing and monitoring flow from multiple fluid sources into a flow system wherein incoming fluid is received in a weighing bag attached to a control system for monitoring the amount of fluid passed through the weighing bag and for preventing admission of air into the flow system. An alarm attached to the weighing bag warns when fluid in the weighing bag is approaching empty, so that the fluid in the weighing bag can be replenished from the fluid source before the weighing bag runs dry. If fluid in the weighing bag is not replenished, the system automatically shuts down.The fluid pump can be absolutely calibrated using the controlled admission of known amounts of fluid into the weighing bag so that the amount of fluid introduced into the flow system through the weighing bag can be calculated automatically.
摘要翻译：提供了一种用于称重和监测从多个流体源流入流动系统的系统，其中进入的流体被接收在附接到控制系统的称重袋中，用于监测通过称重袋的流体的量并防止空气进入流量系统称重袋附近的报警器警告当称重袋中的液体接近空时，使得称重袋内的液体可以在称重袋运行干燥之前从流体源中补充。如果称重袋中的液体未补充，系统将自动关闭。流体泵可以使用已知量的流体进入称重袋进行绝对校准，从而可以自动计算通过称重袋引入流量系统的流量。

9. 发明授权

US5069792A Adaptive filter flow control system and method 失效
标题翻译：自适应滤波器流量控制系统及方法
公开(公告)号：US5069792A
公开(公告)日：1991-12-03
申请号：US551598
申请日：1990-07-10
申请人： Paul R. Prince , William D. Callaway
发明人： Paul R. Prince , William D. Callaway
IPC分类号： A61M1/02 , A61M1/26 , A61M1/34 , B01D61/22
CPC分类号： A61M1/34 , A61M1/262 , B01D61/22
摘要： An adaptive filter concentrate flow control system and method includes a filter system, a pumping system driving feed fluid, concentrate and filtrate flowing through the filter system and a flow control system controlling the pumping system to maintain optimum filtrate flow rates or minimum feed flow rates along a control surface in a three dimensional transmembrane pressure--feed fluid rate--filtrate flow rate space. Actual sensed operating point data is used to locate the control surface so as to assure an optimized filtrate flow rate or minimized feed flow rate at which reversible blocking of the membrane has begun to occur without irreversible blocking or plugging. The system is advantageously employed to control and maximize the flow of plasma in a plasmapheresis system or to minimize the rate at which blood is withdrawn from a donor and introduced into the system while achieving a fixed rate of plasma flow.
摘要翻译：适应性过滤浓缩物流量控制系统和方法包括过滤系统，驱动进料流体的泵送系统，流过过滤系统的浓缩物和滤液以及控制泵送系统的流量控制系统，以保持最佳滤液流速或最小进料流速三维跨膜压力进料流体速率 - 滤液流量空间中的控制表面。实际检测到的工作点数据用于定位控制表面，以确保最佳滤液流速或最小化的进料流速，在此处开始膜的可逆阻塞而没有不可逆的阻塞或堵塞。该系统有利地用于控制和最大化血浆置换系统中的血浆的流动，或者最小化血液从供体中取出并被引入系统中的速率，同时实现固定的血浆流速。

10. 发明授权

US4769001A Method and apparatus for calibrating plural pump fluid flow system 失效
标题翻译：用于校准多个泵流体流动系统的方法和装置
公开(公告)号：US4769001A
公开(公告)日：1988-09-06
申请号：US802330
申请日：1985-11-27
申请人： Paul R. Prince
发明人： Paul R. Prince
IPC分类号： F04B49/06 , A61M1/00 , A61M1/10 , A61M1/14 , A61M1/16 , A61M1/34 , A61M1/36 , A61M37/00 , A61M1/03
CPC分类号： A61M1/3621 , A61M1/3639 , A61M1/3643 , A61M2205/50 , A61M2205/70 , Y10S128/13
摘要： A blood constituent processing system uses a disposable plastic fluid flow path into which an anticoagulant must be accurately metered with respect to pumped blood flow. In a preliminary calibration phase, a closed fluid flow path is provided between the anticoagulant pump and the blood pump. One of the pumps is then controlled to inject fluid into such closed path while the other pump is controlled to withdraw fluid from that path at what is nominally an equal fluid flow rate. Changes in fluid pressure within the closed fluid flow path are then monitored and the flow rate of at least one of the pumps is changed as necessary to achieve an approximately constant fluid pressure within the closed fluid flow path. The relative pump flow control required to achieve constant pressure may then be taken as a relative flow rate calibration between the two pumps so as to permit subsequent accurate pumped metering of anticoagulant into the pumped blood flow. A similar arrangement may be used to derive relative flow calibration constants for the blood pump and a packed cell pump also present in the blood constituent processing system.
摘要翻译：血液成分处理系统使用一次性塑料流体流动路径，相对于泵送的血液流量，必须精确地计量抗凝血剂。在初步校准阶段，在抗凝血泵和血液泵之间提供封闭的流体流路。然后控制其中一个泵将流体注入到这样的闭合路径中，而另一个泵被控制为以标称相等的流体流速从该路径中抽出流体。然后监测闭合流体流动路径内的流体压力的变化，并且根据需要改变至少一个泵的流量，以在闭合流体流动路径内实现近似恒定的流体压力。然后可以将实现恒定压力所需的相对泵流量控制作为两个泵之间的相对流量校准，以便允许将抗凝剂随后精确地泵送到泵送的血液流中。可以使用类似的布置来导出血泵和血液成分处理系统中也存在的填充细胞泵的相对流动校准常数。

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