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1. 发明授权

US07931893B2 Methods for producing and using in vivo pseudotyped retroviruses using envelope glycoproteins from lymphocytic choriomeningitis virus (LCMV) 有权
标题翻译：使用来自淋巴细胞性脉络丛脑膜炎病毒（LCMV）的包膜糖蛋白来生产和使用体内假型逆转录病毒的方法
公开(公告)号：US07931893B2
公开(公告)日：2011-04-26
申请号：US12137316
申请日：2008-06-11
申请人： Paul B. McCray, Jr. , Beverly L. Davidson , Colleen Stein
发明人： Paul B. McCray, Jr. , Beverly L. Davidson , Colleen Stein
IPC分类号： A01N63/00 , A61K48/00 , C12N7/00 , C12N15/63
CPC分类号： C12N15/86 , A61K48/00 , C07K14/005 , C12N2740/15043 , C12N2740/15045 , C12N2760/10022 , C12N2810/6072
摘要： The present invention provides novel pseudotyped retroviral vectors that can transduce human and other cells. Vectors are provided that are packaged efficiently in packaging cells and cell lines to generate high titer recombinant virus stocks expressing novel envelope glycoproteins. The present invention further relates to compositions for gene therapy.
摘要翻译：本发明提供可以转导人和其他细胞的新型假型逆转录病毒载体。提供了在包装细胞和细胞系中有效包装以产生表达新的包膜糖蛋白的高效价重组病毒原种的载体。本发明还涉及用于基因治疗的组合物。

2. 发明申请

US20090118212A1 METHODS FOR PRODUCING AND USING IN VIVO PSEUDOTYPED RETROVIRUSES 审中-公开
标题翻译：用于生产和使用VIVO PSEUDOTYPED RETROVIRUSUS的方法
公开(公告)号：US20090118212A1
公开(公告)日：2009-05-07
申请号：US11943871
申请日：2007-11-21
申请人： Beverly L. Davidson , Paul B. McCray, JR.
发明人： Beverly L. Davidson , Paul B. McCray, JR.
IPC分类号： A61K31/7088 , C12N5/06
CPC分类号： C12N15/85 , A61K48/00 , C12N15/86 , C12N15/867 , C12N2015/8518 , C12N2710/14022 , C12N2740/15043 , C12N2740/15045 , C12N2800/107 , C12N2810/60
摘要： The present invention provides novel pseudotyped retroviral vectors that can transduce human and other cells. Vectors are provided that are packaged efficiently in packaging cells and cell lines to generate high titer recombinant virus stocks expressing novel envelope glycoproteins. The present invention further relates to compositions for gene therapy.
摘要翻译：本发明提供可以转导人和其他细胞的新型假型逆转录病毒载体。提供了在包装细胞和细胞系中有效包装以产生表达新的包膜糖蛋白的高效价重组病毒原种的载体。本发明还涉及用于基因治疗的组合物。

3. 发明授权

US07439066B2 Methods for producing and using in vivo pseudotyped retroviruses using envelope glycoproteins from lymphocytic choriomeningitis virus (LCMV) 有权
标题翻译：使用来自淋巴细胞性脉络丛脑膜炎病毒（LCMV）的包膜糖蛋白来生产和使用体内假型逆转录病毒的方法
公开(公告)号：US07439066B2
公开(公告)日：2008-10-21
申请号：US11593963
申请日：2006-11-07
申请人： Paul B. McCray, Jr. , Beverly L. Davidson , Colleen Stein
发明人： Paul B. McCray, Jr. , Beverly L. Davidson , Colleen Stein
IPC分类号： C12N15/87 , C12N15/88 , C12N15/867 , C12N5/10 , A61K48/00
CPC分类号： C12N15/86 , A61K48/00 , C07K14/005 , C12N2740/15043 , C12N2740/15045 , C12N2760/10022 , C12N2810/6072
摘要： The present invention provides novel pseudotyped retroviral vectors that can transduce human and other cells. Vectors are provided that are packaged efficiently in packaging cells and cell lines to generate high titer recombinant virus stocks expressing novel envelope glycoproteins. The present invention further relates to compositions for gene therapy.
摘要翻译：本发明提供可以转导人和其他细胞的新型假型逆转录病毒载体。提供了在包装细胞和细胞系中有效包装以产生表达新的包膜糖蛋白的高效价重组病毒原种的载体。本发明还涉及用于基因治疗的组合物。

4. 发明申请

US20080260693A1 METHODS FOR PRODUCING AND USING IN VIVO PSEUDOTYPED RETROVIRUSES USING ENVELOPE GLYCOPROTEINS FROM LYMPHOCYTIC CHORIOMENINGITIS VIRUS (LCMV) 有权
标题翻译：使用来自淋巴细胞感染性病毒（LCMV）的包膜糖蛋白生产和使用生殖细胞退行性病毒的方法
公开(公告)号：US20080260693A1
公开(公告)日：2008-10-23
申请号：US12137316
申请日：2008-06-11
申请人： Paul B. McCray, Jr. , Beverly L. Davidson , Colleen Stein
发明人： Paul B. McCray, Jr. , Beverly L. Davidson , Colleen Stein
IPC分类号： A61K35/76 , C12N15/86
CPC分类号： C12N15/86 , A61K48/00 , C07K14/005 , C12N2740/15043 , C12N2740/15045 , C12N2760/10022 , C12N2810/6072
摘要： The present invention provides novel pseudotyped retroviral vectors that can transduce human and other cells. Vectors are provided that are packaged efficiently in packaging cells and cell lines to generate high titer recombinant virus stocks expressing novel envelope glycoproteins. The present invention further relates to compositions for gene therapy.
摘要翻译：本发明提供可以转导人和其他细胞的新型假型逆转录病毒载体。提供了在包装细胞和细胞系中有效包装以产生表达新的包膜糖蛋白的高效价重组病毒原种的载体。本发明还涉及用于基因治疗的组合物。

5. 发明授权

US07160727B2 Methods for producing and using in vivo pseudotyped retroviruses using envelope glycoproteins from lymphocytic choriomeningitis virus (LCMV) 有权
标题翻译：使用来自淋巴细胞性脉络丛脑膜炎病毒（LCMV）的包膜糖蛋白来生产和使用体内假型逆转录病毒的方法
公开(公告)号：US07160727B2
公开(公告)日：2007-01-09
申请号：US10993319
申请日：2004-11-19
申请人： Paul B. McCray, Jr. , Beverly L. Davidson , Colleen Stein
发明人： Paul B. McCray, Jr. , Beverly L. Davidson , Colleen Stein
IPC分类号： C12N15/867 , C12N15/63 , C12N15/64 , A61K48/00
CPC分类号： C12N15/86 , A61K48/00 , C07K14/005 , C12N2740/15043 , C12N2740/15045 , C12N2760/10022 , C12N2810/6072
摘要： The present invention provides novel pseudotyped retroviral vectors that can transduce human and other cells. Vectors are provided that are packaged efficiently in packaging cells and cell lines to generate high titer recombinant virus stocks expressing novel envelope glycoproteins. The present invention further relates to compositions for gene therapy.
摘要翻译：本发明提供可以转导人和其他细胞的新型假型逆转录病毒载体。提供了在包装细胞和细胞系中有效包装以产生表达新的包膜糖蛋白的高效价重组病毒原种的载体。本发明还涉及用于基因治疗的组合物。

6. 发明授权

US07135339B2 Methods for producing and using in vivo pseudotyped retroviruses using envelope glycoproteins from lymphocytic choriomeningitis virus (LCMV) 有权
标题翻译：使用来自淋巴细胞性脉络丛脑膜炎病毒（LCMV）的包膜糖蛋白来生产和使用体内假型逆转录病毒的方法
公开(公告)号：US07135339B2
公开(公告)日：2006-11-14
申请号：US10718262
申请日：2003-11-20
申请人： Paul B. McCray, Jr. , Beverly L. Davidson
发明人： Paul B. McCray, Jr. , Beverly L. Davidson
IPC分类号： C12N5/10 , C12N15/867 , C12N15/63 , C12N15/64 , C12N15/40 , A61K48/00
CPC分类号： C12N15/86 , A61K48/00 , C07K14/005 , C12N2740/15043 , C12N2740/15045 , C12N2760/10022 , C12N2810/6072
摘要： The present invention provides novel pseudotyped retroviral vectors that can transduce human and other cells. Vectors are provided that are packaged efficiently in packaging cells and cell lines to generate high titer recombinant virus stocks expressing novel envelope glycoproteins. The present invention further relates to compositions for gene therapy.
摘要翻译：本发明提供可以转导人和其他细胞的新型假型逆转录病毒载体。提供了在包装细胞和细胞系中有效包装以产生表达新的包膜糖蛋白的高效价重组病毒原种的载体。本发明还涉及用于基因治疗的组合物。

7. 发明授权

US08227592B2 Alternative export pathways for vector expressed RNA interference 有权
标题翻译：用于载体表达的RNA干扰的替代出口途径
公开(公告)号：US08227592B2
公开(公告)日：2012-07-24
申请号：US12515717
申请日：2007-11-28
申请人： Scott Harper , Beverly L. Davidson
发明人： Scott Harper , Beverly L. Davidson
IPC分类号： C07H21/04 , C07H21/02 , C12N15/63 , C12N15/85 , A61K35/00
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2310/141 , C12N2310/53 , C12N2310/531 , C12N2320/50
摘要： The present invention is directed to nucleic acid molecules containing a loop sequence designed to circumvent exportin-5 mediated export, and methods using these novel molecules.
摘要翻译：本发明涉及含有设计用于规避出口5介导出口的环序列的核酸分子，以及使用这些新分子的方法。

8. 发明授权

US06635466B2 Adenovirus serotype 30 (Ad30) 失效
公开(公告)号：US06635466B2
公开(公告)日：2003-10-21
申请号：US09758008
申请日：2001-01-09
申请人： Beverly L. Davidson , Lane K. Law
发明人： Beverly L. Davidson , Lane K. Law
IPC分类号： C12N701
CPC分类号： C07K14/005 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N15/86 , C12N2710/10322 , C12N2710/10344 , C12N2810/6018
摘要： The present invention provides an adenovirus serotype 30 (Ad30) fiber amino acid sequence. The present invention also provides polynucleotides and expression vectors encoding an Ad30 fiber and viral particles and cells containing such expression vectors. The present invention further provides methods of treating genetic diseases or cancers in a mammal using the polynucleotides, polypeptides, expression vectors, viral particles and cells of the present invention.

9. 发明授权

US6048551A Microsphere encapsulation of gene transfer vectors 失效
标题翻译：微球包裹基因转移载体
公开(公告)号：US6048551A
公开(公告)日：2000-04-11
申请号：US824997
申请日：1997-03-27
申请人： John M. Hilfinger , Beverly L. Davidson , Steven J. Beer , John R. Crison , Gordon L. Amidon
发明人： John M. Hilfinger , Beverly L. Davidson , Steven J. Beer , John R. Crison , Gordon L. Amidon
IPC分类号： A61K9/16 , B01J13/02 , A61K9/50 , A61F2/02 , B32B5/16
CPC分类号： B01J13/02 , A61K9/1647 , Y10T428/2985
摘要： A controlled release delivery system includes a functional gene vector in a biodegradable polymeric microsphere encapsulating the vector. The present invention further provides a method of making a controlled release delivery system by encapsulating the functional gene vector in a biologically degradable polymeric microsphere.
摘要翻译：控制释放递送系统包括封装载体的生物可降解聚合物微球中的功能基因载体。本发明还提供了通过将功能基因载体包封在生物可降解聚合物微球体中来制备控制释放递送系统的方法。

10. 发明授权

US5747072A Adenoviral-mediated gene transfer to synovial cells in vivo 失效
标题翻译：腺病毒介导的基因转移到体内滑膜细胞
公开(公告)号：US5747072A
公开(公告)日：1998-05-05
申请号：US422655
申请日：1995-04-14
申请人： Beverly L. Davidson , Blake J. Roessler
发明人： Beverly L. Davidson , Blake J. Roessler
IPC分类号： A61K38/20 , A61K48/00 , C07K14/54 , C12N15/09 , C12N15/63
CPC分类号： C07K14/54 , A61K38/00 , A61K48/00 , C12N2799/022
摘要： This invention provides recombinant adenoviral vectors having an expression control sequence operatively linked to a gene that encodes an anti-inflammatory polypeptide or that produces on transcription an anti-inflammatory ribozyme or antisense RNA molecule. This invention also provides methods of transferring a gene to a synovial cell by transducing the synovial cell in vivo, with a recombinant adenoviral vector. This invention also provides methods of treating an inflammatory condition in the joint of a subject comprising administering to the joint a therapeutically effective amount of a recombinant adenoviral vector having an expression control sequence operatively linked to a gene that encodes an anti-inflammatory polypeptide or that produces on transcription an anti-inflammatory ribozyme or antisense RNA molecule.
摘要翻译：本发明提供重组腺病毒载体，其具有与编码抗炎多肽或在转录上产生抗炎核酶或反义RNA分子的基因有效连接的表达调控序列。本发明还提供了通过用体内重组腺病毒载体转导滑膜细胞将基因转移至滑膜细胞的方法。本发明还提供了治疗受试者关节炎症状况的方法，包括给予关节治疗有效量的重组腺病毒载体，所述重组腺病毒载体具有与编码抗炎多肽的基因有效连接的表达调控序列，或产生转录为抗炎核酶或反义RNA分子。

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